50 Participants Needed

Mixed Spices for Memory

HZ
Overseen ByHila Zelicha, RD PHD
Age: 18+
Sex: Any
Trial Phase: Academic
Sponsor: University of California, Los Angeles

What You Need to Know Before You Apply

What is the purpose of this trial?

This trial aims to determine if a mix of spices can improve memory and brain health in individuals experiencing mild memory decline due to aging. Researchers believe that combining several spices may be more effective than using just one. Participants will take either spice capsules or a placebo (a harmless pill with no active ingredients) daily for three months. Individuals with mild memory issues, but not dementia, who do not regularly consume large amounts of spices might be suitable for this trial. The study will assess changes in memory, fatigue, and mood to evaluate the spices' effectiveness. As an unphased trial, this study offers a unique opportunity to explore natural ways to support brain health.

Will I have to stop taking my current medications?

The trial does not specify if you need to stop taking your current medications. However, if you are taking any medication or dietary supplement that interferes with the absorption of polyphenols, you may not be eligible to participate.

What prior data suggests that this spice mixture is safe for memory enhancement?

Research shows that spices like saffron, turmeric, and cinnamon may help protect memory and improve brain health. Studies have found that these spices can reduce swelling and protect cells from damage due to their anti-inflammatory and antioxidant properties.

Although specific safety data on the exact spice mix used in this trial is unavailable, spices are generally safe when used in normal cooking amounts. Since the study uses similar amounts, side effects are not expected. However, participants should always pay attention to how they feel when trying something new.12345

Why are researchers excited about this trial?

Researchers are excited about the mixed spice treatment for memory enhancement because it taps into the potential cognitive benefits of natural spices, which are not a focus in conventional memory treatments. Unlike standard medications that often target specific neurotransmitters or brain chemicals, this approach harnesses the unique properties of various spices, which may offer a broader, more holistic impact on brain health. Additionally, using a dietary approach like mixed spices could present fewer side effects compared to pharmaceuticals, making it a potentially safer and more accessible option for improving memory.

What evidence suggests that mixed spice consumption might be an effective treatment for age-related mild cognitive decline?

Research shows that certain spices might help maintain brain health and combat memory loss with age. Studies have found that spices like turmeric, cinnamon, and saffron can protect memory due to their antioxidants, which prevent cell damage, and anti-inflammatory effects, which reduce swelling and irritation in the body. Although evidence is limited, it suggests that these spices might enhance thinking skills, especially when combined. This trial will test the effects of mixed spice consumption on memory, comparing it to a placebo. While more detailed human research continues, early results are promising for preserving brain health as people age.12467

Who Is on the Research Team?

ZL

Zhaoping Li

Principal Investigator

University of California, Los Angeles

Are You a Good Fit for This Trial?

This trial is for adults aged 50-80 experiencing mild cognitive decline due to aging, but not suffering from dementia or major neurocognitive disorders. Participants will be given either a spice mixture or a placebo daily for three months and monitored for an additional three months.

Inclusion Criteria

My cognitive issues are due to normal aging or mild cognitive impairment.
I can see and hear well enough for brain function tests.
Screening laboratory tests without significant abnormalities that might interfere with the study
See 1 more

Exclusion Criteria

Current diagnosis of any major psychiatric disorder according to the DSM-IV TR criteria
Frequently using prebiotics, probiotics, yogurt, and/or any fiber supplements
I have a condition that could cause my thinking or memory to get worse.
See 7 more

Timeline for a Trial Participant

Screening

Participants are screened for eligibility to participate in the trial

2-4 weeks

Treatment

Participants are randomized to receive either 4.00 g spice mixture capsules or 4.00 g maltodextrin capsules daily

12 weeks
Visits at baseline, 6, 12, and 24 weeks

Sustainability Assessment

Exploration of the sustainable effect of the treatment over an additional 3 months

12 weeks

Follow-up

Participants are monitored for safety and effectiveness after treatment

4 weeks

What Are the Treatments Tested in This Trial?

Interventions

  • Mixed Spice Consumption
Trial Overview The study tests if consuming a mix of spices known for memory protection can improve cognitive function in older adults. It compares the effects of daily intake of spice capsules against placebo over six months, focusing on cognition, fatigue, and mood.
How Is the Trial Designed?
2Treatment groups
Active Control
Placebo Group
Group I: Mixed spicesActive Control1 Intervention
Group II: PlaceboPlacebo Group1 Intervention

Find a Clinic Near You

Who Is Running the Clinical Trial?

University of California, Los Angeles

Lead Sponsor

Trials
1,594
Recruited
10,430,000+

Citations

Effect of Daily Mixed Spice Consumption on Memory ...Recent research has indicated that various spices may hold the key to enhancing brain health and combating the effects of aging on cognitive ...
Effect of Daily Mixed Spice Consumption on Memory ...In this study, the effects of spice mixture will be evaluated, as well as their anti-oxidant, and anti-inflammatory properties. The proposed ...
Potential Benefit of Spices for Improving Mental HealthEvidence is limited and less consistent linking intakes of these 3 spices to improvements in cognitive function domains.
Mixed Spice Capsules for Memory in Age-related Cognitive ...This study investigates whether consuming a mix of spices can improve memory in middle-aged and older adults experiencing normal age-related ...
Possible Role of Common Spices as a Preventive and ...In this article, we review the role and application of five commonly used dietary spices including saffron turmeric, pepper family, zingiber, and cinnamon.
Mixed Spices for MemoryTrial Overview The study tests if consuming a mix of spices known for memory protection can improve cognitive function in older adults. It compares the effects ...
Neuroprotective Effect of Spice Oleoresins on Memory and ...This study investigates the effect of pepper, chili, and turmeric oleoresins in Alzheimer's type of cognitive impairment in the rat model.
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