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Negative Emotions Impact on Decision-Making

N/A
Recruiting
Led By Silvia Lopez Guzman, M.D.
Research Sponsored by National Institute of Mental Health (NIMH)
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial
Must have
Males and females; Age 18 to 55.
Be between 18 and 65 years old
Timeline
Screening 3 weeks
Treatment Varies
Follow Up right after intervention
Awards & highlights

Study Summary

This trial will study how negative emotions affect thinking and decision-making in healthy people to better understand mental disorders.

Who is the study for?
Healthy adults aged 18 to 55 who can understand and sign consent, read and write English. Excluded are those using psychoactive drugs or corticosteroids, pregnant women, NIMH staff/family, people with chronic pain or metal in the body that affects MRI scans, left-handed individuals for certain tests, and anyone with medical conditions affecting the study.Check my eligibility
What is being tested?
The trial studies how negative emotions like stress, pain, and craving influence decision-making. Participants undergo emotional stressors (videos, math problems, heat/cold exposure), fill out questionnaires about their state of mind and personality traits while some also perform tasks during an fMRI brain scan.See study design
What are the potential side effects?
There may not be direct side effects from the interventions as they involve non-invasive procedures such as watching videos or solving arithmetic problems. However discomfort from heat application or cold immersion could occur.

Eligibility Criteria

Inclusion Criteria

You may be eligible if you check “Yes” for the criteria below
Select...
I am between 18 and 55 years old.

Timeline

Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~right after intervention
This trial's timeline: 3 weeks for screening, Varies for treatment, and right after intervention for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.
Primary outcome measures
BOLD signal in decision-making areas ROI
Value-based decision-making metrics
Secondary outcome measures
Confidence
Interoceptive accuracy

Trial Design

5Treatment groups
Experimental Treatment
Group I: 5Experimental Treatment1 Intervention
within-subjects experimental study, where each subject will receive a neutral state and a negative state induction intervention in a cross-over design (counterbalanced order across participants).
Group II: 4Experimental Treatment1 Intervention
within-subjects experimental study, where each subject will receive a neutral state and a negative state induction intervention in a cross-over design (counterbalanced order across participants).
Group III: 3Experimental Treatment1 Intervention
within-subjects experimental study, where each subject will receive a neutral state and a negative state induction intervention in a cross-over design (counterbalanced order across participants).
Group IV: 2Experimental Treatment1 Intervention
within-subjects experimental study, where each subject will receive a neutral state and a negative state induction intervention in a cross-over design (counterbalanced order across participants).
Group V: 1Experimental Treatment1 Intervention
within-subjects experimental study, where each subject will receive a neutral state and a negative state induction intervention in a cross-over design (counterbalanced order across participants).

Find a Location

Who is running the clinical trial?

National Institute of Mental Health (NIMH)Lead Sponsor
2,783 Previous Clinical Trials
2,688,227 Total Patients Enrolled
5 Trials studying Emotions
581 Patients Enrolled for Emotions
Silvia Lopez Guzman, M.D.Principal InvestigatorNational Institute of Mental Health (NIMH)

Media Library

3 Clinical Trial Eligibility Overview. Trial Name: NCT05666726 — N/A
Emotions Research Study Groups: 3, 1, 4, 2, 5
Emotions Clinical Trial 2023: 3 Highlights & Side Effects. Trial Name: NCT05666726 — N/A
3 2023 Treatment Timeline for Medical Study. Trial Name: NCT05666726 — N/A

Frequently Asked Questions

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

Is the required age for participating in this experiment above fifty-five years?

"This medical experiment is seeking volunteers aged between 18 to 55 years old."

Answered by AI

Are there any open enrollment opportunities for this experiment?

"Reports on clinicaltrials.gov indicate that, while initially posted on the 3rd of January 2023 and most recently updated on 28 December 2022, this medical trial is not seeking participants at present. There are however, 508 other trials actively recruiting patients right now."

Answered by AI

What type of participants is this trial seeking?

"This research study is seeking 900 participants between the ages of 18 and 55 who have some degree of pain. To be considered, they must meet certain prerequisites: demonstrate comprehension by signing a written informed consent document, identify as male or female within this age bracket, possess fluency in English to comprehend verbal and written instructions provided in English language."

Answered by AI
Recent research and studies
clinicaltrials.govStudy
State-dependent Interoception, Value-based Decision-making, and Introspection
2023. "State-dependent Interoception, Value-based Decision-making, and Introspection". ClinicalTrials.gov. https://clinicaltrials.gov/ct2/show/NCT05666726.
~600 spots leftby Dec 2026
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