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Aromatase Inhibitor
Letrozole for Breast Cancer
Phase 4
Waitlist Available
Led By Meghan R. Flanagan
Research Sponsored by University of Washington
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial Must have
Be older than 18 years old
Timeline
Screening 3 weeks
Treatment Varies
Follow Up up to 9 months after surgery
Awards & highlights
Study Summary
This trial examines if a mutation in the HSD3B1 gene affects the efficacy of letrozole in treating stage I-III breast cancer.
Eligible Conditions
- Breast Cancer
Timeline
Screening ~ 3 weeks3 visits
Treatment ~ Varies
Follow Up ~ before (baseline) and up to 9 months after surgery
Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~before (baseline) and up to 9 months after surgery
Treatment Details
Study Objectives
Outcome measures can provide a clearer picture of what you can expect from a treatment.Primary outcome measures
Changes in ER beta
Changes in Ki67
Changes in estrogen receptor (ER)alpha
+4 moreSide effects data
From 2018 Phase 4 trial • 79 Patients • NCT0213753810%
Fracture
8%
Acne
5%
Scoliosis
3%
Hair loss
3%
Sacroiliitis
3%
Neuro event
100%
80%
60%
40%
20%
0%
Study treatment Arm
Anastrozole
Letrozole
Trial Design
1Treatment groups
Experimental Treatment
Group I: Treatment (letrozole)Experimental Treatment3 Interventions
Patients receive letrozole PO QD for 21 days in the absence of disease progression or unacceptable toxicity. Patients also undergo collection of saliva samples. If tumor resection occurs before or after day 22, letrozole administration must occur for a minimum of 14 days and a maximum of 70 days of total treatment.
Treatment
First Studied
Drug Approval Stage
How many patients have taken this drug
Biospecimen Collection
2004
Completed Phase 2
~1730
Letrozole
2002
Completed Phase 4
~3240
Find a Location
Who is running the clinical trial?
University of WashingtonLead Sponsor
1,738 Previous Clinical Trials
1,844,291 Total Patients Enrolled
20 Trials studying Breast Cancer
3,253 Patients Enrolled for Breast Cancer
National Cancer Institute (NCI)NIH
13,655 Previous Clinical Trials
40,933,159 Total Patients Enrolled
940 Trials studying Breast Cancer
1,543,360 Patients Enrolled for Breast Cancer
Meghan R. FlanaganPrincipal InvestigatorFred Hutch/University of Washington Cancer Consortium
Frequently Asked Questions
These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.
What is the total sample size for this clinical research?
"Affirmative. According to information posted on clinicaltrials.gov, this medical research is actively enrolling patients as of October 19th 2022. The study was initially announced on January 23rd and requires 60 participants from one location."
Answered by AI
What potential adverse reactions have been associated with Letrozole?
"As this treatment is approved, the safety of Letrozole was assessed as a 3 on our 1 to 3 scale."
Answered by AI
Are there any opportunities remaining to partake in this experiment?
"Clinicaltrials.gov attests that this medical experiment is presently seeking participants, having been posted on January 23rd 2022 and last updated on October 19th 2022."
Answered by AI
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