10 Participants Needed

Saskatoon Berries for Blood Sugar Management in Healthy Individuals

GX
AH
Overseen ByAmy Hui
No Placebo GroupAll trial participants will receive the active study treatment (no placebo)

Trial Summary

Will I have to stop taking my current medications?

The trial does not specify if you need to stop taking your current medications, but it excludes people who are taking medications for diabetes, cholesterol, or blood pressure.

What data supports the effectiveness of the treatment Saskatoon berry powder for blood sugar management?

Research shows that certain berries, including those similar to Saskatoon berries, contain compounds that can help lower blood sugar levels by reducing the digestion and absorption of starches. These compounds, like phenolic acids and anthocyanins, have been found to improve blood sugar control in various studies.12345

How does Saskatoon berry powder differ from other treatments for blood sugar management?

Saskatoon berry powder is unique because it is a natural treatment rich in antioxidants like anthocyanins and flavonoids, which help regulate blood sugar by improving glucose metabolism and reducing inflammation. Unlike standard drugs, it also supports gut health and has fewer side effects, making it a promising alternative for managing blood sugar levels.678910

What is the purpose of this trial?

The glycemic index (GI) ranks carbohydrate-containing foods based on their effect on postprandial blood glucose levels. Foods or food products with lower GI values (55 or less) are absorbed more slowly, gradually increasing blood glucose and insulin levels. Fruits are believed to have a lower GI, making them potentially beneficial for individuals seeking to manage blood sugar levels. Previous studies from our and other groups suggest that Saskatoon berry (SB) is a potential functional food for glucose management. The glycemic index (GI) of dried SB powder and whole fruit remains undetermined, limiting our ability to make precise dietary recommendations. This study aims to evaluate the GI in both whole fruit and powder forms of SB. The determination of GI on SB products allows us to provide evidence-based guidance for healthcare providers when recommending SB as a functional food for glucose control.

Eligibility Criteria

This trial is for healthy volunteers interested in helping assess the impact of dried Saskatoon berries and their powder on blood sugar levels. Participants should be generally healthy without any major medical conditions.

Inclusion Criteria

I am in good health.
Signed informed consent

Exclusion Criteria

Body Mass Index (BMI) >= 30 kg/m²
I have a history of diabetes, high cholesterol, and high blood pressure.
I am on medication for diabetes, cholesterol, or blood pressure.

Timeline

Screening

Participants are screened for eligibility to participate in the trial

2-4 weeks

Treatment

Participants consume either Saskatoon berry powder or whole fruit and undergo blood glucose monitoring

4 weeks
3 visits (in-person)

Follow-up

Participants are monitored for safety and effectiveness after treatment

2 weeks

Treatment Details

Interventions

  • Saskatoon berry powder
Trial Overview The study is testing how dried Saskatoon berry powder affects blood glucose after eating. It measures the glycemic index, which shows how quickly foods raise blood sugar, to provide dietary recommendations for managing glucose.
Participant Groups
2Treatment groups
Experimental Treatment
Group I: SB powderExperimental Treatment1 Intervention
Volunteers drink 25 g of SB powder (25g carbohydrate equivalent) with 250ml water (consumption within 10 minutes)
Group II: Dried whole SB fruitExperimental Treatment1 Intervention
Volunteers intake Dried whole SB fruit (25g carbohydrate equivalent) within 20 minutes. Participants have option to choose intake one or both SB products. One week interval is required between the interventions.

Find a Clinic Near You

Who Is Running the Clinical Trial?

University of Manitoba

Lead Sponsor

Trials
628
Recruited
209,000+

Findings from Research

In a randomized crossover trial with 20 postmenopausal women, high-fiber rye bread significantly increased acute insulin response compared to white-wheat bread, suggesting it may enhance insulin secretion.
Despite the increase in insulin response, high-fiber rye bread did not change insulin sensitivity, indicating that while it may improve beta cell function, it does not affect how the body responds to insulin in this population.
High-fiber rye bread and insulin secretion and sensitivity in healthy postmenopausal women.Juntunen, KS., Laaksonen, DE., Poutanen, KS., et al.[2022]
In a study with male Wistar rats, adding Saskatoon berry powder to a high-carbohydrate, high-fat diet for 8 weeks significantly improved symptoms of diet-induced metabolic syndrome, including normalizing body weight, reducing visceral fat, and lowering blood pressure.
Saskatoon berry appears to enhance metabolic health by regulating key metabolic processes such as glycolysis and gluconeogenesis, as indicated by changes in liver enzyme expression and improved glucose tolerance.
Saskatoon Berry Amelanchier alnifolia Regulates Glucose Metabolism and Improves Cardiovascular and Liver Signs of Diet-Induced Metabolic Syndrome in Rats.du Preez, R., Wanyonyi, S., Mouatt, P., et al.[2021]
High consumption of berries, particularly bilberries and saskatoon berries, is associated with a reduced risk of cardiovascular diseases and other health issues due to their rich content of bioactive compounds like flavonoids and anthocyanins.
Recent studies suggest that these berries may improve cardiovascular risk factors, especially dyslipidemia, which is a key contributor to the development of atherosclerosis and cardiovascular disease.
Phytonutrients of bilberry fruit and saskatoon berry in the prevention and treatment of dyslipidemia.Kopčeková, J., Mrázová, J.[2022]

References

High-fiber rye bread and insulin secretion and sensitivity in healthy postmenopausal women. [2022]
Phytochemical composition and metabolic performance-enhancing activity of dietary berries traditionally used by Native North Americans. [2021]
Flavonoid-rich beverage effects on lipid profile and blood pressure in diabetic patients. [2020]
Berries reduce postprandial insulin responses to wheat and rye breads in healthy women. [2023]
Wild Strawberry, Blackberry, and Blueberry Leaf Extracts Alleviate Starch-Induced Hyperglycemia in Prediabetic and Diabetic Mice. [2020]
Saskatoon Berry Amelanchier alnifolia Regulates Glucose Metabolism and Improves Cardiovascular and Liver Signs of Diet-Induced Metabolic Syndrome in Rats. [2021]
Bioactive Components and Health Benefits of Saskatoon Berry. [2021]
Phytonutrients of bilberry fruit and saskatoon berry in the prevention and treatment of dyslipidemia. [2022]
Dose-Responses Relationship in Glucose Lowering and Gut Dysbiosis to Saskatoon Berry Powder Supplementation in High Fat-High Sucrose Diet-Induced Insulin Resistant Mice. [2021]
10.United Statespubmed.ncbi.nlm.nih.gov
Phenolics and antioxidant activity of Saskatoon berry (Amelanchier alnifolia) pomace extract. [2014]
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