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What is Xenical
OrlistatThe Generic name of this drug
Treatment SummaryOrlistat is a medication used to treat obesity. It works by blocking the body’s absorption of fat from food. It was approved by the FDA in 1999 and can be obtained over-the-counter or by prescription, depending on the dose. Orlistat is generally a safe and effective weight loss aid and is used in combination with a reduced-calorie diet.
Alliis the brand name
Xenical Overview & Background
Brand Name
Generic Name
First FDA Approval
How many FDA approvals?
Alli
Orlistat
2007
6
Effectiveness
How Xenical Affects PatientsOrlistat helps people lose and maintain weight by preventing the body from absorbing dietary fats. It does this by blocking the enzymes (lipase) that help break down fats.
How Xenical works in the bodyOrlistat is a drug that blocks the digestion of fat. It works by binding to the enzymes in the stomach and intestines that break down fat molecules. When orlistat is taken with food, it prevents some of the fat from being absorbed by the body, which can lead to weight loss.
When to interrupt dosage
The recommended dosage of Xenical is contingent upon the determined condition, like Weight Reduction, Unintentional Weight Loss and Obesity. The quantity of dosage fluctuates based on the procedure of delivery delineated in the table below.Condition
Dosage
Administration
BMI >27 kg/m2
, 120.0 mg, 27.0 mg, 60.0 mg
, Oral, Capsule - Oral, Capsule, Tablet, chewable, Tablet, chewable - Oral
Obesity
, 120.0 mg, 27.0 mg, 60.0 mg
, Oral, Capsule - Oral, Capsule, Tablet, chewable, Tablet, chewable - Oral
Obesity
, 120.0 mg, 27.0 mg, 60.0 mg
, Oral, Capsule - Oral, Capsule, Tablet, chewable, Tablet, chewable - Oral
Caloric Restriction
, 120.0 mg, 27.0 mg, 60.0 mg
, Oral, Capsule - Oral, Capsule, Tablet, chewable, Tablet, chewable - Oral
Weight Reduction
, 120.0 mg, 27.0 mg, 60.0 mg
, Oral, Capsule - Oral, Capsule, Tablet, chewable, Tablet, chewable - Oral
Warnings
Xenical has six contraindications and should not be administered in unison with the conditions provided in the following table.Xenical ContraindicationsCondition
Risk Level
Notes
Malabsorption Syndrome
Do Not Combine
Pulse Frequency
Do Not Combine
Malabsorption
Do Not Combine
known hypersensitivity to the drug or any of the ingredients
Do Not Combine
Not overweight
Do Not Combine
Cholestasis
Do Not Combine
Common Xenical Drug Interactions
Drug Name
Risk Level
Description
Nifedipine
Minor
Orlistat can cause a decrease in the absorption of Nifedipine resulting in a reduced serum concentration and potentially a decrease in efficacy.
Propafenone
Minor
Orlistat can cause a decrease in the absorption of Propafenone resulting in a reduced serum concentration and potentially a decrease in efficacy.
(R)-warfarin
Moderate
Orlistat may increase the anticoagulant activities of (R)-warfarin.
(S)-Warfarin
Moderate
Orlistat may increase the anticoagulant activities of (S)-Warfarin.
1alpha,24S-Dihydroxyvitamin D2
Moderate
Orlistat can cause a decrease in the absorption of 1alpha,24S-Dihydroxyvitamin D2 resulting in a reduced serum concentration and potentially a decrease in efficacy.
Xenical Toxicity & Overdose RiskThe highest amount of orlistat which has been found to be toxic in rats is over 5000mg/kg. In studies, healthy and overweight people have taken 800mg single doses and up to 400mg three times a day for 15 days without any serious side effects. In addition, people who were obese were given 240mg three times a day for 6 months with little to no adverse effects. Reports of overdoses have also shown no significant adverse events or events similar to those reported with recommended doses. If someone takes a large overdose of orlistat, they should be monitored for at least 24 hours. Clinical studies have revealed that any systemic effects
Xenical Novel Uses: Which Conditions Have a Clinical Trial Featuring Xenical?
169 active clinical trials are assessing the potential of Xenical to reduce Weight, Disease and BMI >27 kg/m2.Condition
Clinical Trials
Trial Phases
Caloric Restriction
0 Actively Recruiting
Obesity
44 Actively Recruiting
Phase 4, Not Applicable, Phase 3, Phase 2, Early Phase 1
Weight Reduction
1 Actively Recruiting
Not Applicable
Obesity
135 Actively Recruiting
Phase 2, Not Applicable, Phase 4, Phase 3, Phase 1, Early Phase 1
BMI >27 kg/m2
0 Actively Recruiting
Xenical Reviews: What are patients saying about Xenical?
5Patient Review
5/21/2016 No issues with the medication
5Patient Review
8/18/2020 I've had great results from this treatment so far. I'm down six pounds in one week and haven't experienced any severe side effects.
4.3Patient Review
7/15/2015 I used to take Xenical 120 mg in order to lose weight. I never experienced any negative side effects, which was great. I purchased the medicine from MedsMartDrugs. Now my stomach is almost flat and I can eat anything I want!
3.7Patient Review
9/21/2015 HELP... I need help understanding what is going on... My clothes are fitting bigger but I have gained 10 pds this week,,, This is my first week and I have been on a very low fat low cal diet... What am I doing wrong... I have even rode my stationary bike three days... for thirty mins each day. I have been some what constipated... So any advise out there for me please help me....
3.7Patient Review
9/17/2014 After consuming a fatty meal, I felt lightheaded and breathless about an hour later. Additionally, I needed to use the restroom frequently. Not sure if the benefits outweigh the negatives here.
3.3Patient Review
1/16/2019 I'm really feeling the burn after only one day of this treatment!
3Patient Review
3/21/2016 I've only been using this pill for a couple days, and I'm already noticing some itchy skin. Has anyone else experienced this? I have sensitive skin normally so I use special products in the shower and after, but it's still happening.
3Patient Review
1/17/2019 I started taking this medication last night, and this morning I had an unfortunate side effect. After reading other reviews, I now know what to expect and how to deal with it.
2.7Patient Review
7/12/2022 You definitely will learn quickly what foods to stay away from. I did lose weight at the expense of several severe oily stools and ruined clothing some at the most inopportune times.
2.7Patient Review
9/23/2022 I haven't seen the results I was hoping for after nine weeks. In addition to weight fluctuations, I've also been dealing with a lot of intestinal cramping. Overall, not worth the money.
2.3Patient Review
8/31/2014 I have tried using this product but have not seen any results.
2.3Patient Review
7/9/2022 I didn't use this treatment for very long because it made me oily and I was constantly leaking. It was really unpleasant and not something that I could see myself continuing to use for more than a week or two.
1.7Patient Review
6/21/2016 I used to love this drug because it was effective. Recently, however, I feel like the formula has changed because I no longer see any results. And based on what I've read online, I'm not the only one with this problem.
Patient Q&A Section about xenical
These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.What is the side effect of Xenical?
"If you have serious side effects from Xenical, tell your doctor. This can include blood in your urine, urinating less than usual or not at all, drowsiness, confusion, mood changes, increased thirst, swelling, weight gain, feeling short of breath, severe pain in your upper stomach spreading to your back, or fast heart rate."
Answered by AI
How fast will Xenical work?
"Xenical should be taken every day for it to be effective. People usually start seeing weight loss within 2 weeks, and it continues for 6 to 12 months. After that, Xenical will help you to maintain the new lower weight and prevent any weight regain."
Answered by AI
How much weight will I lose on Xenical?
"Combining Xenical with a healthy diet results in weight loss for 4 out of 10 people. People who use Xenical as part of their weight loss efforts are twice as likely to lose weight as those who don't use Xenical."
Answered by AI
Is Xenical good for weight loss?
"Xenical prevents some of the fat you eat from being absorbed by your body. It's used to aid weight loss or help prevent weight regain after weight loss. This medicine must be used with a reduced-calorie diet and is for use only by adults."
Answered by AI