Valtoco

Athetosis, Lockjaw, Syndrome + 11 more

Treatment

20 Active Studies for Valtoco

What is Valtoco

Diazepam

The Generic name of this drug

Treatment Summary

Diazepam is a type of anti-anxiety medication that helps to reduce seizures, anxiety, and insomnia. It works by increasing the activity of a brain chemical called gamma-aminobutyric acid. It has been used for many years to treat a variety of conditions and recently, an auto-injectable form was approved by the FDA. This form is used to quickly and effectively treat uncontrolled seizures and is an important tool for people with epilepsy.

Valium

is the brand name

image of different drug pills on a surface

Valtoco Overview & Background

Brand Name

Generic Name

First FDA Approval

How many FDA approvals?

Valium

Diazepam

1963

289

Effectiveness

How Valtoco Affects Patients

Diazepam is a type of medicine that helps to reduce anxiety, make people sleepy, relax muscles, and stop seizures. It is believed that these effects come from its ability to help increase the activity of the chemical called GABA in the brain, which helps to slow down the nervous system.

How Valtoco works in the body

Diazepam is a medication that helps relax muscles, reduce seizures, and make you drowsy. It works by attaching to receptors in the brain and spinal cord. This boosts the effects of a chemical in the body called GABA, which helps with sleep, memory, anxiety, and controlling overactivity in the nervous system.

When to interrupt dosage

The prescribed dosage of Valtoco is contingent upon the diagnosed condition, including Muscle Tissue, Seizures and Anger Management Therapy. The amount of dosage depends upon the method of administration outlined in the table beneath.

Condition

Dosage

Administration

Drug Resistant Epilepsy

5.0 mg/mL, , 25.0 mg/mL, 10.0 mg/mL, 20.0 mg/mL, 5.0 mg, 10.0 mg, 2.0 mg, 1.0 mg/mL, 100.0 mg/mL, 50.0 mg/mL, 75.0 mg/mL, 15.0 mg/mL

, Oral, Solution - Oral, Solution, Gel, Gel - Rectal, Rectal, Tablet, Tablet - Oral, Intramuscular; Intravenous, Injection, solution - Intramuscular; Intravenous, Injection, solution, Kit, Liquid - Intramuscular; Intravenous, Liquid, Emulsion, Emulsion - Intramuscular; Intravenous, Solution, concentrate, Solution, concentrate - Oral, Solution - Intramuscular; Intravenous, Injection - Intramuscular, Intramuscular, Injection, Liquid - Intramuscular, Cream - Topical, Cream, Topical, Injection - Intramuscular; Intravenous, Nasal, Spray - Nasal, Spray

Seizures

5.0 mg/mL, , 25.0 mg/mL, 10.0 mg/mL, 20.0 mg/mL, 5.0 mg, 10.0 mg, 2.0 mg, 1.0 mg/mL, 100.0 mg/mL, 50.0 mg/mL, 75.0 mg/mL, 15.0 mg/mL

, Oral, Solution - Oral, Solution, Gel, Gel - Rectal, Rectal, Tablet, Tablet - Oral, Intramuscular; Intravenous, Injection, solution - Intramuscular; Intravenous, Injection, solution, Kit, Liquid - Intramuscular; Intravenous, Liquid, Emulsion, Emulsion - Intramuscular; Intravenous, Solution, concentrate, Solution, concentrate - Oral, Solution - Intramuscular; Intravenous, Injection - Intramuscular, Intramuscular, Injection, Liquid - Intramuscular, Cream - Topical, Cream, Topical, Injection - Intramuscular; Intravenous, Nasal, Spray - Nasal, Spray

Anger Management Therapy

5.0 mg/mL, , 25.0 mg/mL, 10.0 mg/mL, 20.0 mg/mL, 5.0 mg, 10.0 mg, 2.0 mg, 1.0 mg/mL, 100.0 mg/mL, 50.0 mg/mL, 75.0 mg/mL, 15.0 mg/mL

, Oral, Solution - Oral, Solution, Gel, Gel - Rectal, Rectal, Tablet, Tablet - Oral, Intramuscular; Intravenous, Injection, solution - Intramuscular; Intravenous, Injection, solution, Kit, Liquid - Intramuscular; Intravenous, Liquid, Emulsion, Emulsion - Intramuscular; Intravenous, Solution, concentrate, Solution, concentrate - Oral, Solution - Intramuscular; Intravenous, Injection - Intramuscular, Intramuscular, Injection, Liquid - Intramuscular, Cream - Topical, Cream, Topical, Injection - Intramuscular; Intravenous, Nasal, Spray - Nasal, Spray

Muscle Tissue

5.0 mg/mL, , 25.0 mg/mL, 10.0 mg/mL, 20.0 mg/mL, 5.0 mg, 10.0 mg, 2.0 mg, 1.0 mg/mL, 100.0 mg/mL, 50.0 mg/mL, 75.0 mg/mL, 15.0 mg/mL

, Oral, Solution - Oral, Solution, Gel, Gel - Rectal, Rectal, Tablet, Tablet - Oral, Intramuscular; Intravenous, Injection, solution - Intramuscular; Intravenous, Injection, solution, Kit, Liquid - Intramuscular; Intravenous, Liquid, Emulsion, Emulsion - Intramuscular; Intravenous, Solution, concentrate, Solution, concentrate - Oral, Solution - Intramuscular; Intravenous, Injection - Intramuscular, Intramuscular, Injection, Liquid - Intramuscular, Cream - Topical, Cream, Topical, Injection - Intramuscular; Intravenous, Nasal, Spray - Nasal, Spray

Athetosis

5.0 mg/mL, , 25.0 mg/mL, 10.0 mg/mL, 20.0 mg/mL, 5.0 mg, 10.0 mg, 2.0 mg, 1.0 mg/mL, 100.0 mg/mL, 50.0 mg/mL, 75.0 mg/mL, 15.0 mg/mL

, Oral, Solution - Oral, Solution, Gel, Gel - Rectal, Rectal, Tablet, Tablet - Oral, Intramuscular; Intravenous, Injection, solution - Intramuscular; Intravenous, Injection, solution, Kit, Liquid - Intramuscular; Intravenous, Liquid, Emulsion, Emulsion - Intramuscular; Intravenous, Solution, concentrate, Solution, concentrate - Oral, Solution - Intramuscular; Intravenous, Injection - Intramuscular, Intramuscular, Injection, Liquid - Intramuscular, Cream - Topical, Cream, Topical, Injection - Intramuscular; Intravenous, Nasal, Spray - Nasal, Spray

Lockjaw

5.0 mg/mL, , 25.0 mg/mL, 10.0 mg/mL, 20.0 mg/mL, 5.0 mg, 10.0 mg, 2.0 mg, 1.0 mg/mL, 100.0 mg/mL, 50.0 mg/mL, 75.0 mg/mL, 15.0 mg/mL

, Oral, Solution - Oral, Solution, Gel, Gel - Rectal, Rectal, Tablet, Tablet - Oral, Intramuscular; Intravenous, Injection, solution - Intramuscular; Intravenous, Injection, solution, Kit, Liquid - Intramuscular; Intravenous, Liquid, Emulsion, Emulsion - Intramuscular; Intravenous, Solution, concentrate, Solution, concentrate - Oral, Solution - Intramuscular; Intravenous, Injection - Intramuscular, Intramuscular, Injection, Liquid - Intramuscular, Cream - Topical, Cream, Topical, Injection - Intramuscular; Intravenous, Nasal, Spray - Nasal, Spray

Syndrome

5.0 mg/mL, , 25.0 mg/mL, 10.0 mg/mL, 20.0 mg/mL, 5.0 mg, 10.0 mg, 2.0 mg, 1.0 mg/mL, 100.0 mg/mL, 50.0 mg/mL, 75.0 mg/mL, 15.0 mg/mL

, Oral, Solution - Oral, Solution, Gel, Gel - Rectal, Rectal, Tablet, Tablet - Oral, Intramuscular; Intravenous, Injection, solution - Intramuscular; Intravenous, Injection, solution, Kit, Liquid - Intramuscular; Intravenous, Liquid, Emulsion, Emulsion - Intramuscular; Intravenous, Solution, concentrate, Solution, concentrate - Oral, Solution - Intramuscular; Intravenous, Injection - Intramuscular, Intramuscular, Injection, Liquid - Intramuscular, Cream - Topical, Cream, Topical, Injection - Intramuscular; Intravenous, Nasal, Spray - Nasal, Spray

Motor Neuron Disease, Upper

5.0 mg/mL, , 25.0 mg/mL, 10.0 mg/mL, 20.0 mg/mL, 5.0 mg, 10.0 mg, 2.0 mg, 1.0 mg/mL, 100.0 mg/mL, 50.0 mg/mL, 75.0 mg/mL, 15.0 mg/mL

, Oral, Solution - Oral, Solution, Gel, Gel - Rectal, Rectal, Tablet, Tablet - Oral, Intramuscular; Intravenous, Injection, solution - Intramuscular; Intravenous, Injection, solution, Kit, Liquid - Intramuscular; Intravenous, Liquid, Emulsion, Emulsion - Intramuscular; Intravenous, Solution, concentrate, Solution, concentrate - Oral, Solution - Intramuscular; Intravenous, Injection - Intramuscular, Intramuscular, Injection, Liquid - Intramuscular, Cream - Topical, Cream, Topical, Injection - Intramuscular; Intravenous, Nasal, Spray - Nasal, Spray

Sedation therapy

5.0 mg/mL, , 25.0 mg/mL, 10.0 mg/mL, 20.0 mg/mL, 5.0 mg, 10.0 mg, 2.0 mg, 1.0 mg/mL, 100.0 mg/mL, 50.0 mg/mL, 75.0 mg/mL, 15.0 mg/mL

, Oral, Solution - Oral, Solution, Gel, Gel - Rectal, Rectal, Tablet, Tablet - Oral, Intramuscular; Intravenous, Injection, solution - Intramuscular; Intravenous, Injection, solution, Kit, Liquid - Intramuscular; Intravenous, Liquid, Emulsion, Emulsion - Intramuscular; Intravenous, Solution, concentrate, Solution, concentrate - Oral, Solution - Intramuscular; Intravenous, Injection - Intramuscular, Intramuscular, Injection, Liquid - Intramuscular, Cream - Topical, Cream, Topical, Injection - Intramuscular; Intravenous, Nasal, Spray - Nasal, Spray

Sedation

5.0 mg/mL, , 25.0 mg/mL, 10.0 mg/mL, 20.0 mg/mL, 5.0 mg, 10.0 mg, 2.0 mg, 1.0 mg/mL, 100.0 mg/mL, 50.0 mg/mL, 75.0 mg/mL, 15.0 mg/mL

, Oral, Solution - Oral, Solution, Gel, Gel - Rectal, Rectal, Tablet, Tablet - Oral, Intramuscular; Intravenous, Injection, solution - Intramuscular; Intravenous, Injection, solution, Kit, Liquid - Intramuscular; Intravenous, Liquid, Emulsion, Emulsion - Intramuscular; Intravenous, Solution, concentrate, Solution, concentrate - Oral, Solution - Intramuscular; Intravenous, Injection - Intramuscular, Intramuscular, Injection, Liquid - Intramuscular, Cream - Topical, Cream, Topical, Injection - Intramuscular; Intravenous, Nasal, Spray - Nasal, Spray

Generalized Anxiety Disorder

5.0 mg/mL, , 25.0 mg/mL, 10.0 mg/mL, 20.0 mg/mL, 5.0 mg, 10.0 mg, 2.0 mg, 1.0 mg/mL, 100.0 mg/mL, 50.0 mg/mL, 75.0 mg/mL, 15.0 mg/mL

, Oral, Solution - Oral, Solution, Gel, Gel - Rectal, Rectal, Tablet, Tablet - Oral, Intramuscular; Intravenous, Injection, solution - Intramuscular; Intravenous, Injection, solution, Kit, Liquid - Intramuscular; Intravenous, Liquid, Emulsion, Emulsion - Intramuscular; Intravenous, Solution, concentrate, Solution, concentrate - Oral, Solution - Intramuscular; Intravenous, Injection - Intramuscular, Intramuscular, Injection, Liquid - Intramuscular, Cream - Topical, Cream, Topical, Injection - Intramuscular; Intravenous, Nasal, Spray - Nasal, Spray

Anxiety Disorders

5.0 mg/mL, , 25.0 mg/mL, 10.0 mg/mL, 20.0 mg/mL, 5.0 mg, 10.0 mg, 2.0 mg, 1.0 mg/mL, 100.0 mg/mL, 50.0 mg/mL, 75.0 mg/mL, 15.0 mg/mL

, Oral, Solution - Oral, Solution, Gel, Gel - Rectal, Rectal, Tablet, Tablet - Oral, Intramuscular; Intravenous, Injection, solution - Intramuscular; Intravenous, Injection, solution, Kit, Liquid - Intramuscular; Intravenous, Liquid, Emulsion, Emulsion - Intramuscular; Intravenous, Solution, concentrate, Solution, concentrate - Oral, Solution - Intramuscular; Intravenous, Injection - Intramuscular, Intramuscular, Injection, Liquid - Intramuscular, Cream - Topical, Cream, Topical, Injection - Intramuscular; Intravenous, Nasal, Spray - Nasal, Spray

Stiff-Person Syndrome

5.0 mg/mL, , 25.0 mg/mL, 10.0 mg/mL, 20.0 mg/mL, 5.0 mg, 10.0 mg, 2.0 mg, 1.0 mg/mL, 100.0 mg/mL, 50.0 mg/mL, 75.0 mg/mL, 15.0 mg/mL

, Oral, Solution - Oral, Solution, Gel, Gel - Rectal, Rectal, Tablet, Tablet - Oral, Intramuscular; Intravenous, Injection, solution - Intramuscular; Intravenous, Injection, solution, Kit, Liquid - Intramuscular; Intravenous, Liquid, Emulsion, Emulsion - Intramuscular; Intravenous, Solution, concentrate, Solution, concentrate - Oral, Solution - Intramuscular; Intravenous, Injection - Intramuscular, Intramuscular, Injection, Liquid - Intramuscular, Cream - Topical, Cream, Topical, Injection - Intramuscular; Intravenous, Nasal, Spray - Nasal, Spray

Status Epilepticus

5.0 mg/mL, , 25.0 mg/mL, 10.0 mg/mL, 20.0 mg/mL, 5.0 mg, 10.0 mg, 2.0 mg, 1.0 mg/mL, 100.0 mg/mL, 50.0 mg/mL, 75.0 mg/mL, 15.0 mg/mL

, Oral, Solution - Oral, Solution, Gel, Gel - Rectal, Rectal, Tablet, Tablet - Oral, Intramuscular; Intravenous, Injection, solution - Intramuscular; Intravenous, Injection, solution, Kit, Liquid - Intramuscular; Intravenous, Liquid, Emulsion, Emulsion - Intramuscular; Intravenous, Solution, concentrate, Solution, concentrate - Oral, Solution - Intramuscular; Intravenous, Injection - Intramuscular, Intramuscular, Injection, Liquid - Intramuscular, Cream - Topical, Cream, Topical, Injection - Intramuscular; Intravenous, Nasal, Spray - Nasal, Spray

Warnings

Valtoco has six contraindications and should not be combined when suffering from any of the conditions indicated in the table below.

Valtoco Contraindications

Condition

Risk Level

Notes

Pulse Frequency

Do Not Combine

Obstructive Sleep Apnea (OSA)

Do Not Combine

Glaucoma

Do Not Combine

Myasthenia Gravis

Do Not Combine

Liver Failure

Do Not Combine

Respiratory Insufficiency

Do Not Combine

There are 20 known major drug interactions with Valtoco.

Common Valtoco Drug Interactions

Drug Name

Risk Level

Description

Astemizole

Major

The metabolism of Astemizole can be decreased when combined with Diazepam.

Axitinib

Major

The metabolism of Axitinib can be decreased when combined with Diazepam.

Azelastine

Major

Diazepam may increase the central nervous system depressant (CNS depressant) activities of Azelastine.

Cabazitaxel

Major

The metabolism of Cabazitaxel can be decreased when combined with Diazepam.

Copanlisib

Major

The metabolism of Copanlisib can be decreased when combined with Diazepam.

Valtoco Toxicity & Overdose Risk

Overdosing on diazepam can lead to an intensification of the drug's effects, such as drowsiness, difficulty speaking, and weakened muscles. More severe symptoms include coma, loss of reflexes, slowed breathing and heart rate, and lack of oxygen. Taking diazepam with other drugs or alcohol can be fatal and should be avoided. Pregnant women should avoid taking diazepam altogether, and it is not recommended for breastfeeding mothers or children under 6 months of age. Elderly patients should take the smallest dose possible as they are more likely to have side effects. Patients with cirrhosis, hepatic encephal

image of a doctor in a lab doing drug, clinical research

Valtoco Novel Uses: Which Conditions Have a Clinical Trial Featuring Valtoco?

409 active clinical trials are currently investigating the potential of Valtoco to alleviate Anxiety Disorders, Generalized Anxiety Disorder and Stiff Man Syndrome.

Condition

Clinical Trials

Trial Phases

Anxiety Disorders

56 Actively Recruiting

Phase 2, Not Applicable, Phase 4, Phase 3, Early Phase 1

Generalized Anxiety Disorder

183 Actively Recruiting

Not Applicable, Phase 2, Early Phase 1, Phase 4, Phase 1, Phase 3

Syndrome

4 Actively Recruiting

Phase 2, Phase 3, Not Applicable

Lockjaw

0 Actively Recruiting

Stiff-Person Syndrome

4 Actively Recruiting

Phase 2, Phase 1

Sedation

2 Actively Recruiting

Early Phase 1, Not Applicable

Motor Neuron Disease, Upper

0 Actively Recruiting

Athetosis

1 Actively Recruiting

Phase 3

Drug Resistant Epilepsy

1 Actively Recruiting

Not Applicable

Sedation therapy

0 Actively Recruiting

Status Epilepticus

0 Actively Recruiting

Seizures

0 Actively Recruiting

Muscle Tissue

0 Actively Recruiting

Anger Management Therapy

0 Actively Recruiting

Patient Q&A Section about valtoco

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

Is Valtoco a narcotic?

"Valtoco nasal spray is a prescription medicine used to treat seizure clusters in adults and children who are at least 6 years old. Valtoco can be abused and can lead to dependence, so it is classified as a federal controlled substance (C-IV)."

Answered by AI

Can Valtoco be used for anxiety?

"Diazepam - FDA prescribing information, side effects and uses

Diazepam is used to treat anxiety disorders, alcohol withdrawal symptoms, or muscle spasms. It can also be used to relieve seizures."

Answered by AI

Is Valtoco a diazepam?

"Diazepam, which is the active ingredient in VALTOCO, has been used by medical professionals to treat epilepsy for over 50 years. For the last 20 years, patients and their carers have also used diazepam to rescue themselves from episodes of frequent seizure activity outside of a medical setting."

Answered by AI

What is Valtoco used for?

"The FDA has approved Valtoco, a new seizure medicine designed to treat periods of frequent seizures or cluster seizures that are distinct from the person's usual seizure pattern."

Answered by AI

Clinical Trials for Valtoco

Image of Northwestern University in Evanston, United States.

Sleep and Dreaming Practices for Anxiety

18+
All Sexes
Evanston, IL

People spend approximately one-third of their lives asleep, yet sleep is often underused as an opportunity to support psychological well-being. Contemplative traditions, including Tibetan Dream Yoga, have developed practices that use waking imagination and lucid dreaming to explore perception, awareness, and habitual patterns of thinking. Recent advances in sleep monitoring, dream communication, and lucid dream induction now make it possible to study these practices using scientific methods. This study is a randomized controlled trial designed to examine the feasibility and effects of a Dream-Yoga-inspired intervention compared with an active control condition. The intervention combines waking and dreaming practices that are adapted for individuals without prior experience and delivered using virtual reality-based training and home sleep technology. The program is designed to be scalable and culturally neutral, without requiring prior knowledge of contemplative or religious traditions. The primary goals of the study are to characterize sleep and waking neurophysiology associated with Dream-Yoga-inspired practices and to evaluate whether participation is associated with changes in sleep-related brain activity and cognitive processes. Outcomes include measures of lucid dreaming, sleep physiology, and waking cognitive and perceptual processes. Anxiety will be assessed as an exploratory outcome to examine whether participation may be associated with changes in emotional experience. This study is not designed to provide treatment for anxiety or other clinical conditions. Results from this study will help inform the development of scalable sleep-based mental training approaches and guide future research on the use of dreaming and sleep practices to support psychological health and well-being

Phase < 1
Waitlist Available

Northwestern University (+1 Sites)

Image of Michael E. DeBakey VA Medical Center, Houston, TX in Houston, United States.

Acceptance and Commitment Therapy for Inflammatory Bowel Disease

18+
All Sexes
Houston, TX

Many Veterans with gastrointestinal disorders, such as inflammatory bowel disease (IBD), also have mental health conditions. IBD and mental health conditions can worsen one another through the brain-gut axis, leading to dramatic deficits in psychosocial functioning and quality of life (QOL). Yet, few Veterans with comorbid IBD and mental health conditions receive psychotherapy and no evidence-based psychotherapies have been tested in Veterans with these comorbidities. Adapting brief acceptance and commitment therapy (ACT) to the specific to the needs of these patients and embedding treatment into routine gastroenterology care may increase Veterans' access to efficient and effective rehabilitative care. This study aims to adapt and test an integrated, 1-Day ACT intervention tailored to the specific needs of Veterans with IBD and mental health conditions to improve psychosocial functioning and QOL.

Waitlist Available
Has No Placebo

Michael E. DeBakey VA Medical Center, Houston, TX

Mackenzie Lynmarie Shanahan, PhD

Have you considered Valtoco clinical trials?

We made a collection of clinical trials featuring Valtoco, we think they might fit your search criteria.
Go to Trials

Have you considered Valtoco clinical trials?

We made a collection of clinical trials featuring Valtoco, we think they might fit your search criteria.
Go to Trials
Image of Stanford University School of Medicine in Stanford, United States.

BEAR Program for Suicidal Thoughts

18 - 75
Female
Stanford, CA

The current study aims to test the feasibility of a new form of group therapy for women who have a history of interpersonal trauma and current suicidal ideation. The Building Empowerment and Resilience (BEAR) Therapeutic group has been adapted for women who have experienced trauma and have current suicidal ideation. It incorporates psychological skills, psychoeducation about trauma and gender-based violence, and physical self-defense training, all within a therapeutic process. It will be implemented with women who have experienced interpersonal trauma (physical, sexual, or emotional abuse/neglect) and experience various mental health difficulties, including suicidal ideation. We aim to assess the feasibility to recruit and implement the BEAR group. Our ultimate aim is to assess whether the program can effect self-efficacy and suicidal ideation.

Waitlist Available
Has No Placebo

Stanford University School of Medicine

Jennifer Keller, PhD

Have you considered Valtoco clinical trials?

We made a collection of clinical trials featuring Valtoco, we think they might fit your search criteria.
Go to Trials