Your session is about to expire
What is Trimox
TrimethoprimThe Generic name of this drug
Treatment SummarySulfamethoxazole is an antibiotic that stops bacteria from growing. It is usually combined with trimethoprim, which blocks the production of proteins and nucleic acids essential for bacterial growth. This combination is used to treat infections of the urinary, respiratory, and gastrointestinal tracts.
Septra DSis the brand name
Trimox Overview & Background
Brand Name
Generic Name
First FDA Approval
How many FDA approvals?
Septra DS
Trimethoprim
1973
343
Approved as Treatment by the FDA
Trimethoprim, also called Septra DS, is approved by the FDA for 15 uses including Urinary tract infection and Otitis Media .Urinary tract infection
Used to treat Urinary Tract Infection caused by susceptible bacteria in combination with Sulfamethoxazole
Otitis Media
Used to treat Acute Otitis Media caused by susceptible bacteria in combination with Sulfamethoxazole
Shigellosis
Used to treat Dysentery, Bacillary in combination with Sulfamethoxazole
Fluid replacement therapy
Used to treat Fluid replacement therapy in combination with Sulfamethoxazole
Cholera
Used to treat susceptible Cholera in combination with Sulfamethoxazole
Pneumocystis Jirovecii Pneumonia
Used to treat Pneumocystis Jirovecii Pneumonia in combination with Sulfamethoxazole
Bronchitis
Used to treat Acute Exacerbation of Chronic Bronchitis (AECB) caused by susceptible bacteria in combination with Sulfamethoxazole
susceptible Enteritis infectious caused by Shigella sonnei
Used to treat susceptible Enteritis infectious caused by Shigella sonnei in combination with Sulfamethoxazole
Immunocompromised
Used to treat Immunocompromised in combination with Sulfamethoxazole
Electrolyte replacement
Used to treat Electrolyte replacement in combination with Sulfamethoxazole
Diarrhea
Used to treat susceptible Travelers' Diarrhea caused by Enterotoxigenic E. Coli (ETEC) Infection in combination with Sulfamethoxazole
Genus Pneumocystis
Used to treat risk of Pneumocystis jiroveci pneumonia (PCP) in combination with Sulfamethoxazole
susceptible Enteritis infectious caused by Shigella flexneri
Used to treat susceptible Enteritis infectious caused by Shigella flexneri in combination with Sulfamethoxazole
Nocardiosis
Used to treat Nocardiosis in combination with Sulfamethoxazole
Brucellosis
Used to treat Brucellosis in combination with Rifampicin
Effectiveness
How Trimox Affects PatientsSulfamethoxazole is an antibiotic that works by preventing bacteria from making a specific type of folate, a type of vitamin. It is usually given with trimethoprim, another antibiotic, as the combination works better and takes longer for bacteria to become resistant to it. However, sulfamethoxazole can lead to skin reactions such as rashes, Stevens-Johnson syndrome, or toxic epidermal necrolysis, so if any of these occur it should be stopped immediately. Additionally, taking sulfamethoxazole may cause folate deficiency and it should be used cautiously in those at risk.
How Trimox works in the bodySulfamethoxazole prevents bacteria from making folic acid. It works by mimicking a molecule called para-aminobenzoic acid, which bacteria normally use to make folic acid. By taking its place, sulfamethoxazole blocks the enzyme that converts para-aminobenzoic acid into folic acid. This stops bacteria from making the DNA and other molecules that it needs for growth and reproduction, which prevents the bacteria from spreading.
When to interrupt dosage
The sum of Trimox is dependent upon the diagnosed state, including Urinary tract infection, Pneumocystis Jirovecii Pneumonia and Fluid replacement therapy. The quantity of dosage can be determined from the table below, contingent upon the method of administration.Condition
Dosage
Administration
susceptible Enteritis infectious caused by Shigella sonnei
, 1.0 mg/mL, 160.0 mg, 80.0 mg, 40.0 mg/mL, 50.0 mg/mL, 100.0 mg, 0.16 mg, 1.6 mg, 20.0 mg, 200.0 mg, 90.0 mg, 16.0 mg/mL, 300.0 mg, 40.0 mg, 8.0 mg/mL, 9.0 mg/mL
, Ophthalmic, Solution / drops - Ophthalmic, Oral, Tablet, Tablet - Oral, Suspension, Suspension - Oral, Solution, Solution - Oral, Solution - Ophthalmic, Intravenous, Liquid, Liquid - Intravenous, Injection, solution, concentrate, Injection, solution, concentrate - Intravenous, Solution - Intravenous, Injection, Injection - Intravenous, Solution / drops, Liquid - Ophthalmic
Blepharoconjunctivitis caused by susceptible bacteria
, 1.0 mg/mL, 160.0 mg, 80.0 mg, 40.0 mg/mL, 50.0 mg/mL, 100.0 mg, 0.16 mg, 1.6 mg, 20.0 mg, 200.0 mg, 90.0 mg, 16.0 mg/mL, 300.0 mg, 40.0 mg, 8.0 mg/mL, 9.0 mg/mL
, Ophthalmic, Solution / drops - Ophthalmic, Oral, Tablet, Tablet - Oral, Suspension, Suspension - Oral, Solution, Solution - Oral, Solution - Ophthalmic, Intravenous, Liquid, Liquid - Intravenous, Injection, solution, concentrate, Injection, solution, concentrate - Intravenous, Solution - Intravenous, Injection, Injection - Intravenous, Solution / drops, Liquid - Ophthalmic
Urinary tract infection
, 1.0 mg/mL, 160.0 mg, 80.0 mg, 40.0 mg/mL, 50.0 mg/mL, 100.0 mg, 0.16 mg, 1.6 mg, 20.0 mg, 200.0 mg, 90.0 mg, 16.0 mg/mL, 300.0 mg, 40.0 mg, 8.0 mg/mL, 9.0 mg/mL
, Ophthalmic, Solution / drops - Ophthalmic, Oral, Tablet, Tablet - Oral, Suspension, Suspension - Oral, Solution, Solution - Oral, Solution - Ophthalmic, Intravenous, Liquid, Liquid - Intravenous, Injection, solution, concentrate, Injection, solution, concentrate - Intravenous, Solution - Intravenous, Injection, Injection - Intravenous, Solution / drops, Liquid - Ophthalmic
Diarrhea
, 1.0 mg/mL, 160.0 mg, 80.0 mg, 40.0 mg/mL, 50.0 mg/mL, 100.0 mg, 0.16 mg, 1.6 mg, 20.0 mg, 200.0 mg, 90.0 mg, 16.0 mg/mL, 300.0 mg, 40.0 mg, 8.0 mg/mL, 9.0 mg/mL
, Ophthalmic, Solution / drops - Ophthalmic, Oral, Tablet, Tablet - Oral, Suspension, Suspension - Oral, Solution, Solution - Oral, Solution - Ophthalmic, Intravenous, Liquid, Liquid - Intravenous, Injection, solution, concentrate, Injection, solution, concentrate - Intravenous, Solution - Intravenous, Injection, Injection - Intravenous, Solution / drops, Liquid - Ophthalmic
Electrolyte replacement
, 1.0 mg/mL, 160.0 mg, 80.0 mg, 40.0 mg/mL, 50.0 mg/mL, 100.0 mg, 0.16 mg, 1.6 mg, 20.0 mg, 200.0 mg, 90.0 mg, 16.0 mg/mL, 300.0 mg, 40.0 mg, 8.0 mg/mL, 9.0 mg/mL
, Ophthalmic, Solution / drops - Ophthalmic, Oral, Tablet, Tablet - Oral, Suspension, Suspension - Oral, Solution, Solution - Oral, Solution - Ophthalmic, Intravenous, Liquid, Liquid - Intravenous, Injection, solution, concentrate, Injection, solution, concentrate - Intravenous, Solution - Intravenous, Injection, Injection - Intravenous, Solution / drops, Liquid - Ophthalmic
Bronchitis
, 1.0 mg/mL, 160.0 mg, 80.0 mg, 40.0 mg/mL, 50.0 mg/mL, 100.0 mg, 0.16 mg, 1.6 mg, 20.0 mg, 200.0 mg, 90.0 mg, 16.0 mg/mL, 300.0 mg, 40.0 mg, 8.0 mg/mL, 9.0 mg/mL
, Ophthalmic, Solution / drops - Ophthalmic, Oral, Tablet, Tablet - Oral, Suspension, Suspension - Oral, Solution, Solution - Oral, Solution - Ophthalmic, Intravenous, Liquid, Liquid - Intravenous, Injection, solution, concentrate, Injection, solution, concentrate - Intravenous, Solution - Intravenous, Injection, Injection - Intravenous, Solution / drops, Liquid - Ophthalmic
Urinary tract infection
, 1.0 mg/mL, 160.0 mg, 80.0 mg, 40.0 mg/mL, 50.0 mg/mL, 100.0 mg, 0.16 mg, 1.6 mg, 20.0 mg, 200.0 mg, 90.0 mg, 16.0 mg/mL, 300.0 mg, 40.0 mg, 8.0 mg/mL, 9.0 mg/mL
, Ophthalmic, Solution / drops - Ophthalmic, Oral, Tablet, Tablet - Oral, Suspension, Suspension - Oral, Solution, Solution - Oral, Solution - Ophthalmic, Intravenous, Liquid, Liquid - Intravenous, Injection, solution, concentrate, Injection, solution, concentrate - Intravenous, Solution - Intravenous, Injection, Injection - Intravenous, Solution / drops, Liquid - Ophthalmic
Pneumocystis Jirovecii Pneumonia
, 1.0 mg/mL, 160.0 mg, 80.0 mg, 40.0 mg/mL, 50.0 mg/mL, 100.0 mg, 0.16 mg, 1.6 mg, 20.0 mg, 200.0 mg, 90.0 mg, 16.0 mg/mL, 300.0 mg, 40.0 mg, 8.0 mg/mL, 9.0 mg/mL
, Ophthalmic, Solution / drops - Ophthalmic, Oral, Tablet, Tablet - Oral, Suspension, Suspension - Oral, Solution, Solution - Oral, Solution - Ophthalmic, Intravenous, Liquid, Liquid - Intravenous, Injection, solution, concentrate, Injection, solution, concentrate - Intravenous, Solution - Intravenous, Injection, Injection - Intravenous, Solution / drops, Liquid - Ophthalmic
Bacterial conjunctivitis
, 1.0 mg/mL, 160.0 mg, 80.0 mg, 40.0 mg/mL, 50.0 mg/mL, 100.0 mg, 0.16 mg, 1.6 mg, 20.0 mg, 200.0 mg, 90.0 mg, 16.0 mg/mL, 300.0 mg, 40.0 mg, 8.0 mg/mL, 9.0 mg/mL
, Ophthalmic, Solution / drops - Ophthalmic, Oral, Tablet, Tablet - Oral, Suspension, Suspension - Oral, Solution, Solution - Oral, Solution - Ophthalmic, Intravenous, Liquid, Liquid - Intravenous, Injection, solution, concentrate, Injection, solution, concentrate - Intravenous, Solution - Intravenous, Injection, Injection - Intravenous, Solution / drops, Liquid - Ophthalmic
Otitis Media
, 1.0 mg/mL, 160.0 mg, 80.0 mg, 40.0 mg/mL, 50.0 mg/mL, 100.0 mg, 0.16 mg, 1.6 mg, 20.0 mg, 200.0 mg, 90.0 mg, 16.0 mg/mL, 300.0 mg, 40.0 mg, 8.0 mg/mL, 9.0 mg/mL
, Ophthalmic, Solution / drops - Ophthalmic, Oral, Tablet, Tablet - Oral, Suspension, Suspension - Oral, Solution, Solution - Oral, Solution - Ophthalmic, Intravenous, Liquid, Liquid - Intravenous, Injection, solution, concentrate, Injection, solution, concentrate - Intravenous, Solution - Intravenous, Injection, Injection - Intravenous, Solution / drops, Liquid - Ophthalmic
Nocardiosis
, 1.0 mg/mL, 160.0 mg, 80.0 mg, 40.0 mg/mL, 50.0 mg/mL, 100.0 mg, 0.16 mg, 1.6 mg, 20.0 mg, 200.0 mg, 90.0 mg, 16.0 mg/mL, 300.0 mg, 40.0 mg, 8.0 mg/mL, 9.0 mg/mL
, Ophthalmic, Solution / drops - Ophthalmic, Oral, Tablet, Tablet - Oral, Suspension, Suspension - Oral, Solution, Solution - Oral, Solution - Ophthalmic, Intravenous, Liquid, Liquid - Intravenous, Injection, solution, concentrate, Injection, solution, concentrate - Intravenous, Solution - Intravenous, Injection, Injection - Intravenous, Solution / drops, Liquid - Ophthalmic
Immunocompromised
, 1.0 mg/mL, 160.0 mg, 80.0 mg, 40.0 mg/mL, 50.0 mg/mL, 100.0 mg, 0.16 mg, 1.6 mg, 20.0 mg, 200.0 mg, 90.0 mg, 16.0 mg/mL, 300.0 mg, 40.0 mg, 8.0 mg/mL, 9.0 mg/mL
, Ophthalmic, Solution / drops - Ophthalmic, Oral, Tablet, Tablet - Oral, Suspension, Suspension - Oral, Solution, Solution - Oral, Solution - Ophthalmic, Intravenous, Liquid, Liquid - Intravenous, Injection, solution, concentrate, Injection, solution, concentrate - Intravenous, Solution - Intravenous, Injection, Injection - Intravenous, Solution / drops, Liquid - Ophthalmic
Brucellosis
, 1.0 mg/mL, 160.0 mg, 80.0 mg, 40.0 mg/mL, 50.0 mg/mL, 100.0 mg, 0.16 mg, 1.6 mg, 20.0 mg, 200.0 mg, 90.0 mg, 16.0 mg/mL, 300.0 mg, 40.0 mg, 8.0 mg/mL, 9.0 mg/mL
, Ophthalmic, Solution / drops - Ophthalmic, Oral, Tablet, Tablet - Oral, Suspension, Suspension - Oral, Solution, Solution - Oral, Solution - Ophthalmic, Intravenous, Liquid, Liquid - Intravenous, Injection, solution, concentrate, Injection, solution, concentrate - Intravenous, Solution - Intravenous, Injection, Injection - Intravenous, Solution / drops, Liquid - Ophthalmic
Shigellosis
, 1.0 mg/mL, 160.0 mg, 80.0 mg, 40.0 mg/mL, 50.0 mg/mL, 100.0 mg, 0.16 mg, 1.6 mg, 20.0 mg, 200.0 mg, 90.0 mg, 16.0 mg/mL, 300.0 mg, 40.0 mg, 8.0 mg/mL, 9.0 mg/mL
, Ophthalmic, Solution / drops - Ophthalmic, Oral, Tablet, Tablet - Oral, Suspension, Suspension - Oral, Solution, Solution - Oral, Solution - Ophthalmic, Intravenous, Liquid, Liquid - Intravenous, Injection, solution, concentrate, Injection, solution, concentrate - Intravenous, Solution - Intravenous, Injection, Injection - Intravenous, Solution / drops, Liquid - Ophthalmic
Fluid replacement therapy
, 1.0 mg/mL, 160.0 mg, 80.0 mg, 40.0 mg/mL, 50.0 mg/mL, 100.0 mg, 0.16 mg, 1.6 mg, 20.0 mg, 200.0 mg, 90.0 mg, 16.0 mg/mL, 300.0 mg, 40.0 mg, 8.0 mg/mL, 9.0 mg/mL
, Ophthalmic, Solution / drops - Ophthalmic, Oral, Tablet, Tablet - Oral, Suspension, Suspension - Oral, Solution, Solution - Oral, Solution - Ophthalmic, Intravenous, Liquid, Liquid - Intravenous, Injection, solution, concentrate, Injection, solution, concentrate - Intravenous, Solution - Intravenous, Injection, Injection - Intravenous, Solution / drops, Liquid - Ophthalmic
Genus Pneumocystis
, 1.0 mg/mL, 160.0 mg, 80.0 mg, 40.0 mg/mL, 50.0 mg/mL, 100.0 mg, 0.16 mg, 1.6 mg, 20.0 mg, 200.0 mg, 90.0 mg, 16.0 mg/mL, 300.0 mg, 40.0 mg, 8.0 mg/mL, 9.0 mg/mL
, Ophthalmic, Solution / drops - Ophthalmic, Oral, Tablet, Tablet - Oral, Suspension, Suspension - Oral, Solution, Solution - Oral, Solution - Ophthalmic, Intravenous, Liquid, Liquid - Intravenous, Injection, solution, concentrate, Injection, solution, concentrate - Intravenous, Solution - Intravenous, Injection, Injection - Intravenous, Solution / drops, Liquid - Ophthalmic
susceptible Enteritis infectious caused by Shigella flexneri
, 1.0 mg/mL, 160.0 mg, 80.0 mg, 40.0 mg/mL, 50.0 mg/mL, 100.0 mg, 0.16 mg, 1.6 mg, 20.0 mg, 200.0 mg, 90.0 mg, 16.0 mg/mL, 300.0 mg, 40.0 mg, 8.0 mg/mL, 9.0 mg/mL
, Ophthalmic, Solution / drops - Ophthalmic, Oral, Tablet, Tablet - Oral, Suspension, Suspension - Oral, Solution, Solution - Oral, Solution - Ophthalmic, Intravenous, Liquid, Liquid - Intravenous, Injection, solution, concentrate, Injection, solution, concentrate - Intravenous, Solution - Intravenous, Injection, Injection - Intravenous, Solution / drops, Liquid - Ophthalmic
bacterial blepharitis caused by susceptible bacteria
, 1.0 mg/mL, 160.0 mg, 80.0 mg, 40.0 mg/mL, 50.0 mg/mL, 100.0 mg, 0.16 mg, 1.6 mg, 20.0 mg, 200.0 mg, 90.0 mg, 16.0 mg/mL, 300.0 mg, 40.0 mg, 8.0 mg/mL, 9.0 mg/mL
, Ophthalmic, Solution / drops - Ophthalmic, Oral, Tablet, Tablet - Oral, Suspension, Suspension - Oral, Solution, Solution - Oral, Solution - Ophthalmic, Intravenous, Liquid, Liquid - Intravenous, Injection, solution, concentrate, Injection, solution, concentrate - Intravenous, Solution - Intravenous, Injection, Injection - Intravenous, Solution / drops, Liquid - Ophthalmic
Cholera
, 1.0 mg/mL, 160.0 mg, 80.0 mg, 40.0 mg/mL, 50.0 mg/mL, 100.0 mg, 0.16 mg, 1.6 mg, 20.0 mg, 200.0 mg, 90.0 mg, 16.0 mg/mL, 300.0 mg, 40.0 mg, 8.0 mg/mL, 9.0 mg/mL
, Ophthalmic, Solution / drops - Ophthalmic, Oral, Tablet, Tablet - Oral, Suspension, Suspension - Oral, Solution, Solution - Oral, Solution - Ophthalmic, Intravenous, Liquid, Liquid - Intravenous, Injection, solution, concentrate, Injection, solution, concentrate - Intravenous, Solution - Intravenous, Injection, Injection - Intravenous, Solution / drops, Liquid - Ophthalmic
Warnings
Trimox has seven contraindications, so it should not be employed if you have any of the conditions detailed in the subsequent table.Trimox ContraindicationsCondition
Risk Level
Notes
history of immune thrombocytopenia caused by trimethoprim and/or sulfonamide therapy
Do Not Combine
hepatic damage
Do Not Combine
Megaloblastic anemia caused by Folate deficiency
Do Not Combine
unable to monitor renal function
Do Not Combine
Disease
Do Not Combine
Pulse Frequency
Do Not Combine
Severe Hypersensitivity Reactions
Do Not Combine
Trimethoprim may interact with Pulse Frequency
Severe Hypersensitivity Reactions
Do Not Combine
Trimethoprim may interact with Pulse Frequency
Common Trimox Drug Interactions
Drug Name
Risk Level
Description
Abemaciclib
Major
The excretion of Abemaciclib can be decreased when combined with Trimethoprim.
Brigatinib
Major
The metabolism of Brigatinib can be decreased when combined with Trimethoprim.
Cabazitaxel
Major
The metabolism of Cabazitaxel can be decreased when combined with Trimethoprim.
Cisplatin
Major
The serum concentration of Cisplatin can be increased when it is combined with Trimethoprim.
Clofarabine
Major
The serum concentration of Clofarabine can be increased when it is combined with Trimethoprim.
Trimox Toxicity & Overdose RiskThe toxic dose of sulfamethoxazole for mice and rats is 2300 mg/kg and 6200 mg/kg respectively. Signs of an overdose may include loss of appetite, stomach pain, nausea, vomiting, dizziness, headaches, drowsiness, and loss of consciousness. Other symptoms may include fever, blood in the urine, and crystals in the urine. In severe cases, a person may suffer from blood disorders or jaundice. Treatment includes symptomatic and supportive care, including stomach pumping or vomiting if appropriate. Monitor the patient's lab work for signs of blood or electrolyte imbalances.
Trimox Novel Uses: Which Conditions Have a Clinical Trial Featuring Trimox?
Currently, 8 active studies are assessing the potential of Trimox to treat Immunocompromised Individuals, Fluid Replacement Therapy and Infectious Enteritis caused by Shigella sonnei.Condition
Clinical Trials
Trial Phases
Fluid replacement therapy
0 Actively Recruiting
Otitis Media
0 Actively Recruiting
Genus Pneumocystis
0 Actively Recruiting
bacterial blepharitis caused by susceptible bacteria
0 Actively Recruiting
Brucellosis
0 Actively Recruiting
Bronchitis
0 Actively Recruiting
Pneumocystis Jirovecii Pneumonia
1 Actively Recruiting
Phase 3
susceptible Enteritis infectious caused by Shigella sonnei
0 Actively Recruiting
Bacterial conjunctivitis
0 Actively Recruiting
Blepharoconjunctivitis caused by susceptible bacteria
0 Actively Recruiting
Nocardiosis
0 Actively Recruiting
Shigellosis
3 Actively Recruiting
Phase 2, Phase 1
Diarrhea
0 Actively Recruiting
Urinary tract infection
0 Actively Recruiting
susceptible Enteritis infectious caused by Shigella flexneri
0 Actively Recruiting
Immunocompromised
4 Actively Recruiting
Phase 3, Not Applicable, Phase 1
Cholera
0 Actively Recruiting
Electrolyte replacement
0 Actively Recruiting
Urinary tract infection
0 Actively Recruiting
Trimox Reviews: What are patients saying about Trimox?
5Patient Review
4/28/2010 It's now day 5 and my son is still coughing. Unfortunately, today he also has nausea, vomiting and diarrhea.
5Patient Review
3/27/20104.7Patient Review
5/12/2010 I always get a yeast infection on the third day of using this drug, but it's still better than living with a middle ear infection.
3.7Patient Review
3/21/20102.7Patient Review
7/19/2014 I had a lot of complications from strep throat. I had sinusitis, swollen lymph nodes, and a high fever that wouldn't go down. After starting amoxicillin, though, I felt much better within a day.
Patient Q&A Section about trimox
These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.What is Trimox prescribed for?
"Trimox is an antibiotic that kills bacteria and is used to treat infections such as tonsillitis, bronchitis, pneumonia, gonorrhea, and other infections of the ear, nose, throat, skin, or urinary tract."
Answered by AI
What is Trimox 500 mg used for?
"It works by stopping the growth of bacteria.
This antibiotic is used to treat a variety of bacterial infections. It is a penicillin-type antibiotic, which works by stopping the growth of bacteria."
Answered by AI
Is Trimox same as amoxicillin?
"This medication is used to kill bacteria. It belongs to a group of drugs called penicillins. Amoxicillin comes as a capsule, tablet, and liquid suspension. You take it by mouth with or without food."
Answered by AI
What is Amoxicilina used for?
"Amoxicillin is an antibiotic derived from penicillin. It is commonly used to treat bacterial infections of the chest, such as pneumonia, and dental abscesses. It can also be used in conjunction with other antibiotics and medicines to treat stomach ulcers."
Answered by AI