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If Channel Blocker

Propranolol vs Ivabradine for POTS

Phase 2
Recruiting
Led By Satish R Raj, MD
Research Sponsored by University of Calgary
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial
Must have
Age between 18-60 years
Diagnosis of Postural Tachycardia Syndrome
Timeline
Screening 3 weeks
Treatment Varies
Follow Up 4 weeks
Awards & highlights

Study Summary

This trial is designed to study whether the drugs ivabradine or propranolol can help reduce symptoms and improve quality of life for people with postural tachycardia syndrome (POTS).

Who is the study for?
This trial is for adults aged 18-60 with Postural Tachycardia Syndrome (POTS) who can consent to participate. Excluded are those with low heart rates or blood pressure, structural heart disease, diabetes, uncontrolled asthma, pregnancy, severe liver issues, certain medication use and specific heart rhythm problems.Check my eligibility
What is being tested?
The study tests the effectiveness of Ivabradine versus Propranolol in managing POTS symptoms and heart rate upon standing. It's a double-blind placebo-controlled crossover trial where participants try each treatment for 4 weeks with breaks in between.See study design
What are the potential side effects?
Potential side effects include slow heartbeat or high blood pressure from Ivabradine; fatigue, dizziness or breathing difficulties from Propranolol; both may cause other cardiovascular changes.

Eligibility Criteria

Inclusion Criteria

You may be eligible if you check “Yes” for the criteria below
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I am between 18 and 60 years old.
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I have been diagnosed with Postural Tachycardia Syndrome.

Timeline

Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~4 weeks
This trial's timeline: 3 weeks for screening, Varies for treatment, and 4 weeks for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.
Primary outcome measures
Change in HR
Secondary outcome measures
Vanderbilt Orthostatic Symptoms Score

Trial Design

3Treatment groups
Active Control
Group I: 1st drug IvabradineActive Control3 Interventions
Patients will take Ivabradine first followed by Propranolol and Placebo
Group II: 2nd drug IvabradineActive Control3 Interventions
Patients will take either Propranolol or placebo first and then Ivabradine
Group III: 3rd drug IvabradineActive Control3 Interventions
Patients will take Propranolol and placebo first and then Ivabradine

Find a Location

Who is running the clinical trial?

Dysautonomia InternationalOTHER
5 Previous Clinical Trials
399 Total Patients Enrolled
5 Trials studying Postural Orthostatic Tachycardia Syndrome
399 Patients Enrolled for Postural Orthostatic Tachycardia Syndrome
University of CalgaryLead Sponsor
792 Previous Clinical Trials
869,134 Total Patients Enrolled
8 Trials studying Postural Orthostatic Tachycardia Syndrome
593 Patients Enrolled for Postural Orthostatic Tachycardia Syndrome
Satish R Raj, MDPrincipal InvestigatorUniversity of Calgary
2 Previous Clinical Trials
108 Total Patients Enrolled

Media Library

Ivabradine (If Channel Blocker) Clinical Trial Eligibility Overview. Trial Name: NCT04186286 — Phase 2
Postural Orthostatic Tachycardia Syndrome Research Study Groups: 1st drug Ivabradine, 2nd drug Ivabradine, 3rd drug Ivabradine
Postural Orthostatic Tachycardia Syndrome Clinical Trial 2023: Ivabradine Highlights & Side Effects. Trial Name: NCT04186286 — Phase 2
Ivabradine (If Channel Blocker) 2023 Treatment Timeline for Medical Study. Trial Name: NCT04186286 — Phase 2

Frequently Asked Questions

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

Does this experiment extend to those over a quarter-century of age?

"The eligibility requirements of this clinical trial mandate that participants must fall between 18 and 60 years old."

Answered by AI

Are there currently opportunities for individuals to join this experiment?

"Clinicaltrials.gov states that this experiment is currently searching for participants, which began on February 1st 2021 and has seen recent changes as of March 2nd 2022."

Answered by AI

Has research been conducted involving Ivabradine in conjunction with other medications?

"Currently, Ivabradine studies are in progress at 86 different sites across the globe. Of them, 48 trials remain active with 6 reaching Phase 3 status. Most of these investigations into this drug's efficacy have been conducted in Montréal, Quebec."

Answered by AI

Are there any restrictions on the participant capacity of this clinical experiment?

"Affirmative, current data hosted on clinicaltrials.gov verifies that this medical study is actively seeking volunteers; it was first posted in February 2021 and updated at the beginning of 2022. The experiment intends to recruit 20 individuals from a single site."

Answered by AI

Could you outline the potential hazards of administering Ivabradine to patients?

"Due to the lack of efficacy data, but some safety evidence, our experts have assessed Ivabradine's risk potential as a 2 on a scale from 1-3."

Answered by AI

Are my characteristics compatible with the criteria to join this clinical investigation?

"This medical trial requires the recruitment of 20 individuals between 18 to 60 years old, who are suffering from postural orthostatic tachycardia syndrome. To be eligible for participation, candidates must also meet two other requirements: age range and gender (both male and female)."

Answered by AI

To which conditions is Ivabradine typically prescribed?

"Left ventricular dysfunction is often managed with the drug Ivabradine, while other conditions like thyrotoxicosis, hypertensive disease, and catecholamine imbalances can also be remedied using this medication."

Answered by AI
Recent research and studies
clinicaltrials.govStudy
Crossover Study of Propranolol vs Ivabradine in POTS
2021. "Crossover Study of Propranolol vs Ivabradine in POTS". ClinicalTrials.gov. https://clinicaltrials.gov/ct2/show/NCT04186286.
~3 spots leftby Dec 2024
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