Triglide

Hypertriglyceridemia, Hypertriglyceridemia, Primary Hypercholesterolemia + 2 more
Treatment
8 FDA approvals
19 Active Studies for Triglide

What is Triglide

FenofibrateThe Generic name of this drug
Treatment SummaryFenofibrate is a prescription medication used to lower cholesterol and triglyceride levels in people with high cholesterol and triglyceride levels. It is a type of drug similar to clofibrate and gemfibrozil. Fenofibrate was approved by the FDA in 1993 and is commonly prescribed to treat primary hypercholesterolemia, mixed dyslipidemia, and severe hypertriglyceridemia.
Tricoris the brand name
Triglide Overview & Background
Brand Name
Generic Name
First FDA Approval
How many FDA approvals?
Tricor
Fenofibrate
2002
421

Approved as Treatment by the FDA

Fenofibrate, also known as Tricor, is approved by the FDA for 8 uses which include Hypertriglyceridemia and Primary Hypercholesterolemia .
Hypertriglyceridemia
Primary Hypercholesterolemia
Severe Hypertriglyceridemia (sHTG)
severe Fredrickson Type V Hypertriglyceridemia
Hypertriglyceridemia
Hypertriglyceridemia
severe Fredrickson Type IV Hypertriglyceridemia
Dyslipidemias

Effectiveness

How Triglide Affects PatientsFenofibrate is a medication used to treat high cholesterol and triglyceride levels. It works by changing how the body processes lipids, and needs to be taken once a day. Its effects last for 19-27 hours. The recommended dose is 50-150mg daily, so it is considered to be a safe drug. However, patients should be aware of the risks of muscle problems, rhabdomyolysis, and gallstones associated with taking fibrates.
How Triglide works in the bodyFenofibrate helps the body break down fats. It does this by activating a receptor in the nucleus of cells called the peroxisome proliferator activated receptor alpha (PPARα). When PPARα is activated, the body produces enzymes and proteins that help break down fats. This process also creates molecules that can be damaging to the liver and, in rare cases, can lead to liver cirrhosis and chronic active hepatitis.

When to interrupt dosage

The prescribed dosage of Triglide is contingent upon the diagnosed condition, such as serious Fredrickson Type V Hypertriglyceridemia, Dyslipidemias and Hypertriglyceridemia. The portion of dosage is based on the mode of administering (e.g. Oral or Tablet, film coated) as indicated in the following table.
Condition
Dosage
Administration
Hypertriglyceridemia
145.0 mg, 48.0 mg, , 160.0 mg, 54.0 mg, 43.0 mg, 130.0 mg, 67.0 mg, 200.0 mg, 134.0 mg, 1.45 mg, 1.6 mg, 40.0 mg, 120.0 mg, 150.0 mg, 50.0 mg, 100.0 mg, 30.0 mg, 90.0 mg, 87.0 mg
Oral, Tablet, , Tablet - Oral, Tablet, film coated, Tablet, film coated - Oral, Capsule, Capsule - Oral, Tablet, coated, Tablet, coated - Oral
Hypertriglyceridemia
145.0 mg, 48.0 mg, , 160.0 mg, 54.0 mg, 43.0 mg, 130.0 mg, 67.0 mg, 200.0 mg, 134.0 mg, 1.45 mg, 1.6 mg, 40.0 mg, 120.0 mg, 150.0 mg, 50.0 mg, 100.0 mg, 30.0 mg, 90.0 mg, 87.0 mg
Oral, Tablet, , Tablet - Oral, Tablet, film coated, Tablet, film coated - Oral, Capsule, Capsule - Oral, Tablet, coated, Tablet, coated - Oral
Primary Hypercholesterolemia
145.0 mg, 48.0 mg, , 160.0 mg, 54.0 mg, 43.0 mg, 130.0 mg, 67.0 mg, 200.0 mg, 134.0 mg, 1.45 mg, 1.6 mg, 40.0 mg, 120.0 mg, 150.0 mg, 50.0 mg, 100.0 mg, 30.0 mg, 90.0 mg, 87.0 mg
Oral, Tablet, , Tablet - Oral, Tablet, film coated, Tablet, film coated - Oral, Capsule, Capsule - Oral, Tablet, coated, Tablet, coated - Oral
Dyslipidemias
145.0 mg, 48.0 mg, , 160.0 mg, 54.0 mg, 43.0 mg, 130.0 mg, 67.0 mg, 200.0 mg, 134.0 mg, 1.45 mg, 1.6 mg, 40.0 mg, 120.0 mg, 150.0 mg, 50.0 mg, 100.0 mg, 30.0 mg, 90.0 mg, 87.0 mg
Oral, Tablet, , Tablet - Oral, Tablet, film coated, Tablet, film coated - Oral, Capsule, Capsule - Oral, Tablet, coated, Tablet, coated - Oral
Hypertriglyceridemia
145.0 mg, 48.0 mg, , 160.0 mg, 54.0 mg, 43.0 mg, 130.0 mg, 67.0 mg, 200.0 mg, 134.0 mg, 1.45 mg, 1.6 mg, 40.0 mg, 120.0 mg, 150.0 mg, 50.0 mg, 100.0 mg, 30.0 mg, 90.0 mg, 87.0 mg
Oral, Tablet, , Tablet - Oral, Tablet, film coated, Tablet, film coated - Oral, Capsule, Capsule - Oral, Tablet, coated, Tablet, coated - Oral

Warnings

Triglide has three contraindications. It should not be employed in concert with the conditions given in the below table.Triglide Contraindications
Condition
Risk Level
Notes
Liver Diseases
Do Not Combine
Gallbladder Diseases
Do Not Combine
Severe Hypersensitivity Reactions
Do Not Combine
Fenofibrate may interact with Pulse Frequency
There are 20 known major drug interactions with Triglide.
Common Triglide Drug Interactions
Drug Name
Risk Level
Description
Acenocoumarol
Major
The metabolism of Acenocoumarol can be decreased when combined with Fenofibrate.
Aluminium clofibrate
Major
The risk or severity of adverse effects can be increased when Fenofibrate is combined with Aluminium clofibrate.
Axitinib
Major
The metabolism of Axitinib can be decreased when combined with Fenofibrate.
Bezafibrate
Major
The risk or severity of adverse effects can be increased when Fenofibrate is combined with Bezafibrate.
Brigatinib
Major
The metabolism of Brigatinib can be decreased when combined with Fenofibrate.
Triglide Toxicity & Overdose RiskThe lowest toxic dose of fenofibrate in rats has been found to be greater than 2g/kg, and 1600mg/kg in mice. Those experiencing an overdose should be monitored for vital signs and observed for any changes in their clinical status. Vomiting or stomach pumping may be used to treat more recent overdoses, however hemodialysis is unlikely to be effective since most of the drug is protein bound.
image of a doctor in a lab doing drug, clinical research

Triglide Novel Uses: Which Conditions Have a Clinical Trial Featuring Triglide?

15 active clinical trials are presently being conducted to assess the potential of Triglide to ameliorate severe Fredrickson Type V Hypertriglyceridemia, Hypertriglyceridemia and Dyslipidemias.
Condition
Clinical Trials
Trial Phases
Primary Hypercholesterolemia
10 Actively Recruiting
Phase 3, Phase 2, Not Applicable
Hypertriglyceridemia
8 Actively Recruiting
Phase 3, Phase 2
Hypertriglyceridemia
0 Actively Recruiting
Hypertriglyceridemia
0 Actively Recruiting
Dyslipidemias
1 Actively Recruiting
Phase 2

Triglide Reviews: What are patients saying about Triglide?

5Patient Review
7/15/2009
Triglide for High Amount of Triglyceride in the Blood
I was very pleased with this medication. I saw a significant improvement in my condition and experienced no negative side effects.
5Patient Review
9/15/2010
Triglide for Combined High Blood Cholesterol and Triglyceride Level
I found this drug to be effective, but it's now impossible to find.
3.7Patient Review
8/25/2008
Triglide for High Amount of Triglyceride in the Blood
I became forgetful and put on weight soon after starting this medication. Additionally, my liver function tests were irregular for a period of three months.
3.3Patient Review
7/16/2009
Triglide for High Amount of Triglyceride in the Blood
I've been taking this medication for a few years now, and my triglyceride levels are still too high.
3Patient Review
7/27/2008
Triglide for Combined High Blood Cholesterol and Triglyceride Level
I started to get a rash on my arms not long after I began taking this medication. It was itchy and unattractive, but stopped once I stopped taking the medicine.
View All Reviews
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Patient Q&A Section about triglide

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

What drug class is triglide?

"Triglide is a medication used to reduce symptoms related to cholesterol and triglycerides. It may be used alone or with other medications and belongs to a class of drugs called Fibric Acid Agents."

Answered by AI

How much is a triglide?

"Triglide is a brand name drug that is used to treat high cholesterol. The lowest GoodRx price for the most common version of Triglide is around $966.96. Compare fibrates."

Answered by AI

What is triglide used for?

"High cholesterol and triglyceride levels can be reduced by Triglide (fenofibrate). This medication is used to treat high levels of these fats in the blood, which can increase the risk of atherosclerosis (clogged arteries)."

Answered by AI

Clinical Trials for Triglide

Have you considered Triglide clinical trials? We made a collection of clinical trials featuring Triglide, we think they might fit your search criteria.
Have you considered Triglide clinical trials? We made a collection of clinical trials featuring Triglide, we think they might fit your search criteria.
Have you considered Triglide clinical trials? We made a collection of clinical trials featuring Triglide, we think they might fit your search criteria.
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