Tivorbex

Muscle Pain, Bursitis, Tendinopathy + 9 more

Treatment

6 Active Studies for Tivorbex

What is Tivorbex

Indomethacin

The Generic name of this drug

Treatment Summary

Indometacin is a medication used to reduce inflammation, pain and fever. It is classified as a non-steroidal anti-inflammatory drug (NSAID) and works by blocking the enzyme cyclooxygenase (COX), which is responsible for producing prostaglandins and thromboxanes. It is used to treat a variety of conditions, including rheumatoid arthritis, ankylosing spondylitis, osteoarthritis, acute shoulder pains, and acute gouty arthritis. It is available in oral capsules, rectal, and intravenous formulations. Ophthalmic indometacin has

Indomethacin

is the brand name

Tivorbex Overview & Background

Brand Name

Generic Name

First FDA Approval

How many FDA approvals?

Indomethacin

Indomethacin

1984

241

Effectiveness

How Tivorbex Affects Patients

Indometacin is a painkiller and fever reducer that works by reducing the amount of factors that cause pain, fever, and inflammation. When taken for rheumatoid arthritis, it can reduce joint swelling, the number of joints affected, and morning stiffness. It can also reduce the pain, fever, swelling, tenderness, and redness of acute gouty arthritis. Taking indometacin comes with the risk of cardiovascular issues or gastrointestinal effects like bleeding and ulcers. In studies of healthy individuals, taking indometacin decreased their cerebral blood flow for a short period of time, although the significance of this is

How Tivorbex works in the body

Indometacin is a drug that reduces inflammation, pain, and fever. It works by blocking an enzyme called cyclo-oxygenase (COX), which is involved in the production of prostaglandins. Prostaglandins are molecules responsible for inflammation, pain, and fever. Indometacin also blocks the release of arachidonic acid from phospholipids, which further reduces prostaglandin production. Additionally, indometacin can cause vasodilation and increased peripheral blood flow, which helps reduce fever. Indometacin is also used to close a patent ductus arteriosus

When to interrupt dosage

The advisable dosage of Tivorbex is contingent upon the diagnosed state, like Aquaporin 2, Arthritis, Gouty and Moderate to severe ankylosing spondylitis. The amount of dosage fluctuates as per the technique of delivery (e.g. Capsule or Injection, powder, lyophilized, for solution) featured in the table underneath.

Condition

Dosage

Administration

Rheumatoid Arthritis

25.0 mg, , 50.0 mg, 75.0 mg, 100.0 mg, 1.0 mg, 20.0 mg, 40.0 mg, 25.0 mg/mL, 1.0 mg/mL, 10.0 mg/mL

, Capsule - Oral, Capsule, Oral, Capsule, extended release - Oral, Capsule, extended release, Suppository, Suppository - Rectal, Rectal, Liquid; Powder, for solution - Ophthalmic, Suspension - Oral, Injection, powder, lyophilized, for solution - Intravenous, Intravenous, Injection, powder, lyophilized, for solution, Suspension, Injection, powder, for solution, Injection, powder, for solution - Intravenous, Ophthalmic, Liquid; Powder, for solution, Solution / drops, Solution / drops - Ophthalmic

Disease

25.0 mg, , 50.0 mg, 75.0 mg, 100.0 mg, 1.0 mg, 20.0 mg, 40.0 mg, 25.0 mg/mL, 1.0 mg/mL, 10.0 mg/mL

, Capsule - Oral, Capsule, Oral, Capsule, extended release - Oral, Capsule, extended release, Suppository, Suppository - Rectal, Rectal, Liquid; Powder, for solution - Ophthalmic, Suspension - Oral, Injection, powder, lyophilized, for solution - Intravenous, Intravenous, Injection, powder, lyophilized, for solution, Suspension, Injection, powder, for solution, Injection, powder, for solution - Intravenous, Ophthalmic, Liquid; Powder, for solution, Solution / drops, Solution / drops - Ophthalmic

Aquaporin 2

25.0 mg, , 50.0 mg, 75.0 mg, 100.0 mg, 1.0 mg, 20.0 mg, 40.0 mg, 25.0 mg/mL, 1.0 mg/mL, 10.0 mg/mL

, Capsule - Oral, Capsule, Oral, Capsule, extended release - Oral, Capsule, extended release, Suppository, Suppository - Rectal, Rectal, Liquid; Powder, for solution - Ophthalmic, Suspension - Oral, Injection, powder, lyophilized, for solution - Intravenous, Intravenous, Injection, powder, lyophilized, for solution, Suspension, Injection, powder, for solution, Injection, powder, for solution - Intravenous, Ophthalmic, Liquid; Powder, for solution, Solution / drops, Solution / drops - Ophthalmic

Bursitis

25.0 mg, , 50.0 mg, 75.0 mg, 100.0 mg, 1.0 mg, 20.0 mg, 40.0 mg, 25.0 mg/mL, 1.0 mg/mL, 10.0 mg/mL

, Capsule - Oral, Capsule, Oral, Capsule, extended release - Oral, Capsule, extended release, Suppository, Suppository - Rectal, Rectal, Liquid; Powder, for solution - Ophthalmic, Suspension - Oral, Injection, powder, lyophilized, for solution - Intravenous, Intravenous, Injection, powder, lyophilized, for solution, Suspension, Injection, powder, for solution, Injection, powder, for solution - Intravenous, Ophthalmic, Liquid; Powder, for solution, Solution / drops, Solution / drops - Ophthalmic

Tendinopathy

25.0 mg, , 50.0 mg, 75.0 mg, 100.0 mg, 1.0 mg, 20.0 mg, 40.0 mg, 25.0 mg/mL, 1.0 mg/mL, 10.0 mg/mL

, Capsule - Oral, Capsule, Oral, Capsule, extended release - Oral, Capsule, extended release, Suppository, Suppository - Rectal, Rectal, Liquid; Powder, for solution - Ophthalmic, Suspension - Oral, Injection, powder, lyophilized, for solution - Intravenous, Intravenous, Injection, powder, lyophilized, for solution, Suspension, Injection, powder, for solution, Injection, powder, for solution - Intravenous, Ophthalmic, Liquid; Powder, for solution, Solution / drops, Solution / drops - Ophthalmic

Moderate to severe ankylosing spondylitis

25.0 mg, , 50.0 mg, 75.0 mg, 100.0 mg, 1.0 mg, 20.0 mg, 40.0 mg, 25.0 mg/mL, 1.0 mg/mL, 10.0 mg/mL

, Capsule - Oral, Capsule, Oral, Capsule, extended release - Oral, Capsule, extended release, Suppository, Suppository - Rectal, Rectal, Liquid; Powder, for solution - Ophthalmic, Suspension - Oral, Injection, powder, lyophilized, for solution - Intravenous, Intravenous, Injection, powder, lyophilized, for solution, Suspension, Injection, powder, for solution, Injection, powder, for solution - Intravenous, Ophthalmic, Liquid; Powder, for solution, Solution / drops, Solution / drops - Ophthalmic

Arthritis, Gouty

25.0 mg, , 50.0 mg, 75.0 mg, 100.0 mg, 1.0 mg, 20.0 mg, 40.0 mg, 25.0 mg/mL, 1.0 mg/mL, 10.0 mg/mL

, Capsule - Oral, Capsule, Oral, Capsule, extended release - Oral, Capsule, extended release, Suppository, Suppository - Rectal, Rectal, Liquid; Powder, for solution - Ophthalmic, Suspension - Oral, Injection, powder, lyophilized, for solution - Intravenous, Intravenous, Injection, powder, lyophilized, for solution, Suspension, Injection, powder, for solution, Injection, powder, for solution - Intravenous, Ophthalmic, Liquid; Powder, for solution, Solution / drops, Solution / drops - Ophthalmic

Arthralgia

25.0 mg, , 50.0 mg, 75.0 mg, 100.0 mg, 1.0 mg, 20.0 mg, 40.0 mg, 25.0 mg/mL, 1.0 mg/mL, 10.0 mg/mL

, Capsule - Oral, Capsule, Oral, Capsule, extended release - Oral, Capsule, extended release, Suppository, Suppository - Rectal, Rectal, Liquid; Powder, for solution - Ophthalmic, Suspension - Oral, Injection, powder, lyophilized, for solution - Intravenous, Intravenous, Injection, powder, lyophilized, for solution, Suspension, Injection, powder, for solution, Injection, powder, for solution - Intravenous, Ophthalmic, Liquid; Powder, for solution, Solution / drops, Solution / drops - Ophthalmic

Pain

25.0 mg, , 50.0 mg, 75.0 mg, 100.0 mg, 1.0 mg, 20.0 mg, 40.0 mg, 25.0 mg/mL, 1.0 mg/mL, 10.0 mg/mL

, Capsule - Oral, Capsule, Oral, Capsule, extended release - Oral, Capsule, extended release, Suppository, Suppository - Rectal, Rectal, Liquid; Powder, for solution - Ophthalmic, Suspension - Oral, Injection, powder, lyophilized, for solution - Intravenous, Intravenous, Injection, powder, lyophilized, for solution, Suspension, Injection, powder, for solution, Injection, powder, for solution - Intravenous, Ophthalmic, Liquid; Powder, for solution, Solution / drops, Solution / drops - Ophthalmic

Body weight between 500 and 1750 g

25.0 mg, , 50.0 mg, 75.0 mg, 100.0 mg, 1.0 mg, 20.0 mg, 40.0 mg, 25.0 mg/mL, 1.0 mg/mL, 10.0 mg/mL

, Capsule - Oral, Capsule, Oral, Capsule, extended release - Oral, Capsule, extended release, Suppository, Suppository - Rectal, Rectal, Liquid; Powder, for solution - Ophthalmic, Suspension - Oral, Injection, powder, lyophilized, for solution - Intravenous, Intravenous, Injection, powder, lyophilized, for solution, Suspension, Injection, powder, for solution, Injection, powder, for solution - Intravenous, Ophthalmic, Liquid; Powder, for solution, Solution / drops, Solution / drops - Ophthalmic

Muscle Pain

25.0 mg, , 50.0 mg, 75.0 mg, 100.0 mg, 1.0 mg, 20.0 mg, 40.0 mg, 25.0 mg/mL, 1.0 mg/mL, 10.0 mg/mL

, Capsule - Oral, Capsule, Oral, Capsule, extended release - Oral, Capsule, extended release, Suppository, Suppository - Rectal, Rectal, Liquid; Powder, for solution - Ophthalmic, Suspension - Oral, Injection, powder, lyophilized, for solution - Intravenous, Intravenous, Injection, powder, lyophilized, for solution, Suspension, Injection, powder, for solution, Injection, powder, for solution - Intravenous, Ophthalmic, Liquid; Powder, for solution, Solution / drops, Solution / drops - Ophthalmic

Degenerative polyarthritis

25.0 mg, , 50.0 mg, 75.0 mg, 100.0 mg, 1.0 mg, 20.0 mg, 40.0 mg, 25.0 mg/mL, 1.0 mg/mL, 10.0 mg/mL

, Capsule - Oral, Capsule, Oral, Capsule, extended release - Oral, Capsule, extended release, Suppository, Suppository - Rectal, Rectal, Liquid; Powder, for solution - Ophthalmic, Suspension - Oral, Injection, powder, lyophilized, for solution - Intravenous, Intravenous, Injection, powder, lyophilized, for solution, Suspension, Injection, powder, for solution, Injection, powder, for solution - Intravenous, Ophthalmic, Liquid; Powder, for solution, Solution / drops, Solution / drops - Ophthalmic

Warnings

Tivorbex has twenty-three contraindications and should be avoided when encountering any of the conditions specified in the following table.

Tivorbex Contraindications

Condition

Risk Level

Notes

Intracranial Hemorrhage

Do Not Combine

Congenital Heart Defect

Do Not Combine

aspirin

Do Not Combine

Asthma

Do Not Combine

Urticaria caused by NSAIDs

Do Not Combine

Hemorrhage

Do Not Combine

Congenital Heart Defect

Do Not Combine

Blood Coagulation Disorders

Do Not Combine

Gastrointestinal Hemorrhage

Do Not Combine

Hematochezia

Do Not Combine

Pulmonary Atresia

Do Not Combine

Pulse Frequency

Do Not Combine

Ductus Arteriosus, Patent

Do Not Combine

Enterocolitis, Necrotizing

Do Not Combine

proven or suspected untreated infection

Do Not Combine

Enterocolitis, Necrotizing

Do Not Combine

history of proctitis

Do Not Combine

Low Platelet Count

Do Not Combine

Coronary Artery Bypass Grafting

Do Not Combine

NSAID-Induced Asthma

Do Not Combine

Severe Hypersensitivity Reactions

Do Not Combine

Indomethacin may interact with Pulse Frequency

Severe Hypersensitivity Reactions

Do Not Combine

Indomethacin may interact with Pulse Frequency

Severe Hypersensitivity Reactions

Do Not Combine

Indomethacin may interact with Pulse Frequency

There are 20 known major drug interactions with Tivorbex.

Common Tivorbex Drug Interactions

Drug Name

Risk Level

Description

2-Methoxyethanol

Major

The risk or severity of adverse effects can be increased when Indomethacin is combined with 2-Methoxyethanol.

9-(N-methyl-L-isoleucine)-cyclosporin A

Major

The risk or severity of adverse effects can be increased when Indomethacin is combined with 9-(N-methyl-L-isoleucine)-cyclosporin A.

Abetimus

Major

The risk or severity of adverse effects can be increased when Indomethacin is combined with Abetimus.

Acteoside

Major

The risk or severity of adverse effects can be increased when Indomethacin is combined with Acteoside.

Altretamine

Major

The risk or severity of adverse effects can be increased when Indomethacin is combined with Altretamine.

Tivorbex Toxicity & Overdose Risk

The toxic dose of indomethacin for rats is 2.42 mg/kg and 13 mg/kg for mice. Overdosing on indomethacin can cause symptoms like nausea, headache, dizziness, confusion, and extreme tiredness. There have also been reports of numbness and seizures. Treatment for an overdose should include emptying the stomach and taking antacids. The patient should also be closely monitored for any signs of gastrointestinal bleeding or ulcers.

image of a doctor in a lab doing drug, clinical research

Tivorbex Novel Uses: Which Conditions Have a Clinical Trial Featuring Tivorbex?

24 active trials are currently being conducted to assess the potential of Tivorbex in alleviating Joint Pain, Degenerative polyarthritis and Muscle Pain.

Condition

Clinical Trials

Trial Phases

Arthritis, Gouty

0 Actively Recruiting

Muscle Pain

3 Actively Recruiting

Phase 4, Not Applicable, Phase 2

Pain

0 Actively Recruiting

Arthralgia

0 Actively Recruiting

Body weight between 500 and 1750 g

0 Actively Recruiting

Bursitis

0 Actively Recruiting

Tendinopathy

0 Actively Recruiting

Aquaporin 2

3 Actively Recruiting

Phase 3, Not Applicable, Phase 2

Rheumatoid Arthritis

0 Actively Recruiting

Disease

0 Actively Recruiting

Moderate to severe ankylosing spondylitis

0 Actively Recruiting

Degenerative polyarthritis

0 Actively Recruiting

Tivorbex Reviews: What are patients saying about Tivorbex?

5

Patient Review

3/20/2017

Tivorbex for Acute Pain

I have chronic pain in my knees. This medication has eased the swelling and pain, allowing me to move again without having to deal with sharp shooting pains.

2.3

Patient Review

10/29/2016

Tivorbex for Inflammation of the Joints due to Gout

I am experiencing a great deal of pain, particularly in my back. It feels like I've been punched repeatedly. My muscles ache and I'm moving very slowly--I feel like a snail. This is causing me a lot of distress.

Patient Q&A Section about tivorbex

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

What is the difference between ibuprofen and indomethacin?

"Indocin (indomethacin) is a medication that is used to relieve pain, fever, and swelling. Advil (ibuprofen) is a medication that works well for treating fever, inflammation, and a variety of mild to moderate pain conditions, but it does not last as long as other NSAIDs."

Answered by AI

What are indometacin tablets for?

"Indomethacin is used to relieve pain, tenderness, swelling, and stiffness caused by osteoarthritis, rheumatoid arthritis, and ankylosing spondylitis."

Answered by AI

Is Tivorbex discontinued?

"All of the above medications have been discontinued. Note: There may be illegal online pharmacies selling a generic version of Tivorbex."

Answered by AI

What is Tivorbex used for?

"This medication is used to relieve pain and joint stiffness caused by arthritis, gout, bursitis, and tendonitis. It is also used to relieve pain from various other conditions. This medication is known as a nonsteroidal anti-inflammatory drug (NSAID)."

Answered by AI

Clinical Trials for Tivorbex

Image of McMaster Children's Hospital - Neonatal Intensive Care Unit in Hamilton, Canada.

Ibuprofen for Patent Ductus Arteriosus

< 18
All Sexes
Hamilton, Canada

Newborns born early are at risk for a serious health problem called patent ductus arteriosus (PDA). PDA is a passageway between heart and lung that can cause life-threatening complications such as bleeding in the brain or even death if it remains open and large. When closure of PDA is needed, doctors make every attempt to do it as soon as possible. Ibuprofen is the best drug to close the PDA, but it only works for 50% of small newborns. The investigators have shown before that small newborns handle ibuprofen differently and the amount of active ibuprofen that reaches their blood can be very unpredictable. Studies have shown if enough ibuprofen reaches the body, it can close the PDA. Therefore the investigators designed this study to see whether it is possible to give each newborn the right amount of ibuprofen that their body needs to close the PDA. The investigators will compare two ways to give ibuprofen in a small number of newborns: 1 - standard amount of ibuprofen to everyone, which is the usual care or 2 - ibuprofen doses that will be changed based on how much active ibuprofen has reached the body and how well the newborn's PDA is closing. The investigators will then compare the number of PDAs closed in each group and closely monitor any possible challenges for this new practice. By doing this project, the goals can be summarized as below: A. Primary goal: To determine if it is feasible to successfully run a larger study in the future. B. Secondary goals 1. To assess how well and how safely the personalized (MIPD) method works, using a tool called WAPPS-PDA to guide dosing. 2. To compare the effectiveness and safety of the personalized method with standard ibuprofen dosing. 3. To identify drug levels in the blood (Cmin, AUC0-24, AUC0-72) that are associated with complete, partial, or no response to treatment.

Phase 2
Recruiting

McMaster Children's Hospital - Neonatal Intensive Care Unit

Samira Samiee-Zafarghandy, MD, FRCPC

Image of Rutgers School of Dental Medicine in Newark, United States.

Temporo-masseteric Nerve Block for Postoperative Pain

18+
All Sexes
Newark, NJ

The proposed design is a triple-blind, placebo-controlled randomized prospective phase II trial to assess the feasibility of employing the Temporo-masseteric Nerve Block (TMNB) injection to decrease jaw muscle pain, overall pain, improve mouth opening and minimize pain medication consumption. 80 participants undergoing lower third molar removal under sedation will be enrolled. Those who develop significant jaw muscle pain on the following day will be randomized to receive either the TMNB injection or a placebo. Daily ecological momentary assessments (EMAs) will be collected reflecting elements of patient experience for all participants. On Day 8, participants return for an end-of-study evaluation and return their unused pain medications. Up to 40 participants who are randomized to receive TMNB/placebo will be recruited to participate in a qualitative interview regarding their experience.

Phase 2
Waitlist Available

Rutgers School of Dental Medicine

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