Tivorbex

Aquaporin 2, Tendinitis, Joint Pain + 9 more
Treatment
20 Active Studies for Tivorbex

What is Tivorbex

IndomethacinThe Generic name of this drug
Treatment SummaryIndometacin is a medication used to reduce inflammation, pain and fever. It is classified as a non-steroidal anti-inflammatory drug (NSAID) and works by blocking the enzyme cyclooxygenase (COX), which is responsible for producing prostaglandins and thromboxanes. It is used to treat a variety of conditions, including rheumatoid arthritis, ankylosing spondylitis, osteoarthritis, acute shoulder pains, and acute gouty arthritis. It is available in oral capsules, rectal, and intravenous formulations. Ophthalmic indometacin has
Indomethacinis the brand name
Tivorbex Overview & Background
Brand Name
Generic Name
First FDA Approval
How many FDA approvals?
Indomethacin
Indomethacin
1984
239

Effectiveness

How Tivorbex Affects PatientsIndometacin is a painkiller and fever reducer that works by reducing the amount of factors that cause pain, fever, and inflammation. When taken for rheumatoid arthritis, it can reduce joint swelling, the number of joints affected, and morning stiffness. It can also reduce the pain, fever, swelling, tenderness, and redness of acute gouty arthritis. Taking indometacin comes with the risk of cardiovascular issues or gastrointestinal effects like bleeding and ulcers. In studies of healthy individuals, taking indometacin decreased their cerebral blood flow for a short period of time, although the significance of this is
How Tivorbex works in the bodyIndometacin is a drug that reduces inflammation, pain, and fever. It works by blocking an enzyme called cyclo-oxygenase (COX), which is involved in the production of prostaglandins. Prostaglandins are molecules responsible for inflammation, pain, and fever. Indometacin also blocks the release of arachidonic acid from phospholipids, which further reduces prostaglandin production. Additionally, indometacin can cause vasodilation and increased peripheral blood flow, which helps reduce fever. Indometacin is also used to close a patent ductus arteriosus

When to interrupt dosage

The advisable dosage of Tivorbex is contingent upon the diagnosed state, like Aquaporin 2, Arthritis, Gouty and Moderate to severe ankylosing spondylitis. The amount of dosage fluctuates as per the technique of delivery (e.g. Capsule or Injection, powder, lyophilized, for solution) featured in the table underneath.
Condition
Dosage
Administration
Tendinitis
, 1.0 mg, 25.0 mg, 1.0 mg/mL, 50.0 mg, 40.0 mg, 20.0 mg, 75.0 mg, 10.0 mg/mL, 100.0 mg, 25.0 mg/mL
Capsule, Injection, powder, lyophilized, for solution, , Suppository - Rectal, Injection, powder, for solution - Intravenous, Capsule - Oral, Rectal, Liquid; Powder, for solution - Ophthalmic, Intravenous, Suspension - Oral, Suppository, Ophthalmic, Injection, powder, for solution, Oral, Solution / drops, Capsule, extended release, Suspension, Capsule, extended release - Oral, Injection, powder, lyophilized, for solution - Intravenous, Liquid; Powder, for solution, Solution / drops - Ophthalmic
Aquaporin 2
, 1.0 mg, 25.0 mg, 1.0 mg/mL, 50.0 mg, 40.0 mg, 20.0 mg, 75.0 mg, 10.0 mg/mL, 100.0 mg, 25.0 mg/mL
Capsule, Injection, powder, lyophilized, for solution, , Suppository - Rectal, Injection, powder, for solution - Intravenous, Capsule - Oral, Rectal, Liquid; Powder, for solution - Ophthalmic, Intravenous, Suspension - Oral, Suppository, Ophthalmic, Injection, powder, for solution, Oral, Solution / drops, Capsule, extended release, Suspension, Capsule, extended release - Oral, Injection, powder, lyophilized, for solution - Intravenous, Liquid; Powder, for solution, Solution / drops - Ophthalmic
Joint Pain
, 1.0 mg, 25.0 mg, 1.0 mg/mL, 50.0 mg, 40.0 mg, 20.0 mg, 75.0 mg, 10.0 mg/mL, 100.0 mg, 25.0 mg/mL
Capsule, Injection, powder, lyophilized, for solution, , Suppository - Rectal, Injection, powder, for solution - Intravenous, Capsule - Oral, Rectal, Liquid; Powder, for solution - Ophthalmic, Intravenous, Suspension - Oral, Suppository, Ophthalmic, Injection, powder, for solution, Oral, Solution / drops, Capsule, extended release, Suspension, Capsule, extended release - Oral, Injection, powder, lyophilized, for solution - Intravenous, Liquid; Powder, for solution, Solution / drops - Ophthalmic
Arthritis, Gouty
, 1.0 mg, 25.0 mg, 1.0 mg/mL, 50.0 mg, 40.0 mg, 20.0 mg, 75.0 mg, 10.0 mg/mL, 100.0 mg, 25.0 mg/mL
Capsule, Injection, powder, lyophilized, for solution, , Suppository - Rectal, Injection, powder, for solution - Intravenous, Capsule - Oral, Rectal, Liquid; Powder, for solution - Ophthalmic, Intravenous, Suspension - Oral, Suppository, Ophthalmic, Injection, powder, for solution, Oral, Solution / drops, Capsule, extended release, Suspension, Capsule, extended release - Oral, Injection, powder, lyophilized, for solution - Intravenous, Liquid; Powder, for solution, Solution / drops - Ophthalmic
Pain
, 1.0 mg, 25.0 mg, 1.0 mg/mL, 50.0 mg, 40.0 mg, 20.0 mg, 75.0 mg, 10.0 mg/mL, 100.0 mg, 25.0 mg/mL
Capsule, Injection, powder, lyophilized, for solution, , Suppository - Rectal, Injection, powder, for solution - Intravenous, Capsule - Oral, Rectal, Liquid; Powder, for solution - Ophthalmic, Intravenous, Suspension - Oral, Suppository, Ophthalmic, Injection, powder, for solution, Oral, Solution / drops, Capsule, extended release, Suspension, Capsule, extended release - Oral, Injection, powder, lyophilized, for solution - Intravenous, Liquid; Powder, for solution, Solution / drops - Ophthalmic
Body weight between 500 and 1750 g
, 1.0 mg, 25.0 mg, 1.0 mg/mL, 50.0 mg, 40.0 mg, 20.0 mg, 75.0 mg, 10.0 mg/mL, 100.0 mg, 25.0 mg/mL
Capsule, Injection, powder, lyophilized, for solution, , Suppository - Rectal, Injection, powder, for solution - Intravenous, Capsule - Oral, Rectal, Liquid; Powder, for solution - Ophthalmic, Intravenous, Suspension - Oral, Suppository, Ophthalmic, Injection, powder, for solution, Oral, Solution / drops, Capsule, extended release, Suspension, Capsule, extended release - Oral, Injection, powder, lyophilized, for solution - Intravenous, Liquid; Powder, for solution, Solution / drops - Ophthalmic
inadequate response to conventional therapy
, 1.0 mg, 25.0 mg, 1.0 mg/mL, 50.0 mg, 40.0 mg, 20.0 mg, 75.0 mg, 10.0 mg/mL, 100.0 mg, 25.0 mg/mL
Capsule, Injection, powder, lyophilized, for solution, , Suppository - Rectal, Injection, powder, for solution - Intravenous, Capsule - Oral, Rectal, Liquid; Powder, for solution - Ophthalmic, Intravenous, Suspension - Oral, Suppository, Ophthalmic, Injection, powder, for solution, Oral, Solution / drops, Capsule, extended release, Suspension, Capsule, extended release - Oral, Injection, powder, lyophilized, for solution - Intravenous, Liquid; Powder, for solution, Solution / drops - Ophthalmic
Rheumatoid Arthritis
, 1.0 mg, 25.0 mg, 1.0 mg/mL, 50.0 mg, 40.0 mg, 20.0 mg, 75.0 mg, 10.0 mg/mL, 100.0 mg, 25.0 mg/mL
Capsule, Injection, powder, lyophilized, for solution, , Suppository - Rectal, Injection, powder, for solution - Intravenous, Capsule - Oral, Rectal, Liquid; Powder, for solution - Ophthalmic, Intravenous, Suspension - Oral, Suppository, Ophthalmic, Injection, powder, for solution, Oral, Solution / drops, Capsule, extended release, Suspension, Capsule, extended release - Oral, Injection, powder, lyophilized, for solution - Intravenous, Liquid; Powder, for solution, Solution / drops - Ophthalmic
Bursitis
, 1.0 mg, 25.0 mg, 1.0 mg/mL, 50.0 mg, 40.0 mg, 20.0 mg, 75.0 mg, 10.0 mg/mL, 100.0 mg, 25.0 mg/mL
Capsule, Injection, powder, lyophilized, for solution, , Suppository - Rectal, Injection, powder, for solution - Intravenous, Capsule - Oral, Rectal, Liquid; Powder, for solution - Ophthalmic, Intravenous, Suspension - Oral, Suppository, Ophthalmic, Injection, powder, for solution, Oral, Solution / drops, Capsule, extended release, Suspension, Capsule, extended release - Oral, Injection, powder, lyophilized, for solution - Intravenous, Liquid; Powder, for solution, Solution / drops - Ophthalmic
Muscle Pain
, 1.0 mg, 25.0 mg, 1.0 mg/mL, 50.0 mg, 40.0 mg, 20.0 mg, 75.0 mg, 10.0 mg/mL, 100.0 mg, 25.0 mg/mL
Capsule, Injection, powder, lyophilized, for solution, , Suppository - Rectal, Injection, powder, for solution - Intravenous, Capsule - Oral, Rectal, Liquid; Powder, for solution - Ophthalmic, Intravenous, Suspension - Oral, Suppository, Ophthalmic, Injection, powder, for solution, Oral, Solution / drops, Capsule, extended release, Suspension, Capsule, extended release - Oral, Injection, powder, lyophilized, for solution - Intravenous, Liquid; Powder, for solution, Solution / drops - Ophthalmic
Moderate to severe ankylosing spondylitis
, 1.0 mg, 25.0 mg, 1.0 mg/mL, 50.0 mg, 40.0 mg, 20.0 mg, 75.0 mg, 10.0 mg/mL, 100.0 mg, 25.0 mg/mL
Capsule, Injection, powder, lyophilized, for solution, , Suppository - Rectal, Injection, powder, for solution - Intravenous, Capsule - Oral, Rectal, Liquid; Powder, for solution - Ophthalmic, Intravenous, Suspension - Oral, Suppository, Ophthalmic, Injection, powder, for solution, Oral, Solution / drops, Capsule, extended release, Suspension, Capsule, extended release - Oral, Injection, powder, lyophilized, for solution - Intravenous, Liquid; Powder, for solution, Solution / drops - Ophthalmic
Degenerative polyarthritis
, 1.0 mg, 25.0 mg, 1.0 mg/mL, 50.0 mg, 40.0 mg, 20.0 mg, 75.0 mg, 10.0 mg/mL, 100.0 mg, 25.0 mg/mL
Capsule, Injection, powder, lyophilized, for solution, , Suppository - Rectal, Injection, powder, for solution - Intravenous, Capsule - Oral, Rectal, Liquid; Powder, for solution - Ophthalmic, Intravenous, Suspension - Oral, Suppository, Ophthalmic, Injection, powder, for solution, Oral, Solution / drops, Capsule, extended release, Suspension, Capsule, extended release - Oral, Injection, powder, lyophilized, for solution - Intravenous, Liquid; Powder, for solution, Solution / drops - Ophthalmic

Warnings

Tivorbex has twenty-three contraindications and should be avoided when encountering any of the conditions specified in the following table.Tivorbex Contraindications
Condition
Risk Level
Notes
Intracranial Hemorrhage
Do Not Combine
aspirin
Do Not Combine
Hematochezia
Do Not Combine
suspected necrotizing enterocolitis
Do Not Combine
Urticaria caused by NSAIDs
Do Not Combine
Necrotizing Enterocolitis (NEC)
Do Not Combine
history of proctitis
Do Not Combine
Gastrointestinal Hemorrhage
Do Not Combine
NSAID-Induced Asthma
Do Not Combine
Coarctation of the Aorta
Do Not Combine
necessary patency of the ductus arteriosus
Do Not Combine
Pulmonary Atresia
Do Not Combine
Coronary Artery Bypass Grafting
Do Not Combine
proven or suspected untreated infection
Do Not Combine
Low Platelet Count
Do Not Combine
Tetralogy of Fallot (TOF)
Do Not Combine
Coagulation Disorder
Do Not Combine
Aspirin Exacerbated Asthma
Do Not Combine
Hemorrhage
Do Not Combine
Toxoplasma Infections
Do Not Combine
Severe Hypersensitivity Reactions
Do Not Combine
Indomethacin may interact with Toxoplasma Infections
Severe Hypersensitivity Reactions
Do Not Combine
Indomethacin may interact with Toxoplasma Infections
Severe Hypersensitivity Reactions
Do Not Combine
Indomethacin may interact with Toxoplasma Infections
There are 20 known major drug interactions with Tivorbex.
Common Tivorbex Drug Interactions
Drug Name
Risk Level
Description
2-Methoxyethanol
Major
The risk or severity of adverse effects can be increased when Indomethacin is combined with 2-Methoxyethanol.
9-(N-methyl-L-isoleucine)-cyclosporin A
Major
The risk or severity of adverse effects can be increased when Indomethacin is combined with 9-(N-methyl-L-isoleucine)-cyclosporin A.
Abetimus
Major
The risk or severity of adverse effects can be increased when Indomethacin is combined with Abetimus.
Acteoside
Major
The risk or severity of adverse effects can be increased when Indomethacin is combined with Acteoside.
Altretamine
Major
The risk or severity of adverse effects can be increased when Indomethacin is combined with Altretamine.
Tivorbex Toxicity & Overdose RiskThe toxic dose of indomethacin for rats is 2.42 mg/kg and 13 mg/kg for mice. Overdosing on indomethacin can cause symptoms like nausea, headache, dizziness, confusion, and extreme tiredness. There have also been reports of numbness and seizures. Treatment for an overdose should include emptying the stomach and taking antacids. The patient should also be closely monitored for any signs of gastrointestinal bleeding or ulcers.

Tivorbex Novel Uses: Which Conditions Have a Clinical Trial Featuring Tivorbex?

24 active trials are currently being conducted to assess the potential of Tivorbex in alleviating Joint Pain, Degenerative polyarthritis and Muscle Pain.
Condition
Clinical Trials
Trial Phases
Moderate to severe ankylosing spondylitis
0 Actively Recruiting
Joint Pain
4 Actively Recruiting
Not Applicable, Phase 2, Phase 3
Rheumatoid Arthritis
0 Actively Recruiting
Arthritis, Gouty
0 Actively Recruiting
Body weight between 500 and 1750 g
0 Actively Recruiting
Degenerative polyarthritis
0 Actively Recruiting
Muscle Pain
14 Actively Recruiting
Not Applicable, Phase 2, Phase 3, Phase 1
Aquaporin 2
2 Actively Recruiting
Not Applicable, Phase 3
Tendinitis
1 Actively Recruiting
Not Applicable
Bursitis
9 Actively Recruiting
Phase 4, Not Applicable, Phase 1
Pain
0 Actively Recruiting
inadequate response to conventional therapy
0 Actively Recruiting

Tivorbex Reviews: What are patients saying about Tivorbex?

5Patient Review
3/20/2017
Tivorbex for Acute Pain
I have chronic pain in my knees. This medication has eased the swelling and pain, allowing me to move again without having to deal with sharp shooting pains.
2.3Patient Review
10/29/2016
Tivorbex for Inflammation of the Joints due to Gout
I am experiencing a great deal of pain, particularly in my back. It feels like I've been punched repeatedly. My muscles ache and I'm moving very slowly--I feel like a snail. This is causing me a lot of distress.

Patient Q&A Section about tivorbex

What is the difference between ibuprofen and indomethacin?

"Indocin (indomethacin) is a medication that is used to relieve pain, fever, and swelling. Advil (ibuprofen) is a medication that works well for treating fever, inflammation, and a variety of mild to moderate pain conditions, but it does not last as long as other NSAIDs." - Anonymous Online Contributor

Unverified Answer

What are indometacin tablets for?

"Indomethacin is used to relieve pain, tenderness, swelling, and stiffness caused by osteoarthritis, rheumatoid arthritis, and ankylosing spondylitis." - Anonymous Online Contributor

Unverified Answer

Is Tivorbex discontinued?

"All of the above medications have been discontinued. Note: There may be illegal online pharmacies selling a generic version of Tivorbex." - Anonymous Online Contributor

Unverified Answer

What is Tivorbex used for?

"This medication is used to relieve pain and joint stiffness caused by arthritis, gout, bursitis, and tendonitis. It is also used to relieve pain from various other conditions. This medication is known as a nonsteroidal anti-inflammatory drug (NSAID)." - Anonymous Online Contributor

Unverified Answer
Please Note: These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

Clinical Trials for Tivorbex

Have you considered Tivorbex clinical trials? We made a collection of clinical trials featuring Tivorbex, we think they might fit your search criteria.
Have you considered Tivorbex clinical trials? We made a collection of clinical trials featuring Tivorbex, we think they might fit your search criteria.
Have you considered Tivorbex clinical trials? We made a collection of clinical trials featuring Tivorbex, we think they might fit your search criteria.
Unbiased ResultsWe believe in providing patients with all the options.
Your Data Stays Your DataWe only share your information with the clinical trials you're trying to access.
Verified Trials OnlyAll of our trials are run by licensed doctors, researchers, and healthcare companies.
Back to top