Tivorbex

Muscle Pain, Bursitis, Tendinopathy + 9 more
Treatment
3 Active Studies for Tivorbex

What is Tivorbex

IndomethacinThe Generic name of this drug
Treatment SummaryIndometacin is a medication used to reduce inflammation, pain and fever. It is classified as a non-steroidal anti-inflammatory drug (NSAID) and works by blocking the enzyme cyclooxygenase (COX), which is responsible for producing prostaglandins and thromboxanes. It is used to treat a variety of conditions, including rheumatoid arthritis, ankylosing spondylitis, osteoarthritis, acute shoulder pains, and acute gouty arthritis. It is available in oral capsules, rectal, and intravenous formulations. Ophthalmic indometacin has
Indomethacinis the brand name
Tivorbex Overview & Background
Brand Name
Generic Name
First FDA Approval
How many FDA approvals?
Indomethacin
Indomethacin
1984
241

Effectiveness

How Tivorbex Affects PatientsIndometacin is a painkiller and fever reducer that works by reducing the amount of factors that cause pain, fever, and inflammation. When taken for rheumatoid arthritis, it can reduce joint swelling, the number of joints affected, and morning stiffness. It can also reduce the pain, fever, swelling, tenderness, and redness of acute gouty arthritis. Taking indometacin comes with the risk of cardiovascular issues or gastrointestinal effects like bleeding and ulcers. In studies of healthy individuals, taking indometacin decreased their cerebral blood flow for a short period of time, although the significance of this is
How Tivorbex works in the bodyIndometacin is a drug that reduces inflammation, pain, and fever. It works by blocking an enzyme called cyclo-oxygenase (COX), which is involved in the production of prostaglandins. Prostaglandins are molecules responsible for inflammation, pain, and fever. Indometacin also blocks the release of arachidonic acid from phospholipids, which further reduces prostaglandin production. Additionally, indometacin can cause vasodilation and increased peripheral blood flow, which helps reduce fever. Indometacin is also used to close a patent ductus arteriosus

When to interrupt dosage

The advisable dosage of Tivorbex is contingent upon the diagnosed state, like Aquaporin 2, Arthritis, Gouty and Moderate to severe ankylosing spondylitis. The amount of dosage fluctuates as per the technique of delivery (e.g. Capsule or Injection, powder, lyophilized, for solution) featured in the table underneath.
Condition
Dosage
Administration
Rheumatoid Arthritis
25.0 mg, , 50.0 mg, 75.0 mg, 100.0 mg, 1.0 mg, 20.0 mg, 40.0 mg, 25.0 mg/mL, 1.0 mg/mL, 10.0 mg/mL
, Oral, Capsule, Capsule - Oral, Capsule, extended release, Capsule, extended release - Oral, Rectal, Suppository, Suppository - Rectal, Ophthalmic, Liquid; Powder, for solution, Liquid; Powder, for solution - Ophthalmic, Solution / drops, Solution / drops - Ophthalmic, Suspension - Oral, Suspension, Intravenous, Injection, powder, lyophilized, for solution, Injection, powder, lyophilized, for solution - Intravenous, Injection, powder, for solution, Injection, powder, for solution - Intravenous
Aquaporin 2
25.0 mg, , 50.0 mg, 75.0 mg, 100.0 mg, 1.0 mg, 20.0 mg, 40.0 mg, 25.0 mg/mL, 1.0 mg/mL, 10.0 mg/mL
, Oral, Capsule, Capsule - Oral, Capsule, extended release, Capsule, extended release - Oral, Rectal, Suppository, Suppository - Rectal, Ophthalmic, Liquid; Powder, for solution, Liquid; Powder, for solution - Ophthalmic, Solution / drops, Solution / drops - Ophthalmic, Suspension - Oral, Suspension, Intravenous, Injection, powder, lyophilized, for solution, Injection, powder, lyophilized, for solution - Intravenous, Injection, powder, for solution, Injection, powder, for solution - Intravenous
Disease
25.0 mg, , 50.0 mg, 75.0 mg, 100.0 mg, 1.0 mg, 20.0 mg, 40.0 mg, 25.0 mg/mL, 1.0 mg/mL, 10.0 mg/mL
, Oral, Capsule, Capsule - Oral, Capsule, extended release, Capsule, extended release - Oral, Rectal, Suppository, Suppository - Rectal, Ophthalmic, Liquid; Powder, for solution, Liquid; Powder, for solution - Ophthalmic, Solution / drops, Solution / drops - Ophthalmic, Suspension - Oral, Suspension, Intravenous, Injection, powder, lyophilized, for solution, Injection, powder, lyophilized, for solution - Intravenous, Injection, powder, for solution, Injection, powder, for solution - Intravenous
Moderate to severe ankylosing spondylitis
25.0 mg, , 50.0 mg, 75.0 mg, 100.0 mg, 1.0 mg, 20.0 mg, 40.0 mg, 25.0 mg/mL, 1.0 mg/mL, 10.0 mg/mL
, Oral, Capsule, Capsule - Oral, Capsule, extended release, Capsule, extended release - Oral, Rectal, Suppository, Suppository - Rectal, Ophthalmic, Liquid; Powder, for solution, Liquid; Powder, for solution - Ophthalmic, Solution / drops, Solution / drops - Ophthalmic, Suspension - Oral, Suspension, Intravenous, Injection, powder, lyophilized, for solution, Injection, powder, lyophilized, for solution - Intravenous, Injection, powder, for solution, Injection, powder, for solution - Intravenous
Tendinopathy
25.0 mg, , 50.0 mg, 75.0 mg, 100.0 mg, 1.0 mg, 20.0 mg, 40.0 mg, 25.0 mg/mL, 1.0 mg/mL, 10.0 mg/mL
, Oral, Capsule, Capsule - Oral, Capsule, extended release, Capsule, extended release - Oral, Rectal, Suppository, Suppository - Rectal, Ophthalmic, Liquid; Powder, for solution, Liquid; Powder, for solution - Ophthalmic, Solution / drops, Solution / drops - Ophthalmic, Suspension - Oral, Suspension, Intravenous, Injection, powder, lyophilized, for solution, Injection, powder, lyophilized, for solution - Intravenous, Injection, powder, for solution, Injection, powder, for solution - Intravenous
Bursitis
25.0 mg, , 50.0 mg, 75.0 mg, 100.0 mg, 1.0 mg, 20.0 mg, 40.0 mg, 25.0 mg/mL, 1.0 mg/mL, 10.0 mg/mL
, Oral, Capsule, Capsule - Oral, Capsule, extended release, Capsule, extended release - Oral, Rectal, Suppository, Suppository - Rectal, Ophthalmic, Liquid; Powder, for solution, Liquid; Powder, for solution - Ophthalmic, Solution / drops, Solution / drops - Ophthalmic, Suspension - Oral, Suspension, Intravenous, Injection, powder, lyophilized, for solution, Injection, powder, lyophilized, for solution - Intravenous, Injection, powder, for solution, Injection, powder, for solution - Intravenous
Arthritis, Gouty
25.0 mg, , 50.0 mg, 75.0 mg, 100.0 mg, 1.0 mg, 20.0 mg, 40.0 mg, 25.0 mg/mL, 1.0 mg/mL, 10.0 mg/mL
, Oral, Capsule, Capsule - Oral, Capsule, extended release, Capsule, extended release - Oral, Rectal, Suppository, Suppository - Rectal, Ophthalmic, Liquid; Powder, for solution, Liquid; Powder, for solution - Ophthalmic, Solution / drops, Solution / drops - Ophthalmic, Suspension - Oral, Suspension, Intravenous, Injection, powder, lyophilized, for solution, Injection, powder, lyophilized, for solution - Intravenous, Injection, powder, for solution, Injection, powder, for solution - Intravenous
Arthralgia
25.0 mg, , 50.0 mg, 75.0 mg, 100.0 mg, 1.0 mg, 20.0 mg, 40.0 mg, 25.0 mg/mL, 1.0 mg/mL, 10.0 mg/mL
, Oral, Capsule, Capsule - Oral, Capsule, extended release, Capsule, extended release - Oral, Rectal, Suppository, Suppository - Rectal, Ophthalmic, Liquid; Powder, for solution, Liquid; Powder, for solution - Ophthalmic, Solution / drops, Solution / drops - Ophthalmic, Suspension - Oral, Suspension, Intravenous, Injection, powder, lyophilized, for solution, Injection, powder, lyophilized, for solution - Intravenous, Injection, powder, for solution, Injection, powder, for solution - Intravenous
Pain
25.0 mg, , 50.0 mg, 75.0 mg, 100.0 mg, 1.0 mg, 20.0 mg, 40.0 mg, 25.0 mg/mL, 1.0 mg/mL, 10.0 mg/mL
, Oral, Capsule, Capsule - Oral, Capsule, extended release, Capsule, extended release - Oral, Rectal, Suppository, Suppository - Rectal, Ophthalmic, Liquid; Powder, for solution, Liquid; Powder, for solution - Ophthalmic, Solution / drops, Solution / drops - Ophthalmic, Suspension - Oral, Suspension, Intravenous, Injection, powder, lyophilized, for solution, Injection, powder, lyophilized, for solution - Intravenous, Injection, powder, for solution, Injection, powder, for solution - Intravenous
Body weight between 500 and 1750 g
25.0 mg, , 50.0 mg, 75.0 mg, 100.0 mg, 1.0 mg, 20.0 mg, 40.0 mg, 25.0 mg/mL, 1.0 mg/mL, 10.0 mg/mL
, Oral, Capsule, Capsule - Oral, Capsule, extended release, Capsule, extended release - Oral, Rectal, Suppository, Suppository - Rectal, Ophthalmic, Liquid; Powder, for solution, Liquid; Powder, for solution - Ophthalmic, Solution / drops, Solution / drops - Ophthalmic, Suspension - Oral, Suspension, Intravenous, Injection, powder, lyophilized, for solution, Injection, powder, lyophilized, for solution - Intravenous, Injection, powder, for solution, Injection, powder, for solution - Intravenous
Muscle Pain
25.0 mg, , 50.0 mg, 75.0 mg, 100.0 mg, 1.0 mg, 20.0 mg, 40.0 mg, 25.0 mg/mL, 1.0 mg/mL, 10.0 mg/mL
, Oral, Capsule, Capsule - Oral, Capsule, extended release, Capsule, extended release - Oral, Rectal, Suppository, Suppository - Rectal, Ophthalmic, Liquid; Powder, for solution, Liquid; Powder, for solution - Ophthalmic, Solution / drops, Solution / drops - Ophthalmic, Suspension - Oral, Suspension, Intravenous, Injection, powder, lyophilized, for solution, Injection, powder, lyophilized, for solution - Intravenous, Injection, powder, for solution, Injection, powder, for solution - Intravenous
Degenerative polyarthritis
25.0 mg, , 50.0 mg, 75.0 mg, 100.0 mg, 1.0 mg, 20.0 mg, 40.0 mg, 25.0 mg/mL, 1.0 mg/mL, 10.0 mg/mL
, Oral, Capsule, Capsule - Oral, Capsule, extended release, Capsule, extended release - Oral, Rectal, Suppository, Suppository - Rectal, Ophthalmic, Liquid; Powder, for solution, Liquid; Powder, for solution - Ophthalmic, Solution / drops, Solution / drops - Ophthalmic, Suspension - Oral, Suspension, Intravenous, Injection, powder, lyophilized, for solution, Injection, powder, lyophilized, for solution - Intravenous, Injection, powder, for solution, Injection, powder, for solution - Intravenous

Warnings

Tivorbex has twenty-three contraindications and should be avoided when encountering any of the conditions specified in the following table.Tivorbex Contraindications
Condition
Risk Level
Notes
Intracranial Hemorrhage
Do Not Combine
Congenital Heart Defect
Do Not Combine
aspirin
Do Not Combine
Asthma
Do Not Combine
Urticaria caused by NSAIDs
Do Not Combine
Hemorrhage
Do Not Combine
Congenital Heart Defect
Do Not Combine
Blood Coagulation Disorders
Do Not Combine
Gastrointestinal Hemorrhage
Do Not Combine
Hematochezia
Do Not Combine
Pulmonary Atresia
Do Not Combine
Pulse Frequency
Do Not Combine
Ductus Arteriosus, Patent
Do Not Combine
Enterocolitis, Necrotizing
Do Not Combine
proven or suspected untreated infection
Do Not Combine
Enterocolitis, Necrotizing
Do Not Combine
history of proctitis
Do Not Combine
Low Platelet Count
Do Not Combine
Coronary Artery Bypass Grafting
Do Not Combine
NSAID-Induced Asthma
Do Not Combine
Severe Hypersensitivity Reactions
Do Not Combine
Indomethacin may interact with Pulse Frequency
Severe Hypersensitivity Reactions
Do Not Combine
Indomethacin may interact with Pulse Frequency
Severe Hypersensitivity Reactions
Do Not Combine
Indomethacin may interact with Pulse Frequency
There are 20 known major drug interactions with Tivorbex.
Common Tivorbex Drug Interactions
Drug Name
Risk Level
Description
2-Methoxyethanol
Major
The risk or severity of adverse effects can be increased when Indomethacin is combined with 2-Methoxyethanol.
9-(N-methyl-L-isoleucine)-cyclosporin A
Major
The risk or severity of adverse effects can be increased when Indomethacin is combined with 9-(N-methyl-L-isoleucine)-cyclosporin A.
Abetimus
Major
The risk or severity of adverse effects can be increased when Indomethacin is combined with Abetimus.
Acteoside
Major
The risk or severity of adverse effects can be increased when Indomethacin is combined with Acteoside.
Altretamine
Major
The risk or severity of adverse effects can be increased when Indomethacin is combined with Altretamine.
Tivorbex Toxicity & Overdose RiskThe toxic dose of indomethacin for rats is 2.42 mg/kg and 13 mg/kg for mice. Overdosing on indomethacin can cause symptoms like nausea, headache, dizziness, confusion, and extreme tiredness. There have also been reports of numbness and seizures. Treatment for an overdose should include emptying the stomach and taking antacids. The patient should also be closely monitored for any signs of gastrointestinal bleeding or ulcers.
image of a doctor in a lab doing drug, clinical research

Tivorbex Novel Uses: Which Conditions Have a Clinical Trial Featuring Tivorbex?

24 active trials are currently being conducted to assess the potential of Tivorbex in alleviating Joint Pain, Degenerative polyarthritis and Muscle Pain.
Condition
Clinical Trials
Trial Phases
Arthritis, Gouty
0 Actively Recruiting
Muscle Pain
1 Actively Recruiting
Phase 4
Pain
0 Actively Recruiting
Arthralgia
0 Actively Recruiting
Body weight between 500 and 1750 g
0 Actively Recruiting
Bursitis
0 Actively Recruiting
Tendinopathy
0 Actively Recruiting
Aquaporin 2
2 Actively Recruiting
Phase 3, Not Applicable
Rheumatoid Arthritis
0 Actively Recruiting
Disease
0 Actively Recruiting
Moderate to severe ankylosing spondylitis
0 Actively Recruiting
Degenerative polyarthritis
0 Actively Recruiting

Tivorbex Reviews: What are patients saying about Tivorbex?

5Patient Review
3/20/2017
Tivorbex for Acute Pain
I have chronic pain in my knees. This medication has eased the swelling and pain, allowing me to move again without having to deal with sharp shooting pains.
2.3Patient Review
10/29/2016
Tivorbex for Inflammation of the Joints due to Gout
I am experiencing a great deal of pain, particularly in my back. It feels like I've been punched repeatedly. My muscles ache and I'm moving very slowly--I feel like a snail. This is causing me a lot of distress.

Patient Q&A Section about tivorbex

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

What is the difference between ibuprofen and indomethacin?

"Indocin (indomethacin) is a medication that is used to relieve pain, fever, and swelling. Advil (ibuprofen) is a medication that works well for treating fever, inflammation, and a variety of mild to moderate pain conditions, but it does not last as long as other NSAIDs."

Answered by AI

What are indometacin tablets for?

"Indomethacin is used to relieve pain, tenderness, swelling, and stiffness caused by osteoarthritis, rheumatoid arthritis, and ankylosing spondylitis."

Answered by AI

Is Tivorbex discontinued?

"All of the above medications have been discontinued. Note: There may be illegal online pharmacies selling a generic version of Tivorbex."

Answered by AI

What is Tivorbex used for?

"This medication is used to relieve pain and joint stiffness caused by arthritis, gout, bursitis, and tendonitis. It is also used to relieve pain from various other conditions. This medication is known as a nonsteroidal anti-inflammatory drug (NSAID)."

Answered by AI

Clinical Trials for Tivorbex

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Verified Trials OnlyAll of our trials are run by licensed doctors, researchers, and healthcare companies.
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