Timoptic-Xe

Migraine, Open-angle glaucoma, prophylaxis of migraine headaches + 6 more
Treatment
20 Active Studies for Timoptic-Xe

What is Timoptic-Xe

TimololThe Generic name of this drug
Treatment SummaryTimolol is a medication used to lower pressure in the eyes and treat high blood pressure. It comes in the form of an eye drop solution and tablets. The FDA approved Timolol in 1978, and it is now available from multiple manufacturers. It is used to treat open-angle glaucoma and high blood pressure.
Timopticis the brand name
Timoptic-Xe Overview & Background
Brand Name
Generic Name
First FDA Approval
How many FDA approvals?
Timoptic
Timolol
1978
167

Effectiveness

How Timoptic-Xe Affects PatientsTimolol, when taken as eye drops, quickly reduces pressure in the eyes. When taken as a tablet, it lowers blood pressure, heart rate, and amount of blood pumped by the heart. It also decreases how active the sympathetic nervous system is. The effects usually begin within 20 minutes of application of an eye drop dose, and can last up to 24 hours when taken in a 0.5% or 0.25% dose.
How Timoptic-Xe works in the bodyTimolol works by blocking certain receptors in the heart and blood vessels. This reduces the effects of adrenaline, leading to lower heart rate, blood pressure, and reflex orthostatic hypotension. It is unclear how timolol reduces ocular pressure, but it may be related to reducing the flow of aqueous humor in the eye. The reduction of this fluid could be caused by decreasing the blood supply to the ciliary body or interfering with prostaglandin production.

When to interrupt dosage

The suggested dosage of Timoptic-Xe is contingent upon the declared condition, like Open Angle Glaucoma, necessitating adjunctive or substitution treatment and Ocular Hypertension. The quantity of dosage differs, contingent upon the technique of delivery (e.g. Ophthalmic or Solution, gel forming/drops) featured in the table below.
Condition
Dosage
Administration
requiring adjunctive or replacement therapy
5.0 mg/mL, , 5.0 mg, 10.0 mg, 20.0 mg, 2.5 mg/mL, 6.8 mg/mL, 6.83 mg/mL, 2.56 mg/mL, 5.12 mg/mL, 0.5 %, 0.25 %, 3.4 mg/mL, 0.1 mg/mL
, Ophthalmic, Solution, Solution - Ophthalmic, Oral, Tablet, Tablet - Oral, Solution / drops, Solution / drops - Ophthalmic, Solution, gel forming, extended release, Solution, gel forming, extended release - Ophthalmic, Liquid, Liquid - Ophthalmic, Suspension / drops, Suspension / drops - Ophthalmic, Suspension, Suspension - Ophthalmic, Solution, gel forming / drops, Solution, gel forming / drops - Ophthalmic
inadequate response to other therapeutic measures
5.0 mg/mL, , 5.0 mg, 10.0 mg, 20.0 mg, 2.5 mg/mL, 6.8 mg/mL, 6.83 mg/mL, 2.56 mg/mL, 5.12 mg/mL, 0.5 %, 0.25 %, 3.4 mg/mL, 0.1 mg/mL
, Ophthalmic, Solution, Solution - Ophthalmic, Oral, Tablet, Tablet - Oral, Solution / drops, Solution / drops - Ophthalmic, Solution, gel forming, extended release, Solution, gel forming, extended release - Ophthalmic, Liquid, Liquid - Ophthalmic, Suspension / drops, Suspension / drops - Ophthalmic, Suspension, Suspension - Ophthalmic, Solution, gel forming / drops, Solution, gel forming / drops - Ophthalmic
Migraine
5.0 mg/mL, , 5.0 mg, 10.0 mg, 20.0 mg, 2.5 mg/mL, 6.8 mg/mL, 6.83 mg/mL, 2.56 mg/mL, 5.12 mg/mL, 0.5 %, 0.25 %, 3.4 mg/mL, 0.1 mg/mL
, Ophthalmic, Solution, Solution - Ophthalmic, Oral, Tablet, Tablet - Oral, Solution / drops, Solution / drops - Ophthalmic, Solution, gel forming, extended release, Solution, gel forming, extended release - Ophthalmic, Liquid, Liquid - Ophthalmic, Suspension / drops, Suspension / drops - Ophthalmic, Suspension, Suspension - Ophthalmic, Solution, gel forming / drops, Solution, gel forming / drops - Ophthalmic
Increased Intra Ocular Pressure (IOP)
5.0 mg/mL, , 5.0 mg, 10.0 mg, 20.0 mg, 2.5 mg/mL, 6.8 mg/mL, 6.83 mg/mL, 2.56 mg/mL, 5.12 mg/mL, 0.5 %, 0.25 %, 3.4 mg/mL, 0.1 mg/mL
, Ophthalmic, Solution, Solution - Ophthalmic, Oral, Tablet, Tablet - Oral, Solution / drops, Solution / drops - Ophthalmic, Solution, gel forming, extended release, Solution, gel forming, extended release - Ophthalmic, Liquid, Liquid - Ophthalmic, Suspension / drops, Suspension / drops - Ophthalmic, Suspension, Suspension - Ophthalmic, Solution, gel forming / drops, Solution, gel forming / drops - Ophthalmic
Open-angle glaucoma
5.0 mg/mL, , 5.0 mg, 10.0 mg, 20.0 mg, 2.5 mg/mL, 6.8 mg/mL, 6.83 mg/mL, 2.56 mg/mL, 5.12 mg/mL, 0.5 %, 0.25 %, 3.4 mg/mL, 0.1 mg/mL
, Ophthalmic, Solution, Solution - Ophthalmic, Oral, Tablet, Tablet - Oral, Solution / drops, Solution / drops - Ophthalmic, Solution, gel forming, extended release, Solution, gel forming, extended release - Ophthalmic, Liquid, Liquid - Ophthalmic, Suspension / drops, Suspension / drops - Ophthalmic, Suspension, Suspension - Ophthalmic, Solution, gel forming / drops, Solution, gel forming / drops - Ophthalmic
prophylaxis of migraine headaches
5.0 mg/mL, , 5.0 mg, 10.0 mg, 20.0 mg, 2.5 mg/mL, 6.8 mg/mL, 6.83 mg/mL, 2.56 mg/mL, 5.12 mg/mL, 0.5 %, 0.25 %, 3.4 mg/mL, 0.1 mg/mL
, Ophthalmic, Solution, Solution - Ophthalmic, Oral, Tablet, Tablet - Oral, Solution / drops, Solution / drops - Ophthalmic, Solution, gel forming, extended release, Solution, gel forming, extended release - Ophthalmic, Liquid, Liquid - Ophthalmic, Suspension / drops, Suspension / drops - Ophthalmic, Suspension, Suspension - Ophthalmic, Solution, gel forming / drops, Solution, gel forming / drops - Ophthalmic
Ocular Hypertension
5.0 mg/mL, , 5.0 mg, 10.0 mg, 20.0 mg, 2.5 mg/mL, 6.8 mg/mL, 6.83 mg/mL, 2.56 mg/mL, 5.12 mg/mL, 0.5 %, 0.25 %, 3.4 mg/mL, 0.1 mg/mL
, Ophthalmic, Solution, Solution - Ophthalmic, Oral, Tablet, Tablet - Oral, Solution / drops, Solution / drops - Ophthalmic, Solution, gel forming, extended release, Solution, gel forming, extended release - Ophthalmic, Liquid, Liquid - Ophthalmic, Suspension / drops, Suspension / drops - Ophthalmic, Suspension, Suspension - Ophthalmic, Solution, gel forming / drops, Solution, gel forming / drops - Ophthalmic
insufficient response to beta-blockers
5.0 mg/mL, , 5.0 mg, 10.0 mg, 20.0 mg, 2.5 mg/mL, 6.8 mg/mL, 6.83 mg/mL, 2.56 mg/mL, 5.12 mg/mL, 0.5 %, 0.25 %, 3.4 mg/mL, 0.1 mg/mL
, Ophthalmic, Solution, Solution - Ophthalmic, Oral, Tablet, Tablet - Oral, Solution / drops, Solution / drops - Ophthalmic, Solution, gel forming, extended release, Solution, gel forming, extended release - Ophthalmic, Liquid, Liquid - Ophthalmic, Suspension / drops, Suspension / drops - Ophthalmic, Suspension, Suspension - Ophthalmic, Solution, gel forming / drops, Solution, gel forming / drops - Ophthalmic
Open Angle Glaucoma
5.0 mg/mL, , 5.0 mg, 10.0 mg, 20.0 mg, 2.5 mg/mL, 6.8 mg/mL, 6.83 mg/mL, 2.56 mg/mL, 5.12 mg/mL, 0.5 %, 0.25 %, 3.4 mg/mL, 0.1 mg/mL
, Ophthalmic, Solution, Solution - Ophthalmic, Oral, Tablet, Tablet - Oral, Solution / drops, Solution / drops - Ophthalmic, Solution, gel forming, extended release, Solution, gel forming, extended release - Ophthalmic, Liquid, Liquid - Ophthalmic, Suspension / drops, Suspension / drops - Ophthalmic, Suspension, Suspension - Ophthalmic, Solution, gel forming / drops, Solution, gel forming / drops - Ophthalmic

Warnings

Timoptic-Xe Contraindications
Condition
Risk Level
Notes
Lung Diseases, Obstructive
Do Not Combine
Sinus Bradycardia
Do Not Combine
Shock, Cardiogenic
Do Not Combine
second or third degree AV block
Do Not Combine
Asthma
Do Not Combine
overt cardiac failure
Do Not Combine
Severe Hypersensitivity Reactions
Do Not Combine
Timolol may interact with Pulse Frequency
There are 20 known major drug interactions with Timoptic-Xe.
Common Timoptic-Xe Drug Interactions
Drug Name
Risk Level
Description
4-Bromo-2,5-dimethoxyphenethylamine
Major
The therapeutic efficacy of 4-Bromo-2,5-dimethoxyphenethylamine can be decreased when used in combination with Timolol.
4-Methoxyamphetamine
Major
The therapeutic efficacy of 4-Methoxyamphetamine can be decreased when used in combination with Timolol.
Abediterol
Major
Timolol may decrease the bronchodilatory activities of Abediterol.
Adrafinil
Major
The therapeutic efficacy of Adrafinil can be decreased when used in combination with Timolol.
Agrostis gigantea pollen
Major
The risk of a hypersensitivity reaction to Agrostis gigantea pollen is increased when it is combined with Timolol.
Timoptic-Xe Toxicity & Overdose RiskThe lowest toxic dose of timolol for rats is 1028mg/kg and 1137mg/kg in mice. Overdosing on timolol can cause dizziness, headaches, difficulty breathing, slow heart rate, and asthma attack. In severe cases, it can lead to cardiac arrest. If caught in time, the overdose can be treated with dialysis, although this may not be as effective for those with kidney problems.
image of a doctor in a lab doing drug, clinical research

Timoptic-Xe Novel Uses: Which Conditions Have a Clinical Trial Featuring Timoptic-Xe?

172 active clinical trials are assessing the potential of Timoptic-Xe in providing adjunctive or replacement therapy for those who have inadequate responses to beta-blockers and other therapies.
Condition
Clinical Trials
Trial Phases
requiring adjunctive or replacement therapy
0 Actively Recruiting
Increased Intra Ocular Pressure (IOP)
0 Actively Recruiting
prophylaxis of migraine headaches
0 Actively Recruiting
Migraine
52 Actively Recruiting
Not Applicable, Phase 1, Phase 2, Phase 3, Phase 4, Early Phase 1
Open-angle glaucoma
84 Actively Recruiting
Phase 3, Not Applicable, Phase 1, Phase 2, Phase 4, Early Phase 1
inadequate response to other therapeutic measures
0 Actively Recruiting
insufficient response to beta-blockers
0 Actively Recruiting
Ocular Hypertension
22 Actively Recruiting
Phase 1, Phase 2, Not Applicable, Phase 3, Phase 4
Open Angle Glaucoma
11 Actively Recruiting
Not Applicable, Phase 3, Phase 2

Timoptic-Xe Reviews: What are patients saying about Timoptic-Xe?

5Patient Review
1/28/2014
Timoptic-Xe for Increased Pressure in the Eye
If my Timoptic eye drops are frozen, can I still use this medicine when it is thawed out?
image of drug pills surrounding a glass of water symbolizing drug consumption

Patient Q&A Section about timoptic-xe

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

Is Timoptic-XE preservative free?

"TIMOPTIC in OCUDOSE is a preservative-free, sterile solution that should be used immediately after opening for administration to one or both eyes."

Answered by AI

What is the difference between Timoptol and Timoptol-XE?

"Although Timoptol-XE and Timoptol have similar safety profiles, Timoptol-XE may not reduce heart rate as much as Timoptol."

Answered by AI

What are Timoptic-XE used for?

"Timoptic-XE (timolol maleate ophthalmic solution) is a beta-blocker that is used to treat open-angle glaucoma and other causes of high pressure inside the eye. Timoptic-XE is available as a generic drug."

Answered by AI

What is the difference between TIMOPTIC and Timoptic-XE?

"Timoptic is a liquid solution that comes in a multiuse bottle. Timoptic in Ocudose is a liquid solution that comes in a single-use vial. Timoptic-XE is a gel-forming solution, which is a liquid solution that turns into gel in your eye."

Answered by AI

Clinical Trials for Timoptic-Xe

Have you considered Timoptic-Xe clinical trials? We made a collection of clinical trials featuring Timoptic-Xe, we think they might fit your search criteria.
Have you considered Timoptic-Xe clinical trials? We made a collection of clinical trials featuring Timoptic-Xe, we think they might fit your search criteria.
Have you considered Timoptic-Xe clinical trials? We made a collection of clinical trials featuring Timoptic-Xe, we think they might fit your search criteria.