Thiothixene

Schizophrenia
Treatment
1 FDA approval
20 Active Studies for Thiothixene

What is Thiothixene

ThiothixeneThe Generic name of this drug
Treatment SummaryThioxanthine is an antipsychotic medication used to treat mental disorders. It works in a similar way to other antipsychotic medicines known as phenothiazines.
Navaneis the brand name
image of different drug pills on a surface
Thiothixene Overview & Background
Brand Name
Generic Name
First FDA Approval
How many FDA approvals?
Navane
Thiothixene
1967
50

Approved as Treatment by the FDA

Thiothixene, also known as Navane, is approved by the FDA for 1 uses which include Schizophrenia .
Schizophrenia
Helps manage Schizophrenia

Effectiveness

How Thiothixene Affects PatientsThiothixene is an older type of antipsychotic medication that belongs to the thioxanthene class. It is similar to piperazine phenothiazines and different from aliphatic phenothiazines. It was commonly used to treat schizophrenia in the past, but is less commonly used today compared to newer medications such as risperidone.
How Thiothixene works in the bodyThiothixene works as a blocker on certain receptors in the brain, such as dopamine, serotonin, histamine, and acetylcholine. It has different effects on productive and unproductive symptoms, including anti-anxiety, anti-depressive, anti-aggressive, and anti-nausea properties. It can also lead to weight gain, lowered blood pressure, sedation, and difficulty ejaculating. Thiothixene can lower blood pressure, cause vertigo, sedation, hypersalivation, incontinence, and sexual dysfunction. It also causes anticholinergic effects like dry mouth, blurred vision

When to interrupt dosage

The proposed dosage of Thiothixene is contingent upon the established affliction. The dose changes as per the mode of distribution (e.g. Capsule or Capsule - Oral) featured in the table beneath.
Condition
Dosage
Administration
Schizophrenia
, 1.0 mg, 2.0 mg, 5.0 mg, 10.0 mg, 20.0 mg, 5.0 mg/mL
, Capsule, Oral, Capsule - Oral, Tablet - Oral, Tablet, Solution, concentrate, Solution, concentrate - Oral

Warnings

Thiothixene Contraindications
Condition
Risk Level
Notes
Comatose
Do Not Combine
Shock
Do Not Combine
Disease
Do Not Combine
Mental Depression
Do Not Combine
There are 20 known major drug interactions with Thiothixene.
Common Thiothixene Drug Interactions
Drug Name
Risk Level
Description
Amisulpride
Major
Thiothixene may increase the antipsychotic activities of Amisulpride.
Azelastine
Major
Thiothixene may increase the central nervous system depressant (CNS depressant) activities of Azelastine.
Deutetrabenazine
Major
The risk or severity of adverse effects can be increased when Thiothixene is combined with Deutetrabenazine.
Ethanol
Major
Thiothixene may increase the central nervous system depressant (CNS depressant) activities of Ethanol.
Hydroxyzine
Major
The risk or severity of QTc prolongation can be increased when Thiothixene is combined with Hydroxyzine.
Thiothixene Toxicity & Overdose RiskOverdosing on Clonazepam can lead to symptoms such as confusion, difficulty swallowing, dizziness, drowsiness, head tilting, low blood pressure, muscle twitching, stiff muscles, excessive drooling, trembling, trouble walking, and weakness.
image of a doctor in a lab doing drug, clinical research

Thiothixene Novel Uses: Which Conditions Have a Clinical Trial Featuring Thiothixene?

170 active clinical trials are presently evaluating Thiothixene as a potential intervention for Schizophrenia.
Condition
Clinical Trials
Trial Phases
Schizophrenia
175 Actively Recruiting
Not Applicable, Phase 3, Phase 2, Early Phase 1, Phase 4, Phase 1

Thiothixene Reviews: What are patients saying about Thiothixene?

5Patient Review
10/26/2012
Thiothixene for Mental Disorder with Loss of Normal Personality & Reality
I didn't see much benefit from this medication.
5Patient Review
10/11/2008
Thiothixene for Schizophrenia
this was the first drug I tried that didn't give me awful side effects like twitches and tremors.
5Patient Review
2/16/2014
Thiothixene for Schizophrenia
My sister was taking this in the 5 mg capsules and it was working really well for her. She's been trying different drugs to treat her disorder for awhile now and this is by far the best one she's found. But now they're telling her it's not going to be available anymore and she's really worried that she won't be able to find an effective replacement.
5Patient Review
1/13/2016
Thiothixene for Schizophrenia
Thiothixene has been a godsend for my schizophrenia. It's helped me to deal with the distortions in my mind much more effectively, and I'm extremely grateful for that.
4.7Patient Review
4/3/2008
Thiothixene for Mental Disorder with Loss of Normal Personality & Reality
4.3Patient Review
3/13/2010
Thiothixene for Schizophrenia
Withdrawal symptoms can be tough, but they typically subside within a few weeks.
4Patient Review
5/7/2010
Thiothixene for Mental Disorder with Loss of Normal Personality & Reality
My brother stopped taking this medication a month ago because he felt it was causing him to bite his tongue while eating. He checked with his doctor and pharmacist and they never heard of this side effect. His symptoms are gradually returning but he no longer bites his tongue. He stopped against medical advice and soon will be in crisis.
1.7Patient Review
3/19/2012
Thiothixene for Mental Disorder with Loss of Normal Personality & Reality
I just started taking this medication and I am having problems reading. I wonder if this is a side effect.
1Patient Review
12/21/2008
Thiothixene for Schizophrenia
This caused me to have to urinate frequently.
1Patient Review
4/18/2009
Thiothixene for Schizophrenia
This treatment didn't work for me at all.
1Patient Review
1/24/2016
Thiothixene for Schizophrenia
This medication caused me to experience severe depression, which led to suicidal thoughts.
image of drug pills surrounding a glass of water symbolizing drug consumption

Patient Q&A Section about thiothixene

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

What is the drug thiothixene used for?

"This medication is used to treat schizophrenia and should not be used to treat behavioral problems in older adults who have dementia. It is only available with a doctor's prescription."

Answered by AI

Is thiothixene a sedative?

"Use Caution/Monitor.

Brompheniramine and buprenorphine both increase sedation. Use caution when prescribing them together and monitor patients for excessive sedation."

Answered by AI

What is the brand name for thiothixene?

"Thiothixene is a prescription antipsychotic medication used to treat the symptoms of schizophrenia. It may be used alone or with other medications."

Answered by AI

What are the side effects of thiothixene?

"The following are symptoms of dizziness: lightheadedness, feeling unsteady, having trouble keeping your balance, blurred vision, dry mouth, excess saliva, stuffed nose, nausea, vomiting, and constipation."

Answered by AI

Clinical Trials for Thiothixene

Have you considered Thiothixene clinical trials? We made a collection of clinical trials featuring Thiothixene, we think they might fit your search criteria.
Have you considered Thiothixene clinical trials? We made a collection of clinical trials featuring Thiothixene, we think they might fit your search criteria.
Have you considered Thiothixene clinical trials? We made a collection of clinical trials featuring Thiothixene, we think they might fit your search criteria.