Your session is about to expire
What is Tazarotene
TazaroteneThe Generic name of this drug
Treatment SummaryTazarotene is a type of topical medication used to treat skin conditions like psoriasis, acne, and sun damage. It is sold under the brand names Tazorac, Avage, and Zorac and belongs to a class of drugs called acetylenic retinoids.
Tazoracis the brand name
Tazarotene Overview & Background
Brand Name
Generic Name
First FDA Approval
How many FDA approvals?
Tazorac
Tazarotene
1997
29
Approved as Treatment by the FDA
Tazarotene, also known as Tazorac, is approved by the FDA for 7 uses including facial fine wrinkling and Psoriasis Vulgaris .facial fine wrinkling
Psoriasis Vulgaris
Helps manage Psoriasis Vulgaris (Plaque Psoriasis)
Lentigo
Acne Vulgaris
mild Acne vulgaris
facial hyperpigmentation
facial hypopigmentation
Effectiveness
How Tazarotene Affects PatientsAfter it is applied to the skin, tazarotene breaks down into an active form that helps treat acne. When taken with an oral antibiotic, it can reduce skin discoloration, wrinkles, and other signs of sun damage. Studies have also found that taking tazarotene for a long time (more than one year) can reduce the number of cells related to skin cancer. Additionally, it may increase the amount of collagen in the skin, making it look healthier and more organized.
How Tazarotene works in the bodyTazarotene works by binding to several receptor proteins in the body. It is especially attracted to a group called the retinoic acid receptor, which helps control the expression of genes. Tazarotene also binds to other receptors known as RXRs. We're not sure exactly how it works, but it is thought to help regulate gene expression.
When to interrupt dosage
The recommended measure of Tazarotene is contingent upon the determined ailment, including facial fine wrinkling, facial hypopigmentation and facial hyperpigmentation. The amount of dosage is subject to the technique of delivery (e.g. Gel or Gel - Cutaneous) displayed in the table below.Condition
Dosage
Administration
Psoriasis Vulgaris
, 0.001 mg/mg, 0.0005 mg/mg, 0.1 %, 0.05 %, 0.00045 mg/mg, 0.00005 mg/mg, 0.0001 mg/mg, 0.045 %
, Cutaneous, Gel, Gel - Cutaneous, Cream, Cream - Cutaneous, Oral, Gel - Oral, Topical, Gel - Topical, Cream - Topical, Aerosol, foam, Aerosol, foam - Topical, Lotion, Lotion - Topical
facial hypopigmentation
, 0.001 mg/mg, 0.0005 mg/mg, 0.1 %, 0.05 %, 0.00045 mg/mg, 0.00005 mg/mg, 0.0001 mg/mg, 0.045 %
, Cutaneous, Gel, Gel - Cutaneous, Cream, Cream - Cutaneous, Oral, Gel - Oral, Topical, Gel - Topical, Cream - Topical, Aerosol, foam, Aerosol, foam - Topical, Lotion, Lotion - Topical
Acne Vulgaris
, 0.001 mg/mg, 0.0005 mg/mg, 0.1 %, 0.05 %, 0.00045 mg/mg, 0.00005 mg/mg, 0.0001 mg/mg, 0.045 %
, Cutaneous, Gel, Gel - Cutaneous, Cream, Cream - Cutaneous, Oral, Gel - Oral, Topical, Gel - Topical, Cream - Topical, Aerosol, foam, Aerosol, foam - Topical, Lotion, Lotion - Topical
Lentigo
, 0.001 mg/mg, 0.0005 mg/mg, 0.1 %, 0.05 %, 0.00045 mg/mg, 0.00005 mg/mg, 0.0001 mg/mg, 0.045 %
, Cutaneous, Gel, Gel - Cutaneous, Cream, Cream - Cutaneous, Oral, Gel - Oral, Topical, Gel - Topical, Cream - Topical, Aerosol, foam, Aerosol, foam - Topical, Lotion, Lotion - Topical
facial hyperpigmentation
, 0.001 mg/mg, 0.0005 mg/mg, 0.1 %, 0.05 %, 0.00045 mg/mg, 0.00005 mg/mg, 0.0001 mg/mg, 0.045 %
, Cutaneous, Gel, Gel - Cutaneous, Cream, Cream - Cutaneous, Oral, Gel - Oral, Topical, Gel - Topical, Cream - Topical, Aerosol, foam, Aerosol, foam - Topical, Lotion, Lotion - Topical
mild Acne vulgaris
, 0.001 mg/mg, 0.0005 mg/mg, 0.1 %, 0.05 %, 0.00045 mg/mg, 0.00005 mg/mg, 0.0001 mg/mg, 0.045 %
, Cutaneous, Gel, Gel - Cutaneous, Cream, Cream - Cutaneous, Oral, Gel - Oral, Topical, Gel - Topical, Cream - Topical, Aerosol, foam, Aerosol, foam - Topical, Lotion, Lotion - Topical
facial fine wrinkling
, 0.001 mg/mg, 0.0005 mg/mg, 0.1 %, 0.05 %, 0.00045 mg/mg, 0.00005 mg/mg, 0.0001 mg/mg, 0.045 %
, Cutaneous, Gel, Gel - Cutaneous, Cream, Cream - Cutaneous, Oral, Gel - Oral, Topical, Gel - Topical, Cream - Topical, Aerosol, foam, Aerosol, foam - Topical, Lotion, Lotion - Topical
Warnings
There are 20 known major drug interactions with Tazarotene.Common Tazarotene Drug Interactions
Drug Name
Risk Level
Description
Amiodarone
Major
The metabolism of Amiodarone can be decreased when combined with Tazarotene.
Brigatinib
Major
The metabolism of Brigatinib can be decreased when combined with Tazarotene.
Cabazitaxel
Major
The metabolism of Cabazitaxel can be decreased when combined with Tazarotene.
Clomocycline
Major
The risk or severity of pseudotumor cerebri can be increased when Tazarotene is combined with Clomocycline.
Demeclocycline
Major
The risk or severity of pseudotumor cerebri can be increased when Tazarotene is combined with Demeclocycline.
Tazarotene Toxicity & Overdose RiskOverusing topical retinoid can cause redness, peeling, and discomfort. Swallowing the drug can affect liver function and cause high triglyceride levels. Other symptoms include eye irritation, hair loss, headache, swelling, tiredness, rash, nausea, and vision problems. Tests on rabbits and rats have shown that the drug can cause birth defects if given in doses higher than 0.05 mg/kg/day. This has also been seen with other retinoid compounds.
Tazarotene Novel Uses: Which Conditions Have a Clinical Trial Featuring Tazarotene?
18 active trials are underway to assess the potential of Tazarotene to mitigate mild Acne vulgaris, Lentigo and Plaque Psoriasis.Condition
Clinical Trials
Trial Phases
facial hypopigmentation
0 Actively Recruiting
Lentigo
0 Actively Recruiting
mild Acne vulgaris
0 Actively Recruiting
facial fine wrinkling
0 Actively Recruiting
Psoriasis Vulgaris
20 Actively Recruiting
Early Phase 1, Phase 4, Phase 3, Not Applicable, Phase 2
facial hyperpigmentation
0 Actively Recruiting
Acne Vulgaris
0 Actively Recruiting
Tazarotene Reviews: What are patients saying about Tazarotene?
4.7Patient Review
12/21/2013 I had some terrible acne that left dark spots and large pores. I tried a lot of over-the-counter products to no avail. This medication, however, has worked great for me. You don't need much; just apply it every night before bed and wash it off in the morning. Sometimes I have to use it every other night because my face can get sore, but when used as directed, this product is very effective.
4.7Patient Review
9/28/2008 This treatment has been great for my face. I've seen a big reduction in the number of blemishes and spots.
Patient Q&A Section about tazarotene
These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.Is tazarotene stronger than tretinoin?
"The 0.1% tazarotene cream was more effective than the 0.05% tretinoin cream in producing treatment success rates at weeks 12 and 20. However, between the 0.05% formulations, there was not a significant difference in treatment success rates between tazarotene and tretinoin, although tretinoin tended to provide higher improvement rates in OIA."
Answered by AI
Is tazarotene the same as Accutane?
"Both medications work by depressing the production of facial oil and reducing the growth of the skin cells that line the pores of the face.
Are Accutane and Tazorac the same medication? Accutane (isotretinoin) and Tazorac (tazarotene) are both forms of vitamin A, called retinoids, used for the treatment and prevention of severe acne. Tazorac is also used to treat plaque psoriasis (psoriasis with scaly patches). Both medications work by depressing the production of facial oil and reducing the growth of the skin cells that line the pores of the face."
Answered by AI