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THRIVE Intervention for Suicide Crisis (THRIVE Trial)

N/A
Waitlist Available
Led By Jennifer Lockman, PhD
Research Sponsored by Centerstone Research Institute
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial
Must have
Be older than 18 years old
Timeline
Screening 3 weeks
Treatment Varies
Follow Up 3 months
Awards & highlights

Summary

This trial tests THRIVE, a session using a tablet to help suicidal individuals at Crisis Stabilization Centers. It involves talking about their crisis, understanding it better, and setting future goals to increase hope and self-confidence. The goal is to provide more effective care than typical emergency departments. Thrive has been shown to be effective in reducing depression and anxiety symptom severity and improving functioning and resilience among a mostly rural community population of US adults.

Who is the study for?
This trial is for English-speaking residents of Davidson County who are at increased risk for suicide and have been admitted to a Crisis Stabilization Center. Participants must be able to give informed consent, provide contact information for follow-ups, and discuss their suicidal thoughts or attempts. Those acutely psychotic or unable to communicate with the research team cannot join.
What is being tested?
The study tests THRIVE, a new 60-minute recovery-oriented intervention using narrative and technology, against usual care in Crisis Stabilization Centers. It aims to see if THRIVE can better help individuals understand their suicide crisis, reduce suicidal thoughts, and support recovery.
What are the potential side effects?
Since THRIVE is a psychological intervention rather than a medication, it may not have typical 'side effects' but could potentially cause emotional discomfort when discussing sensitive topics like suicide.

Timeline

Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~3 months
This trial's timeline: 3 weeks for screening, Varies for treatment, and 3 months for reporting.

Treatment Details

Study Objectives

Study objectives can provide a clearer picture of what you can expect from a treatment.
Primary study objectives
Hopefulness
Meaning made of stress
Self-efficacy to avoid suicidal action

Trial Design

2Treatment groups
Experimental Treatment
Active Control
Group I: Experimental: THRIVE + Usual CareExperimental Treatment2 Interventions
Individuals presenting to a community-based crisis stabilization center who are age 18-plus and screen positive for suicide risk
Group II: Usual CareActive Control1 Intervention
Individuals presenting to a community-based crisis stabilization center who are age 18-plus and screen positive for suicide risk
Treatment
First Studied
Drug Approval Stage
How many patients have taken this drug
THRIVE
2017
N/A
~560
Usual Care
1990
Completed Phase 4
~7700

Research Highlights

Information in this section is not a recommendation. We encourage patients to speak with their healthcare team when evaluating any treatment decision.
Mechanism Of Action
Side Effect Profile
Prior Approvals
Other Research
Common treatments for suicide, particularly those similar to the THRIVE intervention, include narrative, technology-based, and recovery-oriented approaches. These treatments help patients make sense of their suicidal crises, reduce suicidal ideation, and promote recovery. The narrative component allows patients to articulate their experiences, fostering understanding and control. Technology-based interventions provide accessible support, crucial for immediate crisis management. Recovery-oriented approaches emphasize personal growth and resilience, encouraging coping strategies and meaningful life goals. These mechanisms address emotional and cognitive factors, provide ongoing support, and empower patients to rebuild their lives.
A treatment strategy for meeting life as it is. Patients' and therapists' experiences of brief therapy in a district psychiatric centre: A qualitative study.Use of a Fully Automated Internet-Based Cognitive Behavior Therapy Intervention in a Community Population of Adults With Depression Symptoms: Randomized Controlled Trial.

Find a Location

Who is running the clinical trial?

University of RochesterOTHER
861 Previous Clinical Trials
543,722 Total Patients Enrolled
17 Trials studying Suicide
89,710 Patients Enrolled for Suicide
Centerstone Research InstituteLead Sponsor
3 Previous Clinical Trials
1,642 Total Patients Enrolled
1 Trials studying Suicide
162 Patients Enrolled for Suicide
Jennifer Lockman, PhDPrincipal InvestigatorCenterstone Research Institute

Media Library

THRIVE Clinical Trial Eligibility Overview. Trial Name: NCT05558891 — N/A
Suicide Research Study Groups: Experimental: THRIVE + Usual Care, Usual Care
Suicide Clinical Trial 2023: THRIVE Highlights & Side Effects. Trial Name: NCT05558891 — N/A
THRIVE 2023 Treatment Timeline for Medical Study. Trial Name: NCT05558891 — N/A
~42 spots leftby Oct 2025