What is Symlin
PramlintideThe Generic name of this drug
Treatment SummaryPramlintide is a newly developed diabetes medication created by Amylin Pharmaceuticals. It helps to regulate blood sugar levels by supplementing the hormone amylin, which is usually present in the bloodstream after meals but is deficient in those with diabetes. Pramlintide can be used to treat both type 1 and type 2 diabetes.
SymlinPenis the brand name
Symlin Overview & Background
Brand Name
Generic Name
First FDA Approval
How many FDA approvals?
SymlinPen
Pramlintide
2005
6
Approved as Treatment by the FDA
Pramlintide, also known as SymlinPen, is approved by the FDA for 2 uses including Type 2 Diabetes and Type 1 Diabetes .Type 2 Diabetes
Helps manage Type 2 Diabetes Mellitus
Type 1 Diabetes
Helps manage Type 1 Diabetes Mellitus
Effectiveness
How Symlin Affects PatientsPramlintide is a synthetic hormone-like drug that is meant to replace amylin, a hormone produced by the pancreas that helps regulate sugar levels. People with diabetes often don't have enough amylin in their body. Pramlintide is a chain of 37 amino acids, three of which are different than the amino acids found in human amylin. It is available in the form of an acetate salt.
How Symlin works in the bodyPramlintide is a drug that imitates the effects of the pancreatic hormone amylin in the body. Amylin helps control blood sugar levels, and pramlintide works in the same way. It does this by slowing down the stomach's emptying rate, reducing the body's production of glucagon, and making the user feel fuller, which helps reduce calorie intake and leads to weight loss. Pramlintide attaches to three different receptor complexes in the body, all of which contain the calcitonin receptor and one of three Receptor activity-modifying proteins.
When to interrupt dosage
The recommended dosage of Symlin is contingent upon the identified disorder. The amount of dosage shifts, based on the method of administration (e.g. Injection or Injection - Subcutaneous) listed in the table beneath.Condition
Dosage
Administration
Type 1 Diabetes
, 1.0 mg/mL, 0.6 mg/mL
Injection, Injection - Subcutaneous, , Subcutaneous
Type 2 Diabetes
, 1.0 mg/mL, 0.6 mg/mL
Injection, Injection - Subcutaneous, , Subcutaneous
Warnings
There are 20 known major drug interactions with Symlin.Common Symlin Drug Interactions
Drug Name
Risk Level
Description
Aclidinium
Major
The risk or severity of reduced gastrointestinal motility can be increased when Pramlintide is combined with Aclidinium.
Amitriptyline
Major
The risk or severity of reduced gastrointestinal motility can be increased when Pramlintide is combined with Amitriptyline.
Amoxapine
Major
The risk or severity of reduced gastrointestinal motility can be increased when Pramlintide is combined with Amoxapine.
Anisotropine methylbromide
Major
The risk or severity of reduced gastrointestinal motility can be increased when Pramlintide is combined with Anisotropine methylbromide.
Aripiprazole
Major
The risk or severity of reduced gastrointestinal motility can be increased when Pramlintide is combined with Aripiprazole.
Symlin Novel Uses: Which Conditions Have a Clinical Trial Featuring Symlin?
300 active trials are being conducted to assess the potential of Symlin in managing symptoms associated with Type 2 Diabetes.Condition
Clinical Trials
Trial Phases
Type 2 Diabetes
175 Actively Recruiting
Phase 2, Not Applicable, Phase 4, Early Phase 1, Phase 1, Phase 3
Type 1 Diabetes
147 Actively Recruiting
Phase 3, Phase 1, Not Applicable, Early Phase 1, Phase 2, Phase 4
Symlin Reviews: What are patients saying about Symlin?
5Patient Review
6/1/2010 Symlin has helped me lose 95 pounds in less than a year, and I continue to see benefits from it. My insulin usage has decreased by 150 units per day on average.
5Patient Review
9/20/2015 I've seen vast improvements in my health since using this treatment, both physically and mentally. I highly recommend it to others.
5Patient Review
12/9/2009 I experienced nausea, vomiting, and sweats. My blood sugar also dropped significantly.
5Patient Review
10/16/20084Patient Review
12/29/2010 The price is the only downside to this pen, which otherwise works great. I don't know how they expect people to keep paying $300 a month, so I'll have to look for a different medication.
4Patient Review
2/26/20083.3Patient Review
8/17/2022 I've been using the symlin pen for years, but lately I've had six pens jam up on me, leaving 1/3 of the insulin inaccessible. I changed the pen needles many times, to no avail. Now I have three expired pens with dates from May/June 2023. My pharmacy (Walgreens) won't replace them, so now I'm short on my insulin supply.
2.7Patient Review
11/17/2014 I'm disappointed because I haven't seen any results after a week of use. My weight and sugar levels are the same. The good news is that I haven't experienced any side effects.
2.7Patient Review
8/17/2010 I've been using symlin for a while now, and it hasn't had any impact on my blood sugar levels. I'm starting to lose hope that this drug will have any benefits for me.
2.7Patient Review
9/1/2009 Didn't find this to be very helpful in terms of my appetite, which is why my doctor prescribed it.
2Patient Review
11/9/2009 I didn't see much difference when I was using this medication, but as soon as I stopped taking it, I gained 60 pounds. Once I started taking it again, the weight gain stopped. While it's not a "miracle" drug that causes you to lose a lot of weight, it does seem to help control your weight if you're consistent with taking it.
1.7Patient Review
4/22/2009 I began using Symlin a few weeks ago, injecting 60mcg 3 times per day. I didn't really see much of a difference. However, I recently upped my dosage to 120 mcg 3 times per day and have noticed significantly better blood sugar levels.
1.3Patient Review
9/11/2012 It's difficult to tell if this actually injected anything, as it frequently jammed on me. The injection caps are also incredibly annoying and wasteful; I had to throw away so many of them. On top of that, I experienced severe hypoglycemia several times while using this product. All in all, it has a steep learning curve and can be dangerous if not used properly.
Patient Q&A Section about symlin
What are the side effects of Symlin?
"Nausea, vomiting, lack of appetite, headache, joint pain, fatigue, allergic reaction, and dizziness are all side effects that can occur when taking this medication." - Anonymous Online Contributor
Unverified Answer
Does Symlin cause weight loss?
"Symlin can help with weight loss by making people eat less food overall and snack less often. On average, people who use Symlin lose 6.6 pounds in the first six months." - Anonymous Online Contributor
Unverified Answer
Is Symlin still on the market?
"There is no version of Symlin that is equivalent to what is available in the United States currently. There are online pharmacies that may try to sell a generic version of Symlin, but these could be counterfeit and potentially unsafe." - Anonymous Online Contributor
Unverified Answer
What is the function of Symlin?
"The medication Symlin (pramlintide) can help to lower blood sugar in cases where fast-acting or mealtime insulin isn't enough. However, it can also cause blood sugar levels to drop dangerously low. This medication is used in addition to mealtime insulin, and is injected under the skin before major meals." - Anonymous Online Contributor
Unverified Answer