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Amino Acid

Acetyl-L-Carnitine for Alcoholism

Phase 1
Waitlist Available
Led By Robert Miranda, PhD
Research Sponsored by Brown University
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial
Must have
Be able to take oral medication and be willing to adhere to the medication regimen
Be 14 to 20 years old, inclusive
Timeline
Screening 3 weeks
Treatment Varies
Follow Up week 5
Awards & highlights

Study Summary

This trial is studying the effects of a supplement called acetyl-L-carnitine on teens with alcohol use disorder who also have mild depression.

Who is the study for?
Adolescents aged 14-20 with alcohol use disorder and mild depressive symptoms can join this trial. They must be able to take oral medication, follow the study schedule, and if female of childbearing potential, agree to reliable birth control. Exclusions include liver disease, positive drug screen for certain substances, recent addiction treatment or medical detoxification need.Check my eligibility
What is being tested?
The trial is testing whether acetyl-L-carnitine (ALCAR), taken daily at a dose of 3 grams for four weeks, affects cravings for alcohol in young people with alcohol use disorder compared to a placebo. It also looks at mood, sleep quality, and safety of ALCAR.See study design
What are the potential side effects?
Possible side effects from acetyl-L-carnitine may include stomach upset or pain, nausea/vomiting, restlessness and a 'fishy' odor of the urine/breath/sweat. Rarely it might cause seizures in those with seizure disorders.

Eligibility Criteria

Inclusion Criteria

You may be eligible if you check “Yes” for the criteria below
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I can take pills and will follow the medication schedule.
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I am between 14 and 20 years old.
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I drink alcohol at least 2 days a week.

Timeline

Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~week 5
This trial's timeline: 3 weeks for screening, Varies for treatment, and week 5 for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.
Primary outcome measures
Alcohol Craving (derived from the Alcohol Urge Questionnaire; 0 to 20; higher scores = greater urge to drink)

Trial Design

2Treatment groups
Experimental Treatment
Placebo Group
Group I: Acetyl-L-CarnitineExperimental Treatment1 Intervention
Acetyl-L-carnitine is a nutritional supplement and emerging research shows it has neuroprotective properties and may help treat alcohol use disorder and depression, 3 g daily for 6 weeks
Group II: PlaceboPlacebo Group1 Intervention
Daily for 6 weeks
Treatment
First Studied
Drug Approval Stage
How many patients have taken this drug
Acetyl-l-carnitine
2015
Completed Phase 3
~20

Find a Location

Who is running the clinical trial?

Brown UniversityLead Sponsor
452 Previous Clinical Trials
562,146 Total Patients Enrolled
28 Trials studying Alcoholism
5,065 Patients Enrolled for Alcoholism
Rhode Island HospitalOTHER
257 Previous Clinical Trials
70,934 Total Patients Enrolled
4 Trials studying Alcoholism
350 Patients Enrolled for Alcoholism
Colorado State UniversityOTHER
123 Previous Clinical Trials
37,954 Total Patients Enrolled
2 Trials studying Alcoholism
116 Patients Enrolled for Alcoholism

Media Library

Acetyl-l-carnitine (Amino Acid) Clinical Trial Eligibility Overview. Trial Name: NCT05355311 — Phase 1
Alcoholism Research Study Groups: Placebo, Acetyl-L-Carnitine
Alcoholism Clinical Trial 2023: Acetyl-l-carnitine Highlights & Side Effects. Trial Name: NCT05355311 — Phase 1
Acetyl-l-carnitine (Amino Acid) 2023 Treatment Timeline for Medical Study. Trial Name: NCT05355311 — Phase 1

Frequently Asked Questions

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

Who can be accepted into this scientific experiment?

"Individuals between the ages of 14 and 20 who have a history of alcohol consumption are eligible for this clinical trial, which is accepting up to 50 participants."

Answered by AI

Are researchers currently enrolling participants for this investigation?

"According to clinicaltrials.gov, this trial is no longer actively recruiting participants. It was first published on June 1st 2022 and last updated on April 29th 2022. However, there are still 363 other trials that are currently welcoming new patients for participation."

Answered by AI

Are individuals aged 60 or over being accepted for this experiment?

"This research study will consider patients aged 14 to 20 years old."

Answered by AI

Has the United States Food and Drug Administration authorized Acetyl-l-carnitine?

"Due to the limited data regarding its efficacy and safety, Acetyl-l-carnitine is provisionally rated a 1 on our Power scale. This reflects that it is presently in Phase 1 of clinical trials."

Answered by AI
~14 spots leftby Aug 2024