Sustiva

Antiretroviral Therapy, HIV

Treatment

2 FDA approvals

20 Active Studies for Sustiva

Treatment for

Antiretroviral Therapy

What is Sustiva

EfavirenzThe Generic name of this drug

Treatment SummaryEfavirenz (brand names Sustiva® and Stocrin®) is a type of medicine used to treat HIV. It is part of a combination of drugs called Highly Active Antiretroviral Therapy (HAART) and is usually taken with two other drugs (zidovudine or tenofovir, and lamivudine). Efavirenz is also sometimes prescribed to people who have recently been exposed to HIV, as it can help reduce the risk of transmission.

Sustivais the brand name

image of different drug pills on a surface

Sustiva Overview & Background

Brand Name

Generic Name

First FDA Approval

How many FDA approvals?

Sustiva

Efavirenz

1998

Approved as Treatment by the FDA

Efavirenz, otherwise called Sustiva, is approved by the FDA for 2 uses including Antiretroviral Therapy and HIV .

Antiretroviral Therapy

Used in combination with Efavirenz for Antiretroviral Therapy

HIV

Used in combination with Efavirenz for Human Immunodeficiency Virus Type 1 (HIV-1) Infection

Effectiveness

How Sustiva Affects PatientsEfavirenz is a type of medicine usually taken orally to treat HIV infections. It is usually given in combination with other medicines, such as another type of HIV medicine (nucleoside reverse transcriptase inhibitor) and a protease inhibitor. This combination of medications is recommended by the CDC for the treatment of HIV infection.

How Sustiva works in the bodyEfavirenz works by blocking an enzyme called reverse transcriptase which helps the virus to make copies of itself. This stops the virus from multiplying and spreading. It does not, however, get rid of the virus that is already in the body. The drug is converted into an active form in the body, and this active form can also affect human DNA polymerase, which may be responsible for some of the drug's side effects.

When to interrupt dosage

The measure of Sustiva is contingent upon the diagnosed malady. The dosage additionally changes as indicated by the technique of delivery (e.g. Tablet or Capsule - Oral) featured in the table below.

Condition

Dosage

Administration

Antiretroviral Therapy

600.0 mg, , 50.0 mg, 200.0 mg, 100.0 mg, 30.0 mg/mL, 400.0 mg

, Oral, Tablet, film coated, Tablet, film coated - Oral, Capsule, Capsule - Oral, Tablet, Tablet - Oral, Solution, Solution - Oral, Capsule, gelatin coated, Capsule, gelatin coated - Oral

HIV

600.0 mg, , 50.0 mg, 200.0 mg, 100.0 mg, 30.0 mg/mL, 400.0 mg

, Oral, Tablet, film coated, Tablet, film coated - Oral, Capsule, Capsule - Oral, Tablet, Tablet - Oral, Solution, Solution - Oral, Capsule, gelatin coated, Capsule, gelatin coated - Oral

Warnings

Sustiva Contraindications

Condition

Risk Level

Notes

Pulse Frequency

Do Not Combine

There are 20 known major drug interactions with Sustiva.

Common Sustiva Drug Interactions

Drug Name

Risk Level

Description

(R)-warfarin

Major

The metabolism of (R)-warfarin can be decreased when combined with Efavirenz.

(S)-Warfarin

Major

The metabolism of (S)-Warfarin can be decreased when combined with Efavirenz.

1,2-Benzodiazepine

Major

The metabolism of 1,2-Benzodiazepine can be decreased when combined with Efavirenz.

3,5-diiodothyropropionic acid

Major

The metabolism of 3,5-diiodothyropropionic acid can be decreased when combined with Efavirenz.

5-androstenedione

Major

The metabolism of 5-androstenedione can be decreased when combined with Efavirenz.

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Sustiva Novel Uses: Which Conditions Have a Clinical Trial Featuring Sustiva?

44 active studies are assessing the potential of Sustiva in providing Antiretroviral Therapy for certain conditions.

Condition

Clinical Trials

Trial Phases

Antiretroviral Therapy

1 Actively Recruiting

Phase 2

HIV

38 Actively Recruiting

Phase 2, Phase 3, Early Phase 1, Not Applicable, Phase 1, Phase 4

Sustiva Reviews: What are patients saying about Sustiva?

5Patient Review

4/14/2008

Sustiva for HIV

I've been on Sustiva for just over five years now, and it's been working great in combination with Viread and Ziagen. I have had very few side effects from this medication (just some strange dreams), and it has kept me undetectable for nearly five years now.

5Patient Review

7/15/2009

Sustiva for HIV

I experienced some dizziness when I first started taking Sustiva, but this went away after a couple of weeks. I haven't had any other side effects, and my viral load has stayed undetectable for over 7 years now. The only downside is the increasing cost of the medication.

5Patient Review

3/23/2017

Sustiva for HIV

I was one of the first people to try this medication, and I didn't really have any issues with it. Sometimes my dreams were more real or lucid, but that was manageable. My doctor just decided to switch me to something newer.

5Patient Review

11/20/2007

Sustiva for HIV

4.7Patient Review

2/24/2009

Sustiva for HIV

This medication is doing wonders for me, except for the weight gain side effect. The biggest issue, however, is the monthly cost. I sometimes have difficulty affording it, and was wondering if there are any programs to help with copays.

View All Reviews

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Patient Q&A Section about sustiva

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

Is there a generic for Sustiva?

"The generic version of Sustiva, efavirenz, is used to treat HIV and is available in a 600mg 30ct bottle."

Answered by AI

What type of drug is Sustiva?

"It works by stopping the HIV virus from multiplying.

Sustiva is a prescription medicine used to treat HIV Infection. It may be used alone or with other medications. Sustiva belongs to a class of drugs called HIV NNRTIs. It works by stopping the HIV virus from multiplying."

Answered by AI

Is Sustiva a NNRTI?

"Efavirenz (SUSTIVA), a non-nucleoside reverse transcriptase inhibitor (NNRTI), was approved by the Food and Drug Administration for adults and children. Efavirenz must be taken with other antiretroviral drugs, as with other NNRTIs."

Answered by AI

What is Sustiva used for?

"This drug is one of a combination of drugs used to treat HIV infection.other HIV medications work to control HIV by decreasing the amount of HIV in the body, which allows the immune system to work more effectively. This lowers the chances of developing HIV complications, such as new infections or cancer, and improves patient quality of life."

Answered by AI