Rufinamide

Lennox Gastaut Syndrome (LGS)
Treatment
1 FDA approval
3 Active Studies for Rufinamide

What is Rufinamide

RufinamideThe Generic name of this drug
Treatment SummaryRufinamide is a medication used to treat seizures in people with Lennox-Gastuat syndrome, a rare form of childhood epilepsy. It has been tested in clinical trials and found to be effective in treating partial seizures.
Banzelis the brand name
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Rufinamide Overview & Background
Brand Name
Generic Name
First FDA Approval
How many FDA approvals?
Banzel
Rufinamide
2008
21

Approved as Treatment by the FDA

Rufinamide, also known as Banzel, is approved by the FDA for 1 uses such as Lennox Gastaut Syndrome (LGS) .
Lennox Gastaut Syndrome (LGS)
Used in combination with other therapies

Effectiveness

How Rufinamide Affects PatientsAt high doses, this drug will stop the mGluR5 subtype receptor from working and block the formation of glutamate.
How Rufinamide works in the bodyRufinamide is an anti-epileptic drug that works by making nerve cells less responsive to electrical signals. This helps to stop the spread of seizures in the brain.

When to interrupt dosage

The suggested quantity of Rufinamide is contingent upon the diagnosed circumstance. The dosage is subject to the mode of delivery outlined in the table below.
Condition
Dosage
Administration
Lennox Gastaut Syndrome (LGS)
, 200.0 mg, 400.0 mg, 40.0 mg/mL, 100.0 mg
, Oral, Tablet, film coated, Tablet, film coated - Oral, Suspension, Suspension - Oral, Tablet, Tablet - Oral

Warnings

Rufinamide Contraindications
Condition
Risk Level
Notes
familial short QT syndrome
Do Not Combine
There are 20 known major drug interactions with Rufinamide.
Common Rufinamide Drug Interactions
Drug Name
Risk Level
Description
Abemaciclib
Major
The metabolism of Abemaciclib can be increased when combined with Rufinamide.
Acalabrutinib
Major
The metabolism of Acalabrutinib can be increased when combined with Rufinamide.
Alectinib
Major
The metabolism of Alectinib can be increased when combined with Rufinamide.
Alpelisib
Major
The metabolism of Alpelisib can be increased when combined with Rufinamide.
Aminophylline
Major
The metabolism of Aminophylline can be increased when combined with Rufinamide.
Rufinamide Toxicity & Overdose RiskThe most common side effects experienced when taking this drug (occurring in more than 10% of patients and more often than with a placebo) include headache, dizziness, fatigue, drowsiness, and nausea.
image of a doctor in a lab doing drug, clinical research

Rufinamide Novel Uses: Which Conditions Have a Clinical Trial Featuring Rufinamide?

4 active clinical trials are in progress to assess the potential of Rufinamide as a therapeutic intervention for Lennox Gastaut Syndrome (LGS).
Condition
Clinical Trials
Trial Phases
Lennox Gastaut Syndrome (LGS)
3 Actively Recruiting
Phase 2, Phase 3

Rufinamide Reviews: What are patients saying about Rufinamide?

3.3Patient Review
3/22/2009
Rufinamide for Petit Mal Epilepsy with Multiple Seizure Types
I didn't love the side effects of this treatment, but it did moderately help with my condition.
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Patient Q&A Section about rufinamide

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

Is rufinamide the same as BANZEL?

"BANZEL is a prescription medication that is approved for the treatment of seizures associated with Lennox-Gastaut Syndrome for pediatric patients aged one year and above, as well as adults."

Answered by AI

What is the brand name for rufinamide?

"BANZEL is a prescription medicine that is used with other medications to treat seizures in adults and pediatric patients that are one year of age or older that are associated with Lennox-Gastaut Syndrome."

Answered by AI

What is the mechanism of action for rufinamide?

"The way that rufinamide prevents seizures is not fully understood. However, studies done in test tubes suggest that it works by affecting sodium channels, particularly by lengthening the time they stay in an inactive state."

Answered by AI

What is rufinamide used for?

"Rufinamide is a medication used to control seizures, in combination with other medication(s), in people who have Lennox-Gastaut syndrome. Lennox-Gastaut syndrome is a severe form of epilepsy that begins during childhood and causes several types of seizures, behavioral disturbances, and developmental delays. Rufinamide is classified as an anticonvulsant."

Answered by AI

Clinical Trials for Rufinamide