Rufinamide
Lennox Gastaut Syndrome
Treatment
2 FDA approvals
2 Active Studies for Rufinamide
Treatment for
Lennox Gastaut Syndrome
What is Rufinamide
Rufinamide
The Generic name of this drug
Treatment Summary
Rufinamide is a medication used to treat seizures in people with Lennox-Gastuat syndrome, a rare form of childhood epilepsy. It has been tested in clinical trials and found to be effective in treating partial seizures.
Banzel
is the brand name
Rufinamide Overview & Background
Brand Name
Generic Name
First FDA Approval
How many FDA approvals?
Banzel
Rufinamide
2008
21
Approved as Treatment by the FDA
Rufinamide, also known as Banzel, is approved by the FDA for 2 uses such as Lennox Gastaut Syndrome (LGS) and Lennox Gastaut Syndrome .
Lennox Gastaut Syndrome (LGS)
Used in combination with other therapies
Lennox Gastaut Syndrome
Used in combination with other therapies
Effectiveness
How Rufinamide Affects Patients
At high doses, this drug will stop the mGluR5 subtype receptor from working and block the formation of glutamate.
How Rufinamide works in the body
Rufinamide is an anti-epileptic drug that works by making nerve cells less responsive to electrical signals. This helps to stop the spread of seizures in the brain.
When to interrupt dosage
The suggested quantity of Rufinamide is contingent upon the diagnosed circumstance. The dosage is subject to the mode of delivery outlined in the table below.
Condition
Dosage
Administration
Lennox Gastaut Syndrome
, 200.0 mg, 400.0 mg, 40.0 mg/mL, 100.0 mg
, Oral, Tablet, film coated - Oral, Suspension, Tablet, film coated, Suspension - Oral, Tablet, Tablet - Oral
Warnings
Rufinamide Contraindications
Condition
Risk Level
Notes
familial short QT syndrome
Do Not Combine
There are 20 known major drug interactions with Rufinamide.
Common Rufinamide Drug Interactions
Drug Name
Risk Level
Description
Abemaciclib
Major
The metabolism of Abemaciclib can be increased when combined with Rufinamide.
Acalabrutinib
Major
The metabolism of Acalabrutinib can be increased when combined with Rufinamide.
Alectinib
Major
The metabolism of Alectinib can be increased when combined with Rufinamide.
Alpelisib
Major
The metabolism of Alpelisib can be increased when combined with Rufinamide.
Aminophylline
Major
The metabolism of Aminophylline can be increased when combined with Rufinamide.
Rufinamide Toxicity & Overdose Risk
The most common side effects experienced when taking this drug (occurring in more than 10% of patients and more often than with a placebo) include headache, dizziness, fatigue, drowsiness, and nausea.
Rufinamide Novel Uses: Which Conditions Have a Clinical Trial Featuring Rufinamide?
4 active clinical trials are in progress to assess the potential of Rufinamide as a therapeutic intervention for Lennox Gastaut Syndrome (LGS).
Condition
Clinical Trials
Trial Phases
Lennox Gastaut Syndrome
2 Actively Recruiting
Phase 1, Phase 2, Phase 4
Rufinamide Reviews: What are patients saying about Rufinamide?
3.3
Patient Review
3/22/2009
Rufinamide for Petit Mal Epilepsy with Multiple Seizure Types
Patient Q&A Section about rufinamide
These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.
Is rufinamide the same as BANZEL?
"BANZEL is a prescription medication that is approved for the treatment of seizures associated with Lennox-Gastaut Syndrome for pediatric patients aged one year and above, as well as adults."
Answered by AI
What is the brand name for rufinamide?
"BANZEL is a prescription medicine that is used with other medications to treat seizures in adults and pediatric patients that are one year of age or older that are associated with Lennox-Gastaut Syndrome."
Answered by AI
What is the mechanism of action for rufinamide?
"The way that rufinamide prevents seizures is not fully understood. However, studies done in test tubes suggest that it works by affecting sodium channels, particularly by lengthening the time they stay in an inactive state."
Answered by AI
What is rufinamide used for?
"Rufinamide is a medication used to control seizures, in combination with other medication(s), in people who have Lennox-Gastaut syndrome. Lennox-Gastaut syndrome is a severe form of epilepsy that begins during childhood and causes several types of seizures, behavioral disturbances, and developmental delays. Rufinamide is classified as an anticonvulsant."
Answered by AI