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What is Robaxin
MethocarbamolThe Generic name of this drug
Treatment SummaryMethocarbamol is a medication used to treat muscle spasticity and the associated pain. It is available in both tablets and intramuscular injections and is used to provide relief from aches and pains caused by muscle and joint conditions. In the United States, methocarbamol is only available by prescription, while in Canada it can be purchased over-the-counter in a lower dose. In Canada, it can also be combined with acetaminophen or ibuprofen, or with acetylsalicylic acid and codeine with a prescription. Methocarbamol was approved by the FDA in 1957
Robaxinis the brand name
Robaxin Overview & Background
Brand Name
Generic Name
First FDA Approval
How many FDA approvals?
Robaxin
Methocarbamol
1959
395
Approved as Treatment by the FDA
Methocarbamol, commonly known as Robaxin, is approved by the FDA for 5 uses including Muscle Spasms and Pain .Muscle Spasms
Used to treat Muscle Spasms in combination with Acetaminophen
Pain
Used to treat moderate to severe pain in combination with Acetaminophen
Discomfort
Musculoskeletal Diseases
Lockjaw
Effectiveness
How Robaxin Affects PatientsMethacarbamol is a drug used to relax tense muscles, though how it works is not yet known. It has been shown to block certain nerve signals, reduce nerve transmission in the spine and brain, and lengthen the amount of time between muscle contractions. It does not act as a numbing agent when injected. In animal studies, it has also been seen to prevent seizures after electric shock.
How Robaxin works in the bodyMethocarbamol works by blocking the nerve signals that cause muscles to contract, which helps to reduce pain and muscle spasms. It also helps to prolong the amount of time it takes for a muscle to reach its refractory period, meaning that it takes longer for the muscles to become overworked. Methocarbamol does not directly affect muscle fibers, motor end plates, or nerve fibers.
When to interrupt dosage
The measure of Robaxin is dependent upon the designated affliction, including Physical Therapy, Gouty Arthritis and Muscle Spasms. The magnitude of dosage fluctuates based on the mode of application (e.g. Tablet - Oral or Tablet) featured in the chart beneath.Condition
Dosage
Administration
Discomfort
750.0 mg, , 500.0 mg, 100.0 mg/mL, 400.0 mg
, Oral, Tablet, Tablet - Oral, Intramuscular; Intravenous, Injection, Injection - Intramuscular; Intravenous, Tablet, film coated, Tablet, film coated - Oral, Injection, solution, Injection, solution - Intramuscular; Intravenous, Liquid, Liquid - Intramuscular; Intravenous, Tablet, coated, Tablet, coated - Oral, Kit, Parenteral, Injection - Parenteral, Kit - Oral
Lockjaw
750.0 mg, , 500.0 mg, 100.0 mg/mL, 400.0 mg
, Oral, Tablet, Tablet - Oral, Intramuscular; Intravenous, Injection, Injection - Intramuscular; Intravenous, Tablet, film coated, Tablet, film coated - Oral, Injection, solution, Injection, solution - Intramuscular; Intravenous, Liquid, Liquid - Intramuscular; Intravenous, Tablet, coated, Tablet, coated - Oral, Kit, Parenteral, Injection - Parenteral, Kit - Oral
Physical Therapy
750.0 mg, , 500.0 mg, 100.0 mg/mL, 400.0 mg
, Oral, Tablet, Tablet - Oral, Intramuscular; Intravenous, Injection, Injection - Intramuscular; Intravenous, Tablet, film coated, Tablet, film coated - Oral, Injection, solution, Injection, solution - Intramuscular; Intravenous, Liquid, Liquid - Intramuscular; Intravenous, Tablet, coated, Tablet, coated - Oral, Kit, Parenteral, Injection - Parenteral, Kit - Oral
Chronic Pain
750.0 mg, , 500.0 mg, 100.0 mg/mL, 400.0 mg
, Oral, Tablet, Tablet - Oral, Intramuscular; Intravenous, Injection, Injection - Intramuscular; Intravenous, Tablet, film coated, Tablet, film coated - Oral, Injection, solution, Injection, solution - Intramuscular; Intravenous, Liquid, Liquid - Intramuscular; Intravenous, Tablet, coated, Tablet, coated - Oral, Kit, Parenteral, Injection - Parenteral, Kit - Oral
Muscle Pain
750.0 mg, , 500.0 mg, 100.0 mg/mL, 400.0 mg
, Oral, Tablet, Tablet - Oral, Intramuscular; Intravenous, Injection, Injection - Intramuscular; Intravenous, Tablet, film coated, Tablet, film coated - Oral, Injection, solution, Injection, solution - Intramuscular; Intravenous, Liquid, Liquid - Intramuscular; Intravenous, Tablet, coated, Tablet, coated - Oral, Kit, Parenteral, Injection - Parenteral, Kit - Oral
Rheumatism
750.0 mg, , 500.0 mg, 100.0 mg/mL, 400.0 mg
, Oral, Tablet, Tablet - Oral, Intramuscular; Intravenous, Injection, Injection - Intramuscular; Intravenous, Tablet, film coated, Tablet, film coated - Oral, Injection, solution, Injection, solution - Intramuscular; Intravenous, Liquid, Liquid - Intramuscular; Intravenous, Tablet, coated, Tablet, coated - Oral, Kit, Parenteral, Injection - Parenteral, Kit - Oral
Gouty Arthritis
750.0 mg, , 500.0 mg, 100.0 mg/mL, 400.0 mg
, Oral, Tablet, Tablet - Oral, Intramuscular; Intravenous, Injection, Injection - Intramuscular; Intravenous, Tablet, film coated, Tablet, film coated - Oral, Injection, solution, Injection, solution - Intramuscular; Intravenous, Liquid, Liquid - Intramuscular; Intravenous, Tablet, coated, Tablet, coated - Oral, Kit, Parenteral, Injection - Parenteral, Kit - Oral
Rest
750.0 mg, , 500.0 mg, 100.0 mg/mL, 400.0 mg
, Oral, Tablet, Tablet - Oral, Intramuscular; Intravenous, Injection, Injection - Intramuscular; Intravenous, Tablet, film coated, Tablet, film coated - Oral, Injection, solution, Injection, solution - Intramuscular; Intravenous, Liquid, Liquid - Intramuscular; Intravenous, Tablet, coated, Tablet, coated - Oral, Kit, Parenteral, Injection - Parenteral, Kit - Oral
Muscle Spasms
750.0 mg, , 500.0 mg, 100.0 mg/mL, 400.0 mg
, Oral, Tablet, Tablet - Oral, Intramuscular; Intravenous, Injection, Injection - Intramuscular; Intravenous, Tablet, film coated, Tablet, film coated - Oral, Injection, solution, Injection, solution - Intramuscular; Intravenous, Liquid, Liquid - Intramuscular; Intravenous, Tablet, coated, Tablet, coated - Oral, Kit, Parenteral, Injection - Parenteral, Kit - Oral
Musculoskeletal Diseases
750.0 mg, , 500.0 mg, 100.0 mg/mL, 400.0 mg
, Oral, Tablet, Tablet - Oral, Intramuscular; Intravenous, Injection, Injection - Intramuscular; Intravenous, Tablet, film coated, Tablet, film coated - Oral, Injection, solution, Injection, solution - Intramuscular; Intravenous, Liquid, Liquid - Intramuscular; Intravenous, Tablet, coated, Tablet, coated - Oral, Kit, Parenteral, Injection - Parenteral, Kit - Oral
Inflammation
750.0 mg, , 500.0 mg, 100.0 mg/mL, 400.0 mg
, Oral, Tablet, Tablet - Oral, Intramuscular; Intravenous, Injection, Injection - Intramuscular; Intravenous, Tablet, film coated, Tablet, film coated - Oral, Injection, solution, Injection, solution - Intramuscular; Intravenous, Liquid, Liquid - Intramuscular; Intravenous, Tablet, coated, Tablet, coated - Oral, Kit, Parenteral, Injection - Parenteral, Kit - Oral
Pain
750.0 mg, , 500.0 mg, 100.0 mg/mL, 400.0 mg
, Oral, Tablet, Tablet - Oral, Intramuscular; Intravenous, Injection, Injection - Intramuscular; Intravenous, Tablet, film coated, Tablet, film coated - Oral, Injection, solution, Injection, solution - Intramuscular; Intravenous, Liquid, Liquid - Intramuscular; Intravenous, Tablet, coated, Tablet, coated - Oral, Kit, Parenteral, Injection - Parenteral, Kit - Oral
Warnings
Robaxin has a single contraindication, so it should not be consumed when experiencing any of the circumstances listed in the below table.Robaxin ContraindicationsCondition
Risk Level
Notes
Severe Hypersensitivity Reactions
Do Not Combine
Methocarbamol may interact with Pulse Frequency
Common Robaxin Drug Interactions
Drug Name
Risk Level
Description
Azelastine
Major
Methocarbamol may increase the central nervous system depressant (CNS depressant) activities of Azelastine.
Ethanol
Major
Methocarbamol may increase the central nervous system depressant (CNS depressant) activities of Ethanol.
Oliceridine
Major
The risk or severity of hypotension, sedation, death, somnolence, and respiratory depression can be increased when Methocarbamol is combined with Oliceridine.
Thalidomide
Major
Methocarbamol may increase the central nervous system depressant (CNS depressant) activities of Thalidomide.
Daridorexant
Minor
The risk or severity of CNS depression can be increased when Methocarbamol is combined with Daridorexant.
Robaxin Toxicity & Overdose RiskTaking too much methocarbamol can cause nausea, drowsiness, blurred vision, low blood pressure, seizures, and even coma. Medical treatment for overdose typically involves maintaining airway, monitoring vital signs, and giving fluids. The toxic dose for rats is 3576.2mg/kg. Pregnant women and breastfeeding mothers should exercise caution when taking this medication as it has not been studied for risks to fetuses or infants. There have also been no studies on the effects of methocarbamol on fertility, cancer, or mutation.
Robaxin Novel Uses: Which Conditions Have a Clinical Trial Featuring Robaxin?
356 active studies are currently assessing the potential of Robaxin to provide relief from Gouty Arthritis, Rest and Musculoskeletal Diseases.Condition
Clinical Trials
Trial Phases
Chronic Pain
175 Actively Recruiting
Phase 2, Phase 3, Not Applicable, Phase 1, Phase 4, Early Phase 1
Inflammation
0 Actively Recruiting
Lockjaw
2 Actively Recruiting
Phase 2
Rheumatism
0 Actively Recruiting
Rest
0 Actively Recruiting
Muscle Spasms
0 Actively Recruiting
Physical Therapy
7 Actively Recruiting
Not Applicable
Discomfort
0 Actively Recruiting
Musculoskeletal Diseases
4 Actively Recruiting
Phase 1, Phase 2, Not Applicable
Gouty Arthritis
1 Actively Recruiting
Phase 2, Phase 3
Pain
0 Actively Recruiting
Muscle Pain
8 Actively Recruiting
Not Applicable, Phase 2, Phase 4, Phase 1, Early Phase 1
Robaxin Reviews: What are patients saying about Robaxin?
5Patient Review
12/4/2015 This medication has been an absolute godsend. I had been in pain for four months with no end in sight, but after just a week of taking Robaxin I'm finally feeling better.
5Patient Review
4/2/2018 This drug has been a life-saver for me. I had an allergic reaction to esi, several disc problems, etc.
4.3Patient Review
1/7/2015 I've been managing my MS for half a century now and I'm still relatively mobile. I was previously taking 1/2 Vicodin three times daily, but when I started taking low doses of Robaxin twice per day, it stopped my muscle cramps and spasms almost immediately. I felt so good that I forgot to take my Vicodin!
2.7Patient Review
11/2/2014 I have scoliosis and DDD along with other chronic pain conditions. I had taken Flexeril in the past and it seemed to work a little and it did not make me extremely drowsy. Well I changed doctors due to moving and my new doctor insisted this medication would work better and not make me drowsy. Unfortunately, the complete opposite happened..I now feel like a zombie plus the spasms are still occurring. Not happy!
2.3Patient Review
11/16/2014 I'm taking the 750 mg dosage three times a day to address muscle spasms caused by Fibromyalgia, Spinal Stenosis, and spinal arthritis. However, I'm finding that I'm quite sedated after taking this medication and have also experienced stomach upset. Overall, I'm not very pleased with this drug.
2.3Patient Review
7/28/2016 I began taking robaxin 2 years ago for muscle spasms in my neck. I'm a healthy middle-aged male. I was told to take it with ibuprofen. No help at all. I definitely would not recommend this muscle relaxer.
2.3Patient Review
10/27/2015 I unfortunately had to discontinue use of this medication due to the fact that it caused my vision to become blurry. This made it impossible for me to function normally.
2Patient Review
3/17/2022 I was in a car accident and dislocated my shoulder as well as damaged my c5/c6 vertebrae. I've been prescribed Robaxin for the spasms in my neck, but it does nothing compared to Carisiprodol. The latter might make you groggy, but it's worth it for the relief it provides.
2Patient Review
4/4/2018 I unfortunately didn't have any success with this medication. I still experienced muscle spasms and pain, and in addition felt very sluggish. As someone who needs to be active for my job, this was a real hindrance.
1Patient Review
9/1/2022 If you have or had anxiety / panic attacks, this will cause them to start up again. Starts the next day and first you feel a flushing. Then when in a waking state from sleeping you get the panic. I am so angry this caused it to start up again.
Patient Q&A Section about robaxin
These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.Is Robaxin a painkiller?
"Methocarbamol is used to treat muscle spasms and pain. It works by helping to relax the muscles."
Answered by AI
Is Robaxin 500 mg a narcotic?
"Methocarbamol is not a narcotic, but rather a central nervous system depressant and muscle relaxant used to treat muscle spasms, tension, and pain. Its side effects, which can make it feel like a drug “high,” include drowsiness and dizziness."
Answered by AI
Is Robaxin the same as tramadol?
"Robaxin and Ultram are used to treat different kinds of pain. Robaxin is used to treat muscle pain, while Ultram is used to treat general pain. Both drugs work differently. Robaxin relaxes muscles, while Ultram reduces pain by affecting the brain."
Answered by AI