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What is Risedronate Sodium
Risedronic acidThe Generic name of this drug
Treatment SummaryRisedronic acid is a medication used to treat certain types of bone diseases such as osteoporosis and Paget’s disease. It works by blocking the breakdown of bone tissue, which helps keep bones strong and healthy.
Actonelis the brand name
Risedronate Sodium Overview & Background
Brand Name
Generic Name
First FDA Approval
How many FDA approvals?
Actonel
Risedronic acid
1998
61
Approved as Treatment by the FDA
Risedronic acid, also called Actonel, is approved by the FDA for 5 uses including Bone and Bones and Paget’s Disease .Bone and Bones
Used to treat increased bone mass in combination with Calcium
Paget’s Disease
Therapeutic procedure
Osteoporosis
Used to treat Osteoporosis in combination with Calcium
Postmenopause
Effectiveness
How Risedronate Sodium Affects PatientsRisedronate is a drug that helps prevent bone loss by stopping cells (osteoclasts) from breaking down the bones.
How Risedronate Sodium works in the bodyRisedronatic acid works to stop bone resorption. It binds to the surface of bones, and when the bone is broken down, risedronatic acid is released. The acid is taken up by nearby osteoclasts, which are cells that break down bone. It stops the osteoclasts from functioning, which prevents further bone breakdown.
When to interrupt dosage
The measure of Risedronate Sodium is contingent upon the acknowledged malady, including Therapeutic procedure, Malignant Neoplasms and Postmenopause. The quantity of dosage fluctuates as per the technique of delivery featured in the table beneath.Condition
Dosage
Administration
Osteoporosis
30.0 mg, , 5.0 mg, 35.0 mg, 150.0 mg, 75.0 mg, 129.0 mg, 4.9 mg, 30.1 mg, 64.5 mg, 4.3 mg, 25.8 mg
Oral, , Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral, Granule, effervescent; Kit; Tablet, Granule, effervescent; Kit; Tablet - Oral, Tablet, delayed release, Tablet, delayed release - Oral, Tablet, Delayed Release, Tablet, Delayed Release - Oral, Kit; Tablet, Kit; Tablet - Oral, Kit
Malignant Neoplasms
30.0 mg, , 5.0 mg, 35.0 mg, 150.0 mg, 75.0 mg, 129.0 mg, 4.9 mg, 30.1 mg, 64.5 mg, 4.3 mg, 25.8 mg
Oral, , Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral, Granule, effervescent; Kit; Tablet, Granule, effervescent; Kit; Tablet - Oral, Tablet, delayed release, Tablet, delayed release - Oral, Tablet, Delayed Release, Tablet, Delayed Release - Oral, Kit; Tablet, Kit; Tablet - Oral, Kit
Postmenopause
30.0 mg, , 5.0 mg, 35.0 mg, 150.0 mg, 75.0 mg, 129.0 mg, 4.9 mg, 30.1 mg, 64.5 mg, 4.3 mg, 25.8 mg
Oral, , Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral, Granule, effervescent; Kit; Tablet, Granule, effervescent; Kit; Tablet - Oral, Tablet, delayed release, Tablet, delayed release - Oral, Tablet, Delayed Release, Tablet, Delayed Release - Oral, Kit; Tablet, Kit; Tablet - Oral, Kit
Therapeutic procedure
30.0 mg, , 5.0 mg, 35.0 mg, 150.0 mg, 75.0 mg, 129.0 mg, 4.9 mg, 30.1 mg, 64.5 mg, 4.3 mg, 25.8 mg
Oral, , Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral, Granule, effervescent; Kit; Tablet, Granule, effervescent; Kit; Tablet - Oral, Tablet, delayed release, Tablet, delayed release - Oral, Tablet, Delayed Release, Tablet, Delayed Release - Oral, Kit; Tablet, Kit; Tablet - Oral, Kit
Paget’s Disease
30.0 mg, , 5.0 mg, 35.0 mg, 150.0 mg, 75.0 mg, 129.0 mg, 4.9 mg, 30.1 mg, 64.5 mg, 4.3 mg, 25.8 mg
Oral, , Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral, Granule, effervescent; Kit; Tablet, Granule, effervescent; Kit; Tablet - Oral, Tablet, delayed release, Tablet, delayed release - Oral, Tablet, Delayed Release, Tablet, Delayed Release - Oral, Kit; Tablet, Kit; Tablet - Oral, Kit
Bone and Bones
30.0 mg, , 5.0 mg, 35.0 mg, 150.0 mg, 75.0 mg, 129.0 mg, 4.9 mg, 30.1 mg, 64.5 mg, 4.3 mg, 25.8 mg
Oral, , Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral, Granule, effervescent; Kit; Tablet, Granule, effervescent; Kit; Tablet - Oral, Tablet, delayed release, Tablet, delayed release - Oral, Tablet, Delayed Release, Tablet, Delayed Release - Oral, Kit; Tablet, Kit; Tablet - Oral, Kit
Warnings
Risedronate Sodium ContraindicationsCondition
Risk Level
Notes
Hypocalcemia
Do Not Combine
Inability to stand or sit upright for at least 30 minutes
Do Not Combine
Severe Hypersensitivity Reactions
Do Not Combine
Risedronic Acid may interact with Pulse Frequency
Common Risedronate Sodium Drug Interactions
Drug Name
Risk Level
Description
Etidronic acid
Minor
The risk or severity of adverse effects can be increased when Risedronic acid is combined with Etidronic acid.
Incadronic acid
Minor
The risk or severity of adverse effects can be increased when Risedronic acid is combined with Incadronic acid.
Tiludronic acid
Minor
The risk or severity of adverse effects can be increased when Risedronic acid is combined with Tiludronic acid.
Acipimox
Moderate
The risk or severity of myopathy, rhabdomyolysis, and myoglobinuria can be increased when Risedronic acid is combined with Acipimox.
Aluminium clofibrate
Moderate
The risk or severity of myopathy, rhabdomyolysis, and myoglobinuria can be increased when Risedronic acid is combined with Aluminium clofibrate.
Risedronate Sodium Toxicity & Overdose RiskOver 10% of patients taking this drug may experience back pain, joint pain, abdominal pain, and indigestion. Other rare side effects include swelling of the face, rashes, eye irritation, and inflammation of the eye.An overdose may cause decreased levels of calcium and phosphorus in the blood. Milk or antacids can be taken to reduce absorption of the drug. In more severe cases, doctors may recommend stomach pumping or intravenous calcium. In rats, a fatal dose was found to be 320 to 620 times the dose given to humans.
Risedronate Sodium Novel Uses: Which Conditions Have a Clinical Trial Featuring Risedronate Sodium?
50 active studies are being conducted to explore the potential of Risedronate Sodium to alleviate Paget’s Disease, Postmenopausal symptoms and Malignant Neoplasms.Condition
Clinical Trials
Trial Phases
Postmenopause
5 Actively Recruiting
Phase 2, Not Applicable
Malignant Neoplasms
0 Actively Recruiting
Osteoporosis
40 Actively Recruiting
Phase 1, Phase 2, Not Applicable, Early Phase 1, Phase 4, Phase 3
Paget’s Disease
0 Actively Recruiting
Therapeutic procedure
0 Actively Recruiting
Bone and Bones
0 Actively Recruiting
Risedronate Sodium Reviews: What are patients saying about Risedronate Sodium?
2Patient Review
12/31/2014 I've been taking this medication for a while now, but I'm starting to experience some serious pain in my legs. Additionally, I get bad indigestion and sometimes feel like I'm choking. Going to see the doctor soon.
2Patient Review
4/15/2014 Two days after taking the first pill, one of my eyes was almost completely closed. Is this a big concern?
2Patient Review
6/14/2010 I would rather break my bones than use this again. The side effects were very painful.
1.7Patient Review
5/6/2008 I had to stop taking this medication as it caused stomach ulcers, despite me following all the directions. It also lowered my red blood count because of the bleeding.
1.7Patient Review
7/19/2017 I have a lot of pain in my muscles and joints. It's tough to be active when some days I can hardly move. Many mornings it hurts a lot just to get out of bed.
1Patient Review
1/13/2016 The side effects of this drug were so severe that I had to go to the hospital. They couldn't do anything but tell me it would take a week or two to get out of my system. Definitely not worth it.
Patient Q&A Section about risedronate sodium
These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.How long should you take risedronate sodium?
"You should take risedronate regularly to get the full benefits. Your doctor should review your treatment after five years to make sure the benefits of taking risedronate continue to outweigh any risks."
Answered by AI
Why do you have to stay upright after taking risedronate?
"Do not lie down for 30 minutes after taking risedronate. This will help risedronate reach your stomach faster. It also will help prevent irritation to your esophagus. It is important that you eat a well-balanced diet with adequate amounts of calcium and vitamin d to help prevent bone loss."
Answered by AI
What is risedronate sodium used for?
"This medication is used by adults to treat a disease that weakens bones (Paget's disease). This medication helps to reduce bone pain and may prevent long-term complications from this disease. Risedronate works by slowing bone loss to help maintain strong bones and reduce the risk of broken bones (fractures)."
Answered by AI
What are side effects of risedronate?
"Having trouble with bowel movements, either constipation or diarrhea? experiencing indigestion, bloating, stomach pain or wind? You might also be feeling sick to your stomach (nausea), have headaches, or mild muscle, bone or joint pain."
Answered by AI