Rhopressa

Glaucoma, Open Angle Glaucoma, Ocular Hypertension
Treatment
6 FDA approvals
18 Active Studies for Rhopressa

What is Rhopressa

NetarsudilThe Generic name of this drug
Treatment SummaryRhopressa (netarsudil ophthalmic solution) 0.02% is an FDA-approved medication used to lower high pressure in the eyes of people with open-angle glaucoma or ocular hypertension. It works by blocking the rho kinase and norepinephrine transporters that are found in the trabecular pathway of the eye. This is different from other glaucoma medications that work by affecting protaglandin F2-alpha analogs in the uveoscleral pathway.
Rhopressais the brand name
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Rhopressa Overview & Background
Brand Name
Generic Name
First FDA Approval
How many FDA approvals?
Rhopressa
Netarsudil
2017
2

Approved as Treatment by the FDA

Netarsudil, also called Rhopressa, is approved by the FDA for 6 uses including Ocular Hypertension and Increased Intra Ocular Pressure (IOP) .
Ocular Hypertension
Increased Intra Ocular Pressure (IOP)
Open Angle Glaucoma (OAG)
Ocular Hypertension
Open Angle Glaucoma
Glaucoma

Effectiveness

How Rhopressa Affects PatientsAqueous humour is a liquid that flows out of the eye, taking two pathways: the conventional trabecular pathway and the unconventional uveoscleral pathway. Many medications used to treat glaucoma specifically target the uveoscleral pathway, which can lead to an increase in deterioration of the trabecular pathway. Netarsudil is a new glaucoma medication that is designed to target and inhibit the rho kinase and norepinephrine transport that are found in the conventional trabecular pathway. It is different from other medications, as it focuses on cell and muscle tissue remod
How Rhopressa works in the bodyGlaucoma is an eye condition that can cause progressive vision loss. It's caused by too much pressure in the eye, which is due to a blockage in the outflow of aqueous humor. Netarsudil is a drug that helps reduce this pressure by working on two parts of the eye: the trabecular meshwork and schlemm's canal. It relaxes the muscles and cells around these pathways, allowing aqueous humor to flow more freely. It also works on norepinephrine transporters, slowing down the production of aqueous humor. This helps to reduce

When to interrupt dosage

The recommended dosage of Rhopressa is contingent upon the determined condition, such as Ocular Hypertension, Open Angle Glaucoma and Increased Intra Ocular Pressure (IOP). Dosage also differs, in accordance with the administration technique (e.g. Ophthalmic; Topical or Solution / droplets - Ophthalmic; Topical) detailed in the table below.
Condition
Dosage
Administration
Glaucoma
, 0.2 mg/mL
, Ophthalmic; Topical, Solution / drops, Solution / drops - Ophthalmic; Topical, Ophthalmic, Solution / drops - Ophthalmic
Open Angle Glaucoma
, 0.2 mg/mL
, Ophthalmic; Topical, Solution / drops, Solution / drops - Ophthalmic; Topical, Ophthalmic, Solution / drops - Ophthalmic
Ocular Hypertension
, 0.2 mg/mL
, Ophthalmic; Topical, Solution / drops, Solution / drops - Ophthalmic; Topical, Ophthalmic, Solution / drops - Ophthalmic

Warnings

Common Rhopressa Drug Interactions
Drug Name
Risk Level
Description
Rhopressa Toxicity & Overdose RiskCommon side effects of netarsudil include redness of the eyes, pain in the eye area, corneal staining, blurred vision, increased tearing, and decreased vision. It is possible to contaminate the container of topical ophthalmic products with bacteria, which can lead to infections. There is not enough data available to know how netarsudil might affect pregnant women or breastfeeding mothers. There is also not enough data to know how safe it is for children under 18 to use netarsudil. Elderly people do not appear to have different safety or effectiveness levels than other adults. Long-term studies in animals
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Rhopressa Novel Uses: Which Conditions Have a Clinical Trial Featuring Rhopressa?

34 ongoing clinical trials are examining the potential of Rhopressa to address Open Angle Glaucoma, Ocular Hypertension and elevated Intra Ocular Pressure (IOP).
Condition
Clinical Trials
Trial Phases
Glaucoma
0 Actively Recruiting
Ocular Hypertension
11 Actively Recruiting
Phase 3, Phase 4, Phase 1, Phase 2, Not Applicable
Open Angle Glaucoma
12 Actively Recruiting
Phase 3, Not Applicable, Phase 2, Phase 4, Phase 1

Rhopressa Reviews: What are patients saying about Rhopressa?

5Patient Review
11/14/2019
Rhopressa for Increased Pressure in the Eye
This medication was able to quickly lower my eye pressure from 19 to 13. I experienced few side effects, which were all mild in nature.
4.3Patient Review
10/11/2018
Rhopressa for Wide-Angle Glaucoma
Though I haven't been back for a pressure check since starting this medication, the side effects are really bothersome. My eyes water constantly and the itching is unbearable. At this point, I don't think the benefits outweigh the negatives.
4.3Patient Review
11/4/2019
Rhopressa for Increased Pressure in the Eye
In just five days, this treatment brought my pressure down from 19 to 13. I was also using Timolol at the time, but it wasn't having much of an effect by itself. After two weeks of use, the side effects (red eyes, watery eyes, and slightly reduced vision) weren't too bad. Considering the alternative (going blind), I think it's worth it to deal with these small side effects.
4.3Patient Review
1/2/2019
Rhopressa for Wide-Angle Glaucoma
The side effects of this medication are not worth it in my opinion. I've suffered from teary eyes, dryness, itchiness, and light sensitivity since starting to use Rhopressa. My pressure has only decreased marginally, and I'm still scheduled for surgery. Overall, very disappointed with this drug.
3.7Patient Review
4/9/2019
Rhopressa for Wide-Angle Glaucoma
Bimatoprost kept my pressure down well, but after a few months I started having bad tearing and double vision. Switching back to Diamox cleared things up in a couple weeks.
View All Reviews
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Patient Q&A Section about rhopressa

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

What are Rhopressa eye drops used for?

"Rhopressa is a prescription medication for treating high eye pressure in people with open-angle glaucoma or ocular hypertension."

Answered by AI

Should Rhopressa be refrigerated?

"Rhopressa should be stored in the fridge until opened. After opening, it can be kept at a temperature of 36-77 degrees Fahrenheit for up to 6 weeks. If stored in the fridge at a temperature of 36-46 degrees Fahrenheit after opening, the product can be used until the expiration date stamped on the bottle."

Answered by AI

How much does Rhopressa lower IOP?

"The ROCKET 4 study found that Rhopressa lowered IOP in eyes with a mean baseline IOP of 20.7 to 22.4 mmHg to 16.3 to 17.8 mmHg at three months."

Answered by AI

Is there a generic for Rhopressa?

"The medication Rhopressa is manufactured by Aerie Pharmaceuticals and was approved by the FDA on December 18th, 2017. It is classified as a Rho kinase inhibitor and is used to treat conditions affecting the eyes."

Answered by AI

Clinical Trials for Rhopressa

Have you considered Rhopressa clinical trials? We made a collection of clinical trials featuring Rhopressa, we think they might fit your search criteria.
Have you considered Rhopressa clinical trials? We made a collection of clinical trials featuring Rhopressa, we think they might fit your search criteria.
Have you considered Rhopressa clinical trials? We made a collection of clinical trials featuring Rhopressa, we think they might fit your search criteria.
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