Rhopressa

Glaucoma, Open Angle Glaucoma, Ocular Hypertension

Treatment

6 FDA approvals

18 Active Studies for Rhopressa

What is Rhopressa

Netarsudil

The Generic name of this drug

Treatment Summary

Rhopressa (netarsudil ophthalmic solution) 0.02% is an FDA-approved medication used to lower high pressure in the eyes of people with open-angle glaucoma or ocular hypertension. It works by blocking the rho kinase and norepinephrine transporters that are found in the trabecular pathway of the eye. This is different from other glaucoma medications that work by affecting protaglandin F2-alpha analogs in the uveoscleral pathway.

Rhopressa

is the brand name

image of different drug pills on a surface

Rhopressa Overview & Background

Brand Name

Generic Name

First FDA Approval

How many FDA approvals?

Rhopressa

Netarsudil

2017

2

Approved as Treatment by the FDA

Netarsudil, also called Rhopressa, is approved by the FDA for 6 uses including Ocular Hypertension and Open Angle Glaucoma (OAG) .

Ocular Hypertension

Open Angle Glaucoma (OAG)

Ocular Hypertension

Increased Intra Ocular Pressure (IOP)

Open Angle Glaucoma

Glaucoma

Effectiveness

How Rhopressa Affects Patients

Aqueous humour is a liquid that flows out of the eye, taking two pathways: the conventional trabecular pathway and the unconventional uveoscleral pathway. Many medications used to treat glaucoma specifically target the uveoscleral pathway, which can lead to an increase in deterioration of the trabecular pathway. Netarsudil is a new glaucoma medication that is designed to target and inhibit the rho kinase and norepinephrine transport that are found in the conventional trabecular pathway. It is different from other medications, as it focuses on cell and muscle tissue remod

How Rhopressa works in the body

Glaucoma is an eye condition that can cause progressive vision loss. It's caused by too much pressure in the eye, which is due to a blockage in the outflow of aqueous humor. Netarsudil is a drug that helps reduce this pressure by working on two parts of the eye: the trabecular meshwork and schlemm's canal. It relaxes the muscles and cells around these pathways, allowing aqueous humor to flow more freely. It also works on norepinephrine transporters, slowing down the production of aqueous humor. This helps to reduce

When to interrupt dosage

The recommended dosage of Rhopressa is contingent upon the determined condition, such as Ocular Hypertension, Open Angle Glaucoma and Increased Intra Ocular Pressure (IOP). Dosage also differs, in accordance with the administration technique (e.g. Ophthalmic; Topical or Solution / droplets - Ophthalmic; Topical) detailed in the table below.

Condition

Dosage

Administration

Glaucoma

, 0.2 mg/mL

, Ophthalmic; Topical, Solution / drops, Solution / drops - Ophthalmic; Topical, Ophthalmic, Solution / drops - Ophthalmic

Open Angle Glaucoma

, 0.2 mg/mL

, Ophthalmic; Topical, Solution / drops, Solution / drops - Ophthalmic; Topical, Ophthalmic, Solution / drops - Ophthalmic

Ocular Hypertension

, 0.2 mg/mL

, Ophthalmic; Topical, Solution / drops, Solution / drops - Ophthalmic; Topical, Ophthalmic, Solution / drops - Ophthalmic

Warnings

Common Rhopressa Drug Interactions

Drug Name

Risk Level

Description

Rhopressa Toxicity & Overdose Risk

Common side effects of netarsudil include redness of the eyes, pain in the eye area, corneal staining, blurred vision, increased tearing, and decreased vision. It is possible to contaminate the container of topical ophthalmic products with bacteria, which can lead to infections. There is not enough data available to know how netarsudil might affect pregnant women or breastfeeding mothers. There is also not enough data to know how safe it is for children under 18 to use netarsudil. Elderly people do not appear to have different safety or effectiveness levels than other adults. Long-term studies in animals

image of a doctor in a lab doing drug, clinical research

Rhopressa Novel Uses: Which Conditions Have a Clinical Trial Featuring Rhopressa?

34 ongoing clinical trials are examining the potential of Rhopressa to address Open Angle Glaucoma, Ocular Hypertension and elevated Intra Ocular Pressure (IOP).

Condition

Clinical Trials

Trial Phases

Glaucoma

0 Actively Recruiting

Ocular Hypertension

10 Actively Recruiting

Phase 3, Phase 1, Phase 2, Not Applicable, Phase 4

Open Angle Glaucoma

10 Actively Recruiting

Phase 3, Not Applicable, Phase 4

Rhopressa Reviews: What are patients saying about Rhopressa?

5

Patient Review

11/14/2019

Rhopressa for Increased Pressure in the Eye

This medication was able to quickly lower my eye pressure from 19 to 13. I experienced few side effects, which were all mild in nature.

4.3

Patient Review

10/11/2018

Rhopressa for Wide-Angle Glaucoma

Though I haven't been back for a pressure check since starting this medication, the side effects are really bothersome. My eyes water constantly and the itching is unbearable. At this point, I don't think the benefits outweigh the negatives.

4.3

Patient Review

11/4/2019

Rhopressa for Increased Pressure in the Eye

In just five days, this treatment brought my pressure down from 19 to 13. I was also using Timolol at the time, but it wasn't having much of an effect by itself. After two weeks of use, the side effects (red eyes, watery eyes, and slightly reduced vision) weren't too bad. Considering the alternative (going blind), I think it's worth it to deal with these small side effects.

4.3

Patient Review

1/2/2019

Rhopressa for Wide-Angle Glaucoma

The side effects of this medication are not worth it in my opinion. I've suffered from teary eyes, dryness, itchiness, and light sensitivity since starting to use Rhopressa. My pressure has only decreased marginally, and I'm still scheduled for surgery. Overall, very disappointed with this drug.

3.7

Patient Review

4/9/2019

Rhopressa for Wide-Angle Glaucoma

Bimatoprost kept my pressure down well, but after a few months I started having bad tearing and double vision. Switching back to Diamox cleared things up in a couple weeks.

3.3

Patient Review

6/5/2021

Rhopressa for Wide-Angle Glaucoma

The medication is effective, but the bottle lids are way too tight. My wife had to use two wrenches just to get it open, and most of the liquid seeped out in the process. We're paying $90 per 2.5ml bottle under our insurance plan, so this is pretty frustrating.

2.7

Patient Review

12/25/2018

Rhopressa for Increased Pressure in the Eye

Immediately experienced moderate to severe redness and blurring of vision upon starting treatment with Rhopressa. Also, though there was a small reduction in pressure, the side effects (which included excessive tearing and itching of eyelids) worsened over the course of six weeks. I discontinued use about five or six days ago; while the blurring of vision has recovered somewhat, and the tearing anditching have also improved marginally, I am still experiencing severe intermittent redness.

2.3

Patient Review

12/21/2018

Rhopressa for Increased Pressure in the Eye

In combination with Lumigan and Cosopt, this treatment successfully lowered my ocular pressure from 24 to 14.

2.3

Patient Review

3/12/2019

Rhopressa for Wide-Angle Glaucoma

Causes redness, blurriness, and pain in the eyes.

1.7

Patient Review

3/9/2019

Rhopressa for Wide-Angle Glaucoma

I've been experiencing symptoms similar to a sty, with redness and itching. My doctor said the medication would help, but after two months I haven't seen any improvement.

1.7

Patient Review

3/11/2019

Rhopressa for Wide-Angle Glaucoma

My eyes were extremely red and blurry, and I felt very dizzy.

1.7

Patient Review

1/6/2022

Rhopressa for Increased Pressure in the Eye

This caused extreme light sensitivity, crusting, irritation, and eye pain in me. My grandfather also had a mild stroke and came home blind after using this medication; I believe that there needs to be more testing on seniors before releasing this drug.

1.7

Patient Review

8/16/2018

Rhopressa for Wide-Angle Glaucoma

1.7

Patient Review

4/6/2019

Rhopressa for Wide-Angle Glaucoma

Made my eyes itchy and red

1

Patient Review

1/10/2019

Rhopressa for Increased Pressure in the Eye

The pressure in my eye dropped quickly after using this medication, but I experienced some redness and tearing. The price is quite high, which makes it difficult to access for many people.
image of drug pills surrounding a glass of water symbolizing drug consumption

Patient Q&A Section about rhopressa

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

What are Rhopressa eye drops used for?

"Rhopressa is a prescription medication for treating high eye pressure in people with open-angle glaucoma or ocular hypertension."

Answered by AI

Should Rhopressa be refrigerated?

"Rhopressa should be stored in the fridge until opened. After opening, it can be kept at a temperature of 36-77 degrees Fahrenheit for up to 6 weeks. If stored in the fridge at a temperature of 36-46 degrees Fahrenheit after opening, the product can be used until the expiration date stamped on the bottle."

Answered by AI

How much does Rhopressa lower IOP?

"The ROCKET 4 study found that Rhopressa lowered IOP in eyes with a mean baseline IOP of 20.7 to 22.4 mmHg to 16.3 to 17.8 mmHg at three months."

Answered by AI

Is there a generic for Rhopressa?

"The medication Rhopressa is manufactured by Aerie Pharmaceuticals and was approved by the FDA on December 18th, 2017. It is classified as a Rho kinase inhibitor and is used to treat conditions affecting the eyes."

Answered by AI

Clinical Trials for Rhopressa

Have you considered Rhopressa clinical trials?

We made a collection of clinical trials featuring Rhopressa, we think they might fit your search criteria.
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Have you considered Rhopressa clinical trials?

We made a collection of clinical trials featuring Rhopressa, we think they might fit your search criteria.
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Image of Department of Ophthalmology and Visual Sciences, University of Alabama at Birmingham in Birmingham, United States.

AI-Based Screening for Glaucoma

18+
All Sexes
Birmingham, AL

The goal of this clinical trial is to learn if implementation of an eye screening program at Federally Qualified Health Center (FQHC) clinics provides results that participants may have glaucoma, and/or other eye conditions (diabetic retinopathy, cataract, visual acuity impairment). The glaucoma screening will incorporate use of an artificial intelligence (AI)-assisted screening tool. This project is called AI-RONA. The main questions it aims to answer are: * How does this eye screening program compare to the rate of glaucoma and other eye conditions detected at other FQHC clinics where the screening program has not been implemented? * Do particpants who screen positive for these conditions adhere to the physician's recommendation for a follow-up examination by an optometrist or ophthalmologist? * Are referral rates for a follow-up comprehensive eye exam by an optometrist or ophthalmologist similar to those implemented by an ophthalmologist using telemedicine (that is, using the results of the screening to make a diagnosis remotely)? * What is the cost-effectiveness of the AI-assisted screening program in diagnosing glaucoma as compared to a physician-guided program? * Are participants completing the screening satisfied with it? * Are physicians at the FQHC clinics administering the screening satisfied with it? Participants will: * Undergo an ocular screening whose goal is to detect glaucoma, diabetic retinopathy, cataract, and/or impairment in visual acuity. If the screening indicates that participants may have these conditions, participants will be referred for a comprehensive eye examination by an optometrist or ophthalmologist. * Following the screening, participants and physicians will complete a survey on their satisfaction with the program.

Recruiting
Has No Placebo

Department of Ophthalmology and Visual Sciences, University of Alabama at Birmingham

Cynthia Owsley, PhD

Have you considered Rhopressa clinical trials?

We made a collection of clinical trials featuring Rhopressa, we think they might fit your search criteria.
Go to Trials