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What is Rhopressa
NetarsudilThe Generic name of this drug
Treatment SummaryRhopressa (netarsudil ophthalmic solution) 0.02% is an FDA-approved medication used to lower high pressure in the eyes of people with open-angle glaucoma or ocular hypertension. It works by blocking the rho kinase and norepinephrine transporters that are found in the trabecular pathway of the eye. This is different from other glaucoma medications that work by affecting protaglandin F2-alpha analogs in the uveoscleral pathway.
Rhopressais the brand name
Rhopressa Overview & Background
Brand Name
Generic Name
First FDA Approval
How many FDA approvals?
Rhopressa
Netarsudil
2017
2
Approved as Treatment by the FDA
Netarsudil, also called Rhopressa, is approved by the FDA for 3 uses including Open Angle Glaucoma and Increased Intra Ocular Pressure (IOP) .Open Angle Glaucoma
Increased Intra Ocular Pressure (IOP)
Ocular Hypertension
Effectiveness
How Rhopressa Affects PatientsAqueous humour is a liquid that flows out of the eye, taking two pathways: the conventional trabecular pathway and the unconventional uveoscleral pathway. Many medications used to treat glaucoma specifically target the uveoscleral pathway, which can lead to an increase in deterioration of the trabecular pathway. Netarsudil is a new glaucoma medication that is designed to target and inhibit the rho kinase and norepinephrine transport that are found in the conventional trabecular pathway. It is different from other medications, as it focuses on cell and muscle tissue remod
How Rhopressa works in the bodyGlaucoma is an eye condition that can cause progressive vision loss. It's caused by too much pressure in the eye, which is due to a blockage in the outflow of aqueous humor. Netarsudil is a drug that helps reduce this pressure by working on two parts of the eye: the trabecular meshwork and schlemm's canal. It relaxes the muscles and cells around these pathways, allowing aqueous humor to flow more freely. It also works on norepinephrine transporters, slowing down the production of aqueous humor. This helps to reduce
When to interrupt dosage
The recommended dosage of Rhopressa is contingent upon the determined condition, such as Ocular Hypertension, Open Angle Glaucoma and Increased Intra Ocular Pressure (IOP). Dosage also differs, in accordance with the administration technique (e.g. Ophthalmic; Topical or Solution / droplets - Ophthalmic; Topical) detailed in the table below.Condition
Dosage
Administration
Increased Intra Ocular Pressure (IOP)
, 0.2 mg/mL
, Ophthalmic; Topical, Solution / drops, Solution / drops - Ophthalmic; Topical, Ophthalmic, Solution / drops - Ophthalmic
Ocular Hypertension
, 0.2 mg/mL
, Ophthalmic; Topical, Solution / drops, Solution / drops - Ophthalmic; Topical, Ophthalmic, Solution / drops - Ophthalmic
Open Angle Glaucoma
, 0.2 mg/mL
, Ophthalmic; Topical, Solution / drops, Solution / drops - Ophthalmic; Topical, Ophthalmic, Solution / drops - Ophthalmic
Warnings
Common Rhopressa Drug Interactions
Drug Name
Risk Level
Description
Rhopressa Toxicity & Overdose RiskCommon side effects of netarsudil include redness of the eyes, pain in the eye area, corneal staining, blurred vision, increased tearing, and decreased vision. It is possible to contaminate the container of topical ophthalmic products with bacteria, which can lead to infections. There is not enough data available to know how netarsudil might affect pregnant women or breastfeeding mothers. There is also not enough data to know how safe it is for children under 18 to use netarsudil. Elderly people do not appear to have different safety or effectiveness levels than other adults. Long-term studies in animals
Rhopressa Novel Uses: Which Conditions Have a Clinical Trial Featuring Rhopressa?
34 ongoing clinical trials are examining the potential of Rhopressa to address Open Angle Glaucoma, Ocular Hypertension and elevated Intra Ocular Pressure (IOP).Condition
Clinical Trials
Trial Phases
Increased Intra Ocular Pressure (IOP)
0 Actively Recruiting
Open Angle Glaucoma
12 Actively Recruiting
Not Applicable, Phase 3, Phase 2
Ocular Hypertension
22 Actively Recruiting
Phase 1, Phase 2, Not Applicable, Phase 3, Phase 4
Rhopressa Reviews: What are patients saying about Rhopressa?
5Patient Review
11/14/2019 This medication was able to quickly lower my eye pressure from 19 to 13. I experienced few side effects, which were all mild in nature.
4.3Patient Review
10/11/2018 Though I haven't been back for a pressure check since starting this medication, the side effects are really bothersome. My eyes water constantly and the itching is unbearable. At this point, I don't think the benefits outweigh the negatives.
4.3Patient Review
11/4/2019 In just five days, this treatment brought my pressure down from 19 to 13. I was also using Timolol at the time, but it wasn't having much of an effect by itself. After two weeks of use, the side effects (red eyes, watery eyes, and slightly reduced vision) weren't too bad. Considering the alternative (going blind), I think it's worth it to deal with these small side effects.
4.3Patient Review
1/2/2019 The side effects of this medication are not worth it in my opinion. I've suffered from teary eyes, dryness, itchiness, and light sensitivity since starting to use Rhopressa. My pressure has only decreased marginally, and I'm still scheduled for surgery. Overall, very disappointed with this drug.
3.7Patient Review
4/9/2019 Bimatoprost kept my pressure down well, but after a few months I started having bad tearing and double vision. Switching back to Diamox cleared things up in a couple weeks.
3.3Patient Review
6/5/2021 The medication is effective, but the bottle lids are way too tight. My wife had to use two wrenches just to get it open, and most of the liquid seeped out in the process. We're paying $90 per 2.5ml bottle under our insurance plan, so this is pretty frustrating.
2.7Patient Review
12/25/2018 Immediately experienced moderate to severe redness and blurring of vision upon starting treatment with Rhopressa. Also, though there was a small reduction in pressure, the side effects (which included excessive tearing and itching of eyelids) worsened over the course of six weeks. I discontinued use about five or six days ago; while the blurring of vision has recovered somewhat, and the tearing anditching have also improved marginally, I am still experiencing severe intermittent redness.
2.3Patient Review
12/21/2018 In combination with Lumigan and Cosopt, this treatment successfully lowered my ocular pressure from 24 to 14.
2.3Patient Review
3/12/2019 Causes redness, blurriness, and pain in the eyes.
1.7Patient Review
3/9/2019 I've been experiencing symptoms similar to a sty, with redness and itching. My doctor said the medication would help, but after two months I haven't seen any improvement.
1.7Patient Review
3/11/2019 My eyes were extremely red and blurry, and I felt very dizzy.
1.7Patient Review
1/6/2022 This caused extreme light sensitivity, crusting, irritation, and eye pain in me. My grandfather also had a mild stroke and came home blind after using this medication; I believe that there needs to be more testing on seniors before releasing this drug.
1.7Patient Review
8/16/20181.7Patient Review
4/6/2019 Made my eyes itchy and red
1Patient Review
1/10/2019 The pressure in my eye dropped quickly after using this medication, but I experienced some redness and tearing. The price is quite high, which makes it difficult to access for many people.
Patient Q&A Section about rhopressa
These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.What are Rhopressa eye drops used for?
"Rhopressa is a prescription medication for treating high eye pressure in people with open-angle glaucoma or ocular hypertension."
Answered by AI
Should Rhopressa be refrigerated?
"Rhopressa should be stored in the fridge until opened. After opening, it can be kept at a temperature of 36-77 degrees Fahrenheit for up to 6 weeks. If stored in the fridge at a temperature of 36-46 degrees Fahrenheit after opening, the product can be used until the expiration date stamped on the bottle."
Answered by AI
How much does Rhopressa lower IOP?
"The ROCKET 4 study found that Rhopressa lowered IOP in eyes with a mean baseline IOP of 20.7 to 22.4 mmHg to 16.3 to 17.8 mmHg at three months."
Answered by AI
Is there a generic for Rhopressa?
"The medication Rhopressa is manufactured by Aerie Pharmaceuticals and was approved by the FDA on December 18th, 2017. It is classified as a Rho kinase inhibitor and is used to treat conditions affecting the eyes."
Answered by AI