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What is Relafen
NabumetoneThe Generic name of this drug
Treatment SummaryNabumetone is a non-steroidal anti-inflammatory drug (NSAID) used to reduce pain, swelling, and inflammation. While it doesn't usually irritate the stomach as much as other NSAIDs, it can still cause some stomach side effects. Nabumetone works by blocking an enzyme that helps create inflammation in the body. It was developed by Smithkline Beecham and was approved by the FDA in 1991.
Relafenis the brand name
Relafen Overview & Background
Brand Name
Generic Name
First FDA Approval
How many FDA approvals?
Relafen
Nabumetone
1993
192
Approved as Treatment by the FDA
Nabumetone, otherwise called Relafen, is approved by the FDA for 2 uses including Osteoarthritis (OA) and Rheumatoid Arthritis .Osteoarthritis (OA)
Rheumatoid Arthritis
Effectiveness
How Relafen Affects PatientsNabumetone is a type of painkiller called a NSAID. It works by reducing inflammation and blocking chemicals that cause pain. This can help to reduce both mild-moderate acute and chronic pain, though it is not as effective for neuropathic pain. NSAIDs also reduce fever and can prevent further damage and inflammation from the immune system. However, taking NSAIDs long-term can lead to issues with the kidneys, stomach, and an increased risk of thrombosis.
How Relafen works in the bodyNabumetone works by blocking two enzymes, COX-1 and COX-2, from converting arachidonic acid into prostanoids. Prostanoids help to reduce pain, inflammation, and fever. They also help to protect the gastrointestinal tract and regulate blood flow in the kidneys. When nabumetone blocks these enzymes, it reduces the amount of prostanoids being produced. This can lead to an increase in inflammation and pain, as well as a decrease in gastrointestinal protection and kidney function. It can also lead to an imbalance between prostanoids and thromboxane, which can increase the risk of th
When to interrupt dosage
The suggested dosage of Relafen is contingent upon the specified condition. The measure of dosage deviates, in correspondence to the method of administration featured in the table beneath.Condition
Dosage
Administration
Osteoarthritis (OA)
750.0 mg, , 500.0 mg, 1000.0 mg
, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral, Kit, Oral; Topical, Kit - Oral; Topical
Rheumatoid Arthritis
750.0 mg, , 500.0 mg, 1000.0 mg
, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral, Kit, Oral; Topical, Kit - Oral; Topical
Warnings
Relafen ContraindicationsCondition
Risk Level
Notes
Pulse Frequency
Do Not Combine
NSAID-Induced Asthma
Do Not Combine
Liver Disease
Do Not Combine
Rhinitis caused by NSAIDs
Do Not Combine
Coronary Artery Bypass Grafting
Do Not Combine
worsening renal impairment
Do Not Combine
Polyps, Nasal
Do Not Combine
Gastrointestinal Diseases
Do Not Combine
active liver disease
Do Not Combine
Peptic Ulcer
Do Not Combine
recurrent Peptic Ulcer
Do Not Combine
Common Relafen Drug Interactions
Drug Name
Risk Level
Description
Macimorelin
Major
The therapeutic efficacy of Macimorelin can be decreased when used in combination with Nabumetone.
Methotrexate
Major
The serum concentration of Methotrexate can be increased when it is combined with Nabumetone.
Mifamurtide
Major
The therapeutic efficacy of Mifamurtide can be decreased when used in combination with Nabumetone.
Neomycin
Major
The risk or severity of nephrotoxicity can be increased when Nabumetone is combined with Neomycin.
Omacetaxine mepesuccinate
Major
The risk or severity of bleeding can be increased when Nabumetone is combined with Omacetaxine mepesuccinate.
Relafen Toxicity & Overdose RiskThe toxic dose of nabumetone in mice is 4290mg/kg when taken orally and 2380mg/kg when taken intraperitoneally. In rats, the toxic dose is 3880mg/kg when taken orally, 1520mg/kg when taken intraperitoneally, and more than 10g/kg when taken subcutaneously. Signs of overdose include lethargy, drowsiness, nausea, vomiting, and abdominal pain. Rarely, hypertension, kidney damage, respiratory depression, or coma may occur. If the overdose occurred within 4 hours, activated charcoal and/or emesis can be
Relafen Novel Uses: Which Conditions Have a Clinical Trial Featuring Relafen?
75 active trials are currently in progress to investigate the potential of Relafen to alleviate Osteoarthritis (OA).Condition
Clinical Trials
Trial Phases
Rheumatoid Arthritis
61 Actively Recruiting
Not Applicable, Phase 4, Phase 3, Phase 2, Phase 1
Osteoarthritis (OA)
0 Actively Recruiting
Relafen Reviews: What are patients saying about Relafen?
5Patient Review
1/17/2014 I've found this to be an effective treatment for my bulging disc and arthritis. I only have to take it for three nights in a row, which is great, and I wake up feeling much better each morning. However, like any NSAID, I would not recommend excessive use of alcohol while taking this medication to avoid liver damage.
5Patient Review
8/12/2014 Tramadol just wasn't cutting it for me. I was in a lot of pain and could hardly move. Realfen really helped me out and now I'm able to sleep, walk, and use my hands without any problems.
5Patient Review
9/30/2013 I can finally put pressure on my foot without pain!
5Patient Review
8/3/2021 I was born with my hip out of the socket, which didn't grow properly. I'm 45 now and the pain is really bad. Nothing worked until this one. This treatment is a godsend!
4.7Patient Review
2/11/2014 I was on this medication for about six months and it helped me go into remission. I've been in remission for about 10 years now and don't take the meds anymore.
4.7Patient Review
6/30/2015 This treatment works great for me, but I've been having heart palpitations and I am concerned. Is this a common problem?
3.7Patient Review
9/19/2013 For the first two weeks, this medication was effective; however, then it stopped working. Additionally, it caused fatigue, dizziness, and tightness in my chest. As a result, I went back to using Ibuprofen and Turmeric.
3.7Patient Review
5/29/2013 At first, this medication really helped with the pain I experience from an old knee injury. Now, however, it doesn't seem to work at all and that's quite disappointing.
3.7Patient Review
11/8/20123.3Patient Review
11/5/20122.7Patient Review
2/18/2013 This seems to work well.
1Patient Review
6/7/2013 My daughter takes RElafen and has hardly any relief from this medication.
Patient Q&A Section about relafen
These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.What is Relafen used for?
"Relafen is a prescription medicine used to treat the symptoms of osteoarthritis and rheumatoid arthritis. Relafen may be used alone or with other medications. Relafen belongs to a class of drugs called nonsteroidal anti-inflammatory drugs (NSAIDs)."
Answered by AI
Is Relafen the same as ibuprofen?
"May be used for the relief of pain, fever, and swelling.
Relafen is a good medication for reducing pain and swelling, but it can take up to a week for it to take effect. Advil is also a good medication for reducing fever, swelling, and pain, but it does not work for as long as some other NSAIDs. Both medications may be used to help relieve pain, fever, and swelling."
Answered by AI
Is Relafen a narcotic?
"Relafen is a non-steroidal anti-inflammatory drug (NSAID), while Norco is a combination of an opioid analgesic, antitussive (cough suppressant), and analgesic. The brand name Relafen is no longer available in the United States, but generic versions may be."
Answered by AI
How strong is Relafen?
"Relafen has been discontinued and is now only available as a generic under the name Nabumetone. It is a prescription medication used primarily to relieve pain from osteoarthritis and rheumatoid arthritis. Nabumetone is available in strengths of 500 mg and 750 mg."
Answered by AI