Relafen

Q: Is Relafen the same as ibuprofen?

<p>May be used for the relief of <a href="https://www.withpower.com/clinical-trials/pain">pain</a>, fever, and swelling.</p> <p>Relafen is a good medication for reducing pain and swelling, but it can take up to a week for it to take effect. Advil is also a good medication for reducing fever, swelling, and pain, but it does not work for as long as some other NSAIDs. Both medications may be used to help relieve pain, fever, and swelling.</p>

Rheumatoid Arthritis, Osteoarthritis

Treatment

3 FDA approvals

20 Active Studies for Relafen

Treatment for

Rheumatoid Arthritis

What is Relafen

NabumetoneThe Generic name of this drug

Treatment SummaryNabumetone is a non-steroidal anti-inflammatory drug (NSAID) used to reduce pain, swelling, and inflammation. While it doesn't usually irritate the stomach as much as other NSAIDs, it can still cause some stomach side effects. Nabumetone works by blocking an enzyme that helps create inflammation in the body. It was developed by Smithkline Beecham and was approved by the FDA in 1991.

Relafenis the brand name

image of different drug pills on a surface

Relafen Overview & Background

Brand Name

Generic Name

First FDA Approval

How many FDA approvals?

Relafen

Nabumetone

1993

192

Approved as Treatment by the FDA

Nabumetone, otherwise called Relafen, is approved by the FDA for 3 uses including Osteoarthritis (OA) and Rheumatoid Arthritis .

Osteoarthritis (OA)

Rheumatoid Arthritis

Osteoarthritis

Effectiveness

How Relafen Affects PatientsNabumetone is a type of painkiller called a NSAID. It works by reducing inflammation and blocking chemicals that cause pain. This can help to reduce both mild-moderate acute and chronic pain, though it is not as effective for neuropathic pain. NSAIDs also reduce fever and can prevent further damage and inflammation from the immune system. However, taking NSAIDs long-term can lead to issues with the kidneys, stomach, and an increased risk of thrombosis.

How Relafen works in the bodyNabumetone works by blocking two enzymes, COX-1 and COX-2, from converting arachidonic acid into prostanoids. Prostanoids help to reduce pain, inflammation, and fever. They also help to protect the gastrointestinal tract and regulate blood flow in the kidneys. When nabumetone blocks these enzymes, it reduces the amount of prostanoids being produced. This can lead to an increase in inflammation and pain, as well as a decrease in gastrointestinal protection and kidney function. It can also lead to an imbalance between prostanoids and thromboxane, which can increase the risk of th

When to interrupt dosage

The suggested dosage of Relafen is contingent upon the specified condition. The measure of dosage deviates, in correspondence to the method of administration featured in the table beneath.

Condition

Dosage

Administration

Rheumatoid Arthritis

750.0 mg, , 500.0 mg, 1000.0 mg

, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral, Kit, Oral; Topical, Kit - Oral; Topical

Osteoarthritis

750.0 mg, , 500.0 mg, 1000.0 mg

, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral, Kit, Oral; Topical, Kit - Oral; Topical

Warnings

Relafen Contraindications

Condition

Risk Level

Notes

Pulse Frequency

Do Not Combine

NSAID-Induced Asthma

Do Not Combine

Liver Disease

Do Not Combine

Rhinitis

Do Not Combine

Coronary Artery Bypass Grafting

Do Not Combine

Renal Insufficiency

Do Not Combine

Nasal Polyps

Do Not Combine

Gastrointestinal Diseases

Do Not Combine

Liver Diseases

Do Not Combine

Peptic Ulcer

Do Not Combine

Peptic Ulcer

Do Not Combine

There are 20 known major drug interactions with Relafen.

Common Relafen Drug Interactions

Drug Name

Risk Level

Description

Macimorelin

Major

The therapeutic efficacy of Macimorelin can be decreased when used in combination with Nabumetone.

Methotrexate

Major

The serum concentration of Methotrexate can be increased when it is combined with Nabumetone.

Mifamurtide

Major

The therapeutic efficacy of Mifamurtide can be decreased when used in combination with Nabumetone.

Neomycin

Major

The risk or severity of nephrotoxicity can be increased when Nabumetone is combined with Neomycin.

Omacetaxine mepesuccinate

Major

The risk or severity of bleeding can be increased when Nabumetone is combined with Omacetaxine mepesuccinate.

Relafen Toxicity & Overdose RiskThe toxic dose of nabumetone in mice is 4290mg/kg when taken orally and 2380mg/kg when taken intraperitoneally. In rats, the toxic dose is 3880mg/kg when taken orally, 1520mg/kg when taken intraperitoneally, and more than 10g/kg when taken subcutaneously. Signs of overdose include lethargy, drowsiness, nausea, vomiting, and abdominal pain. Rarely, hypertension, kidney damage, respiratory depression, or coma may occur. If the overdose occurred within 4 hours, activated charcoal and/or emesis can be

image of a doctor in a lab doing drug, clinical research

Relafen Novel Uses: Which Conditions Have a Clinical Trial Featuring Relafen?

75 active trials are currently in progress to investigate the potential of Relafen to alleviate Osteoarthritis (OA).

Condition

Clinical Trials

Trial Phases

Rheumatoid Arthritis

54 Actively Recruiting

Not Applicable, Phase 4, Phase 3, Phase 2, Phase 1

Osteoarthritis

0 Actively Recruiting

Relafen Reviews: What are patients saying about Relafen?

5Patient Review

1/17/2014

Relafen for Rheumatoid Arthritis

I've found this to be an effective treatment for my bulging disc and arthritis. I only have to take it for three nights in a row, which is great, and I wake up feeling much better each morning. However, like any NSAID, I would not recommend excessive use of alcohol while taking this medication to avoid liver damage.

5Patient Review

8/12/2014

Relafen for Joint Damage causing Pain and Loss of Function

Tramadol just wasn't cutting it for me. I was in a lot of pain and could hardly move. Realfen really helped me out and now I'm able to sleep, walk, and use my hands without any problems.

5Patient Review

9/30/2013

Relafen for Joint Damage causing Pain and Loss of Function

I can finally put pressure on my foot without pain!

5Patient Review

8/3/2021

Relafen for Joint Damage causing Pain and Loss of Function

I was born with my hip out of the socket, which didn't grow properly. I'm 45 now and the pain is really bad. Nothing worked until this one. This treatment is a godsend!

4.7Patient Review

2/11/2014

Relafen for Joint Damage causing Pain and Loss of Function

I was on this medication for about six months and it helped me go into remission. I've been in remission for about 10 years now and don't take the meds anymore.

View All Reviews

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Patient Q&A Section about relafen

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

What is Relafen used for?

"Relafen is a prescription medicine used to treat the symptoms of osteoarthritis and rheumatoid arthritis. Relafen may be used alone or with other medications. Relafen belongs to a class of drugs called nonsteroidal anti-inflammatory drugs (NSAIDs)."

Answered by AI

Is Relafen the same as ibuprofen?

"May be used for the relief of pain, fever, and swelling.

Relafen is a good medication for reducing pain and swelling, but it can take up to a week for it to take effect. Advil is also a good medication for reducing fever, swelling, and pain, but it does not work for as long as some other NSAIDs. Both medications may be used to help relieve pain, fever, and swelling."

Answered by AI

Is Relafen a narcotic?

"Relafen is a non-steroidal anti-inflammatory drug (NSAID), while Norco is a combination of an opioid analgesic, antitussive (cough suppressant), and analgesic. The brand name Relafen is no longer available in the United States, but generic versions may be."

Answered by AI

How strong is Relafen?

"Relafen has been discontinued and is now only available as a generic under the name Nabumetone. It is a prescription medication used primarily to relieve pain from osteoarthritis and rheumatoid arthritis. Nabumetone is available in strengths of 500 mg and 750 mg."

Answered by AI