Qinlock

Advanced Gastrointestinal Stromal Tumor (GIST), Therapeutic procedure

Treatment

2 Active Studies for Qinlock

Treatment for

Advanced Gastrointestinal Stromal Tumor (GIST)

What is Qinlock

RipretinibThe Generic name of this drug

Treatment SummaryRipretinib, also known as Qinlock, is a prescription drug used to treat advanced gastrointestinal stromal tumors (GIST) that have not responded to other kinase inhibitors such as sunitinib and imatinib. It was approved by the FDA in 2020 as the first drug to be used as a fourth-line treatment for GIST after three other kinase inhibitor treatments have been tried.

Qinlockis the brand name

image of different drug pills on a surface

Qinlock Overview & Background

Brand Name

Generic Name

First FDA Approval

How many FDA approvals?

Qinlock

Ripretinib

2020

Effectiveness

How Qinlock Affects PatientsRipretinib is a medication that helps stop the growth of tumors in the gastrointestinal system. It can help treat cancer that is resistant to other kinase inhibitors, such as imatinib. However, taking this drug can cause issues with the heart and skin, such as decreased heart function and new malignant skin tumors. It is important to have regular check-ups to monitor your heart and skin health while taking this drug.

How Qinlock works in the bodyRipretinib is a drug that works by targeting and blocking certain protein kinases. These proteins can cause cells to grow abnormally, leading to cancer. Ripretinib binds to mutated KIT and PDGFRA receptors, which helps to turn off the protein kinases and stop them from causing abnormal cell growth. It does this by binding to the activation loop and the switch pocket of the protein kinase, blocking it from working.

When to interrupt dosage

The recommended amount of Qinlock is contingent upon the diagnosed condition. The dosage fluctuates, in accordance with the delivery technique (e.g. Tablet - Oral or Oral) noted in the table below.

Condition

Dosage

Administration

Advanced Gastrointestinal Stromal Tumor (GIST)

50.0 mg,

Tablet - Oral, Oral, Tablet,

Therapeutic procedure

50.0 mg,

Tablet - Oral, Oral, Tablet,

Warnings

Qinlock Contraindications

Condition

Risk Level

Notes

Hypertensive disease

Do Not Combine

There are 20 known major drug interactions with Qinlock.

Common Qinlock Drug Interactions

Drug Name

Risk Level

Description

Abemaciclib

Major

The serum concentration of Abemaciclib can be increased when it is combined with Ripretinib.

Axitinib

Major

The serum concentration of Axitinib can be increased when it is combined with Ripretinib.

Bendamustine

Major

The serum concentration of Bendamustine can be increased when it is combined with Ripretinib.

Binimetinib

Major

The serum concentration of Binimetinib can be increased when it is combined with Ripretinib.

Bortezomib

Major

The serum concentration of Bortezomib can be increased when it is combined with Ripretinib.

Qinlock Toxicity & Overdose RiskVery little is known about what would happen in the event of a ripretinib overdose. However, it is likely to cause blood toxicity, skin problems, and toxicity in the muscles, liver, and digestive system, similar to other kinase inhibitors.

image of a doctor in a lab doing drug, clinical research

Qinlock Novel Uses: Which Conditions Have a Clinical Trial Featuring Qinlock?

A single clinical trial is presently underway to assess the effectiveness of Qinlock for Therapeutic procedures.

Condition

Clinical Trials

Trial Phases

Therapeutic procedure

0 Actively Recruiting

Advanced Gastrointestinal Stromal Tumor (GIST)

2 Actively Recruiting

Phase 2, Phase 3

Patient Q&A Section about qinlock

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

What type of drug is QINLOCK?

"Qinlock is a cancer treatment drug that works by inhibiting a type of enzyme called a kinase. This enzyme is necessary for cancer cell growth, so by blocking it, Qinlock can help to keep cancer cells from growing."

Answered by AI

Who makes QINLOCK?

"Deciphera Pharmaceuticals is a company with one FDA-approved product, QINLOCK. QINLOCK is a broad-spectrum KIT and PDGFRα inhibitor used to treat patients with fourth-line GIST. The company is using its platform to develop a diverse pipeline of drug candidates designed to improve outcomes for patients with cancer."

Answered by AI

What is QINLOCK used for?

"Qinlock is a prescription medicine used to treat adults with advanced gastrointestinal stromal tumor (GIST) who have received 3 or more prior treatments for their GIST. Qinlock is pronounced "kin-lok.""

Answered by AI

What is Ripretinib used for?

"Ripretinib is a medication used to treat gastrointestinal stromal tumors (GIST) in patients who have already received treatment with at least three other medications. GIST is a type of cancer that begins growing in the wall of the stomach, bowels, or rectum."

Answered by AI