Propranolol Hydrochloride

Thyroid Crisis, Atrial Fibrillation, Migraine + 23 more
Treatment
5 FDA approvals
20 Active Studies for Propranolol Hydrochloride

What is Propranolol Hydrochloride

PropranololThe Generic name of this drug
Treatment SummaryPropranolol is a medication used to treat high blood pressure. It is a combination of two enantiomers, one of which binds to beta-adrenergic receptors much more strongly than the other. Propranolol has been approved by the FDA since 1967 and is generally safe and effective for its intended use.
Inderalis the brand name
image of different drug pills on a surface
Propranolol Hydrochloride Overview & Background
Brand Name
Generic Name
First FDA Approval
How many FDA approvals?
Inderal
Propranolol
1967
471

Approved as Treatment by the FDA

Propranolol, also known as Inderal, is approved by the FDA for 5 uses including Obstructive Hypertrophic Cardiomyopathy and Tremor, Essential .
Obstructive Hypertrophic Cardiomyopathy
Tremor, Essential
Helps manage Tremor, Essential
Essential Tremor
Helps manage Tremor, Essential
Cardiomyopathy, Hypertrophic
Hypertensive disease
Used to treat High Blood Pressure (Hypertension) in combination with Hydrochlorothiazide

Effectiveness

How Propranolol Hydrochloride Affects PatientsPropranolol is a drug used to treat high blood pressure. It usually only needs to be taken once or twice a day. Suddenly stopping propranolol can cause chest pain and heart attack-like symptoms.
How Propranolol Hydrochloride works in the bodyPropranolol blocks beta-receptors, which are involved in blood vessel growth and constriction. Blocking these receptors can decrease the growth of new blood vessels, reduce the activity of a hormone system involved in blood pressure regulation, and induce apoptosis in certain types of cells.

When to interrupt dosage

The suggested measure of Propranolol Hydrochloride is contingent upon the recognized disorder, including Catecholamines, Hypertensive disease and Hemangiomas. The quantity of dosage deviates as per the mode of delivery (e.g. Solution - Oral or Capsule, extended release - Oral) mentioned in the table below.
Condition
Dosage
Administration
Heart Attack
, 1.0 mg/mL, 60.0 mg, 80.0 mg, 120.0 mg, 160.0 mg, 40.0 mg, 10.0 mg, 20.0 mg, 50.0 mg, 0.1 mg, 4.28 mg/mL, 4.0 mg/mg, 2.0 mg/mg, 20.0 mg/mL, 40.0 mg/mL, 3.75 mg/mL
, Intravenous, Injection, Injection - Intravenous, Oral, Capsule, extended release, Capsule, extended release - Oral, Tablet, Tablet - Oral, Injection, solution - Intravenous, Injection, solution, Solution, Solution - Oral, Solution - Intravenous, Liquid, Liquid - Intravenous, Capsule, gelatin coated, Capsule, gelatin coated - Oral
Adrenergic Alpha-Antagonists
, 1.0 mg/mL, 60.0 mg, 80.0 mg, 120.0 mg, 160.0 mg, 40.0 mg, 10.0 mg, 20.0 mg, 50.0 mg, 0.1 mg, 4.28 mg/mL, 4.0 mg/mg, 2.0 mg/mg, 20.0 mg/mL, 40.0 mg/mL, 3.75 mg/mL
, Intravenous, Injection, Injection - Intravenous, Oral, Capsule, extended release, Capsule, extended release - Oral, Tablet, Tablet - Oral, Injection, solution - Intravenous, Injection, solution, Solution, Solution - Oral, Solution - Intravenous, Liquid, Liquid - Intravenous, Capsule, gelatin coated, Capsule, gelatin coated - Oral
Tachyarrhythmia caused by Digitalis intoxication
, 1.0 mg/mL, 60.0 mg, 80.0 mg, 120.0 mg, 160.0 mg, 40.0 mg, 10.0 mg, 20.0 mg, 50.0 mg, 0.1 mg, 4.28 mg/mL, 4.0 mg/mg, 2.0 mg/mg, 20.0 mg/mL, 40.0 mg/mL, 3.75 mg/mL
, Intravenous, Injection, Injection - Intravenous, Oral, Capsule, extended release, Capsule, extended release - Oral, Tablet, Tablet - Oral, Injection, solution - Intravenous, Injection, solution, Solution, Solution - Oral, Solution - Intravenous, Liquid, Liquid - Intravenous, Capsule, gelatin coated, Capsule, gelatin coated - Oral
Psychomotor Agitation
, 1.0 mg/mL, 60.0 mg, 80.0 mg, 120.0 mg, 160.0 mg, 40.0 mg, 10.0 mg, 20.0 mg, 50.0 mg, 0.1 mg, 4.28 mg/mL, 4.0 mg/mg, 2.0 mg/mg, 20.0 mg/mL, 40.0 mg/mL, 3.75 mg/mL
, Intravenous, Injection, Injection - Intravenous, Oral, Capsule, extended release, Capsule, extended release - Oral, Tablet, Tablet - Oral, Injection, solution - Intravenous, Injection, solution, Solution, Solution - Oral, Solution - Intravenous, Liquid, Liquid - Intravenous, Capsule, gelatin coated, Capsule, gelatin coated - Oral
Tremor
, 1.0 mg/mL, 60.0 mg, 80.0 mg, 120.0 mg, 160.0 mg, 40.0 mg, 10.0 mg, 20.0 mg, 50.0 mg, 0.1 mg, 4.28 mg/mL, 4.0 mg/mg, 2.0 mg/mg, 20.0 mg/mL, 40.0 mg/mL, 3.75 mg/mL
, Intravenous, Injection, Injection - Intravenous, Oral, Capsule, extended release, Capsule, extended release - Oral, Tablet, Tablet - Oral, Injection, solution - Intravenous, Injection, solution, Solution, Solution - Oral, Solution - Intravenous, Liquid, Liquid - Intravenous, Capsule, gelatin coated, Capsule, gelatin coated - Oral
Thyrotoxicosis
, 1.0 mg/mL, 60.0 mg, 80.0 mg, 120.0 mg, 160.0 mg, 40.0 mg, 10.0 mg, 20.0 mg, 50.0 mg, 0.1 mg, 4.28 mg/mL, 4.0 mg/mg, 2.0 mg/mg, 20.0 mg/mL, 40.0 mg/mL, 3.75 mg/mL
, Intravenous, Injection, Injection - Intravenous, Oral, Capsule, extended release, Capsule, extended release - Oral, Tablet, Tablet - Oral, Injection, solution - Intravenous, Injection, solution, Solution, Solution - Oral, Solution - Intravenous, Liquid, Liquid - Intravenous, Capsule, gelatin coated, Capsule, gelatin coated - Oral
Chest Pain
, 1.0 mg/mL, 60.0 mg, 80.0 mg, 120.0 mg, 160.0 mg, 40.0 mg, 10.0 mg, 20.0 mg, 50.0 mg, 0.1 mg, 4.28 mg/mL, 4.0 mg/mg, 2.0 mg/mg, 20.0 mg/mL, 40.0 mg/mL, 3.75 mg/mL
, Intravenous, Injection, Injection - Intravenous, Oral, Capsule, extended release, Capsule, extended release - Oral, Tablet, Tablet - Oral, Injection, solution - Intravenous, Injection, solution, Solution, Solution - Oral, Solution - Intravenous, Liquid, Liquid - Intravenous, Capsule, gelatin coated, Capsule, gelatin coated - Oral
Supraventricular Arrhythmias
, 1.0 mg/mL, 60.0 mg, 80.0 mg, 120.0 mg, 160.0 mg, 40.0 mg, 10.0 mg, 20.0 mg, 50.0 mg, 0.1 mg, 4.28 mg/mL, 4.0 mg/mg, 2.0 mg/mg, 20.0 mg/mL, 40.0 mg/mL, 3.75 mg/mL
, Intravenous, Injection, Injection - Intravenous, Oral, Capsule, extended release, Capsule, extended release - Oral, Tablet, Tablet - Oral, Injection, solution - Intravenous, Injection, solution, Solution, Solution - Oral, Solution - Intravenous, Liquid, Liquid - Intravenous, Capsule, gelatin coated, Capsule, gelatin coated - Oral
Hemangioma
, 1.0 mg/mL, 60.0 mg, 80.0 mg, 120.0 mg, 160.0 mg, 40.0 mg, 10.0 mg, 20.0 mg, 50.0 mg, 0.1 mg, 4.28 mg/mL, 4.0 mg/mg, 2.0 mg/mg, 20.0 mg/mL, 40.0 mg/mL, 3.75 mg/mL
, Intravenous, Injection, Injection - Intravenous, Oral, Capsule, extended release, Capsule, extended release - Oral, Tablet, Tablet - Oral, Injection, solution - Intravenous, Injection, solution, Solution, Solution - Oral, Solution - Intravenous, Liquid, Liquid - Intravenous, Capsule, gelatin coated, Capsule, gelatin coated - Oral
Cardiomyopathy, Hypertrophic
, 1.0 mg/mL, 60.0 mg, 80.0 mg, 120.0 mg, 160.0 mg, 40.0 mg, 10.0 mg, 20.0 mg, 50.0 mg, 0.1 mg, 4.28 mg/mL, 4.0 mg/mg, 2.0 mg/mg, 20.0 mg/mL, 40.0 mg/mL, 3.75 mg/mL
, Intravenous, Injection, Injection - Intravenous, Oral, Capsule, extended release, Capsule, extended release - Oral, Tablet, Tablet - Oral, Injection, solution - Intravenous, Injection, solution, Solution, Solution - Oral, Solution - Intravenous, Liquid, Liquid - Intravenous, Capsule, gelatin coated, Capsule, gelatin coated - Oral
Proliferating Infantile Hemangioma
, 1.0 mg/mL, 60.0 mg, 80.0 mg, 120.0 mg, 160.0 mg, 40.0 mg, 10.0 mg, 20.0 mg, 50.0 mg, 0.1 mg, 4.28 mg/mL, 4.0 mg/mg, 2.0 mg/mg, 20.0 mg/mL, 40.0 mg/mL, 3.75 mg/mL
, Intravenous, Injection, Injection - Intravenous, Oral, Capsule, extended release, Capsule, extended release - Oral, Tablet, Tablet - Oral, Injection, solution - Intravenous, Injection, solution, Solution, Solution - Oral, Solution - Intravenous, Liquid, Liquid - Intravenous, Capsule, gelatin coated, Capsule, gelatin coated - Oral
Hypertensive disease
, 1.0 mg/mL, 60.0 mg, 80.0 mg, 120.0 mg, 160.0 mg, 40.0 mg, 10.0 mg, 20.0 mg, 50.0 mg, 0.1 mg, 4.28 mg/mL, 4.0 mg/mg, 2.0 mg/mg, 20.0 mg/mL, 40.0 mg/mL, 3.75 mg/mL
, Intravenous, Injection, Injection - Intravenous, Oral, Capsule, extended release, Capsule, extended release - Oral, Tablet, Tablet - Oral, Injection, solution - Intravenous, Injection, solution, Solution, Solution - Oral, Solution - Intravenous, Liquid, Liquid - Intravenous, Capsule, gelatin coated, Capsule, gelatin coated - Oral
Performance Anxiety
, 1.0 mg/mL, 60.0 mg, 80.0 mg, 120.0 mg, 160.0 mg, 40.0 mg, 10.0 mg, 20.0 mg, 50.0 mg, 0.1 mg, 4.28 mg/mL, 4.0 mg/mg, 2.0 mg/mg, 20.0 mg/mL, 40.0 mg/mL, 3.75 mg/mL
, Intravenous, Injection, Injection - Intravenous, Oral, Capsule, extended release, Capsule, extended release - Oral, Tablet, Tablet - Oral, Injection, solution - Intravenous, Injection, solution, Solution, Solution - Oral, Solution - Intravenous, Liquid, Liquid - Intravenous, Capsule, gelatin coated, Capsule, gelatin coated - Oral
Pheochromocytoma
, 1.0 mg/mL, 60.0 mg, 80.0 mg, 120.0 mg, 160.0 mg, 40.0 mg, 10.0 mg, 20.0 mg, 50.0 mg, 0.1 mg, 4.28 mg/mL, 4.0 mg/mg, 2.0 mg/mg, 20.0 mg/mL, 40.0 mg/mL, 3.75 mg/mL
, Intravenous, Injection, Injection - Intravenous, Oral, Capsule, extended release, Capsule, extended release - Oral, Tablet, Tablet - Oral, Injection, solution - Intravenous, Injection, solution, Solution, Solution - Oral, Solution - Intravenous, Liquid, Liquid - Intravenous, Capsule, gelatin coated, Capsule, gelatin coated - Oral
Ventricular Tachycardia
, 1.0 mg/mL, 60.0 mg, 80.0 mg, 120.0 mg, 160.0 mg, 40.0 mg, 10.0 mg, 20.0 mg, 50.0 mg, 0.1 mg, 4.28 mg/mL, 4.0 mg/mg, 2.0 mg/mg, 20.0 mg/mL, 40.0 mg/mL, 3.75 mg/mL
, Intravenous, Injection, Injection - Intravenous, Oral, Capsule, extended release, Capsule, extended release - Oral, Tablet, Tablet - Oral, Injection, solution - Intravenous, Injection, solution, Solution, Solution - Oral, Solution - Intravenous, Liquid, Liquid - Intravenous, Capsule, gelatin coated, Capsule, gelatin coated - Oral
Migraine
, 1.0 mg/mL, 60.0 mg, 80.0 mg, 120.0 mg, 160.0 mg, 40.0 mg, 10.0 mg, 20.0 mg, 50.0 mg, 0.1 mg, 4.28 mg/mL, 4.0 mg/mg, 2.0 mg/mg, 20.0 mg/mL, 40.0 mg/mL, 3.75 mg/mL
, Intravenous, Injection, Injection - Intravenous, Oral, Capsule, extended release, Capsule, extended release - Oral, Tablet, Tablet - Oral, Injection, solution - Intravenous, Injection, solution, Solution, Solution - Oral, Solution - Intravenous, Liquid, Liquid - Intravenous, Capsule, gelatin coated, Capsule, gelatin coated - Oral
Gastroesophageal variceal hemorrhage prophylaxis
, 1.0 mg/mL, 60.0 mg, 80.0 mg, 120.0 mg, 160.0 mg, 40.0 mg, 10.0 mg, 20.0 mg, 50.0 mg, 0.1 mg, 4.28 mg/mL, 4.0 mg/mg, 2.0 mg/mg, 20.0 mg/mL, 40.0 mg/mL, 3.75 mg/mL
, Intravenous, Injection, Injection - Intravenous, Oral, Capsule, extended release, Capsule, extended release - Oral, Tablet, Tablet - Oral, Injection, solution - Intravenous, Injection, solution, Solution, Solution - Oral, Solution - Intravenous, Liquid, Liquid - Intravenous, Capsule, gelatin coated, Capsule, gelatin coated - Oral
Catecholamines
, 1.0 mg/mL, 60.0 mg, 80.0 mg, 120.0 mg, 160.0 mg, 40.0 mg, 10.0 mg, 20.0 mg, 50.0 mg, 0.1 mg, 4.28 mg/mL, 4.0 mg/mg, 2.0 mg/mg, 20.0 mg/mL, 40.0 mg/mL, 3.75 mg/mL
, Intravenous, Injection, Injection - Intravenous, Oral, Capsule, extended release, Capsule, extended release - Oral, Tablet, Tablet - Oral, Injection, solution - Intravenous, Injection, solution, Solution, Solution - Oral, Solution - Intravenous, Liquid, Liquid - Intravenous, Capsule, gelatin coated, Capsule, gelatin coated - Oral
Migraine Disorders
, 1.0 mg/mL, 60.0 mg, 80.0 mg, 120.0 mg, 160.0 mg, 40.0 mg, 10.0 mg, 20.0 mg, 50.0 mg, 0.1 mg, 4.28 mg/mL, 4.0 mg/mg, 2.0 mg/mg, 20.0 mg/mL, 40.0 mg/mL, 3.75 mg/mL
, Intravenous, Injection, Injection - Intravenous, Oral, Capsule, extended release, Capsule, extended release - Oral, Tablet, Tablet - Oral, Injection, solution - Intravenous, Injection, solution, Solution, Solution - Oral, Solution - Intravenous, Liquid, Liquid - Intravenous, Capsule, gelatin coated, Capsule, gelatin coated - Oral
Atrial Fibrillation
, 1.0 mg/mL, 60.0 mg, 80.0 mg, 120.0 mg, 160.0 mg, 40.0 mg, 10.0 mg, 20.0 mg, 50.0 mg, 0.1 mg, 4.28 mg/mL, 4.0 mg/mg, 2.0 mg/mg, 20.0 mg/mL, 40.0 mg/mL, 3.75 mg/mL
, Intravenous, Injection, Injection - Intravenous, Oral, Capsule, extended release, Capsule, extended release - Oral, Tablet, Tablet - Oral, Injection, solution - Intravenous, Injection, solution, Solution, Solution - Oral, Solution - Intravenous, Liquid, Liquid - Intravenous, Capsule, gelatin coated, Capsule, gelatin coated - Oral

Warnings

Propranolol Hydrochloride Contraindications
Condition
Risk Level
Notes
Heart Decompensation
Do Not Combine
Bronchial Spasm
Do Not Combine
Asthma
Do Not Combine
Infants Weighing <2kg
Do Not Combine
Low Blood Pressure
Do Not Combine
Sick Sinus Syndrome
Do Not Combine
Asthma
Do Not Combine
Pheochromocytoma
Do Not Combine
Atrioventricular Block
Do Not Combine
Slow Heart Rate
Do Not Combine
Shock, Cardiogenic
Do Not Combine
Heart Decompensation
Do Not Combine
Prematurity
Do Not Combine
Sinus Bradycardia
Do Not Combine
Severe Hypersensitivity Reactions
Do Not Combine
Propranolol may interact with Pulse Frequency
There are 20 known major drug interactions with Propranolol Hydrochloride.
Common Propranolol Hydrochloride Drug Interactions
Drug Name
Risk Level
Description
4-Bromo-2,5-dimethoxyphenethylamine
Major
The therapeutic efficacy of 4-Bromo-2,5-dimethoxyphenethylamine can be decreased when used in combination with Propranolol.
4-Methoxyamphetamine
Major
The therapeutic efficacy of 4-Methoxyamphetamine can be decreased when used in combination with Propranolol.
Abediterol
Major
Propranolol may decrease the bronchodilatory activities of Abediterol.
Adrafinil
Major
The therapeutic efficacy of Adrafinil can be decreased when used in combination with Propranolol.
Agrostis gigantea pollen
Major
The risk of a hypersensitivity reaction to Agrostis gigantea pollen is increased when it is combined with Propranolol.
Propranolol Hydrochloride Toxicity & Overdose RiskOverdosing on propranolol can lead to low blood pressure, seizures from low blood sugar, restlessness, and difficulty sleeping. Asthmatic individuals may experience bronchospasm. To treat an overdose, monitor vital signs, mental state, and blood sugar levels. Low blood pressure can be treated with intravenous fluids, bradycardia with atropine and isoproterenol, and bronchospasm with aminophylline. If these treatments are ineffective, glucagon should be given intravenously followed by catecholamines. Dialysis will not be effective as propranolol is strongly bound
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Propranolol Hydrochloride Novel Uses: Which Conditions Have a Clinical Trial Featuring Propranolol Hydrochloride?

249 active trials are currently being conducted to assess the effectiveness of Propranolol Hydrochloride in reducing the symptoms of Migraine, Catecholamines and Hypertensive Disease.
Condition
Clinical Trials
Trial Phases
Atrial Fibrillation
96 Actively Recruiting
Not Applicable, Phase 2, Phase 4, Phase 1, Phase 3, Early Phase 1
Heart Attack
26 Actively Recruiting
Not Applicable, Phase 4, Phase 1, Phase 2, Early Phase 1, Phase 3
Coronary Artery Disease
1 Actively Recruiting
Not Applicable
Chest Pain
2 Actively Recruiting
Not Applicable, Phase 2, Phase 3
Adrenergic Alpha-Antagonists
0 Actively Recruiting
Migraine
54 Actively Recruiting
Phase 4, Not Applicable, Phase 2, Phase 1, Phase 3, Early Phase 1
Hemangioma
0 Actively Recruiting
Gastroesophageal variceal hemorrhage prophylaxis
0 Actively Recruiting
Migraine Disorders
1 Actively Recruiting
Phase 3
Catecholamines
0 Actively Recruiting
Thyroid Crisis
0 Actively Recruiting
Hypertensive disease
23 Actively Recruiting
Not Applicable, Phase 1, Phase 2, Phase 3
Pheochromocytoma
0 Actively Recruiting
Thyrotoxicosis
0 Actively Recruiting
Cardiovascular Mortality
0 Actively Recruiting
Myocardial Infarction
0 Actively Recruiting
Tremor
0 Actively Recruiting
Cardiomyopathy, Hypertrophic
0 Actively Recruiting
Proliferating Infantile Hemangioma
0 Actively Recruiting
Psychomotor Agitation
0 Actively Recruiting

Propranolol Hydrochloride Reviews: What are patients saying about Propranolol Hydrochloride?

5Patient Review
3/30/2021
Propranolol Hydrochloride for Anxious
I'm 61 and have been struggling with anxiety for the past year. This medication really helps to take the edge off within half an hour.
5Patient Review
2/14/2020
Propranolol Hydrochloride for Anxious
This medication has been extremely helpful for me in managing my anxiety, bipolar disorder, and panic attacks. After being taken off of Xanax (which I had been taking for 20 years), the withdrawals were awful; but this medication has really helped to ease those symptoms and manage my overall mental health.
4.7Patient Review
11/15/2019
Propranolol Hydrochloride for Migraine Prevention
I've only just started taking this medication, but it seems to be going well so far. I'm still experiencing some pain, but that could just be because it's the first day.
4.3Patient Review
3/12/2022
Propranolol Hydrochloride for Anxious
This treatment was very effective at reducing my anxiety in the moment, but it did make me feel quite relaxed and slow. I wouldn't recommend it for long-term use, but it was excellent and very safe.
4Patient Review
11/13/2019
Propranolol Hydrochloride for High Blood Pressure
So far, I'm really pleased with this medication. It's helped lower my blood pressure and anxiety levels; however, I am feeling pretty tired most of the time. I'm hoping that side-effect will go away soon.
View All Reviews
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Patient Q&A Section about propranolol hydrochloride

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

Should I take propranolol in the morning or at night?

"This medicine should be taken at bedtime. You can take it with or without food."

Answered by AI

How fast does propranolol hydrochloride work?

"It can take up to an hour for the physical effects of propranolol to be noticeable. If you have been prescribed propranolol for performance anxiety, your healthcare provider may suggest that you take the medication at a specific time before an event."

Answered by AI

What are side effects of propranolol?

"You may feel dizzy, lightheaded, or tired as your body adjusts to the medication. You may also have nausea or vomiting, stomach pain, vision changes, trouble sleeping, and unusual dreams. If you have any of these side effects, call your doctor or pharmacist."

Answered by AI

Does propranolol hydrochloride help anxiety?

"Propranolol is sometimes used to help with anxiety that is unrelated to its approved uses. This includes anxiety related to physical performance, such as dry mouth, nausea, fast pulse, or shaky hands. Propranolol is approved by the FDA to treat many other conditions, such as high blood pressure and tremors."

Answered by AI

Clinical Trials for Propranolol Hydrochloride

Have you considered Propranolol Hydrochloride clinical trials? We made a collection of clinical trials featuring Propranolol Hydrochloride, we think they might fit your search criteria.
Have you considered Propranolol Hydrochloride clinical trials? We made a collection of clinical trials featuring Propranolol Hydrochloride, we think they might fit your search criteria.
Have you considered Propranolol Hydrochloride clinical trials? We made a collection of clinical trials featuring Propranolol Hydrochloride, we think they might fit your search criteria.
Unbiased ResultsWe believe in providing patients with all the options.
Your Data Stays Your DataWe only share your information with the clinical trials you're trying to access.
Verified Trials OnlyAll of our trials are run by licensed doctors, researchers, and healthcare companies.
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