Prinzide

Migraine, Heart Attack, prophylaxis of cardiovascular event + 6 more
Treatment
3 FDA approvals
20 Active Studies for Prinzide

What is Prinzide

LisinoprilThe Generic name of this drug
Treatment SummaryLisinopril is an anti-hypertension medication used to treat high blood pressure, heart failure, and heart attack. It is a type of ACE inhibitor, a group of drugs that are often the first line of treatment for hypertension. Lisinopril works by blocking the action of a certain enzyme and the renin-angiotensin-aldosterone system, which helps to regulate blood pressure. It was approved by the FDA in 1987 and is commonly prescribed to treat hypertension.
Prinivilis the brand name
image of different drug pills on a surface
Prinzide Overview & Background
Brand Name
Generic Name
First FDA Approval
How many FDA approvals?
Prinivil
Lisinopril
1987
1222

Approved as Treatment by the FDA

Lisinopril, commonly known as Prinivil, is approved by the FDA for 3 uses which include Hypertensive disease and Heart Attack .
Hypertensive disease
Helps manage High Blood Pressure (Hypertension)
Heart Attack
Helps manage Acute Myocardial Infarction (AMI)
Congestive Heart Failure
Used in combination with other therapies

Effectiveness

How Prinzide Affects PatientsLisinopril helps with high blood pressure, heart failure, and heart attack by blocking enzymes and hormones that work to regulate blood pressure and blood flow. It has a wide range of safe dosages, and most people take 10-80mg every day for long-lasting effects.
How Prinzide works in the bodyLisinopril works by blocking the conversion of angiotensin I to angiotensin II. Angiotensin II is what causes blood vessels to constrict and increases oxygen consumption. Without this, Lisinopril prevents the overgrowth of muscle cells and stops the blood vessels from narrowing. It also increases levels of bradykinin, which has a natural vasodilating effect, helping to keep blood vessels wide open. Lisinopril also stops renin from converting angiotensin to angiotensin I.

When to interrupt dosage

The dosage of Prinzide is dependent upon the confirmed disorder, including Migraine, Congestive Heart Failure and prophylaxis of cardiovascular event. The portion of medication likewise depends on the technique of delivery (e.g. Tablet - Oral or Tablet) outlined in the table beneath.
Condition
Dosage
Administration
Diabetes
, 2.5 mg, 5.0 mg, 10.0 mg, 20.0 mg, 30.0 mg, 40.0 mg, 0.1 mg, 1.0 mg/mL
, Oral, Tablet, Tablet - Oral, Tablet, film coated, Tablet, film coated - Oral, Kit, Solution, Solution - Oral
Heart Attack
, 2.5 mg, 5.0 mg, 10.0 mg, 20.0 mg, 30.0 mg, 40.0 mg, 0.1 mg, 1.0 mg/mL
, Oral, Tablet, Tablet - Oral, Tablet, film coated, Tablet, film coated - Oral, Kit, Solution, Solution - Oral
prophylaxis of cardiovascular event
, 2.5 mg, 5.0 mg, 10.0 mg, 20.0 mg, 30.0 mg, 40.0 mg, 0.1 mg, 1.0 mg/mL
, Oral, Tablet, Tablet - Oral, Tablet, film coated, Tablet, film coated - Oral, Kit, Solution, Solution - Oral
prophylaxis of migraine headaches
, 2.5 mg, 5.0 mg, 10.0 mg, 20.0 mg, 30.0 mg, 40.0 mg, 0.1 mg, 1.0 mg/mL
, Oral, Tablet, Tablet - Oral, Tablet, film coated, Tablet, film coated - Oral, Kit, Solution, Solution - Oral
Congestive Heart Failure
, 2.5 mg, 5.0 mg, 10.0 mg, 20.0 mg, 30.0 mg, 40.0 mg, 0.1 mg, 1.0 mg/mL
, Oral, Tablet, Tablet - Oral, Tablet, film coated, Tablet, film coated - Oral, Kit, Solution, Solution - Oral
Diabetic Nephropathy
, 2.5 mg, 5.0 mg, 10.0 mg, 20.0 mg, 30.0 mg, 40.0 mg, 0.1 mg, 1.0 mg/mL
, Oral, Tablet, Tablet - Oral, Tablet, film coated, Tablet, film coated - Oral, Kit, Solution, Solution - Oral
Hypertensive disease
, 2.5 mg, 5.0 mg, 10.0 mg, 20.0 mg, 30.0 mg, 40.0 mg, 0.1 mg, 1.0 mg/mL
, Oral, Tablet, Tablet - Oral, Tablet, film coated, Tablet, film coated - Oral, Kit, Solution, Solution - Oral
Migraine
, 2.5 mg, 5.0 mg, 10.0 mg, 20.0 mg, 30.0 mg, 40.0 mg, 0.1 mg, 1.0 mg/mL
, Oral, Tablet, Tablet - Oral, Tablet, film coated, Tablet, film coated - Oral, Kit, Solution, Solution - Oral
Cardiovascular Events
, 2.5 mg, 5.0 mg, 10.0 mg, 20.0 mg, 30.0 mg, 40.0 mg, 0.1 mg, 1.0 mg/mL
, Oral, Tablet, Tablet - Oral, Tablet, film coated, Tablet, film coated - Oral, Kit, Solution, Solution - Oral

Warnings

Prinzide has five contraindications. Consequently, it should not be taken in cases of the conditions described in the table below.Prinzide Contraindications
Condition
Risk Level
Notes
Pulse Frequency
Do Not Combine
Type 2 Diabetes
Do Not Combine
Angioedema
Do Not Combine
Pulse Frequency
Do Not Combine
Angioedemas, Hereditary
Do Not Combine
There are 20 known major drug interactions with Prinzide.
Common Prinzide Drug Interactions
Drug Name
Risk Level
Description
Amifostine
Major
Lisinopril may increase the hypotensive activities of Amifostine.
Azathioprine
Major
The risk or severity of myelosuppression, anemia, and severe leukopenia can be increased when Lisinopril is combined with Azathioprine.
Lithium carbonate
Major
The serum concentration of Lithium carbonate can be increased when it is combined with Lisinopril.
Lithium citrate
Major
The serum concentration of Lithium citrate can be increased when it is combined with Lisinopril.
Lithium hydroxide
Major
The serum concentration of Lithium hydroxide can be increased when it is combined with Lisinopril.
Prinzide Toxicity & Overdose RiskThe lowest toxic dose of lisinopril in rats has been found to be greater than 8500mg/kg in rats and greater than 9100mg/kg in mice. Those who overdose on lisinopril may experience low blood pressure, which can be reversed by administering saline intravenously. Since lisinopril does not bind to protein, dialysis can be used to remove the drug from the bloodstream.
image of a doctor in a lab doing drug, clinical research

Prinzide Novel Uses: Which Conditions Have a Clinical Trial Featuring Prinzide?

647 active studies are being conducted to gauge the effectiveness of Prinzide in treating Type 2 Diabetes, Diabetic Nephropathy and Hypertensive Disease.
Condition
Clinical Trials
Trial Phases
prophylaxis of cardiovascular event
0 Actively Recruiting
Migraine
52 Actively Recruiting
Not Applicable, Phase 1, Phase 2, Phase 3, Phase 4, Early Phase 1
Heart Attack
8 Actively Recruiting
Not Applicable, Phase 4, Phase 3
Diabetes
540 Actively Recruiting
Phase 2, Phase 1, Phase 3, Not Applicable, Phase 4, Early Phase 1
Hypertensive disease
18 Actively Recruiting
Not Applicable, Phase 1, Phase 2, Phase 3
Diabetic Nephropathy
1 Actively Recruiting
Phase 4
prophylaxis of migraine headaches
0 Actively Recruiting
Congestive Heart Failure
22 Actively Recruiting
Phase 2, Phase 3, Not Applicable, Phase 1
Cardiovascular Events
3 Actively Recruiting
Not Applicable

Prinzide Reviews: What are patients saying about Prinzide?

5Patient Review
4/25/2009
Prinzide for High Blood Pressure
I switched to this treatment from atenolol because it was making me lightheaded and my blood pressure wasn't responding well. I much prefer Prinzide oral because the only downside is a occasional cough, which is manageable.
5Patient Review
5/21/2011
Prinzide for High Blood Pressure
This treatment has been great for relieving my itching and swelling. My blood pressure is also down, which is a huge plus.
5Patient Review
9/22/2008
Prinzide for High Blood Pressure
5Patient Review
12/14/2008
Prinzide for High Blood Pressure
4.3Patient Review
5/20/2015
Prinzide for High Blood Pressure
There have been times when this pill gets stuck in my throat and it's quite painful. I drink lots of water but my throat still burns for hours afterwards. My voice also becomes hoarse.
4.3Patient Review
4/11/2009
Prinzide for High Blood Pressure
I've only just started taking this medication, but so far it's been going well.
4.3Patient Review
11/10/2010
Prinzide for High Blood Pressure
While this did help my overall condition, I found the side effects to be really tough to deal with. My throat swelled up and I had a hard time coughing.
4.3Patient Review
1/14/2012
Prinzide for High Blood Pressure
I'm not sure if it's a side effect, but this treatment made me cough quite a bit.
4.3Patient Review
4/15/2010
Prinzide for High Blood Pressure
Unfortunately, I had a really severe reaction to this medication. My upper lip swelled up so badly that I went back to the ER. After they gave me a large dose of Benadryl, I finally started to look normal again after about 12 hours.
4Patient Review
9/9/2009
Prinzide for High Blood Pressure
I wish the flavor was better, and that it wasn't so easy to lose track of such a small pill.
3.7Patient Review
3/30/2009
Prinzide for High Blood Pressure
3.3Patient Review
8/30/2010
Prinzide for High Blood Pressure
I haven't experienced any negative side effects from this medication. I take the smallest dosage available, and then split the dose into two halves - one in the morning, and one at night. This has been effective in keeping my blood pressure level stable.
3Patient Review
12/4/2008
Prinzide for High Blood Pressure
3Patient Review
12/21/2010
Prinzide for High Blood Pressure
I experienced no negative side effects, but it took a full six months to see any results.
2.7Patient Review
4/20/2009
Prinzide for High Blood Pressure
I had a severe reaction to prinizide that was diagnosed as angio-edema. My face, lips, and cheeks swelled up nearly twice their usual size. It seems I'm allergic to the drug; very scary!!
2.7Patient Review
5/15/2009
Prinzide for High Blood Pressure
Although this medication has only slightly increased my urination, it has lowered my blood pressure from hypertension to a type 1. I am hoping that with further exercise, it will lower even more.
2.3Patient Review
12/4/2008
Prinzide for High Blood Pressure
2Patient Review
1/14/2011
Prinzide for High Blood Pressure
I found that this medication made it difficult to speak clearly and think straight. I also experienced jerking in my limbs, which was unpleasant.
image of drug pills surrounding a glass of water symbolizing drug consumption

Patient Q&A Section about prinzide

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

What are side effects of Prinzide?

"You may experience dizziness, lightheadedness, tiredness, depression, or headache as your body adjusts to the medication."

Answered by AI

How long does it take for Prinzide to work?

"The medication may take a few weeks to have its full effect."

Answered by AI

Is Prinzide the same as lisinopril?

"Angiotensin converting enzyme inhibitors are used to treat hypertension, heart failure, and myocardial infarction. Prinivil and Prinzide are two such drugs that contain ACE inhibitors."

Answered by AI

What is the drug Prinzide used for?

"Hydrochlorothiazide is a "water pill" (diuretic) that causes you to make more urine, which helps your body get rid of extra salt and water.

This medication is used to treat high blood pressure. Lowering high blood pressure helps prevent strokes, heart attacks, and kidney problems. This product contains two medications: lisinopril and hydrochlorothiazide. Lisinopril is an ACE inhibitor and works by relaxing blood vessels so that blood can flow more easily. Hydrochlorothiazide is a "water pill" (diuretic) that causes you to make more urine, which helps your body get rid of extra salt and water."

Answered by AI

Clinical Trials for Prinzide

Have you considered Prinzide clinical trials? We made a collection of clinical trials featuring Prinzide, we think they might fit your search criteria.
Have you considered Prinzide clinical trials? We made a collection of clinical trials featuring Prinzide, we think they might fit your search criteria.
Have you considered Prinzide clinical trials? We made a collection of clinical trials featuring Prinzide, we think they might fit your search criteria.