Pentostatin

Sezary Syndrome, Graft-vs-Host Disease, Chronic Lymphocytic Leukemia + 4 more
Treatment
1 FDA approval
20 Active Studies for Pentostatin

What is Pentostatin

PentostatinThe Generic name of this drug
Treatment SummaryAdenosine deaminase inhibitors are powerful drugs used to treat certain types of cancer, particularly hairy-cell leukemia. They can also be used in combination with other cancer treatments, and have the ability to suppress the immune system.
Pentostatinis the brand name
image of different drug pills on a surface
Pentostatin Overview & Background
Brand Name
Generic Name
First FDA Approval
How many FDA approvals?
Pentostatin
Pentostatin
2007
3

Approved as Treatment by the FDA

Pentostatin, also called Pentostatin, is approved by the FDA for 1 uses including Hairy Cell Leukemia .
Hairy Cell Leukemia

Effectiveness

How Pentostatin Affects PatientsPentostatin is a drug used to treat certain types of leukemia, such as acute nonlymphocytic leukemia and hairy cell leukemia. It works by fooling the body into thinking it is a natural building block of DNA, like purine or pyrimidine, but then prevents the body from using it to make DNA. Once inside the cells, it gets incorporated into the DNA and RNA, disrupting the cell cycle and causing the cells to die.
How Pentostatin works in the bodyPentostatin is an inhibitor of adenosine deaminase, a molecule found in high amounts in T-cell lymphocytes. By blocking the breakdown of adenosine and deoxyadenosine, Pentostatin causes an increase in dATP levels which blocks DNA synthesis. It also gets incorporated into DNA and RNA which stops the cell from reproducing and kills it. This effect is specific to cells in the S-phase.

When to interrupt dosage

The suggested portion of Pentostatin is contingent upon the identified condition, for example Hairy Cell Leukemia, Prolymphocytic Leukemia and Chronic Lymphocytic Leukemia. The measure of dosage fluctuates in light of the method of administration indicated in the table beneath.
Condition
Dosage
Administration
Graft-vs-Host Disease
, 10.0 mg, 2.0 mg/mL, 10.0 mg/mL
, Intravenous, Powder, for solution, Powder, for solution - Intravenous, Injection, powder, lyophilized, for solution - Intravenous, Injection, powder, lyophilized, for solution
Graft-vs-Host Disease
, 10.0 mg, 2.0 mg/mL, 10.0 mg/mL
, Intravenous, Powder, for solution, Powder, for solution - Intravenous, Injection, powder, lyophilized, for solution - Intravenous, Injection, powder, lyophilized, for solution
Mycosis Fungoides (MF)
, 10.0 mg, 2.0 mg/mL, 10.0 mg/mL
, Intravenous, Powder, for solution, Powder, for solution - Intravenous, Injection, powder, lyophilized, for solution - Intravenous, Injection, powder, lyophilized, for solution
Hairy Cell Leukemia
, 10.0 mg, 2.0 mg/mL, 10.0 mg/mL
, Intravenous, Powder, for solution, Powder, for solution - Intravenous, Injection, powder, lyophilized, for solution - Intravenous, Injection, powder, lyophilized, for solution
Sezary Syndrome
, 10.0 mg, 2.0 mg/mL, 10.0 mg/mL
, Intravenous, Powder, for solution, Powder, for solution - Intravenous, Injection, powder, lyophilized, for solution - Intravenous, Injection, powder, lyophilized, for solution
Prolymphocytic Leukemia
, 10.0 mg, 2.0 mg/mL, 10.0 mg/mL
, Intravenous, Powder, for solution, Powder, for solution - Intravenous, Injection, powder, lyophilized, for solution - Intravenous, Injection, powder, lyophilized, for solution
Chronic Lymphocytic Leukemia
, 10.0 mg, 2.0 mg/mL, 10.0 mg/mL
, Intravenous, Powder, for solution, Powder, for solution - Intravenous, Injection, powder, lyophilized, for solution - Intravenous, Injection, powder, lyophilized, for solution

Warnings

There are 20 known major drug interactions with Pentostatin.
Common Pentostatin Drug Interactions
Drug Name
Risk Level
Description
2-Methoxyethanol
Major
The risk or severity of adverse effects can be increased when Pentostatin is combined with 2-Methoxyethanol.
9-(N-methyl-L-isoleucine)-cyclosporin A
Major
The risk or severity of adverse effects can be increased when Pentostatin is combined with 9-(N-methyl-L-isoleucine)-cyclosporin A.
Abatacept
Major
The risk or severity of adverse effects can be increased when Pentostatin is combined with Abatacept.
Abetimus
Major
The risk or severity of adverse effects can be increased when Pentostatin is combined with Abetimus.
Acteoside
Major
The risk or severity of adverse effects can be increased when Pentostatin is combined with Acteoside.
Pentostatin Toxicity & Overdose RiskThe lowest toxic dose of the drug for mice is 128mg/kg. Side effects of overdosing may include drowsiness, a rash, tiredness, nausea, and an impaired production of blood cells.

Pentostatin Novel Uses: Which Conditions Have a Clinical Trial Featuring Pentostatin?

206 active clinical trials are investigating the potential of Pentostatin to provide relief from Chronic Lymphocytic Leukemia, Graft-vs-Host Disease and Sezary Syndrome.
Condition
Clinical Trials
Trial Phases
Chronic Lymphocytic Leukemia
164 Actively Recruiting
Phase 1, Phase 2, Not Applicable, Phase 3
Mycosis Fungoides (MF)
0 Actively Recruiting
Sezary Syndrome
18 Actively Recruiting
Phase 2, Phase 1
Graft-vs-Host Disease
0 Actively Recruiting
Prolymphocytic Leukemia
0 Actively Recruiting
Hairy Cell Leukemia
15 Actively Recruiting
Phase 2, Phase 1
Graft-vs-Host Disease
8 Actively Recruiting
Phase 1, Phase 2, Phase 3, Not Applicable

Pentostatin Reviews: What are patients saying about Pentostatin?

1Patient Review
6/28/2008
Pentostatin for Progressive Chronic Lymphocytic Leukemia
My mother has cml and her doctor prescribed pentostatin, which costs $40,000. Her insurance won't help cover the cost. We're struggling to figure out how to pay for it.
image of drug pills surrounding a glass of water symbolizing drug consumption

Patient Q&A Section about pentostatin

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

What cyclophosphamide is used for?

"Cyclophosphamide is a drug used to treat various forms of cancer, including ovarian cancer, breast cancer, blood cancer, lymphatic cancer, and nervous system cancer (primarily in children). Cyclophosphamide is also used to treat retinoblastoma (a type of eye cancer that affects primarily children), multiple myeloma (a cancer of the bone marrow), and mycosis fungoides (a skin cancer)."

Answered by AI

Who makes pentostatin?

"Pentostatin is an anticancer drug that is manufactured by SuperGen."

Answered by AI

What are the side effects of pentostatin?

"The following are some potential side effects of the medication: feeling nauseous, vomiting, having diarrhea, loss of appetite, increased sweating, or mouth sores. If you experience any of these effects, speak to your doctor or pharmacist. There is a potential for serious side effects with this medication."

Answered by AI

How do you administer pentostatin?

"Pentostatin is a powder that is mixed with liquid and injected into a vein. It is usually injected once every other week."

Answered by AI

Clinical Trials for Pentostatin

Have you considered Pentostatin clinical trials? We made a collection of clinical trials featuring Pentostatin, we think they might fit your search criteria.
Have you considered Pentostatin clinical trials? We made a collection of clinical trials featuring Pentostatin, we think they might fit your search criteria.
Have you considered Pentostatin clinical trials? We made a collection of clinical trials featuring Pentostatin, we think they might fit your search criteria.
Unbiased ResultsWe believe in providing patients with all the options.
Your Data Stays Your DataWe only share your information with the clinical trials you're trying to access.
Verified Trials OnlyAll of our trials are run by licensed doctors, researchers, and healthcare companies.
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