This trial is evaluating whether Radiation therapy will improve 1 primary outcome and 3 secondary outcomes in patients with Rectal Carcinoma. Measurement will happen over the course of Week 24.
This trial requires 43 total participants across 1 different treatment group
This trial involves a single treatment. Radiation Therapy is the primary treatment being studied. Participants will all receive the same treatment. There is no placebo group. The treatments being tested are in Phase 2 and have already been tested with other people.
"Radiation plays an important role in the management of locally advanced rectal cancer. However, RT was not always used in combination with other treatments except for chemoradiotherapy, chemotherapy, and surgery." - Anonymous Online Contributor
"Recent findings from this large sample of people undergoing [colorectal cancer](https://www.withpower.com/clinical-trials/colorectal-cancer) screening indicate that the average age of diagnosis is 77 years old. It is important to use this information when counseling people about their risk of developing cancer of the rectum." - Anonymous Online Contributor
"The leading cause of cancer of rectum In a recent study was alcohol consumption (14%), followed by tobacco smoking (15%), cirrhosis of liver (13%), infections (3%) and hereditary colon diseases (2%). As the number of patients who had not been exposed to any risk factors increased, the incidence of cancer decreased (P<0.001)." - Anonymous Online Contributor
"The most recent research papers were published between 2011 and 2013 and mainly focused on the diagnosis of rectal cancer, prognosis of rectal cancer, chemotherapy protocols for rectal cancer and its treatments, and the impacts of radiotherapy and chemoradiotherapy on rectal cancer. Additionally, some studies indicated that the patient's age played an important role in determining the survival rate after surgery, especially for older patients (> or = 70 yr); however, it was limited in terms of number of patients." - Anonymous Online Contributor
"For patients with localized rectal cancer, RT appears to be effective for controlling local disease and improving overall survival. Tomotherapy appears to be particularly effective in treating early stage tumors." - Anonymous Online Contributor
"The number of new cases of [colorectal cancer](https://www.withpower.com/clinical-trials/colorectal-cancer) in the US increased from 8.6 per 100,000 in 1992 to 10.3 per 100,000 in 2000. This increase was driven primarily by an increase in cancers of the distal colon (increased 42%) and rectum (increased 71%). Because of demographic changes in the demographics of the US population, the incidence of colorectal cancer has not changed significantly recently." - Anonymous Online Contributor
"Survival rates for rectal cancer vary widely between studies because staging and grading systems differ. One study indicates that the 5-year survival rate is 70%. This compares favorably with results for colon cancer, where the 5-year survival rate is only 37% at best. Rectal cancer has previously been considered a disease of advanced stage, but recent studies indicate that rectal cancer is often diagnosed early stage I. According to this finding, the survival rates may be higher than previously thought. Rectal cancer should no longer be considered a disease of advanced stage. Although the 5-year survival rates are still very low, it is possible that rectal cancer could become a curable disease if the disease was detected early enough." - Anonymous Online Contributor
"The 5 treatments most commonly used were: surgery (37%), radiation (21%), chemotherapy (19%), and radiation + chemotherapy (11%). Chemotherapy was reported by nearly half of respondents." - Anonymous Online Contributor
"Rectal cancer affects approximately 17% of U.S. men annually. Most cases are diagnosed at an advanced stage and are inoperable. The outcomes are poor, especially among patients who present with node-positive disease." - Anonymous Online Contributor
"The disease affects about 3% of patients who undergo surgery for [colorectal cancer](https://www.withpower.com/clinical-trials/colorectal-cancer). It is more common in males, especially in patients over 60 years old. Most cases occur in the lower third of the colon (approximately 70%), but can affect any part of the intestine. Rectal cancers are uncommon unless they involve the rectosigmoid junction. They generally occur in older persons who have had colonic resection and may be difficult to detect. In general, these tumors are well differentiated and carry a good prognosis. However, local recurrence frequently occurs, and this often leads to distant metastases." - Anonymous Online Contributor
"Radiation almost never causes acute intestinal injury. Most cases of gastrointestinal toxicity resulting from radiotherapy occur more than 12 months after completion of treatment. Nevertheless, it is prudent to limit risk factors in this group of patients." - Anonymous Online Contributor