Radiation therapy for Rectal Carcinoma

Phase-Based Progress Estimates
1
Effectiveness
2
Safety
Weill Cornell Medical College, New York, NY
Rectal Carcinoma+1 More
Radiation therapy - Radiation
Eligibility
18+
All Sexes
Eligible conditions
Select

Study Summary

This study is evaluating whether a drug called AB928 can help treat people with cancer.

See full description

Eligible Conditions

  • Rectal Carcinoma

Treatment Effectiveness

Effectiveness Progress

1 of 3

Other trials for Rectal Carcinoma

Study Objectives

This trial is evaluating whether Radiation therapy will improve 1 primary outcome and 3 secondary outcomes in patients with Rectal Carcinoma. Measurement will happen over the course of Week 24.

36 months
Progression free survival
60 months
Number of patients who experience treatment-related adverse events
Overall survival
Week 24
Number of treated patients who achieve complete pathologic response

Trial Safety

Safety Progress

2 of 3
This is further along than 68% of similar trials

Other trials for Rectal Carcinoma

Trial Design

1 Treatment Group

Radiation therapy and etrumadenant (AB928)
1 of 1
Experimental Treatment

This trial requires 43 total participants across 1 different treatment group

This trial involves a single treatment. Radiation Therapy is the primary treatment being studied. Participants will all receive the same treatment. There is no placebo group. The treatments being tested are in Phase 2 and have already been tested with other people.

Radiation therapy and etrumadenant (AB928)Enrolled patients will receive Radiation therapy of 25 Gy in 5 fractions along with etrumadenant 150mg oral drug taken once daily. this will then be followed by 9 cycles of FOLFOX in combination of etrumadenant and zimberelimab investigational drugs.
Treatment
First Studied
Drug Approval Stage
How many patients have taken this drug
Radiation therapy
2013
Completed Phase 3
~2840
FOLFOX regimen
2009
Completed Phase 3
~2440

Trial Logistics

Trial Timeline

Approximate Timeline
Screening: ~3 weeks
Treatment: Varies
Reporting: 60 months
This trial has the following approximate timeline: 3 weeks for initial screening, variable treatment timelines, and roughly 60 months for reporting.

Closest Location

Weill Cornell Medical College - New York, NY

Eligibility Criteria

This trial is for patients born any sex aged 18 and older. There are 10 eligibility criteria to participate in this trial as listed below.

Mark “yes” if the following statements are true for you:
The text states that the person has a histologically confirmed diagnosis of adenocarcinoma of the rectum. show original
A person with an ECOG performance status of 0-1 is considered to have a good performance status. show original
Rectal cancer that can be removed through surgery that removes the entire mesorectal region. show original
is necessary No previous radiation therapy is required. show original
No chemotherapy or surgery is necessary for rectal cancer. show original
is the perianal skin show original
Age ≥ 18 years
cT3N0 or cT1-3N1
No evidence of distant metastases
No infections requiring systemic antibiotic treatment

Patient Q&A Section

Is radiation therapy typically used in combination with any other treatments?

"Radiation plays an important role in the management of locally advanced rectal cancer. However, RT was not always used in combination with other treatments except for chemoradiotherapy, chemotherapy, and surgery." - Anonymous Online Contributor

Unverified Answer

What is the average age someone gets cancer of rectum?

"Recent findings from this large sample of people undergoing [colorectal cancer](https://www.withpower.com/clinical-trials/colorectal-cancer) screening indicate that the average age of diagnosis is 77 years old. It is important to use this information when counseling people about their risk of developing cancer of the rectum." - Anonymous Online Contributor

Unverified Answer

What causes cancer of rectum?

"The leading cause of cancer of rectum In a recent study was alcohol consumption (14%), followed by tobacco smoking (15%), cirrhosis of liver (13%), infections (3%) and hereditary colon diseases (2%). As the number of patients who had not been exposed to any risk factors increased, the incidence of cancer decreased (P<0.001)." - Anonymous Online Contributor

Unverified Answer

What is the latest research for cancer of rectum?

"The most recent research papers were published between 2011 and 2013 and mainly focused on the diagnosis of rectal cancer, prognosis of rectal cancer, chemotherapy protocols for rectal cancer and its treatments, and the impacts of radiotherapy and chemoradiotherapy on rectal cancer. Additionally, some studies indicated that the patient's age played an important role in determining the survival rate after surgery, especially for older patients (> or = 70 yr); however, it was limited in terms of number of patients." - Anonymous Online Contributor

Unverified Answer

What does radiation therapy usually treat?

"For patients with localized rectal cancer, RT appears to be effective for controlling local disease and improving overall survival. Tomotherapy appears to be particularly effective in treating early stage tumors." - Anonymous Online Contributor

Unverified Answer

How many people get cancer of rectum a year in the United States?

"The number of new cases of [colorectal cancer](https://www.withpower.com/clinical-trials/colorectal-cancer) in the US increased from 8.6 per 100,000 in 1992 to 10.3 per 100,000 in 2000. This increase was driven primarily by an increase in cancers of the distal colon (increased 42%) and rectum (increased 71%). Because of demographic changes in the demographics of the US population, the incidence of colorectal cancer has not changed significantly recently." - Anonymous Online Contributor

Unverified Answer

What is the survival rate for cancer of rectum?

"Survival rates for rectal cancer vary widely between studies because staging and grading systems differ. One study indicates that the 5-year survival rate is 70%. This compares favorably with results for colon cancer, where the 5-year survival rate is only 37% at best. Rectal cancer has previously been considered a disease of advanced stage, but recent studies indicate that rectal cancer is often diagnosed early stage I. According to this finding, the survival rates may be higher than previously thought. Rectal cancer should no longer be considered a disease of advanced stage. Although the 5-year survival rates are still very low, it is possible that rectal cancer could become a curable disease if the disease was detected early enough." - Anonymous Online Contributor

Unverified Answer

What are common treatments for cancer of rectum?

"The 5 treatments most commonly used were: surgery (37%), radiation (21%), chemotherapy (19%), and radiation + chemotherapy (11%). Chemotherapy was reported by nearly half of respondents." - Anonymous Online Contributor

Unverified Answer

What is cancer of rectum?

"Rectal cancer affects approximately 17% of U.S. men annually. Most cases are diagnosed at an advanced stage and are inoperable. The outcomes are poor, especially among patients who present with node-positive disease." - Anonymous Online Contributor

Unverified Answer

How serious can cancer of rectum be?

"The disease affects about 3% of patients who undergo surgery for [colorectal cancer](https://www.withpower.com/clinical-trials/colorectal-cancer). It is more common in males, especially in patients over 60 years old. Most cases occur in the lower third of the colon (approximately 70%), but can affect any part of the intestine. Rectal cancers are uncommon unless they involve the rectosigmoid junction. They generally occur in older persons who have had colonic resection and may be difficult to detect. In general, these tumors are well differentiated and carry a good prognosis. However, local recurrence frequently occurs, and this often leads to distant metastases." - Anonymous Online Contributor

Unverified Answer

Is radiation therapy safe for people?

"Radiation almost never causes acute intestinal injury. Most cases of gastrointestinal toxicity resulting from radiotherapy occur more than 12 months after completion of treatment. Nevertheless, it is prudent to limit risk factors in this group of patients." - Anonymous Online Contributor

Unverified Answer
Please Note: These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.
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