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What is Parlodel
BromocriptineThe Generic name of this drug
Treatment SummaryBromocriptine mesylate is a medication used to treat the symptoms of Parkinson's disease. It also helps to reduce the production of the hormone prolactin, which makes it useful for treating conditions related to high prolactin levels. In some cases, bromocriptine can also reduce the amount of growth hormone being produced. However, this drug can cause side effects such as pulmonary fibrosis.
Parlodelis the brand name
Parlodel Overview & Background
Brand Name
Generic Name
First FDA Approval
How many FDA approvals?
Parlodel
Bromocriptine
1978
25
Approved as Treatment by the FDA
Bromocriptine, commonly known as Parlodel, is approved by the FDA for 4 uses like Hyperprolactinemia and Type 2 Diabetes .Hyperprolactinemia
Helps manage Hyperprolactinemia
Type 2 Diabetes
Helps manage Type 2 Diabetes Mellitus
Acromegaly
Helps manage Acromegaly
Parkinson's Disease
Effectiveness
How Parlodel Affects PatientsBromocriptine affects the dopamine receptors in the brain, which help control movement, balance, and walking. It can improve symptoms of movement disorders, but high doses can cause hallucinations and delusions. It also decreases the hormone prolactin, which is associated with some disorders. Side effects may include pulmonary fibrosis.
How Parlodel works in the bodyThe dopamine D2 receptor is a type of molecule that sits on the outside of cells. When it's activated, it has a few effects. First, it decreases the amount of certain substances that move into cells. This can decrease the amount of calcium inside the cell, which affects how cells communicate with each other. It also decreases the activity of some proteins that help cells communicate. Finally, it increases the release of a hormone from the pituitary gland, which may help improve coordination in people with movement disorders.
When to interrupt dosage
The recommended dosage of Parlodel is contingent upon the determined condition, such as Hyperprolactinemia, Acromegaly and Parkinson's Disease. The amount of dose varies, according to the delivery technique (e.g. Oral or Capsule) listed in the table hereunder.Condition
Dosage
Administration
neuroleptic malignant syndrome (NMS)
2.5 mg, , 5.0 mg, 0.8 mg
, Oral, Tablet, Tablet - Oral, Capsule, Capsule - Oral, Capsule, gelatin coated, Capsule, gelatin coated - Oral
Type 2 Diabetes
2.5 mg, , 5.0 mg, 0.8 mg
, Oral, Tablet, Tablet - Oral, Capsule, Capsule - Oral, Capsule, gelatin coated, Capsule, gelatin coated - Oral
Acromegaly
2.5 mg, , 5.0 mg, 0.8 mg
, Oral, Tablet, Tablet - Oral, Capsule, Capsule - Oral, Capsule, gelatin coated, Capsule, gelatin coated - Oral
Hyperprolactinemia
2.5 mg, , 5.0 mg, 0.8 mg
, Oral, Tablet, Tablet - Oral, Capsule, Capsule - Oral, Capsule, gelatin coated, Capsule, gelatin coated - Oral
Parkinson's Disease
2.5 mg, , 5.0 mg, 0.8 mg
, Oral, Tablet, Tablet - Oral, Capsule, Capsule - Oral, Capsule, gelatin coated, Capsule, gelatin coated - Oral
Warnings
Parlodel ContraindicationsCondition
Risk Level
Notes
Acromegaly, Prolactinoma, Parkinson's Disease
Do Not Combine
Hypertensive disease
Do Not Combine
Coronary Artery Disease
Do Not Combine
Heart Disease
Do Not Combine
treatment withdrawal during pregnancy
Do Not Combine
Pulse Frequency
Do Not Combine
Common Parlodel Drug Interactions
Drug Name
Risk Level
Description
4-Bromo-2,5-dimethoxyphenethylamine
Major
Bromocriptine may increase the hypertensive and vasoconstricting activities of 4-Bromo-2,5-dimethoxyphenethylamine.
4-Methoxyamphetamine
Major
Bromocriptine may increase the hypertensive and vasoconstricting activities of 4-Methoxyamphetamine.
5-methoxy-N,N-dimethyltryptamine
Major
Bromocriptine may increase the vasoconstricting activities of 5-methoxy-N,N-dimethyltryptamine.
Abediterol
Major
Bromocriptine may increase the hypertensive and vasoconstricting activities of Abediterol.
Acepromazine
Major
Bromocriptine may increase the orthostatic hypotensive, hypotensive, and antihypertensive activities of Acepromazine.
Parlodel Toxicity & Overdose RiskOverdosing on Metoprolol can lead to nausea, vomiting, lightheadedness, abdominal pain, stuffy nose, diarrhea, and low blood pressure. Nausea, headaches, dizziness, constipation, and other milder symptoms may also occur.
Parlodel Novel Uses: Which Conditions Have a Clinical Trial Featuring Parlodel?
Presently, there are 217 active studies assessing the suitability of Parlodel for use in the treatment of Acromegaly, Hyperprolactinemia and Neuroleptic Malignant Syndrome (NMS).Condition
Clinical Trials
Trial Phases
Parkinson's Disease
46 Actively Recruiting
Phase 3, Not Applicable, Phase 1, Phase 2, Early Phase 1
Type 2 Diabetes
192 Actively Recruiting
Phase 2, Not Applicable, Early Phase 1, Phase 1, Phase 4, Phase 3
neuroleptic malignant syndrome (NMS)
0 Actively Recruiting
Hyperprolactinemia
1 Actively Recruiting
Phase 1
Acromegaly
6 Actively Recruiting
Phase 3, Phase 2, Not Applicable
Parlodel Reviews: What are patients saying about Parlodel?
5Patient Review
4/23/2016 I was diagnosed with a prolactinoma, and my doctor put me on this medication. My prolactin levels dropped from 70 to 13 in just a few weeks, and I'm feeling great! There were some side effects at first (drowsiness and nausea), but they've mostly gone away now.
5Patient Review
3/4/2020 Bromocriptine has been working great for me over the long term. Within a few weeks, my prolactin levels had decreased significantly. The only downside is that I occasionally get headaches and restless sleep.
4Patient Review
7/4/2011 Since taking bromocriptine, I have experienced decreased weight and improved menstrual regularity. Additionally, my prolactin levels were very high when I first started the medication (79), but have since lowered to a more normal range.
4Patient Review
7/3/2016 This medication was great. I started with 2.5mg at 277 prolactin levels and, after one month on the medication and one week off, my prolactin decreased to 219. The doctor recommended 5mg, but the side effects were severe headaches and numbness on the right side of face. I'm waiting on another round of prolactin level results in a week.
3.7Patient Review
5/1/2012 The first time I took this medication, I experienced a lot of nausea. I was also very dizzy and could barely get out of bed for the first few days. When the doctor increased the dosage, I had the same effects.
3.3Patient Review
5/13/2010 I found that if I took less than the recommended dosage, I didn't experience any negative side effects.
3.3Patient Review
6/11/2011 I became very dizzy at night after taking this medication, to the point where I was running into walls and falling down. Be extra careful if you take this at night. It has helped with my sweating during the day and hopefully will shrink the tumors.
3Patient Review
4/13/2014 I've been struggling with acromegaly and a macro-adenoma since 2007. My growth hormone levels are currently at 120. As a result, I'm overweight and my hands, feet, and lower jaw have all increased in size. I'm wondering if this medication will be helpful for me.
3Patient Review
1/19/2021 I've been taking bromocriptine for a little over two years, and I was switched to this brand about two weeks ago. Since then, I've had really bad constipation. I'm going back to the old stuff.
2.3Patient Review
1/29/2021 Though this drug did lower my serum prolactin levels, the side effects were not worth it. I suffered from severe congestion, lightheadedness, nausea, and hair loss while taking this medication. I've been off of it for over a year now and still experience alopecia and congestion occasionally.
1Patient Review
1/23/2011 I had to stop taking this medication three different times because every time I took it, I woke up early with a severe migraine. My doctor says it couldn't be the medication, but after doing some research online, I've found that many other people have had similar experiences.
1Patient Review
5/7/2018 I'm extremely ill while taking this medication. My prolactin levels were 444.10. I'm on my second round of this drug, and the side effects are really severe. I hope they stop soon.
1Patient Review
7/25/2016 Sadly, this didn't work for me. On top of that, the side effects were incredibly unpleasant. For two weeks straight I had headaches and my blood pressure was through the roof.
Patient Q&A Section about parlodel
These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.Is Parlodel a fertility drug?
"Parlodel is a medication used to lower prolactin levels. High prolactin levels can cause irregular or absent periods, and fertility problems."
Answered by AI
How many days should I take Parlodel?
"To prevent breast milk production, Parlodel is taken twice daily for 2 weeks. Sometimes milk production will start again 2 or 3 days after the medicine is finished, but a further 1 week course of Parlodel will usually bring this under control."
Answered by AI
What is the side effect of Parlodel?
"You may experience some side effects while taking this medication, such as nausea, vomiting, dizziness, drowsiness, lightheadedness, tiredness, constipation or headache. If you experience any of these side effects for an extended period of time, be sure to speak to your doctor or pharmacist."
Answered by AI
Can Parlodel be used to treat hormonal imbalance?
"Parlodel is used to treat hyperprolactinemia, which is caused by an imbalance of hormones in the body that results in too much prolactin in the blood."
Answered by AI