Parlodel

Hyperprolactinemia, Acromegaly, Type 2 Diabetes + 2 more
Treatment
7 FDA approvals
20 Active Studies for Parlodel

What is Parlodel

BromocriptineThe Generic name of this drug
Treatment SummaryBromocriptine mesylate is a medication used to treat the symptoms of Parkinson's disease. It also helps to reduce the production of the hormone prolactin, which makes it useful for treating conditions related to high prolactin levels. In some cases, bromocriptine can also reduce the amount of growth hormone being produced. However, this drug can cause side effects such as pulmonary fibrosis.
Parlodelis the brand name
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Parlodel Overview & Background
Brand Name
Generic Name
First FDA Approval
How many FDA approvals?
Parlodel
Bromocriptine
1978
25

Approved as Treatment by the FDA

Bromocriptine, commonly known as Parlodel, is approved by the FDA for 7 uses like Parkinson's Disease (PD) and Hyperprolactinemia .
Parkinson's Disease (PD)
Hyperprolactinemia
Helps manage Hyperprolactinemia
Type 2 Diabetes Mellitus
Helps manage Type 2 Diabetes Mellitus
Hyperprolactinemia
Helps manage Hyperprolactinemia
Type 2 Diabetes
Helps manage Type 2 Diabetes Mellitus
Parkinson's Disease
Acromegaly
Helps manage Acromegaly

Effectiveness

How Parlodel Affects PatientsBromocriptine affects the dopamine receptors in the brain, which help control movement, balance, and walking. It can improve symptoms of movement disorders, but high doses can cause hallucinations and delusions. It also decreases the hormone prolactin, which is associated with some disorders. Side effects may include pulmonary fibrosis.
How Parlodel works in the bodyThe dopamine D2 receptor is a type of molecule that sits on the outside of cells. When it's activated, it has a few effects. First, it decreases the amount of certain substances that move into cells. This can decrease the amount of calcium inside the cell, which affects how cells communicate with each other. It also decreases the activity of some proteins that help cells communicate. Finally, it increases the release of a hormone from the pituitary gland, which may help improve coordination in people with movement disorders.

When to interrupt dosage

The recommended dosage of Parlodel is contingent upon the determined condition, such as Hyperprolactinemia, Acromegaly and Parkinson's Disease. The amount of dose varies, according to the delivery technique (e.g. Oral or Capsule) listed in the table hereunder.
Condition
Dosage
Administration
Neuroleptic Malignant Syndrome
2.5 mg, , 5.0 mg, 0.8 mg
, Oral, Tablet, Tablet - Oral, Capsule, Capsule - Oral, Capsule, gelatin coated, Capsule, gelatin coated - Oral
Hyperprolactinemia
2.5 mg, , 5.0 mg, 0.8 mg
, Oral, Tablet, Tablet - Oral, Capsule, Capsule - Oral, Capsule, gelatin coated, Capsule, gelatin coated - Oral
Acromegaly
2.5 mg, , 5.0 mg, 0.8 mg
, Oral, Tablet, Tablet - Oral, Capsule, Capsule - Oral, Capsule, gelatin coated, Capsule, gelatin coated - Oral
Type 2 Diabetes
2.5 mg, , 5.0 mg, 0.8 mg
, Oral, Tablet, Tablet - Oral, Capsule, Capsule - Oral, Capsule, gelatin coated, Capsule, gelatin coated - Oral
Parkinson's Disease
2.5 mg, , 5.0 mg, 0.8 mg
, Oral, Tablet, Tablet - Oral, Capsule, Capsule - Oral, Capsule, gelatin coated, Capsule, gelatin coated - Oral

Warnings

Parlodel Contraindications
Condition
Risk Level
Notes
Acromegaly, Prolactinoma, Parkinson's Disease
Do Not Combine
Hypertensive disease
Do Not Combine
Coronary Artery Disease
Do Not Combine
Heart Disease
Do Not Combine
treatment withdrawal during pregnancy
Do Not Combine
Pulse Frequency
Do Not Combine
There are 20 known major drug interactions with Parlodel.
Common Parlodel Drug Interactions
Drug Name
Risk Level
Description
4-Bromo-2,5-dimethoxyphenethylamine
Major
Bromocriptine may increase the hypertensive and vasoconstricting activities of 4-Bromo-2,5-dimethoxyphenethylamine.
4-Methoxyamphetamine
Major
Bromocriptine may increase the hypertensive and vasoconstricting activities of 4-Methoxyamphetamine.
5-methoxy-N,N-dimethyltryptamine
Major
Bromocriptine may increase the vasoconstricting activities of 5-methoxy-N,N-dimethyltryptamine.
Abediterol
Major
Bromocriptine may increase the hypertensive and vasoconstricting activities of Abediterol.
Acepromazine
Major
Bromocriptine may increase the orthostatic hypotensive, hypotensive, and antihypertensive activities of Acepromazine.
Parlodel Toxicity & Overdose RiskOverdosing on Metoprolol can lead to nausea, vomiting, lightheadedness, abdominal pain, stuffy nose, diarrhea, and low blood pressure. Nausea, headaches, dizziness, constipation, and other milder symptoms may also occur.
image of a doctor in a lab doing drug, clinical research

Parlodel Novel Uses: Which Conditions Have a Clinical Trial Featuring Parlodel?

Presently, there are 217 active studies assessing the suitability of Parlodel for use in the treatment of Acromegaly, Hyperprolactinemia and Neuroleptic Malignant Syndrome (NMS).
Condition
Clinical Trials
Trial Phases
Parkinson's Disease
39 Actively Recruiting
Not Applicable, Phase 1, Phase 4, Phase 2, Phase 3, Early Phase 1
Acromegaly
5 Actively Recruiting
Phase 3, Phase 2
Neuroleptic Malignant Syndrome
0 Actively Recruiting
Hyperprolactinemia
0 Actively Recruiting
Type 2 Diabetes
177 Actively Recruiting
Not Applicable, Phase 1, Phase 2, Phase 3, Phase 4, Early Phase 1

Parlodel Reviews: What are patients saying about Parlodel?

5Patient Review
4/23/2016
Parlodel for Prolactin Excreting Tumor of the Pituitary Gland
I was diagnosed with a prolactinoma, and my doctor put me on this medication. My prolactin levels dropped from 70 to 13 in just a few weeks, and I'm feeling great! There were some side effects at first (drowsiness and nausea), but they've mostly gone away now.
5Patient Review
3/4/2020
Parlodel for Prolactin Excreting Tumor of the Pituitary Gland
Bromocriptine has been working great for me over the long term. Within a few weeks, my prolactin levels had decreased significantly. The only downside is that I occasionally get headaches and restless sleep.
4Patient Review
7/4/2011
Parlodel for Prolactin Excreting Tumor of the Pituitary Gland
Since taking bromocriptine, I have experienced decreased weight and improved menstrual regularity. Additionally, my prolactin levels were very high when I first started the medication (79), but have since lowered to a more normal range.
4Patient Review
7/3/2016
Parlodel for Prolactin Excreting Tumor of the Pituitary Gland
This medication was great. I started with 2.5mg at 277 prolactin levels and, after one month on the medication and one week off, my prolactin decreased to 219. The doctor recommended 5mg, but the side effects were severe headaches and numbness on the right side of face. I'm waiting on another round of prolactin level results in a week.
3.7Patient Review
5/1/2012
Parlodel for Increased Levels of Prolactin in the Blood
The first time I took this medication, I experienced a lot of nausea. I was also very dizzy and could barely get out of bed for the first few days. When the doctor increased the dosage, I had the same effects.
View All Reviews
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Patient Q&A Section about parlodel

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

Is Parlodel a fertility drug?

"Parlodel is a medication used to lower prolactin levels. High prolactin levels can cause irregular or absent periods, and fertility problems."

Answered by AI

How many days should I take Parlodel?

"To prevent breast milk production, Parlodel is taken twice daily for 2 weeks. Sometimes milk production will start again 2 or 3 days after the medicine is finished, but a further 1 week course of Parlodel will usually bring this under control."

Answered by AI

What is the side effect of Parlodel?

"You may experience some side effects while taking this medication, such as nausea, vomiting, dizziness, drowsiness, lightheadedness, tiredness, constipation or headache. If you experience any of these side effects for an extended period of time, be sure to speak to your doctor or pharmacist."

Answered by AI

Can Parlodel be used to treat hormonal imbalance?

"Parlodel is used to treat hyperprolactinemia, which is caused by an imbalance of hormones in the body that results in too much prolactin in the blood."

Answered by AI

Clinical Trials for Parlodel

Have you considered Parlodel clinical trials? We made a collection of clinical trials featuring Parlodel, we think they might fit your search criteria.
Have you considered Parlodel clinical trials? We made a collection of clinical trials featuring Parlodel, we think they might fit your search criteria.
Have you considered Parlodel clinical trials? We made a collection of clinical trials featuring Parlodel, we think they might fit your search criteria.
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