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What is Oruvail
KetoprofenThe Generic name of this drug
Treatment SummaryKetoprofen is a pain reliever and fever reducer that belongs to a group of drugs called nonsteroidal anti-inflammatory drugs (NSAIDs). It works by reducing hormones that cause inflammation and pain in the body.
Ketoprofenis the brand name
Oruvail Overview & Background
Brand Name
Generic Name
First FDA Approval
How many FDA approvals?
Ketoprofen
Ketoprofen
1993
51
Approved as Treatment by the FDA
Ketoprofen, also known as Ketoprofen, is approved by the FDA for 3 uses such as Ankylosing Spondylitis and Post Partum Pain .Ankylosing Spondylitis
Helps manage Ankylosing Spondylitis (AS)
Post Partum Pain
Helps manage Post Partum Pain
Postoperative Pain
Helps manage Postoperative pain
Effectiveness
How Oruvail Affects PatientsKetoprofen is a type of medicine that works to reduce inflammation and pain. It is similar to other similar drugs, in that it stops the body from producing chemicals that cause inflammation. Ketoprofen is used to treat conditions like rheumatoid arthritis, osteoarthritis, and menstrual cramps, as well as for moderate pain relief.
How Oruvail works in the bodyKetoprofen works by inhibiting the enzyme cyclooxygenase-2 (COX-2). COX-2 helps create prostaglandins, which are molecules that cause pain, fever, and inflammation. By blocking COX-2, ketoprofen reduces the levels of prostaglandins and so reduces pain, fever and inflammation. Ketoprofen also has anti-bradykinin activity, which helps prevent the constriction of blood vessels, and lysosomal membrane-stabilizing action, which helps protect cells. Its anti-fever effects may be due to increased peripheral blood
When to interrupt dosage
The amount of Oruvail is contingent upon the identified condition, including Sprains, Ankylosing Spondylitis and Pain. The quantity of dosage is contingent upon the administration process (e.g. Capsule, extended release - Oral or Tablet, delayed release) presented in the table below.Condition
Dosage
Administration
Rheumatoid Arthritis
, 50.0 mg, 75.0 mg, 200.0 mg, 100.0 mg, 150.0 mg, 0.05 mg/mg, 25.0 mg, 3.35 mg/mg, 0.5525 mg/mg
, Oral, Capsule, Capsule - Oral, Capsule, extended release, Capsule, extended release - Oral, Kit, Tablet - Oral, Tablet, Tablet, delayed release, Tablet, delayed release - Oral, Rectal, Suppository, Suppository - Rectal, Tablet, extended release, Tablet, extended release - Oral, Powder - Topical, Topical
Sprains
, 50.0 mg, 75.0 mg, 200.0 mg, 100.0 mg, 150.0 mg, 0.05 mg/mg, 25.0 mg, 3.35 mg/mg, 0.5525 mg/mg
, Oral, Capsule, Capsule - Oral, Capsule, extended release, Capsule, extended release - Oral, Kit, Tablet - Oral, Tablet, Tablet, delayed release, Tablet, delayed release - Oral, Rectal, Suppository, Suppository - Rectal, Tablet, extended release, Tablet, extended release - Oral, Powder - Topical, Topical
Postoperative Pain
, 50.0 mg, 75.0 mg, 200.0 mg, 100.0 mg, 150.0 mg, 0.05 mg/mg, 25.0 mg, 3.35 mg/mg, 0.5525 mg/mg
, Oral, Capsule, Capsule - Oral, Capsule, extended release, Capsule, extended release - Oral, Kit, Tablet - Oral, Tablet, Tablet, delayed release, Tablet, delayed release - Oral, Rectal, Suppository, Suppository - Rectal, Tablet, extended release, Tablet, extended release - Oral, Powder - Topical, Topical
Post Partum Pain
, 50.0 mg, 75.0 mg, 200.0 mg, 100.0 mg, 150.0 mg, 0.05 mg/mg, 25.0 mg, 3.35 mg/mg, 0.5525 mg/mg
, Oral, Capsule, Capsule - Oral, Capsule, extended release, Capsule, extended release - Oral, Kit, Tablet - Oral, Tablet, Tablet, delayed release, Tablet, delayed release - Oral, Rectal, Suppository, Suppository - Rectal, Tablet, extended release, Tablet, extended release - Oral, Powder - Topical, Topical
Migraine
, 50.0 mg, 75.0 mg, 200.0 mg, 100.0 mg, 150.0 mg, 0.05 mg/mg, 25.0 mg, 3.35 mg/mg, 0.5525 mg/mg
, Oral, Capsule, Capsule - Oral, Capsule, extended release, Capsule, extended release - Oral, Kit, Tablet - Oral, Tablet, Tablet, delayed release, Tablet, delayed release - Oral, Rectal, Suppository, Suppository - Rectal, Tablet, extended release, Tablet, extended release - Oral, Powder - Topical, Topical
prophylaxis of migraine headaches
, 50.0 mg, 75.0 mg, 200.0 mg, 100.0 mg, 150.0 mg, 0.05 mg/mg, 25.0 mg, 3.35 mg/mg, 0.5525 mg/mg
, Oral, Capsule, Capsule - Oral, Capsule, extended release, Capsule, extended release - Oral, Kit, Tablet - Oral, Tablet, Tablet, delayed release, Tablet, delayed release - Oral, Rectal, Suppository, Suppository - Rectal, Tablet, extended release, Tablet, extended release - Oral, Powder - Topical, Topical
Pain
, 50.0 mg, 75.0 mg, 200.0 mg, 100.0 mg, 150.0 mg, 0.05 mg/mg, 25.0 mg, 3.35 mg/mg, 0.5525 mg/mg
, Oral, Capsule, Capsule - Oral, Capsule, extended release, Capsule, extended release - Oral, Kit, Tablet - Oral, Tablet, Tablet, delayed release, Tablet, delayed release - Oral, Rectal, Suppository, Suppository - Rectal, Tablet, extended release, Tablet, extended release - Oral, Powder - Topical, Topical
Osteoarthritis (OA)
, 50.0 mg, 75.0 mg, 200.0 mg, 100.0 mg, 150.0 mg, 0.05 mg/mg, 25.0 mg, 3.35 mg/mg, 0.5525 mg/mg
, Oral, Capsule, Capsule - Oral, Capsule, extended release, Capsule, extended release - Oral, Kit, Tablet - Oral, Tablet, Tablet, delayed release, Tablet, delayed release - Oral, Rectal, Suppository, Suppository - Rectal, Tablet, extended release, Tablet, extended release - Oral, Powder - Topical, Topical
Ankylosing Spondylitis
, 50.0 mg, 75.0 mg, 200.0 mg, 100.0 mg, 150.0 mg, 0.05 mg/mg, 25.0 mg, 3.35 mg/mg, 0.5525 mg/mg
, Oral, Capsule, Capsule - Oral, Capsule, extended release, Capsule, extended release - Oral, Kit, Tablet - Oral, Tablet, Tablet, delayed release, Tablet, delayed release - Oral, Rectal, Suppository, Suppository - Rectal, Tablet, extended release, Tablet, extended release - Oral, Powder - Topical, Topical
Primary Dysmenorrhoea
, 50.0 mg, 75.0 mg, 200.0 mg, 100.0 mg, 150.0 mg, 0.05 mg/mg, 25.0 mg, 3.35 mg/mg, 0.5525 mg/mg
, Oral, Capsule, Capsule - Oral, Capsule, extended release, Capsule, extended release - Oral, Kit, Tablet - Oral, Tablet, Tablet, delayed release, Tablet, delayed release - Oral, Rectal, Suppository, Suppository - Rectal, Tablet, extended release, Tablet, extended release - Oral, Powder - Topical, Topical
Mild pain
, 50.0 mg, 75.0 mg, 200.0 mg, 100.0 mg, 150.0 mg, 0.05 mg/mg, 25.0 mg, 3.35 mg/mg, 0.5525 mg/mg
, Oral, Capsule, Capsule - Oral, Capsule, extended release, Capsule, extended release - Oral, Kit, Tablet - Oral, Tablet, Tablet, delayed release, Tablet, delayed release - Oral, Rectal, Suppository, Suppository - Rectal, Tablet, extended release, Tablet, extended release - Oral, Powder - Topical, Topical
Muscle Strain
, 50.0 mg, 75.0 mg, 200.0 mg, 100.0 mg, 150.0 mg, 0.05 mg/mg, 25.0 mg, 3.35 mg/mg, 0.5525 mg/mg
, Oral, Capsule, Capsule - Oral, Capsule, extended release, Capsule, extended release - Oral, Kit, Tablet - Oral, Tablet, Tablet, delayed release, Tablet, delayed release - Oral, Rectal, Suppository, Suppository - Rectal, Tablet, extended release, Tablet, extended release - Oral, Powder - Topical, Topical
Warnings
Oruvail ContraindicationsCondition
Risk Level
Notes
Pulse Frequency
Do Not Combine
Coronary Artery Bypass Grafting
Do Not Combine
Common Oruvail Drug Interactions
Drug Name
Risk Level
Description
Allantoin
Major
The risk or severity of adverse effects can be increased when Ketoprofen is combined with Allantoin.
Amiodarone
Major
The metabolism of Amiodarone can be decreased when combined with Ketoprofen.
Brigatinib
Major
The metabolism of Brigatinib can be decreased when combined with Ketoprofen.
Cabazitaxel
Major
The metabolism of Cabazitaxel can be decreased when combined with Ketoprofen.
Dabrafenib
Major
The metabolism of Dabrafenib can be decreased when combined with Ketoprofen.
Oruvail Toxicity & Overdose RiskThe lowest toxic dose of the drug in rats is 62.4mg/kg. Overdosing on the drug can cause drowsiness, vomiting, and abdominal pain. Side effects are usually mild and cause digestive issues such as indigestion (in 11% of cases), nausea, diarrhea, abdominal pain, constipation, and gas (in more than 3% of cases).
Oruvail Novel Uses: Which Conditions Have a Clinical Trial Featuring Oruvail?
153 active studies are investigating the potential of Oruvail to alleviate Post Partum Pain, Rheumatoid Arthritis and Ankylosing Spondylitis.Condition
Clinical Trials
Trial Phases
Migraine
51 Actively Recruiting
Not Applicable, Phase 1, Phase 2, Phase 3, Phase 4, Early Phase 1
Rheumatoid Arthritis
61 Actively Recruiting
Not Applicable, Phase 4, Phase 3, Phase 2, Phase 1
Mild pain
0 Actively Recruiting
Muscle Strain
1 Actively Recruiting
Not Applicable
Ankylosing Spondylitis
2 Actively Recruiting
Phase 3, Not Applicable
Osteoarthritis (OA)
0 Actively Recruiting
prophylaxis of migraine headaches
0 Actively Recruiting
Sprains
0 Actively Recruiting
Primary Dysmenorrhoea
2 Actively Recruiting
Phase 4, Not Applicable
Pain
0 Actively Recruiting
Postoperative Pain
21 Actively Recruiting
Phase 4, Phase 1, Not Applicable, Phase 3, Early Phase 1, Phase 2
Post Partum Pain
0 Actively Recruiting
Oruvail Reviews: What are patients saying about Oruvail?
5Patient Review
3/26/2008 For me, this medication is nothing short of miraculous - it quickly takes away the pain and keeps it at bay for a significant amount of time.
5Patient Review
6/9/2008 I did experience some lower GI bleeding, but it was manageable with taking breaks from the treatment (i.e. using it for a month then taking a week off). Once-a-day usage was effective, especially if taken at bedtime to best manage morning pain and stiffness.
5Patient Review
9/16/2013 This medication is more effective than anything else I've tried, both prescribed and over the counter. If I miss a dose, the pain comes back after a few hours, but it lasts for 24 hrs if taken on time.
5Patient Review
7/3/2016 I really rely on this medication to get me through the day.
Patient Q&A Section about oruvail
These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.Does ketoprofen make you sleepy?
"The following effects may occur: an upset stomach, constipation, diarrhea, dizziness, lightheadedness, drowsiness, loss of appetite, or headache. If any of these persist or worsen, tell your doctor or pharmacist."
Answered by AI
What is oruvail used for?
"Oruvail Capsules can be used to relieve swelling, pain, heat, redness, and stiffness in joints and muscles associated with rheumatoid arthritis and osteoarthritis."
Answered by AI
Is ketoprofen same as ibuprofen?
"Our previous meta-analysis showed that ketoprofen is better than ibuprofen and/or diclofenac in relieving different types of moderate to severe pain, including rheumatic disorders."
Answered by AI
How long does it take for oruvail to work?
"For certain conditions (such as arthritis), it is common for it to take up to 2 weeks of taking this drug regularly until the full benefit is achieved. If you notice your condition worsens or if your pain is not relieved, be sure to tell your doctor."
Answered by AI