Orphenadrine Citrate

Muscle Pain, Bursitis, Pain + 17 more
Treatment
6 FDA approvals
20 Active Studies for Orphenadrine Citrate

What is Orphenadrine Citrate

OrphenadrineThe Generic name of this drug
Treatment SummaryCaffeine is a drug used to treat various conditions, such as respiratory issues in premature newborns, pain relief, and drowsiness. It is similar in chemical structure to Theophylline and Theobromine and can be sourced from coffee beans, teas, and cacao beans. Caffeine is also found in a variety of cosmetic products and can be taken orally, through inhalation, or via injection. In 1999, the FDA approved the use of caffeine citrate injection to treat apnea of the premature newborn. Caffeine helps to prevent and treat apnea and bronchopulmonary dysplasia
Norflexis the brand name
image of different drug pills on a surface
Orphenadrine Citrate Overview & Background
Brand Name
Generic Name
First FDA Approval
How many FDA approvals?
Norflex
Orphenadrine
1959
68

Approved as Treatment by the FDA

Orphenadrine, otherwise called Norflex, is approved by the FDA for 6 uses which include Rest and Muscle Spasms .
Rest
Used to treat Rest in combination with Acetylsalicylic acid
Muscle Spasms
Musculoskeletal Diseases
Used to treat mild Musculoskeletal Disorder in combination with Acetylsalicylic acid
Musculoskeletal Diseases
Used to treat moderate Musculoskeletal Disorder in combination with Acetylsalicylic acid
other pain relief measures
Used to treat other pain relief measures in combination with Acetylsalicylic acid
Physical Therapy
Used to treat Physical Therapy in combination with Acetylsalicylic acid

Effectiveness

How Orphenadrine Citrate Affects PatientsCaffeine wakes up the brain and body, making you more alert and often resulting in feeling jittery. It can also help relax muscles, make the heart beat faster, and improve athletic performance. Caffeine also increases the production of stomach acid and helps speed up digestive activities. It is often used in combination with pain relievers to help with migraine and other types of headaches. As a bonus, caffeine can act as a mild diuretic.
How Orphenadrine Citrate works in the bodyCaffeine affects many parts of the body. It works by blocking certain enzymes and molecules, which can help keep you awake, increase your alertness, and stimulate your heart and blood vessels. In the cells, it helps regulate calcium and lipolysis, which is the breakdown of fat. In the respiratory system, it increases your breathing rate and helps you take in oxygen more efficiently. In the central nervous system, it blocks receptors that promote drowsiness. In the kidneys, it causes you to urinate more frequently. Finally, in the cardiovascular system, it causes blood vessels to relax, increases blood flow, and can raise your

When to interrupt dosage

The prescribed dosage of Orphenadrine Citrate is conditioned by the evaluated disorder, such as Overdose, Drug, Catarrh and Athletic Performance. The measure of dosage can be located in the below table, contingent on the delivery modality (e.g. Tablet or Tablet - Oral).
Condition
Dosage
Administration
Pain
30.0 mg/mL, , 100.0 mg, 50.0 mg, 25.0 mg, 60.0 mg/mL
, Intramuscular; Intravenous, Injection, Injection - Intramuscular; Intravenous, Oral, Tablet, extended release, Tablet, extended release - Oral, Tablet, multilayer, Tablet, multilayer - Oral, Injection, solution, Injection, solution - Intramuscular; Intravenous, Tablet, Tablet - Oral, Liquid, Liquid - Intramuscular; Intravenous
other pain relief measures
30.0 mg/mL, , 100.0 mg, 50.0 mg, 25.0 mg, 60.0 mg/mL
, Intramuscular; Intravenous, Injection, Injection - Intramuscular; Intravenous, Oral, Tablet, extended release, Tablet, extended release - Oral, Tablet, multilayer, Tablet, multilayer - Oral, Injection, solution, Injection, solution - Intramuscular; Intravenous, Tablet, Tablet - Oral, Liquid, Liquid - Intramuscular; Intravenous
Traumatic Injuries
30.0 mg/mL, , 100.0 mg, 50.0 mg, 25.0 mg, 60.0 mg/mL
, Intramuscular; Intravenous, Injection, Injection - Intramuscular; Intravenous, Oral, Tablet, extended release, Tablet, extended release - Oral, Tablet, multilayer, Tablet, multilayer - Oral, Injection, solution, Injection, solution - Intramuscular; Intravenous, Tablet, Tablet - Oral, Liquid, Liquid - Intramuscular; Intravenous
Muscle Strain
30.0 mg/mL, , 100.0 mg, 50.0 mg, 25.0 mg, 60.0 mg/mL
, Intramuscular; Intravenous, Injection, Injection - Intramuscular; Intravenous, Oral, Tablet, extended release, Tablet, extended release - Oral, Tablet, multilayer, Tablet, multilayer - Oral, Injection, solution, Injection, solution - Intramuscular; Intravenous, Tablet, Tablet - Oral, Liquid, Liquid - Intramuscular; Intravenous
Rheumatism
30.0 mg/mL, , 100.0 mg, 50.0 mg, 25.0 mg, 60.0 mg/mL
, Intramuscular; Intravenous, Injection, Injection - Intramuscular; Intravenous, Oral, Tablet, extended release, Tablet, extended release - Oral, Tablet, multilayer, Tablet, multilayer - Oral, Injection, solution, Injection, solution - Intramuscular; Intravenous, Tablet, Tablet - Oral, Liquid, Liquid - Intramuscular; Intravenous
Rest
30.0 mg/mL, , 100.0 mg, 50.0 mg, 25.0 mg, 60.0 mg/mL
, Intramuscular; Intravenous, Injection, Injection - Intramuscular; Intravenous, Oral, Tablet, extended release, Tablet, extended release - Oral, Tablet, multilayer, Tablet, multilayer - Oral, Injection, solution, Injection, solution - Intramuscular; Intravenous, Tablet, Tablet - Oral, Liquid, Liquid - Intramuscular; Intravenous
Muscle Pain
30.0 mg/mL, , 100.0 mg, 50.0 mg, 25.0 mg, 60.0 mg/mL
, Intramuscular; Intravenous, Injection, Injection - Intramuscular; Intravenous, Oral, Tablet, extended release, Tablet, extended release - Oral, Tablet, multilayer, Tablet, multilayer - Oral, Injection, solution, Injection, solution - Intramuscular; Intravenous, Tablet, Tablet - Oral, Liquid, Liquid - Intramuscular; Intravenous
Pain
30.0 mg/mL, , 100.0 mg, 50.0 mg, 25.0 mg, 60.0 mg/mL
, Intramuscular; Intravenous, Injection, Injection - Intramuscular; Intravenous, Oral, Tablet, extended release, Tablet, extended release - Oral, Tablet, multilayer, Tablet, multilayer - Oral, Injection, solution, Injection, solution - Intramuscular; Intravenous, Tablet, Tablet - Oral, Liquid, Liquid - Intramuscular; Intravenous
Bursitis
30.0 mg/mL, , 100.0 mg, 50.0 mg, 25.0 mg, 60.0 mg/mL
, Intramuscular; Intravenous, Injection, Injection - Intramuscular; Intravenous, Oral, Tablet, extended release, Tablet, extended release - Oral, Tablet, multilayer, Tablet, multilayer - Oral, Injection, solution, Injection, solution - Intramuscular; Intravenous, Tablet, Tablet - Oral, Liquid, Liquid - Intramuscular; Intravenous
Musculoskeletal Diseases
30.0 mg/mL, , 100.0 mg, 50.0 mg, 25.0 mg, 60.0 mg/mL
, Intramuscular; Intravenous, Injection, Injection - Intramuscular; Intravenous, Oral, Tablet, extended release, Tablet, extended release - Oral, Tablet, multilayer, Tablet, multilayer - Oral, Injection, solution, Injection, solution - Intramuscular; Intravenous, Tablet, Tablet - Oral, Liquid, Liquid - Intramuscular; Intravenous
Fever
30.0 mg/mL, , 100.0 mg, 50.0 mg, 25.0 mg, 60.0 mg/mL
, Intramuscular; Intravenous, Injection, Injection - Intramuscular; Intravenous, Oral, Tablet, extended release, Tablet, extended release - Oral, Tablet, multilayer, Tablet, multilayer - Oral, Injection, solution, Injection, solution - Intramuscular; Intravenous, Tablet, Tablet - Oral, Liquid, Liquid - Intramuscular; Intravenous
Menstrual Distress (Dysmenorrhea)
30.0 mg/mL, , 100.0 mg, 50.0 mg, 25.0 mg, 60.0 mg/mL
, Intramuscular; Intravenous, Injection, Injection - Intramuscular; Intravenous, Oral, Tablet, extended release, Tablet, extended release - Oral, Tablet, multilayer, Tablet, multilayer - Oral, Injection, solution, Injection, solution - Intramuscular; Intravenous, Tablet, Tablet - Oral, Liquid, Liquid - Intramuscular; Intravenous
Muscle Spasms
30.0 mg/mL, , 100.0 mg, 50.0 mg, 25.0 mg, 60.0 mg/mL
, Intramuscular; Intravenous, Injection, Injection - Intramuscular; Intravenous, Oral, Tablet, extended release, Tablet, extended release - Oral, Tablet, multilayer, Tablet, multilayer - Oral, Injection, solution, Injection, solution - Intramuscular; Intravenous, Tablet, Tablet - Oral, Liquid, Liquid - Intramuscular; Intravenous
Physical Therapy
30.0 mg/mL, , 100.0 mg, 50.0 mg, 25.0 mg, 60.0 mg/mL
, Intramuscular; Intravenous, Injection, Injection - Intramuscular; Intravenous, Oral, Tablet, extended release, Tablet, extended release - Oral, Tablet, multilayer, Tablet, multilayer - Oral, Injection, solution, Injection, solution - Intramuscular; Intravenous, Tablet, Tablet - Oral, Liquid, Liquid - Intramuscular; Intravenous
Inflammation
30.0 mg/mL, , 100.0 mg, 50.0 mg, 25.0 mg, 60.0 mg/mL
, Intramuscular; Intravenous, Injection, Injection - Intramuscular; Intravenous, Oral, Tablet, extended release, Tablet, extended release - Oral, Tablet, multilayer, Tablet, multilayer - Oral, Injection, solution, Injection, solution - Intramuscular; Intravenous, Tablet, Tablet - Oral, Liquid, Liquid - Intramuscular; Intravenous
Musculoskeletal Diseases
30.0 mg/mL, , 100.0 mg, 50.0 mg, 25.0 mg, 60.0 mg/mL
, Intramuscular; Intravenous, Injection, Injection - Intramuscular; Intravenous, Oral, Tablet, extended release, Tablet, extended release - Oral, Tablet, multilayer, Tablet, multilayer - Oral, Injection, solution, Injection, solution - Intramuscular; Intravenous, Tablet, Tablet - Oral, Liquid, Liquid - Intramuscular; Intravenous
Sprains
30.0 mg/mL, , 100.0 mg, 50.0 mg, 25.0 mg, 60.0 mg/mL
, Intramuscular; Intravenous, Injection, Injection - Intramuscular; Intravenous, Oral, Tablet, extended release, Tablet, extended release - Oral, Tablet, multilayer, Tablet, multilayer - Oral, Injection, solution, Injection, solution - Intramuscular; Intravenous, Tablet, Tablet - Oral, Liquid, Liquid - Intramuscular; Intravenous
Back Pain Lower Back
30.0 mg/mL, , 100.0 mg, 50.0 mg, 25.0 mg, 60.0 mg/mL
, Intramuscular; Intravenous, Injection, Injection - Intramuscular; Intravenous, Oral, Tablet, extended release, Tablet, extended release - Oral, Tablet, multilayer, Tablet, multilayer - Oral, Injection, solution, Injection, solution - Intramuscular; Intravenous, Tablet, Tablet - Oral, Liquid, Liquid - Intramuscular; Intravenous
Mild pain
30.0 mg/mL, , 100.0 mg, 50.0 mg, 25.0 mg, 60.0 mg/mL
, Intramuscular; Intravenous, Injection, Injection - Intramuscular; Intravenous, Oral, Tablet, extended release, Tablet, extended release - Oral, Tablet, multilayer, Tablet, multilayer - Oral, Injection, solution, Injection, solution - Intramuscular; Intravenous, Tablet, Tablet - Oral, Liquid, Liquid - Intramuscular; Intravenous
Musculoskeletal Diseases
30.0 mg/mL, , 100.0 mg, 50.0 mg, 25.0 mg, 60.0 mg/mL
, Intramuscular; Intravenous, Injection, Injection - Intramuscular; Intravenous, Oral, Tablet, extended release, Tablet, extended release - Oral, Tablet, multilayer, Tablet, multilayer - Oral, Injection, solution, Injection, solution - Intramuscular; Intravenous, Tablet, Tablet - Oral, Liquid, Liquid - Intramuscular; Intravenous

Warnings

Orphenadrine Citrate Contraindications
Condition
Risk Level
Notes
Prostatic Hypertrophy
Do Not Combine
Peptic Ulcer
Do Not Combine
Duodenal Obstruction
Do Not Combine
Achalasia, Esophageal
Do Not Combine
pyloric obstruction
Do Not Combine
Open-angle glaucoma
Do Not Combine
Bladder Neck Obstruction
Do Not Combine
Myasthenia Gravis
Do Not Combine
There are 20 known major drug interactions with Orphenadrine Citrate.
Common Orphenadrine Citrate Drug Interactions
Drug Name
Risk Level
Description
Abemaciclib
Major
The metabolism of Abemaciclib can be decreased when combined with Orphenadrine.
Acalabrutinib
Major
The metabolism of Acalabrutinib can be decreased when combined with Orphenadrine.
Acebutolol
Major
The metabolism of Acebutolol can be decreased when combined with Orphenadrine.
Aclidinium
Major
The risk or severity of adverse effects can be increased when Orphenadrine is combined with Aclidinium.
Alectinib
Major
The metabolism of Alectinib can be decreased when combined with Orphenadrine.
Orphenadrine Citrate Toxicity & Overdose RiskConsuming too much caffeine can be dangerous. In rats, the toxic dose of caffeine is 192mg/kg. In humans, an overdose is considered to be around 10-14 grams (roughly 150-200mg/kg of body weight). Symptoms of overdose may include nausea, vomiting, diarrhea, restlessness, insomnia, heart palpitations, anxiety, and agitation. More severe symptoms such as seizures, psychomotor agitation, and death are possible depending on the amount of caffeine consumed. To treat a mild caffeine overdose, symptomatic treatment should be provided. In severe cases, emergency treatment such as intubation, activated charcoal
image of a doctor in a lab doing drug, clinical research

Orphenadrine Citrate Novel Uses: Which Conditions Have a Clinical Trial Featuring Orphenadrine Citrate?

429 active trials are investigating the potential of Orphenadrine Citrate to combat Chronic Fatigue Syndrome, Chronic Pain and Migraine.
Condition
Clinical Trials
Trial Phases
Sprains
0 Actively Recruiting
Musculoskeletal Diseases
4 Actively Recruiting
Phase 1, Phase 2, Not Applicable
Muscle Pain
8 Actively Recruiting
Not Applicable, Phase 2, Phase 4, Phase 1, Early Phase 1
Mild pain
0 Actively Recruiting
Bursitis
6 Actively Recruiting
Phase 4, Not Applicable
Pain
0 Actively Recruiting
Physical Therapy
7 Actively Recruiting
Not Applicable
Inflammation
0 Actively Recruiting
Rheumatism
0 Actively Recruiting
Muscle Spasms
0 Actively Recruiting
Musculoskeletal Diseases
0 Actively Recruiting
Menstrual Distress (Dysmenorrhea)
1 Actively Recruiting
Phase 4
Musculoskeletal Diseases
0 Actively Recruiting
Pain
0 Actively Recruiting
Traumatic Injuries
6 Actively Recruiting
Phase 3, Not Applicable
Muscle Strain
1 Actively Recruiting
Not Applicable
Rest
0 Actively Recruiting
Back Pain Lower Back
5 Actively Recruiting
Not Applicable, Phase 4
other pain relief measures
0 Actively Recruiting
Fever
18 Actively Recruiting
Phase 3, Phase 4, Phase 2, Phase 1, Not Applicable

Orphenadrine Citrate Reviews: What are patients saying about Orphenadrine Citrate?

5Patient Review
7/21/2014
Orphenadrine Citrate for Muscle Spasm
After my third surgery on my left foot, I experienced some very intense muscle spasms.
5Patient Review
4/9/2016
Orphenadrine Citrate for Muscle Spasm
I was dealing with a really bad spasm in my rhomboid muscle and this treatment completely relieved it.
4.3Patient Review
7/14/2013
Orphenadrine Citrate for Muscle Spasm
This medication effectively alleviated my back muscle spasms; however, I began experiencing anxiety attacks and vivid dreams.
4.3Patient Review
11/2/2013
Orphenadrine Citrate for Muscle Spasm
While this treatment didn't exactly relieve my spasms as I'd hoped, it did help me avoid having to take painkillers.
4.3Patient Review
10/1/2012
Orphenadrine Citrate for Muscle Spasm
4Patient Review
5/12/2014
Orphenadrine Citrate for Muscle Spasm
I really appreciate how this product is not invasive.
3.7Patient Review
1/3/2013
Orphenadrine Citrate for Muscle Spasm
3.7Patient Review
6/28/2013
Orphenadrine Citrate for Muscle Spasm
3.3Patient Review
2/9/2013
Orphenadrine Citrate for Muscle Spasm
3.3Patient Review
5/11/2013
Orphenadrine Citrate for Muscle Spasm
3Patient Review
5/18/2012
Orphenadrine Citrate for Muscle Spasm
2.7Patient Review
5/5/2016
Orphenadrine Citrate for Muscle Spasm
I experienced muscle spasms in my neck and left arm.
2.3Patient Review
1/22/2013
Orphenadrine Citrate for Muscle Spasm
2Patient Review
7/31/2013
Orphenadrine Citrate for Muscle Spasm
I was prescribed this medication for back strain, but saw no relief even after taking the full course. Additionally, the naproxen and norco made me nauseous.
1Patient Review
1/11/2020
Orphenadrine Citrate for Muscle Spasm
Unfortunately, this drug has made my anxiety worse and caused restless legs syndrome. On top of that, it's actually increased the pain I was already experiencing.
image of drug pills surrounding a glass of water symbolizing drug consumption

Patient Q&A Section about orphenadrine citrate

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

Does orphenadrine make you sleep?

"Some of the dosage forms listed on this page may not apply to the brand name Orphenadrine..

Orphenadrine may cause drowsiness as well as other side effects. Some of the listed dosage forms may not apply to the brand name Orphenadrine."

Answered by AI

What is orphenadrine citrate used for?

"Orphenadrine is a medication used to help relax muscles and relieve stiffness, pain, and discomfort caused by strains, sprains, or other injuries. One form of orphenadrine is also used to relieve trembling caused by Parkinson's disease."

Answered by AI

What is orphenadrine side effect?

"The following side effects may occur: dry mouth, dizziness, drowsiness, lightheadedness, blurred vision, nausea, vomiting, and constipation. If you experience any of these effects for an extended period of time, or if they worsen, contact your doctor or pharmacist."

Answered by AI

Is orphenadrine citrate a painkiller?

"Norgesic consists of a muscle relaxant, a pain reliever, and caffeine. It is usually used in conjunction with rest and physical therapy to treat injuries and other painful muscular conditions. Caffeine increases the pain relieving effects of the other drugs."

Answered by AI

Clinical Trials for Orphenadrine Citrate

Have you considered Orphenadrine Citrate clinical trials? We made a collection of clinical trials featuring Orphenadrine Citrate, we think they might fit your search criteria.
Have you considered Orphenadrine Citrate clinical trials? We made a collection of clinical trials featuring Orphenadrine Citrate, we think they might fit your search criteria.
Have you considered Orphenadrine Citrate clinical trials? We made a collection of clinical trials featuring Orphenadrine Citrate, we think they might fit your search criteria.