<p>Kenacort 0.1% Oral Paste helps to reduce <a href="https://www.withpower.com/clinical-trials/pain">pain</a> and inflammation by blocking chemicals in the brain. This makes it easier to carry out daily activities.</p>

Oralone

Macular Edema, Stomatitis, Denture, Ophthalmia, Sympathetic + 113 more

Treatment

16 FDA approvals

20 Active Studies for Oralone

Treatment for

Macular Edema

What is Oralone

Triamcinolone

The Generic name of this drug

Treatment Summary

Triamcinolone is a steroid medication used to reduce inflammation in the body and treat a range of conditions from allergies to multiple sclerosis. It is available in several forms and can be used to treat osteoarthritis knee pain, some skin conditions, and macular edema associated with uveitis. Triamcinolone was approved by the FDA in 1957 and a suspension form was approved in 2021 for suprachoroidal injection.

Aristocort

is the brand name

image of different drug pills on a surface

Oralone Overview & Background

Brand Name

Generic Name

First FDA Approval

How many FDA approvals?

Aristocort

Triamcinolone

1961

532

Approved as Treatment by the FDA

Triamcinolone, also called Aristocort, is approved by the FDA for 16 uses which include Lichen Planus and Ganglia .

Lichen Planus

Helps manage Lichen Planus (LP)

Ganglia

Helps manage cystic tumour of the ganglia

Granuloma Annulare

Helps manage granuloma annulare lesions

Psoriasis

Helps manage Psoriatic plaque

Neurodermatitis

Helps manage Lichen simplex chronicus

Lupus Erythematosus, Discoid

Helps manage Discoid Lupus Erythematosus (DLE)

granuloma annulare lesions

Helps manage granuloma annulare lesions

cystic tumour of the ganglia

Helps manage cystic tumour of the ganglia

Lichen simplex chronicus

Helps manage Lichen simplex chronicus

Lichen Planus (LP)

Helps manage Lichen Planus (LP)

Discoid Lupus Erythematosus (DLE)

Helps manage Discoid Lupus Erythematosus (DLE)

Alopecia Areata (AA)

Helps manage Alopecia Areata (AA)

Keloids Scars

Helps manage Keloids Scars

Necrobiosis Lipoidica

Helps manage Necrobiosis lipoidica diabeticorum

Alopecia Areata

Helps manage Alopecia Areata (AA)

Psoriatic plaque

Helps manage Psoriatic plaque

Effectiveness

How Oralone Affects Patients

Triamcinolone is a type of medicine that reduces inflammation and can be used to treat conditions that affect different parts of the body. Triamcinolone should not be injected directly into the spine.

How Oralone works in the body

Triamcinolone is a type of corticosteroid that works to reduce inflammation. It does this by preventing cells from breaking down lysosomal membranes, which stops arachidonic acid from forming. This prevents the production of prostaglandins and leukotrienes, which are known to cause inflammation. Triamcinolone also helps by preventing the dilation and increased permeability of blood vessels, which stops macrophages and leukocytes from entering the area. Finally, it reduces the production of pro-inflammatory signals such as interleukin-6, interleukin-8,

When to interrupt dosage

The measure of Oralone is dependent upon the determined affliction, like Mycosis Fungoides (MF), Mycoses and Alopecia Areata (AA). The dosage varies depending on the technique of delivery (e.g. Ointment or Injection, suspension - Intralesional; Parenteral) recorded in the table below.

Condition

Dosage

Administration

Atopic Dermatitis

, 40.0 mg/mL, 10.0 mg/mL, 0.055 mg, 0.001 mg/mg, 0.25 mg/mL, 1.0 mg/mL, 0.0005 mg/mg, 0.00025 mg/mg, 0.005 mg/mg, 5.0 mg/mL, 20.0 mg/mL, 0.000147 mg/mg, 0.5 mg/mL, 40.0 mg, 1.0 mg, 0.000025 mg/mg, 0.1 %, 0.025 %, 5.0 mg, 0.25 mg, 2.0 mg, 4.0 mg, 0.5 %, 15.0 mg/mL, 6.5 mg, 80.0 mg/mL, 0.075 mg, 200.0 mg/mL, 32.0 mg, 0.055 mg/dose, 0.5 mg, 0.2 mg/pump actuation, 0.1 mg/dose, 25.0 mg/mL, 0.055 mg/pump actuation, 2.0 mg/mL, 0.4 mg/mL

Injection, suspension, Intra-articular; Intramuscular, Injection, suspension - Intra-articular; Intramuscular, , Injection, suspension - Intra-articular; Intralesional, Intra-articular; Intralesional, Spray, metered, Nasal, Spray, metered - Nasal, Cream - Topical, Topical, Ointment - Topical, Lotion - Topical, Lotion, Cream, Ointment, Injection, suspension - Intralesional; Parenteral, Intra-articular; Parenteral, Injection, suspension - Intra-articular; Parenteral, Intralesional; Parenteral, Intra-articular; Intrabursal; Intradermal; Intralesional, Injection, suspension - Intra-articular; Intrabursal; Intradermal; Intralesional, Aerosol, spray, Aerosol, spray - Topical, Paste - Topical, Paste, Intramuscular, Injection, suspension - Intramuscular, Paste - Dental, Dental, Suspension - Intra-articular; Intramuscular, Suspension - Intra-articular; Intrabursal; Intradermal; Intrasynovial, Suspension, Suspension - Intra-articular; Intrabursal; Intramuscular, Intra-articular; Intrabursal; Intramuscular, Intralesional, Suspension - Intralesional, Tablet, Tablet - Oral, Oral, Intra-articular; Intramuscular; Intrasynovial, Liquid - Intra-articular; Intramuscular; Intrasynovial, Intra-articular; Intradermal; Intramuscular, Syrup - Oral, Syrup, Suspension - Intramuscular, Liquid, Liquid - Intra-articular; Intradermal; Intramuscular, Kit, Intra-articular; Intradermal; Intralesional; Intramuscular, Suspension - Intra-articular; Intradermal; Intralesional; Intramuscular, Spray, suspension - Nasal, Injection, solution, Injection, solution - Intra-articular; Intramuscular, Kit - Epidural; Infiltration; Intra-articular; Intramuscular; Topical, Epidural; Infiltration; Intra-articular; Intramuscular; Topical, Ophthalmic, Injection, suspension - Ophthalmic, Suspension - Intravitreal, Intravitreal, Suspension - Intra-articular, Intra-articular, Spray - Topical, Spray, Intra-articular; Intrasynovial; Periarticular, Suspension - Intra-articular; Intrasynovial; Periarticular, Kit - Intra-articular; Intramuscular, Subcutaneous, Implant - Subcutaneous, Injection, suspension - Intra-articular; Intramuscular; Intravitreal, Intra-articular; Intramuscular; Intravitreal, Epidural; Infiltration; Intra-articular; Intramuscular, Intra-articular; Intrabursal; Intradermal; Intrasynovial, Aerosol, metered - Nasal, Aerosol, metered, Aerosol, metered - Respiratory (inhalation), Respiratory (inhalation), Infiltration; Intra-articular; Intramuscular; Respiratory (inhalation); Topical, Kit - Infiltration; Intra-articular; Intramuscular; Respiratory (inhalation); Topical, Suspension - Ophthalmic, Implant, Kit - Epidural; Infiltration; Intra-articular; Intramuscular, Epidural; Infiltration; Intra-articular; Intralesional, Kit - Epidural; Infiltration; Intra-articular; Intralesional, Injection, suspension - Intra-articular; Intralesional; Intramuscular; Intrasynovial; Parenteral, Intra-articular; Intralesional; Intramuscular; Intrasynovial; Parenteral, Kit - Intra-articular, Paste, dentifrice, Paste, dentifrice - Dental, Kit - Infiltration; Soft tissue; Topical, Infiltration; Soft tissue; Topical, Epidural; Intra-articular; Intramuscular; Topical, Kit - Epidural; Intra-articular; Intramuscular; Topical, Emulsion - Topical, Emulsion, Intra-articular; Intramuscular; Topical, Kit - Topical, Injection, suspension - Intra-articular, Ointment - Buccal, Buccal, Gel, Gel - Topical, Infiltration; Intra-articular; Intramuscular; Topical, Kit - Infiltration; Intra-articular; Intramuscular; Topical

Skin Diseases

Bullous dermatitis herpetiformis

Ulcerative Colitis

Lupus Erythematosus

Lichen Planus

Ankylosing Spondylitis

Keloids Scars

Gingivitis, Necrotizing Ulcerative

Hand

Secondary Immunization

Trichinosis

Ganglia

Lupus Erythematosus, Discoid

Inflammation

Multiple Sclerosis

Hives

Lupus

Intertrigo

Stomatitis, Aphthous

Warnings

Oralone has four contraindications, and thus should be avoided when confronting the conditions in the following table.

Oralone Contraindications

Condition

Risk Level

Notes

Severe Hypersensitivity Reactions

Do Not Combine

Triamcinolone may interact with Pulse Frequency

Mycoses

Do Not Combine

active periocular infections

Do Not Combine

Eye Infections

Do Not Combine

There are 20 known major drug interactions with Oralone.

Common Oralone Drug Interactions

Drug Name

Risk Level

Description

2-Methoxyethanol

Major

The risk or severity of adverse effects can be increased when Triamcinolone is combined with 2-Methoxyethanol.

9-(N-methyl-L-isoleucine)-cyclosporin A

Major

The risk or severity of adverse effects can be increased when Triamcinolone is combined with 9-(N-methyl-L-isoleucine)-cyclosporin A.

Abemaciclib

Major

The metabolism of Abemaciclib can be increased when combined with Triamcinolone.

Abetimus

Major

The risk or severity of adverse effects can be increased when Triamcinolone is combined with Abetimus.

Acalabrutinib

Major

The metabolism of Acalabrutinib can be increased when combined with Triamcinolone.

Oralone Toxicity & Overdose Risk

The toxic dose of triamcinolone acetonide in rats is 13,100µg/kg when applied subcutaneously and 1451mg/kg when taken orally. In mice, the toxic dose is 132mg/kg when applied subcutaneously and 2168mg/kg when taken orally. The toxic dose of triamcinolone acetonide in mice is 105mg/kg when applied intraperitoneally. Overdosing on triamcinolone acetonide may cause Cushing's syndrome, which can be treated with supportive therapy and a medication called mifepristone.

image of a doctor in a lab doing drug, clinical research

Oralone Novel Uses: Which Conditions Have a Clinical Trial Featuring Oralone?

1076 active studies are currently examining the potential of Oralone in alleviating Lupus, Atopic Dermatitis and Brain Metastases.

Condition

Clinical Trials

Trial Phases

Macular Edema

1 Actively Recruiting

Phase 2

Asthma

84 Actively Recruiting

Phase 1, Phase 4, Early Phase 1, Not Applicable, Phase 2, Phase 3

Anemia, Hemolytic, Autoimmune

0 Actively Recruiting

Rheumatoid Arthritis

56 Actively Recruiting

Not Applicable, Phase 3, Phase 1, Phase 2, Phase 4

Vitrectomy therapy

0 Actively Recruiting

Dermatitis, Seborrheic

0 Actively Recruiting

Crohn's Disease

52 Actively Recruiting

Phase 1, Phase 2, Not Applicable, Phase 3, Phase 4, Early Phase 1

Metastatic Brain Tumors

56 Actively Recruiting

Not Applicable, Phase 1, Phase 2, Phase 3, Early Phase 1, Phase 4

Thyroiditis

0 Actively Recruiting

Brain

0 Actively Recruiting

Stomatitis

0 Actively Recruiting

Dermatitis

0 Actively Recruiting

Tinea

0 Actively Recruiting

Conjunctivitis, Bacterial

0 Actively Recruiting

Tenosynovitis

0 Actively Recruiting

Mycoses

0 Actively Recruiting

Synovitis

1 Actively Recruiting

Phase 4

Dermatitis, Allergic Contact

0 Actively Recruiting

Keloids Scars

1 Actively Recruiting

Phase 3

Ulcer

0 Actively Recruiting

Patient Q&A Section about oralone

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

Is Oralone over the counter?

"There is no generic version of the prescription medication Oralone, which is manufactured by Taro Pharmaceutical Industries, Limited. A similar medication is Kenalog in Orabase Dental paste and triamcinolone acetonide dental paste."

Answered by AI

What is oral paste?

"Kenacort 0.1% Oral Paste helps to reduce pain and inflammation by blocking chemicals in the brain. This makes it easier to carry out daily activities."

Answered by AI

What is triamcinolone dental paste used for?

"This medication is used to treat and relieve discomfort caused by mouth sores. It works by decreasing inflammation in the mouth. It belongs to a group of medications called topical steroids. This medicine may be used for other purposes; ask your health care provider or pharmacist if you have questions."

Answered by AI

What is Oralone used for?

"This medication is used to relieve the symptoms of mouth sores that are the result of an injury. The medication is in the form of a dental paste that adheres to the inside of the mouth/cheeks/gums.It works by reducing the swelling, itching, and pain that can occur with mouth sores."

Answered by AI