Olmesartan Medoxomil

Diabetic Nephropathy, Hypertensive disease, multiple antihypertensive drugs likely required + 1 more
Treatment
2 FDA approvals
19 Active Studies for Olmesartan Medoxomil

What is Olmesartan Medoxomil

OlmesartanThe Generic name of this drug
Treatment SummaryOlmesartan is a type of drug called an angiotensin II receptor blocker (ARB). It works by blocking the action of a protein called angiotensin II which helps regulate blood pressure. Olmesartan is used to treat hypertension and can also help slow the progression of kidney damage caused by diabetes. It is usually taken orally as olmesartan medoxomil, a prodrug which is converted to the active form, olmesartan, in the body. Olmesartan was developed by Daiichi Sankyo Pharmaceuticals and approved in 2002.
Benicaris the brand name
image of different drug pills on a surface
Olmesartan Medoxomil Overview & Background
Brand Name
Generic Name
First FDA Approval
How many FDA approvals?
Benicar
Olmesartan
2002
340

Approved as Treatment by the FDA

Olmesartan, also called Benicar, is approved by the FDA for 2 uses which include Therapeutic procedure and Hypertensive disease .
Therapeutic procedure
Used to treat failed primary treatment in combination with Hydrochlorothiazide
Hypertensive disease
Used to treat High Blood Pressure (Hypertension) in combination with Hydrochlorothiazide

Effectiveness

How Olmesartan Medoxomil Affects PatientsOlmesartan works by lowering blood pressure, decreasing aldosterone levels, and helping the body get rid of salt. It may cause low blood pressure in those who are dehydrated or taking high doses of diuretics. People with aortic stenosis may be at risk of decreased blood flow to their heart. Olmesartan may also cause changes in kidney function and electrolyte imbalances. Long-term use may lead to severe, chronic diarrhea with weight loss, and it can cause villous atrophy in the intestines. Monitor electrolyte levels regularly while taking olmesartan.
How Olmesartan Medoxomil works in the bodyOlmesartan belongs to a group of drugs called angiotensin receptor blockers (ARBs). These drugs block a protein called angiotensin II from binding to the angiotensin receptor 1 (AT1) in your blood vessels. This helps reduce blood pressure, lower aldosterone levels, reduce heart activity, and help your kidneys excrete more sodium. Olmesartan also works on the renin-angiotensin-aldosterone system (RAAS). This system helps control kidney, vascular, and cardiac functions. By blocking the RAAS, it can help protect the heart from malfunctioning and improve

When to interrupt dosage

The proposed dosage of Olmesartan Medoxomil relies upon the diagnosed circumstance, including Diabetic Nephropathy, Hypertensive malady and Therapeutic procedure. The measure of dosage fluctuates as per the technique of delivery (e.g. Oral or Tablet, film coated) specified in the table underneath.
Condition
Dosage
Administration
Therapeutic procedure
40.0 mg, , 20.0 mg, 5.0 mg, 10.0 mg
, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral, Tablet, coated, Tablet, coated - Oral
Diabetic Nephropathy
40.0 mg, , 20.0 mg, 5.0 mg, 10.0 mg
, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral, Tablet, coated, Tablet, coated - Oral
multiple antihypertensive drugs likely required
40.0 mg, , 20.0 mg, 5.0 mg, 10.0 mg
, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral, Tablet, coated, Tablet, coated - Oral
Hypertensive disease
40.0 mg, , 20.0 mg, 5.0 mg, 10.0 mg
, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral, Tablet, coated, Tablet, coated - Oral

Warnings

Olmesartan Medoxomil has a single contraindication and should not be ingested if you are afflicted with any of the conditions presented in the table below.Olmesartan Medoxomil Contraindications
Condition
Risk Level
Notes
Type 2 Diabetes
Do Not Combine
There are 20 known major drug interactions with Olmesartan Medoxomil.
Common Olmesartan Medoxomil Drug Interactions
Drug Name
Risk Level
Description
Amifostine
Major
Olmesartan may increase the hypotensive activities of Amifostine.
Lithium carbonate
Major
The serum concentration of Lithium carbonate can be increased when it is combined with Olmesartan.
Lithium citrate
Major
The serum concentration of Lithium citrate can be increased when it is combined with Olmesartan.
Lithium hydroxide
Major
The serum concentration of Lithium hydroxide can be increased when it is combined with Olmesartan.
Acebutolol
Minor
Olmesartan may increase the hypotensive activities of Acebutolol.
Olmesartan Medoxomil Toxicity & Overdose RiskTests have shown that the toxic dose of olmesartan in dogs is greater than 1500 mg/kg. Symptoms of an overdose may include low blood pressure, fast heart rate, and slow heart rate when the parasympathetic nervous system is stimulated. If someone overdoses on olmesartan, supportive care is recommended. Tests have not found any cancer-causing or fertility-related effects from taking olmesartan, however laboratory tests have shown that it may cause chromosomal abnormalities or mutations in cells.
image of a doctor in a lab doing drug, clinical research

Olmesartan Medoxomil Novel Uses: Which Conditions Have a Clinical Trial Featuring Olmesartan Medoxomil?

19 active trials are currently in progress to investigate the potential of Olmesartan Medoxomil in providing Therapeutic relief, managing Hypertension and determining when multiple antihypertensive agents are likely necessary.
Condition
Clinical Trials
Trial Phases
Hypertensive disease
18 Actively Recruiting
Not Applicable, Phase 1, Phase 2, Phase 3
Diabetic Nephropathy
1 Actively Recruiting
Phase 4
Therapeutic procedure
0 Actively Recruiting
multiple antihypertensive drugs likely required
0 Actively Recruiting

Olmesartan Medoxomil Reviews: What are patients saying about Olmesartan Medoxomil?

5Patient Review
4/19/2016
Olmesartan Medoxomil for High Blood Pressure
I had tried numerous prescription drugs to control my high blood pressure brought on by my fibromyalgia and diabetes. This is the ONLY drug that has worked for me, period. No side effects. Downside - very expensive.
5Patient Review
8/27/2016
Olmesartan Medoxomil for Diastolic Heart Failure
I didn't have any issues with this treatment.
5Patient Review
4/19/2016
Olmesartan Medoxomil for High Blood Pressure
This treatment was the only one that worked for me to control my high blood pressure. It's very expensive, but it doesn't have any side effects. The downside is that it's very expensive and my insurance wouldn't cover the dosage my doctor prescribed, so we had to come up with a plan that would be acceptable to Medicare. So far, so good.
5Patient Review
8/27/2016
Olmesartan Medoxomil for Diastolic Heart Failure
I had no issues with this treatment.
4.7Patient Review
3/26/2018
Olmesartan Medoxomil for High Blood Pressure
The only downside to this medication is that, since I've been taking it, mosquitos love me. Other than that, it's great!
4.7Patient Review
11/15/2016
Olmesartan Medoxomil for High Blood Pressure
I've been taking this for two years now with great results. My blood pressure was 145/90 and is now 128/80. I haven't experienced any negative side effects that I know of.
4.7Patient Review
11/15/2016
Olmesartan Medoxomil for High Blood Pressure
I've been taking benicar for a few years now and it's really helped to lower my blood pressure. I'm 51 years old, and have had no negative side effects that I know of.
4.7Patient Review
3/26/2018
Olmesartan Medoxomil for High Blood Pressure
The only downside to this medication is that, since I've been taking it, mosquitos are really drawn to me. It's quite frustrating because I get bitten way more than anyone else does.
4Patient Review
3/19/2019
Olmesartan Medoxomil for High Blood Pressure
I've been on Benicar Hctz for a long time, and it suddenly started making me feel dizzy. My doctor took me off of it and just put me on regular Benicar. I'm starting tomorrow and hoping for the best.
4Patient Review
3/19/2019
Olmesartan Medoxomil for High Blood Pressure
I've been taking Benicar for over a decade and it's helped me immensely. Recently, I started getting dizzy so my doctor took me off of the medication. I'm starting back on it tomorrow sans Hctz to see how that goes.
3.7Patient Review
1/3/2019
Olmesartan Medoxomil for High Blood Pressure
I'm experiencing a lot of negative side effects from this drug that are really impacting my quality of life. I'm hoping to be able to change or discontinue the medication soon.
3.7Patient Review
1/3/2019
Olmesartan Medoxomil for High Blood Pressure
I'm hoping to get off this drug because it's causing me a lot of problems like acid reflux, stomach swelling, pain in my joints and tendons, fatigue, and weight gain. The only plus is that it controls my blood pressure.
3.3Patient Review
11/20/2015
Olmesartan Medoxomil for High Blood Pressure
While Benicar does help to control my blood pressure better than other medications, it has caused me a great deal of dehydration and higher creatinine levels. I also sweat profusely from even small amounts of work, which is extremely inconvenient.
3.3Patient Review
5/12/2016
Olmesartan Medoxomil for High Blood Pressure
I had heartburn within moments of taking this medication, and it also really messed with my bowel movements. The worst part, by far, was the constant heartburn. I stopped taking it as a result.
3.3Patient Review
11/20/2015
Olmesartan Medoxomil for High Blood Pressure
Even though Benicar has controlled my blood pressure better than some other medications I've tried, I have had many problems with dehydration and higher than normal creatinine levels. I have terrible head sweating when doing even small amounts of work. Doing any work at all results in sopping wet hair.
3.3Patient Review
5/12/2016
Olmesartan Medoxomil for High Blood Pressure
I got heartburn as soon as I took this medication, and it also really messed up my bowel movements. The constant heartburn was the worst part, so I stopped taking it.
2.3Patient Review
12/21/2015
Olmesartan Medoxomil for High Blood Pressure
I found that there were too many negative side effects to justify taking this medication long-term. It did help keep my blood pressure down, but not enough to make up for everything else.
2.3Patient Review
12/21/2015
Olmesartan Medoxomil for High Blood Pressure
I saw too many negative long-term changes as a result of taking this medication. It did help to lower my blood pressure, but not without some serious trade-offs that I wasn't willing to make.
2.3Patient Review
8/28/2016
Olmesartan Medoxomil for High Blood Pressure
I cannot recommend this drug, as it has the potential to be deadly. I don't understand why it's still on the market, given that there are over 1200 pending lawsuits against the company.
2.3Patient Review
8/28/2016
Olmesartan Medoxomil for High Blood Pressure
I would not recommend this drug to anyone. There are a lot of pending lawsuits against the company for deaths allegedly caused by this medication, which is inexcusable.
2Patient Review
11/22/2015
Olmesartan Medoxomil for High Blood Pressure
Terrible side effects. I experienced severe migraines and the worst back pain I've ever felt between my shoulders. My whole body felt like it was being crushed. Do not take this medicine.
2Patient Review
11/22/2015
Olmesartan Medoxomil for High Blood Pressure
Really not worth it. The migraines and back pain were unbearable, plus all the other cold symptoms. And on top of that, it makes your urine smell weird. So tired all the time too.
1.7Patient Review
8/8/2018
Olmesartan Medoxomil for High Blood Pressure
I found that this drug caused me to lose some of my memories. I would forget numbers that I had known for years, and I had to start looking them up in the phone book. Once I stopped taking the medication, my memory came back.
1.7Patient Review
2/17/2016
Olmesartan Medoxomil for High Blood Pressure
I didn't have a good experience with this medication. I felt incredibly tense and edgy, like all my muscles had been overworked. It also wasn't very effective at controlling my blood pressure.
1.7Patient Review
2/17/2016
Olmesartan Medoxomil for High Blood Pressure
I found this medication to be incredibly ineffective and, frankly, dangerous. My blood pressure readings were all over the place while I was on it, and I felt awful – like my muscles had been worked to exhaustion. If you're considering this treatment, I would urge you to look elsewhere.
1.7Patient Review
8/8/2018
Olmesartan Medoxomil for High Blood Pressure
I experienced memory loss while taking this drug. I went from being able to recite telephone numbers that I had known for years to having to look them up in the directory. Once I stopped taking the drug, my memory came back.
image of drug pills surrounding a glass of water symbolizing drug consumption

Patient Q&A Section about olmesartan medoxomil

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

What is the difference between olmesartan and olmesartan medoxomil?

"The discontinuation of olmesartan has resulted in an improvement of symptoms in all patients that were taking the medication for sprue-like enteropathy. Olmesartan medoxomil is a drug that is approved to treat high blood pressure, either by itself or with other medications. It is one of eight similar drugs that are currently on the market."

Answered by AI

How long does it take for olmesartan medoxomil to work?

"They usually start working within 1-2 hours and their effects usually last all day with one dose."

Answered by AI

What are the side effects of olmesartan medoxomil?

"If you are feeling dizzy or tired, have a headache, flu-like symptoms, a runny or stuffy nose, a cough, or bronchitis, you may have COVID-19. You may also have pain in your back, bones, or joints; feel sick (nausea) or have indigestion; have a stomach ache; or diarrhoea. Other symptoms include swollen feet, ankles, legs, or hands (oedema), or a urinary tract infection (UTI)."

Answered by AI

What is olmesartan medoxomil used for?

"Olmesartan is used by itself or with other medications to manage high blood pressure (hypertension). High blood pressure puts added strain on the heart and arteries. If it continues for a long time, it can damage the heart and arteries so they don't function properly."

Answered by AI

Clinical Trials for Olmesartan Medoxomil

Have you considered Olmesartan Medoxomil clinical trials? We made a collection of clinical trials featuring Olmesartan Medoxomil, we think they might fit your search criteria.
Have you considered Olmesartan Medoxomil clinical trials? We made a collection of clinical trials featuring Olmesartan Medoxomil, we think they might fit your search criteria.
Have you considered Olmesartan Medoxomil clinical trials? We made a collection of clinical trials featuring Olmesartan Medoxomil, we think they might fit your search criteria.