Olmesartan Medoxomil

Diabetic Nephropathies, Hypertensive disease, multiple antihypertensive drugs likely required + 1 more
Treatment
2 FDA approvals
20 Active Studies for Olmesartan Medoxomil

What is Olmesartan Medoxomil

OlmesartanThe Generic name of this drug
Treatment SummaryOlmesartan is a type of drug called an angiotensin II receptor blocker (ARB). It works by blocking the action of a protein called angiotensin II which helps regulate blood pressure. Olmesartan is used to treat hypertension and can also help slow the progression of kidney damage caused by diabetes. It is usually taken orally as olmesartan medoxomil, a prodrug which is converted to the active form, olmesartan, in the body. Olmesartan was developed by Daiichi Sankyo Pharmaceuticals and approved in 2002.
Benicaris the brand name
image of different drug pills on a surface
Olmesartan Medoxomil Overview & Background
Brand Name
Generic Name
First FDA Approval
How many FDA approvals?
Benicar
Olmesartan
2002
340

Approved as Treatment by the FDA

Olmesartan, also called Benicar, is approved by the FDA for 2 uses which include Therapeutic procedure and Hypertensive disease .
Therapeutic procedure
Used to treat failed primary treatment in combination with Hydrochlorothiazide
Hypertensive disease
Used to treat High Blood Pressure (Hypertension) in combination with Hydrochlorothiazide

Effectiveness

How Olmesartan Medoxomil Affects PatientsOlmesartan works by lowering blood pressure, decreasing aldosterone levels, and helping the body get rid of salt. It may cause low blood pressure in those who are dehydrated or taking high doses of diuretics. People with aortic stenosis may be at risk of decreased blood flow to their heart. Olmesartan may also cause changes in kidney function and electrolyte imbalances. Long-term use may lead to severe, chronic diarrhea with weight loss, and it can cause villous atrophy in the intestines. Monitor electrolyte levels regularly while taking olmesartan.
How Olmesartan Medoxomil works in the bodyOlmesartan belongs to a group of drugs called angiotensin receptor blockers (ARBs). These drugs block a protein called angiotensin II from binding to the angiotensin receptor 1 (AT1) in your blood vessels. This helps reduce blood pressure, lower aldosterone levels, reduce heart activity, and help your kidneys excrete more sodium. Olmesartan also works on the renin-angiotensin-aldosterone system (RAAS). This system helps control kidney, vascular, and cardiac functions. By blocking the RAAS, it can help protect the heart from malfunctioning and improve

When to interrupt dosage

The proposed dosage of Olmesartan Medoxomil relies upon the diagnosed circumstance, including Diabetic Nephropathy, Hypertensive malady and Therapeutic procedure. The measure of dosage fluctuates as per the technique of delivery (e.g. Oral or Tablet, film coated) specified in the table underneath.
Condition
Dosage
Administration
Diabetic Nephropathies
40.0 mg, , 20.0 mg, 5.0 mg, 10.0 mg
, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral, Tablet, coated, Tablet, coated - Oral
Hypertensive disease
40.0 mg, , 20.0 mg, 5.0 mg, 10.0 mg
, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral, Tablet, coated, Tablet, coated - Oral
multiple antihypertensive drugs likely required
40.0 mg, , 20.0 mg, 5.0 mg, 10.0 mg
, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral, Tablet, coated, Tablet, coated - Oral
Therapeutic procedure
40.0 mg, , 20.0 mg, 5.0 mg, 10.0 mg
, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral, Tablet, coated, Tablet, coated - Oral

Warnings

Olmesartan Medoxomil has a single contraindication and should not be ingested if you are afflicted with any of the conditions presented in the table below.Olmesartan Medoxomil Contraindications
Condition
Risk Level
Notes
Type 2 Diabetes
Do Not Combine
There are 20 known major drug interactions with Olmesartan Medoxomil.
Common Olmesartan Medoxomil Drug Interactions
Drug Name
Risk Level
Description
Amifostine
Major
Olmesartan may increase the hypotensive activities of Amifostine.
Lithium carbonate
Major
The serum concentration of Lithium carbonate can be increased when it is combined with Olmesartan.
Lithium citrate
Major
The serum concentration of Lithium citrate can be increased when it is combined with Olmesartan.
Lithium hydroxide
Major
The serum concentration of Lithium hydroxide can be increased when it is combined with Olmesartan.
Acebutolol
Minor
Olmesartan may increase the hypotensive activities of Acebutolol.
Olmesartan Medoxomil Toxicity & Overdose RiskTests have shown that the toxic dose of olmesartan in dogs is greater than 1500 mg/kg. Symptoms of an overdose may include low blood pressure, fast heart rate, and slow heart rate when the parasympathetic nervous system is stimulated. If someone overdoses on olmesartan, supportive care is recommended. Tests have not found any cancer-causing or fertility-related effects from taking olmesartan, however laboratory tests have shown that it may cause chromosomal abnormalities or mutations in cells.
image of a doctor in a lab doing drug, clinical research

Olmesartan Medoxomil Novel Uses: Which Conditions Have a Clinical Trial Featuring Olmesartan Medoxomil?

19 active trials are currently in progress to investigate the potential of Olmesartan Medoxomil in providing Therapeutic relief, managing Hypertension and determining when multiple antihypertensive agents are likely necessary.
Condition
Clinical Trials
Trial Phases
Hypertensive disease
23 Actively Recruiting
Not Applicable, Phase 1, Phase 2, Phase 3
Diabetic Nephropathies
0 Actively Recruiting
Therapeutic procedure
0 Actively Recruiting
multiple antihypertensive drugs likely required
0 Actively Recruiting

Olmesartan Medoxomil Reviews: What are patients saying about Olmesartan Medoxomil?

5Patient Review
4/19/2016
Olmesartan Medoxomil for High Blood Pressure
I had tried numerous prescription drugs to control my high blood pressure brought on by my fibromyalgia and diabetes. This is the ONLY drug that has worked for me, period. No side effects. Downside - very expensive.
5Patient Review
8/27/2016
Olmesartan Medoxomil for Diastolic Heart Failure
I didn't have any issues with this treatment.
5Patient Review
4/19/2016
Olmesartan Medoxomil for High Blood Pressure
This treatment was the only one that worked for me to control my high blood pressure. It's very expensive, but it doesn't have any side effects. The downside is that it's very expensive and my insurance wouldn't cover the dosage my doctor prescribed, so we had to come up with a plan that would be acceptable to Medicare. So far, so good.
5Patient Review
8/27/2016
Olmesartan Medoxomil for Diastolic Heart Failure
I had no issues with this treatment.
4.7Patient Review
3/26/2018
Olmesartan Medoxomil for High Blood Pressure
The only downside to this medication is that, since I've been taking it, mosquitos love me. Other than that, it's great!
View All Reviews
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Patient Q&A Section about olmesartan medoxomil

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

What is the difference between olmesartan and olmesartan medoxomil?

"The discontinuation of olmesartan has resulted in an improvement of symptoms in all patients that were taking the medication for sprue-like enteropathy. Olmesartan medoxomil is a drug that is approved to treat high blood pressure, either by itself or with other medications. It is one of eight similar drugs that are currently on the market."

Answered by AI

How long does it take for olmesartan medoxomil to work?

"They usually start working within 1-2 hours and their effects usually last all day with one dose."

Answered by AI

What are the side effects of olmesartan medoxomil?

"If you are feeling dizzy or tired, have a headache, flu-like symptoms, a runny or stuffy nose, a cough, or bronchitis, you may have COVID-19. You may also have pain in your back, bones, or joints; feel sick (nausea) or have indigestion; have a stomach ache; or diarrhoea. Other symptoms include swollen feet, ankles, legs, or hands (oedema), or a urinary tract infection (UTI)."

Answered by AI

What is olmesartan medoxomil used for?

"Olmesartan is used by itself or with other medications to manage high blood pressure (hypertension). High blood pressure puts added strain on the heart and arteries. If it continues for a long time, it can damage the heart and arteries so they don't function properly."

Answered by AI

Clinical Trials for Olmesartan Medoxomil

Have you considered Olmesartan Medoxomil clinical trials? We made a collection of clinical trials featuring Olmesartan Medoxomil, we think they might fit your search criteria.
Have you considered Olmesartan Medoxomil clinical trials? We made a collection of clinical trials featuring Olmesartan Medoxomil, we think they might fit your search criteria.
Have you considered Olmesartan Medoxomil clinical trials? We made a collection of clinical trials featuring Olmesartan Medoxomil, we think they might fit your search criteria.