Olanzapine

Delirium, Delusional Parasitosis, Schizophrenia + 11 more
Treatment
4 FDA approvals
20 Active Studies for Olanzapine

What is Olanzapine

OlanzapineThe Generic name of this drug
Treatment SummaryOlanzapine is an atypical antipsychotic medication that was developed in the 1990s and is used to treat mental health conditions. This drug is similar to clozapine but has two additional methyl groups and does not contain a chloride moiety. Olanzapine was approved by the U.S. Food and Drug Administration in 1996 and is known for its effectiveness and reduced risk of side effects compared to other antipsychotic medications.
Zyprexais the brand name
image of different drug pills on a surface
Olanzapine Overview & Background
Brand Name
Generic Name
First FDA Approval
How many FDA approvals?
Zyprexa
Olanzapine
1996
546

Approved as Treatment by the FDA

Olanzapine, otherwise known as Zyprexa, is approved by the FDA for 4 uses which include Unipolar Depression and Bipolar Disorder .
Unipolar Depression
Used to treat Major depressive disorder, recurrent episode in combination with Fluoxetine
Bipolar Disorder
Used to treat Bipolar Disorder With Manic or Mixed Episodes in combination with Lithium cation
Mental Depression
Used to treat Acute Depressive Episode in combination with Fluoxetine
Bipolar Disorder
Used to treat Bipolar 1 Disorder in combination with Fluoxetine

Effectiveness

How Olanzapine Affects PatientsOlanzapine is used to reduce the symptoms of schizophrenia and bipolar disorder in adults, and manic or mixed episodes in adolescents. It works by targeting certain receptors in the brain like the dopamine D2 receptor and serotonin 5HT2A receptor. This helps to reduce hallucinations, delusions, disorganized speech, disorganized thought, disorganized behavior, anhedonia, flat affect, alogia, avolition and poor attention. Olanzapine may also be used to reduce chemotherapy-induced nausea and vomiting as it has been found to be effective in providing complete response on the delay phase in 84% of individuals and control of emesis
How Olanzapine works in the bodyOlanzapine works by blocking several different types of receptors in the brain. It blocks dopamine receptors, serotonin receptors, adrenergic receptors, histamine receptors, and muscarinic receptors. Out of these, blocking the dopamine receptors in the mesolimbic pathway is the most important action. Olanzapine also blocks serotonin 5HT2A receptors in the frontal cortex, which reduces the severity of side effects.

When to interrupt dosage

The encouraged dosage of Olanzapine is contingent upon the identified condition, such as Schizophrenia, Bipolar Disorder and Delirium. The measure of dosage changes, in accordance with the method of delivery (e.g. Kit - Intramuscular or Tablet, film coated - Oral) noted in the table beneath.
Condition
Dosage
Administration
Delirium
2.5 mg, , 5.0 mg, 20.0 mg, 15.0 mg, 10.0 mg, 10.0 mg/mL, 7.5 mg, 3.0 mg, 6.0 mg, 12.0 mg, 210.0 mg, 300.0 mg, 405.0 mg, 405.0 mg/mL, 300.0 mg/mL, 210.0 mg/mL
, Oral, Tablet, film coated, Tablet, film coated - Oral, Injection, powder, for solution, Intramuscular, Injection, powder, for solution - Intramuscular, Tablet - Oral, Tablet, Capsule, Capsule - Oral, Tablet, orally disintegrating, Tablet, orally disintegrating - Oral, Injection, powder, lyophilized, for solution, Injection, powder, lyophilized, for solution - Intramuscular, Powder, for solution, Powder, for solution - Intramuscular, Tablet, coated, Tablet, coated - Oral, Injection, powder, for suspension, extended release, Injection, powder, for suspension, extended release - Intramuscular, Kit - Intramuscular, Kit
Schizophrenia
2.5 mg, , 5.0 mg, 20.0 mg, 15.0 mg, 10.0 mg, 10.0 mg/mL, 7.5 mg, 3.0 mg, 6.0 mg, 12.0 mg, 210.0 mg, 300.0 mg, 405.0 mg, 405.0 mg/mL, 300.0 mg/mL, 210.0 mg/mL
, Oral, Tablet, film coated, Tablet, film coated - Oral, Injection, powder, for solution, Intramuscular, Injection, powder, for solution - Intramuscular, Tablet - Oral, Tablet, Capsule, Capsule - Oral, Tablet, orally disintegrating, Tablet, orally disintegrating - Oral, Injection, powder, lyophilized, for solution, Injection, powder, lyophilized, for solution - Intramuscular, Powder, for solution, Powder, for solution - Intramuscular, Tablet, coated, Tablet, coated - Oral, Injection, powder, for suspension, extended release, Injection, powder, for suspension, extended release - Intramuscular, Kit - Intramuscular, Kit
Schizophrenia
2.5 mg, , 5.0 mg, 20.0 mg, 15.0 mg, 10.0 mg, 10.0 mg/mL, 7.5 mg, 3.0 mg, 6.0 mg, 12.0 mg, 210.0 mg, 300.0 mg, 405.0 mg, 405.0 mg/mL, 300.0 mg/mL, 210.0 mg/mL
, Oral, Tablet, film coated, Tablet, film coated - Oral, Injection, powder, for solution, Intramuscular, Injection, powder, for solution - Intramuscular, Tablet - Oral, Tablet, Capsule, Capsule - Oral, Tablet, orally disintegrating, Tablet, orally disintegrating - Oral, Injection, powder, lyophilized, for solution, Injection, powder, lyophilized, for solution - Intramuscular, Powder, for solution, Powder, for solution - Intramuscular, Tablet, coated, Tablet, coated - Oral, Injection, powder, for suspension, extended release, Injection, powder, for suspension, extended release - Intramuscular, Kit - Intramuscular, Kit
Alzheimer's Disease
2.5 mg, , 5.0 mg, 20.0 mg, 15.0 mg, 10.0 mg, 10.0 mg/mL, 7.5 mg, 3.0 mg, 6.0 mg, 12.0 mg, 210.0 mg, 300.0 mg, 405.0 mg, 405.0 mg/mL, 300.0 mg/mL, 210.0 mg/mL
, Oral, Tablet, film coated, Tablet, film coated - Oral, Injection, powder, for solution, Intramuscular, Injection, powder, for solution - Intramuscular, Tablet - Oral, Tablet, Capsule, Capsule - Oral, Tablet, orally disintegrating, Tablet, orally disintegrating - Oral, Injection, powder, lyophilized, for solution, Injection, powder, lyophilized, for solution - Intramuscular, Powder, for solution, Powder, for solution - Intramuscular, Tablet, coated, Tablet, coated - Oral, Injection, powder, for suspension, extended release, Injection, powder, for suspension, extended release - Intramuscular, Kit - Intramuscular, Kit
Delusional Parasitosis
2.5 mg, , 5.0 mg, 20.0 mg, 15.0 mg, 10.0 mg, 10.0 mg/mL, 7.5 mg, 3.0 mg, 6.0 mg, 12.0 mg, 210.0 mg, 300.0 mg, 405.0 mg, 405.0 mg/mL, 300.0 mg/mL, 210.0 mg/mL
, Oral, Tablet, film coated, Tablet, film coated - Oral, Injection, powder, for solution, Intramuscular, Injection, powder, for solution - Intramuscular, Tablet - Oral, Tablet, Capsule, Capsule - Oral, Tablet, orally disintegrating, Tablet, orally disintegrating - Oral, Injection, powder, lyophilized, for solution, Injection, powder, lyophilized, for solution - Intramuscular, Powder, for solution, Powder, for solution - Intramuscular, Tablet, coated, Tablet, coated - Oral, Injection, powder, for suspension, extended release, Injection, powder, for suspension, extended release - Intramuscular, Kit - Intramuscular, Kit
Bipolar Disorder
2.5 mg, , 5.0 mg, 20.0 mg, 15.0 mg, 10.0 mg, 10.0 mg/mL, 7.5 mg, 3.0 mg, 6.0 mg, 12.0 mg, 210.0 mg, 300.0 mg, 405.0 mg, 405.0 mg/mL, 300.0 mg/mL, 210.0 mg/mL
, Oral, Tablet, film coated, Tablet, film coated - Oral, Injection, powder, for solution, Intramuscular, Injection, powder, for solution - Intramuscular, Tablet - Oral, Tablet, Capsule, Capsule - Oral, Tablet, orally disintegrating, Tablet, orally disintegrating - Oral, Injection, powder, lyophilized, for solution, Injection, powder, lyophilized, for solution - Intramuscular, Powder, for solution, Powder, for solution - Intramuscular, Tablet, coated, Tablet, coated - Oral, Injection, powder, for suspension, extended release, Injection, powder, for suspension, extended release - Intramuscular, Kit - Intramuscular, Kit
Unipolar Depression
2.5 mg, , 5.0 mg, 20.0 mg, 15.0 mg, 10.0 mg, 10.0 mg/mL, 7.5 mg, 3.0 mg, 6.0 mg, 12.0 mg, 210.0 mg, 300.0 mg, 405.0 mg, 405.0 mg/mL, 300.0 mg/mL, 210.0 mg/mL
, Oral, Tablet, film coated, Tablet, film coated - Oral, Injection, powder, for solution, Intramuscular, Injection, powder, for solution - Intramuscular, Tablet - Oral, Tablet, Capsule, Capsule - Oral, Tablet, orally disintegrating, Tablet, orally disintegrating - Oral, Injection, powder, lyophilized, for solution, Injection, powder, lyophilized, for solution - Intramuscular, Powder, for solution, Powder, for solution - Intramuscular, Tablet, coated, Tablet, coated - Oral, Injection, powder, for suspension, extended release, Injection, powder, for suspension, extended release - Intramuscular, Kit - Intramuscular, Kit
Bipolar Disorder
2.5 mg, , 5.0 mg, 20.0 mg, 15.0 mg, 10.0 mg, 10.0 mg/mL, 7.5 mg, 3.0 mg, 6.0 mg, 12.0 mg, 210.0 mg, 300.0 mg, 405.0 mg, 405.0 mg/mL, 300.0 mg/mL, 210.0 mg/mL
, Oral, Tablet, film coated, Tablet, film coated - Oral, Injection, powder, for solution, Intramuscular, Injection, powder, for solution - Intramuscular, Tablet - Oral, Tablet, Capsule, Capsule - Oral, Tablet, orally disintegrating, Tablet, orally disintegrating - Oral, Injection, powder, lyophilized, for solution, Injection, powder, lyophilized, for solution - Intramuscular, Powder, for solution, Powder, for solution - Intramuscular, Tablet, coated, Tablet, coated - Oral, Injection, powder, for suspension, extended release, Injection, powder, for suspension, extended release - Intramuscular, Kit - Intramuscular, Kit
Post Traumatic Stress Disorder
2.5 mg, , 5.0 mg, 20.0 mg, 15.0 mg, 10.0 mg, 10.0 mg/mL, 7.5 mg, 3.0 mg, 6.0 mg, 12.0 mg, 210.0 mg, 300.0 mg, 405.0 mg, 405.0 mg/mL, 300.0 mg/mL, 210.0 mg/mL
, Oral, Tablet, film coated, Tablet, film coated - Oral, Injection, powder, for solution, Intramuscular, Injection, powder, for solution - Intramuscular, Tablet - Oral, Tablet, Capsule, Capsule - Oral, Tablet, orally disintegrating, Tablet, orally disintegrating - Oral, Injection, powder, lyophilized, for solution, Injection, powder, lyophilized, for solution - Intramuscular, Powder, for solution, Powder, for solution - Intramuscular, Tablet, coated, Tablet, coated - Oral, Injection, powder, for suspension, extended release, Injection, powder, for suspension, extended release - Intramuscular, Kit - Intramuscular, Kit
Acute Agitation
2.5 mg, , 5.0 mg, 20.0 mg, 15.0 mg, 10.0 mg, 10.0 mg/mL, 7.5 mg, 3.0 mg, 6.0 mg, 12.0 mg, 210.0 mg, 300.0 mg, 405.0 mg, 405.0 mg/mL, 300.0 mg/mL, 210.0 mg/mL
, Oral, Tablet, film coated, Tablet, film coated - Oral, Injection, powder, for solution, Intramuscular, Injection, powder, for solution - Intramuscular, Tablet - Oral, Tablet, Capsule, Capsule - Oral, Tablet, orally disintegrating, Tablet, orally disintegrating - Oral, Injection, powder, lyophilized, for solution, Injection, powder, lyophilized, for solution - Intramuscular, Powder, for solution, Powder, for solution - Intramuscular, Tablet, coated, Tablet, coated - Oral, Injection, powder, for suspension, extended release, Injection, powder, for suspension, extended release - Intramuscular, Kit - Intramuscular, Kit
Mental Depression
2.5 mg, , 5.0 mg, 20.0 mg, 15.0 mg, 10.0 mg, 10.0 mg/mL, 7.5 mg, 3.0 mg, 6.0 mg, 12.0 mg, 210.0 mg, 300.0 mg, 405.0 mg, 405.0 mg/mL, 300.0 mg/mL, 210.0 mg/mL
, Oral, Tablet, film coated, Tablet, film coated - Oral, Injection, powder, for solution, Intramuscular, Injection, powder, for solution - Intramuscular, Tablet - Oral, Tablet, Capsule, Capsule - Oral, Tablet, orally disintegrating, Tablet, orally disintegrating - Oral, Injection, powder, lyophilized, for solution, Injection, powder, lyophilized, for solution - Intramuscular, Powder, for solution, Powder, for solution - Intramuscular, Tablet, coated, Tablet, coated - Oral, Injection, powder, for suspension, extended release, Injection, powder, for suspension, extended release - Intramuscular, Kit - Intramuscular, Kit
Acute Coryza
2.5 mg, , 5.0 mg, 20.0 mg, 15.0 mg, 10.0 mg, 10.0 mg/mL, 7.5 mg, 3.0 mg, 6.0 mg, 12.0 mg, 210.0 mg, 300.0 mg, 405.0 mg, 405.0 mg/mL, 300.0 mg/mL, 210.0 mg/mL
, Oral, Tablet, film coated, Tablet, film coated - Oral, Injection, powder, for solution, Intramuscular, Injection, powder, for solution - Intramuscular, Tablet - Oral, Tablet, Capsule, Capsule - Oral, Tablet, orally disintegrating, Tablet, orally disintegrating - Oral, Injection, powder, lyophilized, for solution, Injection, powder, lyophilized, for solution - Intramuscular, Powder, for solution, Powder, for solution - Intramuscular, Tablet, coated, Tablet, coated - Oral, Injection, powder, for suspension, extended release, Injection, powder, for suspension, extended release - Intramuscular, Kit - Intramuscular, Kit
Bipolar Disorder
2.5 mg, , 5.0 mg, 20.0 mg, 15.0 mg, 10.0 mg, 10.0 mg/mL, 7.5 mg, 3.0 mg, 6.0 mg, 12.0 mg, 210.0 mg, 300.0 mg, 405.0 mg, 405.0 mg/mL, 300.0 mg/mL, 210.0 mg/mL
, Oral, Tablet, film coated, Tablet, film coated - Oral, Injection, powder, for solution, Intramuscular, Injection, powder, for solution - Intramuscular, Tablet - Oral, Tablet, Capsule, Capsule - Oral, Tablet, orally disintegrating, Tablet, orally disintegrating - Oral, Injection, powder, lyophilized, for solution, Injection, powder, lyophilized, for solution - Intramuscular, Powder, for solution, Powder, for solution - Intramuscular, Tablet, coated, Tablet, coated - Oral, Injection, powder, for suspension, extended release, Injection, powder, for suspension, extended release - Intramuscular, Kit - Intramuscular, Kit
Gilles de la Tourette's Syndrome
2.5 mg, , 5.0 mg, 20.0 mg, 15.0 mg, 10.0 mg, 10.0 mg/mL, 7.5 mg, 3.0 mg, 6.0 mg, 12.0 mg, 210.0 mg, 300.0 mg, 405.0 mg, 405.0 mg/mL, 300.0 mg/mL, 210.0 mg/mL
, Oral, Tablet, film coated, Tablet, film coated - Oral, Injection, powder, for solution, Intramuscular, Injection, powder, for solution - Intramuscular, Tablet - Oral, Tablet, Capsule, Capsule - Oral, Tablet, orally disintegrating, Tablet, orally disintegrating - Oral, Injection, powder, lyophilized, for solution, Injection, powder, lyophilized, for solution - Intramuscular, Powder, for solution, Powder, for solution - Intramuscular, Tablet, coated, Tablet, coated - Oral, Injection, powder, for suspension, extended release, Injection, powder, for suspension, extended release - Intramuscular, Kit - Intramuscular, Kit

Warnings

There are 20 known major drug interactions with Olanzapine.
Common Olanzapine Drug Interactions
Drug Name
Risk Level
Description
Acenocoumarol
Major
The metabolism of Acenocoumarol can be decreased when combined with Olanzapine.
Acepromazine
Major
Olanzapine may increase the orthostatic hypotensive, hypotensive, and antihypertensive activities of Acepromazine.
Aclidinium
Major
The risk or severity of adverse effects can be increased when Olanzapine is combined with Aclidinium.
Alfuzosin
Major
Olanzapine may increase the hypotensive activities of Alfuzosin.
Amisulpride
Major
Olanzapine may increase the antipsychotic activities of Amisulpride.
Olanzapine Toxicity & Overdose RiskTaking too much olanzapine can cause drowsiness, dilated pupils, difficulty breathing, low blood pressure, involuntary muscle movement, and other anticholinergic effects. In some cases, people have experienced agitation, slurred speech, rapid heartbeat, reduced consciousness, and even death after taking more than 300 mg. If someone takes too much olanzapine, they should be given oxygen, have their stomach emptied, and be given activated charcoal with a laxative. Long-term use of olanzapine has been linked to increased risk of liver and breast tumors and fertility problems in males.
image of a doctor in a lab doing drug, clinical research

Olanzapine Novel Uses: Which Conditions Have a Clinical Trial Featuring Olanzapine?

Presently, 578 active clinical trials are assessing the potential of Olanzapine to remediate Schizophrenia, Post Traumatic Stress Disorder and Delusional Parasitosis.
Condition
Clinical Trials
Trial Phases
Bipolar Disorder
0 Actively Recruiting
Schizophrenia
174 Actively Recruiting
Not Applicable, Phase 3, Phase 2, Early Phase 1, Phase 4, Phase 1
Bipolar Disorder
0 Actively Recruiting
Post Traumatic Stress Disorder
252 Actively Recruiting
Phase 4, Phase 1, Not Applicable, Early Phase 1, Phase 2, Phase 3
Mental Depression
3 Actively Recruiting
Not Applicable
Unipolar Depression
52 Actively Recruiting
Not Applicable, Phase 4, Early Phase 1, Phase 2, Phase 3, Phase 1
Gilles de la Tourette's Syndrome
0 Actively Recruiting
Delusional Parasitosis
0 Actively Recruiting
Delirium
51 Actively Recruiting
Phase 2, Not Applicable, Phase 3, Phase 4, Phase 1, Early Phase 1
Acute Coryza
1 Actively Recruiting
Not Applicable
Acute Agitation
0 Actively Recruiting
Alzheimer's Disease
41 Actively Recruiting
Phase 2, Phase 3, Phase 4, Not Applicable, Phase 1
Schizophrenia
35 Actively Recruiting
Early Phase 1, Not Applicable, Phase 4
Bipolar Disorder
1 Actively Recruiting
Phase 4

Olanzapine Reviews: What are patients saying about Olanzapine?

5Patient Review
2/16/2021
Olanzapine for Schizophrenia
Zyprexa has been a game-changer for me. I've been on it since 2000 and it's helped me immensely. I'm employed, living a good life, and generally happy. If you're struggling, I believe this medication can help certain people. There's hope out there!
5Patient Review
5/21/2022
Olanzapine for Bipolar Disorder in Remission
As a 16 year old girl who has been taking this medication since she was 5, I can say with certainty that it is incredibly effective in treating bipolar disorder and anger management. I take 20 mg.
3.3Patient Review
9/10/2022
Olanzapine for Bipolar Disorder in Remission
Olanzipine is effective, but it can cause weight gain and increased appetite at night. I struggled with my weight for a while after starting this medication, but have managed to get it under control by exercising regularly. If you don't want to deal with potential weight gain, I suggest looking into other medications.
2.7Patient Review
8/7/2022
Olanzapine for Mental Disorder with Loss of Normal Personality & Reality
I gained a lot of weight when taking this medicine and it made me really tired and grouchy. I'm glad I found an alternative a few weeks ago that's helped me lose some weight.
1Patient Review
10/15/2022
Olanzapine for Manic-Depression
At first, this medication prescribed to me for mania (5mg) was effective. However, it made me very drowsy and I experienced a lot of side effects like weight gain (I went from 78kg to 115kg), almost becoming prediabetic.
image of drug pills surrounding a glass of water symbolizing drug consumption

Patient Q&A Section about olanzapine

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

Is olanzapine a powerful drug?

"In conclusion, olanzapine may be a more efficacious drug than some other second-generation antipsychotic drugs. However, this small superiority in efficacy needs to be weighed against the risk of larger weight gain and associated metabolic problems than most other second-generation antipsychotic drugs, except clozapine."

Answered by AI

What are the side effects to olanzapine?

"If you experience any of the following symptoms, you should speak with a doctor: dizziness, feeling unsteady, difficulty keeping your balance, restlessness, unusual behavior, depression, difficulty falling asleep or staying asleep, weakness, difficulty walking, constipation."

Answered by AI

Can olanzapine be used for anxiety?

"Olanzapine is often prescribed to target multiple symptoms at once, as it is effective in treating nausea, delirium, anxiety, insomnia, and cachexia. However, it is important to note that olanzapine is a second-generation atypical antipsychotic and as such, palliative care clinicians should be aware of potential side effects."

Answered by AI

What is olanzapine is used for?

"Olanzapine can help relieve symptoms for people with mental health conditions such as schizophrenia and bipolar disorder. These symptoms can include seeing or hearing things that others do not, feeling unusually suspicious, having muddled thoughts, feeling agitated or hyperactive, being very excited or impulsive."

Answered by AI

Clinical Trials for Olanzapine

Have you considered Olanzapine clinical trials? We made a collection of clinical trials featuring Olanzapine, we think they might fit your search criteria.
Have you considered Olanzapine clinical trials? We made a collection of clinical trials featuring Olanzapine, we think they might fit your search criteria.
Have you considered Olanzapine clinical trials? We made a collection of clinical trials featuring Olanzapine, we think they might fit your search criteria.