Ocuflox

Corneal Ulcer, Gonorrhea, Urinary Tract Infection (UTI) + 17 more

Treatment

1 FDA approval

20 Active Studies for Ocuflox

Treatment for

Corneal Ulcer

What is Ocuflox

OfloxacinThe Generic name of this drug

Treatment SummaryA synthetic fluoroquinolone is an antibiotic that works by stopping bacteria from replicating their DNA. This prevents the bacteria from reproducing and spreading, allowing the body to fight the infection.

Floxinis the brand name

Ocuflox Overview & Background

Brand Name

Generic Name

First FDA Approval

How many FDA approvals?

Floxin

Ofloxacin

1990

148

Approved as Treatment by the FDA

Ofloxacin, also called Floxin, is approved by the FDA for 1 uses which include Urinary Tract Infection (UTI) .

Urinary Tract Infection (UTI)

Effectiveness

How Ocuflox Affects PatientsOfloxacin is an antibiotic that works by stopping bacteria from copying their DNA. It attaches to an enzyme called DNA gyrase, which is needed for bacteria to reproduce, and is 100 times more powerful on bacterial DNA than on human DNA. Ofloxacin is effective against both Gram-positive and Gram-negative bacteria.

How Ocuflox works in the bodyOfloxacin interferes with the enzymes responsible for keeping DNA from becoming too tightly wound during replication. This prevents cells from dividing normally and helps to kill bacteria.

When to interrupt dosage

The quantity of Ocuflox is contingent upon the diagnosed condition, for instance Urethritis, Cervicitis and Urinary Tract Infection (UTI). The measure of dosage fluctuates as per the approach of delivery (e.g. Oral or Solution) illustrated in the table below.

Condition

Dosage

Administration

Acute Coryza

, 20.0 mg/mL, 3.0 mg/mL, 200.0 mg, 400.0 mg, 300.0 mg, 0.3 %, 600.0 mg

Oral, Solution, Tablet, , Tablet - Oral, Tablet, coated, Solution - Auricular (otic), Ophthalmic, Tablet, coated - Oral, Solution - Ophthalmic, Solution / drops - Ophthalmic, Intravenous, Tablet, film coated, Solution / drops, Liquid, Tablet, film coated - Oral, Liquid - Intravenous, Auricular (otic), Solution / drops - Auricular (otic)

Otitis Media

, 20.0 mg/mL, 3.0 mg/mL, 200.0 mg, 400.0 mg, 300.0 mg, 0.3 %, 600.0 mg

Oral, Solution, Tablet, , Tablet - Oral, Tablet, coated, Solution - Auricular (otic), Ophthalmic, Tablet, coated - Oral, Solution - Ophthalmic, Solution / drops - Ophthalmic, Intravenous, Tablet, film coated, Solution / drops, Liquid, Tablet, film coated - Oral, Liquid - Intravenous, Auricular (otic), Solution / drops - Auricular (otic)

Cervicitis

, 20.0 mg/mL, 3.0 mg/mL, 200.0 mg, 400.0 mg, 300.0 mg, 0.3 %, 600.0 mg

Oral, Solution, Tablet, , Tablet - Oral, Tablet, coated, Solution - Auricular (otic), Ophthalmic, Tablet, coated - Oral, Solution - Ophthalmic, Solution / drops - Ophthalmic, Intravenous, Tablet, film coated, Solution / drops, Liquid, Tablet, film coated - Oral, Liquid - Intravenous, Auricular (otic), Solution / drops - Auricular (otic)

Epididymitis

, 20.0 mg/mL, 3.0 mg/mL, 200.0 mg, 400.0 mg, 300.0 mg, 0.3 %, 600.0 mg

Oral, Solution, Tablet, , Tablet - Oral, Tablet, coated, Solution - Auricular (otic), Ophthalmic, Tablet, coated - Oral, Solution - Ophthalmic, Solution / drops - Ophthalmic, Intravenous, Tablet, film coated, Solution / drops, Liquid, Tablet, film coated - Oral, Liquid - Intravenous, Auricular (otic), Solution / drops - Auricular (otic)

Spontaneous Bacterial Peritonitis (SBP)

, 20.0 mg/mL, 3.0 mg/mL, 200.0 mg, 400.0 mg, 300.0 mg, 0.3 %, 600.0 mg

Oral, Solution, Tablet, , Tablet - Oral, Tablet, coated, Solution - Auricular (otic), Ophthalmic, Tablet, coated - Oral, Solution - Ophthalmic, Solution / drops - Ophthalmic, Intravenous, Tablet, film coated, Solution / drops, Liquid, Tablet, film coated - Oral, Liquid - Intravenous, Auricular (otic), Solution / drops - Auricular (otic)

Corneal Ulcer

, 20.0 mg/mL, 3.0 mg/mL, 200.0 mg, 400.0 mg, 300.0 mg, 0.3 %, 600.0 mg

Oral, Solution, Tablet, , Tablet - Oral, Tablet, coated, Solution - Auricular (otic), Ophthalmic, Tablet, coated - Oral, Solution - Ophthalmic, Solution / drops - Ophthalmic, Intravenous, Tablet, film coated, Solution / drops, Liquid, Tablet, film coated - Oral, Liquid - Intravenous, Auricular (otic), Solution / drops - Auricular (otic)

Acute Bacterial Exacerbation of Chronic Bronchitis (ABECB)

, 20.0 mg/mL, 3.0 mg/mL, 200.0 mg, 400.0 mg, 300.0 mg, 0.3 %, 600.0 mg

Oral, Solution, Tablet, , Tablet - Oral, Tablet, coated, Solution - Auricular (otic), Ophthalmic, Tablet, coated - Oral, Solution - Ophthalmic, Solution / drops - Ophthalmic, Intravenous, Tablet, film coated, Solution / drops, Liquid, Tablet, film coated - Oral, Liquid - Intravenous, Auricular (otic), Solution / drops - Auricular (otic)

Gonorrhea

, 20.0 mg/mL, 3.0 mg/mL, 200.0 mg, 400.0 mg, 300.0 mg, 0.3 %, 600.0 mg

Oral, Solution, Tablet, , Tablet - Oral, Tablet, coated, Solution - Auricular (otic), Ophthalmic, Tablet, coated - Oral, Solution - Ophthalmic, Solution / drops - Ophthalmic, Intravenous, Tablet, film coated, Solution / drops, Liquid, Tablet, film coated - Oral, Liquid - Intravenous, Auricular (otic), Solution / drops - Auricular (otic)

Urinary Tract Infection (UTI)

, 20.0 mg/mL, 3.0 mg/mL, 200.0 mg, 400.0 mg, 300.0 mg, 0.3 %, 600.0 mg

Oral, Solution, Tablet, , Tablet - Oral, Tablet, coated, Solution - Auricular (otic), Ophthalmic, Tablet, coated - Oral, Solution - Ophthalmic, Solution / drops - Ophthalmic, Intravenous, Tablet, film coated, Solution / drops, Liquid, Tablet, film coated - Oral, Liquid - Intravenous, Auricular (otic), Solution / drops - Auricular (otic)

Urethritis

, 20.0 mg/mL, 3.0 mg/mL, 200.0 mg, 400.0 mg, 300.0 mg, 0.3 %, 600.0 mg

Oral, Solution, Tablet, , Tablet - Oral, Tablet, coated, Solution - Auricular (otic), Ophthalmic, Tablet, coated - Oral, Solution - Ophthalmic, Solution / drops - Ophthalmic, Intravenous, Tablet, film coated, Solution / drops, Liquid, Tablet, film coated - Oral, Liquid - Intravenous, Auricular (otic), Solution / drops - Auricular (otic)

Community Acquired Pneumonia (CAP)

, 20.0 mg/mL, 3.0 mg/mL, 200.0 mg, 400.0 mg, 300.0 mg, 0.3 %, 600.0 mg

Oral, Solution, Tablet, , Tablet - Oral, Tablet, coated, Solution - Auricular (otic), Ophthalmic, Tablet, coated - Oral, Solution - Ophthalmic, Solution / drops - Ophthalmic, Intravenous, Tablet, film coated, Solution / drops, Liquid, Tablet, film coated - Oral, Liquid - Intravenous, Auricular (otic), Solution / drops - Auricular (otic)

Urinary tract infection

, 20.0 mg/mL, 3.0 mg/mL, 200.0 mg, 400.0 mg, 300.0 mg, 0.3 %, 600.0 mg

Oral, Solution, Tablet, , Tablet - Oral, Tablet, coated, Solution - Auricular (otic), Ophthalmic, Tablet, coated - Oral, Solution - Ophthalmic, Solution / drops - Ophthalmic, Intravenous, Tablet, film coated, Solution / drops, Liquid, Tablet, film coated - Oral, Liquid - Intravenous, Auricular (otic), Solution / drops - Auricular (otic)

Diarrhea

, 20.0 mg/mL, 3.0 mg/mL, 200.0 mg, 400.0 mg, 300.0 mg, 0.3 %, 600.0 mg

Oral, Solution, Tablet, , Tablet - Oral, Tablet, coated, Solution - Auricular (otic), Ophthalmic, Tablet, coated - Oral, Solution - Ophthalmic, Solution / drops - Ophthalmic, Intravenous, Tablet, film coated, Solution / drops, Liquid, Tablet, film coated - Oral, Liquid - Intravenous, Auricular (otic), Solution / drops - Auricular (otic)

Bacterial Infections

, 20.0 mg/mL, 3.0 mg/mL, 200.0 mg, 400.0 mg, 300.0 mg, 0.3 %, 600.0 mg

Oral, Solution, Tablet, , Tablet - Oral, Tablet, coated, Solution - Auricular (otic), Ophthalmic, Tablet, coated - Oral, Solution - Ophthalmic, Solution / drops - Ophthalmic, Intravenous, Tablet, film coated, Solution / drops, Liquid, Tablet, film coated - Oral, Liquid - Intravenous, Auricular (otic), Solution / drops - Auricular (otic)

Hansen's Disease

, 20.0 mg/mL, 3.0 mg/mL, 200.0 mg, 400.0 mg, 300.0 mg, 0.3 %, 600.0 mg

Oral, Solution, Tablet, , Tablet - Oral, Tablet, coated, Solution - Auricular (otic), Ophthalmic, Tablet, coated - Oral, Solution - Ophthalmic, Solution / drops - Ophthalmic, Intravenous, Tablet, film coated, Solution / drops, Liquid, Tablet, film coated - Oral, Liquid - Intravenous, Auricular (otic), Solution / drops - Auricular (otic)

Cystitis

, 20.0 mg/mL, 3.0 mg/mL, 200.0 mg, 400.0 mg, 300.0 mg, 0.3 %, 600.0 mg

Oral, Solution, Tablet, , Tablet - Oral, Tablet, coated, Solution - Auricular (otic), Ophthalmic, Tablet, coated - Oral, Solution - Ophthalmic, Solution / drops - Ophthalmic, Intravenous, Tablet, film coated, Solution / drops, Liquid, Tablet, film coated - Oral, Liquid - Intravenous, Auricular (otic), Solution / drops - Auricular (otic)

Acute Otitis Media (AOM)

, 20.0 mg/mL, 3.0 mg/mL, 200.0 mg, 400.0 mg, 300.0 mg, 0.3 %, 600.0 mg

Oral, Solution, Tablet, , Tablet - Oral, Tablet, coated, Solution - Auricular (otic), Ophthalmic, Tablet, coated - Oral, Solution - Ophthalmic, Solution / drops - Ophthalmic, Intravenous, Tablet, film coated, Solution / drops, Liquid, Tablet, film coated - Oral, Liquid - Intravenous, Auricular (otic), Solution / drops - Auricular (otic)

Pink Eye

, 20.0 mg/mL, 3.0 mg/mL, 200.0 mg, 400.0 mg, 300.0 mg, 0.3 %, 600.0 mg

Oral, Solution, Tablet, , Tablet - Oral, Tablet, coated, Solution - Auricular (otic), Ophthalmic, Tablet, coated - Oral, Solution - Ophthalmic, Solution / drops - Ophthalmic, Intravenous, Tablet, film coated, Solution / drops, Liquid, Tablet, film coated - Oral, Liquid - Intravenous, Auricular (otic), Solution / drops - Auricular (otic)

Otitis Externa

, 20.0 mg/mL, 3.0 mg/mL, 200.0 mg, 400.0 mg, 300.0 mg, 0.3 %, 600.0 mg

Oral, Solution, Tablet, , Tablet - Oral, Tablet, coated, Solution - Auricular (otic), Ophthalmic, Tablet, coated - Oral, Solution - Ophthalmic, Solution / drops - Ophthalmic, Intravenous, Tablet, film coated, Solution / drops, Liquid, Tablet, film coated - Oral, Liquid - Intravenous, Auricular (otic), Solution / drops - Auricular (otic)

Prostatitis

, 20.0 mg/mL, 3.0 mg/mL, 200.0 mg, 400.0 mg, 300.0 mg, 0.3 %, 600.0 mg

Oral, Solution, Tablet, , Tablet - Oral, Tablet, coated, Solution - Auricular (otic), Ophthalmic, Tablet, coated - Oral, Solution - Ophthalmic, Solution / drops - Ophthalmic, Intravenous, Tablet, film coated, Solution / drops, Liquid, Tablet, film coated - Oral, Liquid - Intravenous, Auricular (otic), Solution / drops - Auricular (otic)

Warnings

Ocuflox has two counter-indications, so it must not be consumed when dealing with the ailments listed in the following table.Ocuflox Contraindications

Condition

Risk Level

Notes

Toxoplasma Infections

Do Not Combine

Toxoplasma Infections

Do Not Combine

There are 20 known major drug interactions with Ocuflox.

Common Ocuflox Drug Interactions

Drug Name

Risk Level

Description

Amiodarone

Major

The risk or severity of QTc prolongation can be increased when Ofloxacin is combined with Amiodarone.

Amitriptyline

Major

Ofloxacin may increase the QTc-prolonging activities of Amitriptyline.

Anagrelide

Major

The risk or severity of QTc prolongation can be increased when Ofloxacin is combined with Anagrelide.

Arsenic trioxide

Major

The risk or severity of QTc prolongation can be increased when Ofloxacin is combined with Arsenic trioxide.

Artemether

Major

The risk or severity of QTc prolongation can be increased when Ofloxacin is combined with Artemether.

Ocuflox Toxicity & Overdose RiskThe lowest toxic dose of the drug in mice, when given orally, has been found to be 5450mg/kg.

Ocuflox Novel Uses: Which Conditions Have a Clinical Trial Featuring Ocuflox?

Presently, 46 active studies are underway to assess the potential of Ocuflox in providing relief from Corneal Ulcers, Acute Coryza and Otitis Media.

Condition

Clinical Trials

Trial Phases

Acute Bacterial Exacerbation of Chronic Bronchitis (ABECB)

0 Actively Recruiting

Cervicitis

1 Actively Recruiting

Not Applicable

Community Acquired Pneumonia (CAP)

1 Actively Recruiting

Not Applicable

Acute Coryza

0 Actively Recruiting

Epididymitis

0 Actively Recruiting

Cystitis

0 Actively Recruiting

Corneal Ulcer

0 Actively Recruiting

Urethritis

0 Actively Recruiting

Otitis Media

0 Actively Recruiting

Bacterial Infections

1 Actively Recruiting

Phase 4

Otitis Externa

0 Actively Recruiting

Spontaneous Bacterial Peritonitis (SBP)

0 Actively Recruiting

Acute Otitis Media (AOM)

1 Actively Recruiting

Not Applicable

Diarrhea

0 Actively Recruiting

Gonorrhea

0 Actively Recruiting

Hansen's Disease

0 Actively Recruiting

Pink Eye

10 Actively Recruiting

Phase 4, Phase 3, Phase 1, Phase 2, Not Applicable

Urinary tract infection

2 Actively Recruiting

Phase 2, Phase 3

Prostatitis

4 Actively Recruiting

Phase 2, Not Applicable, Phase 4

Urinary Tract Infection (UTI)

25 Actively Recruiting

Phase 2, Phase 1, Phase 4, Phase 3, Not Applicable

Ocuflox Reviews: What are patients saying about Ocuflox?

2Patient Review

10/29/2016

Ocuflox for Pink Eye from Bacterial Infection

My eye inflammation actually got worse after the second day of using this treatment.

Patient Q&A Section about ocuflox

Is Ocuflox a steroid?

"Tobradex and Floxin both treat bacterial eye infections, but Tobradex also contains a steroid." - Anonymous Online Contributor

Unverified Answer

Is Ocuflox used for pink eye?

"Any specific brand name of this medication may not be available in all of the forms or approved for all of the conditions discussed here.

Ofloxacin eye drops are used to kill bacteria that cause bacterial conjunctivitis (pink eye). The eye drops come in different forms and brand names." - Anonymous Online Contributor

Unverified Answer

What is the generic name for Ocuflox?

"Ofloxacin is an antibiotic. It treats bacterial infections of the eye.

This medication is used to treat bacterial eye infections. Ofloxacin belongs to a class of drugs called quinolone antibiotics. It works by stopping the growth of bacteria." - Anonymous Online Contributor

Unverified Answer

How long does Ocuflox take to work?

"When Ocuflox (ofloxacin) is placed directly on an infection or ulcer, it begins to work immediately. For pink eye, symptoms should start to improve within a few days. With corneal ulcers, it typically takes around 11 days for the ulcer to disappear." - Anonymous Online Contributor

Unverified Answer

Please Note: These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

Clinical Trials for Ocuflox

Image of Altasciences Inc - Kansas City in Overland Park, United States.

Phase-Based Progress Estimates

Cohort 1for Bacterial Infection

Overland Park, KS

This trial is assessing the safety and tolerability of a combination of two medicines and their individual doses in healthy adults.

Altasciences Inc - Kansas City

Image of Optimed Research, LLC in Columbus, United States.

Phase-Based Progress Estimates

XEMBIFY + Standard Medical Treatment (SMT)for Chronic Lymphocytic Leukemia

This trial is to see if a new drug can help reduce bacterial infections in people with a type of leukemia.

1 Prior Treatment

Optimed Research, LLC (+1 Sites)Grifols Therapeutics LLC

Image of Le Bonheur Children's Hospital in Memphis, United States.

Phase-Based Progress Estimates

ATM-AVIfor Bacterial Infections

This trial is studying the safety/effectiveness of ATM/AVI as a treatment for children with serious infections. They will be given an intravenous dose based on weight/kidney function, and may be switched to oral therapy.

Waitlist Available

Le Bonheur Children's Hospital (+1 Sites)Pfizer CT.gov Call CenterPfizer

Image of Hospital of the University of Pennsylvania in Philadelphia, United States.

Phase-Based Progress Estimates

PsA BL-BLIfor Infection

Philadelphia, PA

This trial will test if a new treatment using bacteria from poop can help get rid of bacteria that don't respond to antibiotics.

Waitlist Available

Hospital of the University of Pennsylvania

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Image of University of Louisville Physicians in Louisville, United States.

Phase-Based Progress Estimates

Cohort Afor Bacterial Infection

This trial will study how a drug behaves in critically ill people with bacterial infections to ensure it's safe and effective.

University of Louisville Physicians (+2 Sites)Clinical TrialsHoffmann-La Roche

Image of Beckman Laser Institute in Irvine, United States.

Phase-Based Progress Estimates

Lumineux Oral Essentials Rinsefor Oral Bacterial Infection

This trial studies the effects of two mouthwashes on bacteria and 3 viruses in the mouth and gut. Participants will make 5 visits over 180 days, spending 2.5 hours in total. Fecal matter will be collected in some.

Senior-friendly

Beckman Laser InstituteDr. Petra Wilder-Smith

Image of Bausch & Lomb site 101 in Andover, United States.

Phase-Based Progress Estimates

Brimonidine Tartrate 0.025%/ Ketotifen Fumarate 0.035% Ophthalmic Solution (n = 56)for Seasonal Allergy

This trial tests if a treatment combo works better than its individual components to treat seasonal allergy eye irritation.

Waitlist Available

Bausch & Lomb site 101 (+1 Sites)Dan DonatelloBausch & Lomb Incorporated

Image of Alliance for Multispecialty Research, LLC - Knoxville in Knoxville, United States.

Phase-Based Progress Estimates

T1for Bacterial Infection

This trial studies the safety & effectiveness of a single dose of medicine administered intravenously in 20 healthy people. Blood & lung samples are taken to assess the medicine's pharmacokinetics & penetration.

Waitlist Available

Alliance for Multispecialty Research, LLC - Knoxville

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Image of Massachusetts General Hospital in Boston, United States.

Phase-Based Progress Estimates

Rapid STI Testfor Urethritis

This trial will test two methods of rapid diagnosis for urethritis & cervicitis in a clinic setting. 100 patients will be tested to compare the methods.

Massachusetts General HospitalIngrid V. Bassett, MD, MPH

Image of University of California San Diego School of Medicine - Pathology in La Jolla, United States.

Phase-Based Progress Estimates

Stage 1/2a Arm 2for Cystic Fibrosis

This trial is testing the safety and effectiveness of a single dose of an IV bacteriophage therapy for treating Pseudomonas aeruginosa in people with Cystic Fibrosis.

No Cost For Treatment

University of California San Diego School of Medicine - Pathology (+35 Sites)

Image of Kingston General Health Research Institute in Kingston, Canada.

Phase-Based Progress Estimates

REGN5713-5714-5715for Allergy or Hay Fever

Kingston, Canada

This trialtests if anti-birch allergy antibodies reduce symptoms of allergic reaction to birch pollen.

Kingston General Health Research Institute (+2 Sites)Clinical Trial ManagementRegeneron Pharmaceuticals

Image of University of Saskatchewan in Saskatoon, Canada.

Phase-Based Progress Estimates

Aliquoted Allogeneic Donor Plasma In Patient's Conjunctivafor Plasminogen Deficiency

Saskatoon, Canada

This trial will help us to determine whether plasminogen concentrate is an effective and safe treatment for patients with ligneous conjunctivitis.

Waitlist Available

University of Saskatchewan

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