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Stem Cell Therapy

Microfracture vs ADSC for Knee Cartilage Repair

N/A
Recruiting
Led By Jason Dragoo, MD
Research Sponsored by University of Colorado, Denver
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial
Must have
Must be between ages 18 and 50 years
Must have a discrete, contained chondral defect less than 400mm^2 located on the medial or lateral femoral condyle
Timeline
Screening 3 weeks
Treatment Varies
Follow Up assessed at baseline, 6 months, 12 months, and 24 months post-operatively.
Awards & highlights

Study Summary

This trial is testing two different methods for repairing damage to cartilage in the knee. The first, microfracture, is commonly used. The second, which uses stem cells from fat tissue, is being tested to see if it results in better repair.

Who is the study for?
This trial is for individuals aged 18-50 with a specific knee cartilage defect less than 400mm^2 on the femoral condyle and neutral leg alignment. It's not for those over 50 or under 18, with a BMI over 30, advanced osteoarthritis, or previous knee cartilage procedures.Check my eligibility
What is being tested?
The study compares two treatments for knee cartilage defects: microfracture (standard care) and application of adipose-derived stem cells (ADSCs) on a collagen scaffold to potentially improve regeneration at the injury site.See study design
What are the potential side effects?
Possible side effects may include pain at the treatment site, swelling, infection risk from procedures, and potential differences in how well each method repairs the cartilage which could affect joint function.

Eligibility Criteria

Inclusion Criteria

You may be eligible if you check “Yes” for the criteria below
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I am between 18 and 50 years old.
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I have a specific knee cartilage damage smaller than 400mm^2.

Timeline

Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~assessed at baseline, 6 months, 12 months, and 24 months post-operatively.
This trial's timeline: 3 weeks for screening, Varies for treatment, and assessed at baseline, 6 months, 12 months, and 24 months post-operatively. for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.
Primary outcome measures
Health Scores on the KOOS Questionnaire
Secondary outcome measures
Activity Level on the Tegner Activity Scale
Cartilage Composition Assessment by MRI Scan
Functionality Scores on the Lysholm Scale
+2 more

Trial Design

2Treatment groups
Experimental Treatment
Active Control
Group I: ADSC ApplicationExperimental Treatment1 Intervention
Patients undergo an arthroscopic surgical procedure, ADSC application, followed by physical therapy.
Group II: Microfracture ArmActive Control1 Intervention
Patients undergo an arthroscopic surgical procedure, microfracture, followed by physical therapy.

Find a Location

Who is running the clinical trial?

Stanford UniversityOTHER
2,378 Previous Clinical Trials
17,333,342 Total Patients Enrolled
17 Trials studying Osteoarthritis
5,055 Patients Enrolled for Osteoarthritis
University of KentuckyOTHER
184 Previous Clinical Trials
226,549 Total Patients Enrolled
1 Trials studying Osteoarthritis
64 Patients Enrolled for Osteoarthritis
University of Colorado, DenverLead Sponsor
1,729 Previous Clinical Trials
2,143,675 Total Patients Enrolled
13 Trials studying Osteoarthritis
837 Patients Enrolled for Osteoarthritis

Media Library

ADSC Application (Stem Cell Therapy) Clinical Trial Eligibility Overview. Trial Name: NCT02090140 — N/A
Osteoarthritis Research Study Groups: ADSC Application, Microfracture Arm
Osteoarthritis Clinical Trial 2023: ADSC Application Highlights & Side Effects. Trial Name: NCT02090140 — N/A
ADSC Application (Stem Cell Therapy) 2023 Treatment Timeline for Medical Study. Trial Name: NCT02090140 — N/A
Osteoarthritis Patient Testimony for trial: Trial Name: NCT02090140 — N/A

Frequently Asked Questions

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

What is the scope of recruitment for this experiment?

"Affirmative. Clinicaltrials.gov verifies that this research trial, which was first publicized on November 1st 2015, is actively recruiting for participants. Specifically, 17 patients must be recruited from two separate medical centres."

Answered by AI

Are there any vacancies left to join this clinical research?

"Affirmative. Accessing clinicaltrials.gov reveals that this medical trial is still recruiting participants, with 17 patients required from two locations since its initial posting on November 1st 2015 and most recent edit on July 1 2021."

Answered by AI

Is this experiment limited to seniors or are younger individuals accepted?

"This medical trial is only open to adults aged between 18 and 50. For minors and elderly persons, there are 5 different studies for the former group and 17 specific trials for those over 65 years of age."

Answered by AI

Am I eligible to partake in this research endeavor?

"This medical experiment is accepting a cohort of 17 individuals aged 18 to 50 with an articular cartilage abnormality. In order to qualify, the following conditions must be met: age range between 18 and 50 years; a limited chondral defect (less than 400mm^2) at either the femoral condyle's medial or lateral end; lower limb mechanical alignment of no more than 5 degrees varus or valgus."

Answered by AI

Who else is applying?

What state do they live in?
California
Washington
What site did they apply to?
Stanford Medical Outpatient Center
UC Health Steadman Hawkins Clinic - Denver Inverness
Kerlan Jobe Orthopedic Institute
What portion of applicants met pre-screening criteria?
Met criteria
Did not meet criteria
How many prior treatments have patients received?
2
0

Why did patients apply to this trial?

osteo arthtirits of both knees. I have not tried any drugs or injections. I am looking for natural treatments for osteoarthritis. I’m not looking to take medication or have surgery if at all possible.
PatientReceived no prior treatments
I’ve had PRP on my left knee with good results but nothing on my right knee that is now showing signs of osteoarthritis degeneration. I’d like to try out therapy on my right, untreated knee.
PatientReceived 2+ prior treatments
I know you have an age restriction, that people in their 60s and 70s who are very active are not eligible for knee replacement would find this procedure very powerful for their lifestyle and could keep people active. You may not be able to change this trial, but why don’t we get one going for us older folks .
PatientReceived 2+ prior treatments

What questions have other patients asked about this trial?

What all does the trial entail?
PatientReceived 2+ prior treatments
Recent research and studies
~3 spots leftby Dec 2025