Numorphan

Generalized Anxiety Disorder, Dyspnea, Pain + 3 more
Treatment
20 Active Studies for Numorphan

What is Numorphan

OxymorphoneThe Generic name of this drug
Treatment SummaryPentazocine is a painkiller similar to morphine, but does not have the same effect on coughing. It is used to treat moderate to severe pain, including pain during childbirth. It can also be used in combination with anesthesia. In 2017, the FDA asked Endo Pharmaceuticals to remove this drug from the market due to potential misuse and abuse of the injectable form of the drug.
Numorphanis the brand name
image of different drug pills on a surface
Numorphan Overview & Background
Brand Name
Generic Name
First FDA Approval
How many FDA approvals?
Numorphan
Oxymorphone
1959
118

Effectiveness

How Numorphan Affects PatientsOxymorphone is a type of drug similar to morphine that helps reduce pain. It works by affecting the brain and digestive system, and can also cause drowsiness. Oxymorphone can cause slowed breathing by decreasing the responsiveness of certain parts of the brain responsible for controlling breath.
How Numorphan works in the bodyOxymorphone primarily affects the opioid mu-receptor. This receptor is located in many parts of the brain, including the amygdalae, hypothalamus, thalamus, and cortex. Oxymorphone also binds to and blocks GABA inhibitory neurons, which are responsible for pain regulation. By blocking these neurons, oxymorphone helps reduce pain signals in the body.

When to interrupt dosage

The proposed dosage of Numorphan is contingent upon the diagnosed condition, including Dyspnea, obstetrical analgesia therapy and Perioperative analgesia. The dose is contingent upon the method of administration, as specified in the table below.
Condition
Dosage
Administration
Pain
, 5.0 mg, 10.0 mg, 20.0 mg, 40.0 mg, 7.5 mg, 15.0 mg, 30.0 mg, 1.0 mg/mL, 1.5 mg/mL
, Oral, Tablet, Tablet - Oral, Tablet, extended release, Tablet, extended release - Oral, Tablet, film coated, extended release, Tablet, film coated, extended release - Oral, Rectal, Suppository, Suppository - Rectal, Intramuscular; Intravenous; Subcutaneous, Liquid, Liquid - Intramuscular; Intravenous; Subcutaneous, Injection, Injection - Intramuscular; Intravenous; Subcutaneous, Parenteral, Injection - Parenteral
Pain
, 5.0 mg, 10.0 mg, 20.0 mg, 40.0 mg, 7.5 mg, 15.0 mg, 30.0 mg, 1.0 mg/mL, 1.5 mg/mL
, Oral, Tablet, Tablet - Oral, Tablet, extended release, Tablet, extended release - Oral, Tablet, film coated, extended release, Tablet, film coated, extended release - Oral, Rectal, Suppository, Suppository - Rectal, Intramuscular; Intravenous; Subcutaneous, Liquid, Liquid - Intramuscular; Intravenous; Subcutaneous, Injection, Injection - Intramuscular; Intravenous; Subcutaneous, Parenteral, Injection - Parenteral
Perioperative analgesia
, 5.0 mg, 10.0 mg, 20.0 mg, 40.0 mg, 7.5 mg, 15.0 mg, 30.0 mg, 1.0 mg/mL, 1.5 mg/mL
, Oral, Tablet, Tablet - Oral, Tablet, extended release, Tablet, extended release - Oral, Tablet, film coated, extended release, Tablet, film coated, extended release - Oral, Rectal, Suppository, Suppository - Rectal, Intramuscular; Intravenous; Subcutaneous, Liquid, Liquid - Intramuscular; Intravenous; Subcutaneous, Injection, Injection - Intramuscular; Intravenous; Subcutaneous, Parenteral, Injection - Parenteral
Generalized Anxiety Disorder
, 5.0 mg, 10.0 mg, 20.0 mg, 40.0 mg, 7.5 mg, 15.0 mg, 30.0 mg, 1.0 mg/mL, 1.5 mg/mL
, Oral, Tablet, Tablet - Oral, Tablet, extended release, Tablet, extended release - Oral, Tablet, film coated, extended release, Tablet, film coated, extended release - Oral, Rectal, Suppository, Suppository - Rectal, Intramuscular; Intravenous; Subcutaneous, Liquid, Liquid - Intramuscular; Intravenous; Subcutaneous, Injection, Injection - Intramuscular; Intravenous; Subcutaneous, Parenteral, Injection - Parenteral
Dyspnea
, 5.0 mg, 10.0 mg, 20.0 mg, 40.0 mg, 7.5 mg, 15.0 mg, 30.0 mg, 1.0 mg/mL, 1.5 mg/mL
, Oral, Tablet, Tablet - Oral, Tablet, extended release, Tablet, extended release - Oral, Tablet, film coated, extended release, Tablet, film coated, extended release - Oral, Rectal, Suppository, Suppository - Rectal, Intramuscular; Intravenous; Subcutaneous, Liquid, Liquid - Intramuscular; Intravenous; Subcutaneous, Injection, Injection - Intramuscular; Intravenous; Subcutaneous, Parenteral, Injection - Parenteral
obstetrical analgesia therapy
, 5.0 mg, 10.0 mg, 20.0 mg, 40.0 mg, 7.5 mg, 15.0 mg, 30.0 mg, 1.0 mg/mL, 1.5 mg/mL
, Oral, Tablet, Tablet - Oral, Tablet, extended release, Tablet, extended release - Oral, Tablet, film coated, extended release, Tablet, film coated, extended release - Oral, Rectal, Suppository, Suppository - Rectal, Intramuscular; Intravenous; Subcutaneous, Liquid, Liquid - Intramuscular; Intravenous; Subcutaneous, Injection, Injection - Intramuscular; Intravenous; Subcutaneous, Parenteral, Injection - Parenteral

Warnings

Numorphan has five contra-indications, so it must not be amalgamated while experiencing any of the conditions in the following table.Numorphan Contraindications
Condition
Risk Level
Notes
Liver Disease
Do Not Combine
Respiratory Depression
Do Not Combine
Hypercarbia
Do Not Combine
Paralytic Ileus
Do Not Combine
Bronchial Asthma
Do Not Combine
There are 20 known major drug interactions with Numorphan.
Common Numorphan Drug Interactions
Drug Name
Risk Level
Description
7,8-Dichloro-1,2,3,4-tetrahydroisoquinoline
Major
The risk or severity of adverse effects can be increased when Oxymorphone is combined with 7,8-Dichloro-1,2,3,4-tetrahydroisoquinoline.
Astemizole
Major
The metabolism of Astemizole can be decreased when combined with Oxymorphone.
Azelastine
Major
Oxymorphone may increase the central nervous system depressant (CNS depressant) activities of Azelastine.
Benmoxin
Major
The risk or severity of adverse effects can be increased when Oxymorphone is combined with Benmoxin.
Brofaromine
Major
The risk or severity of adverse effects can be increased when Oxymorphone is combined with Brofaromine.
Numorphan Toxicity & Overdose RiskAn overdose of oxymorphone can cause severe drowsiness, weak muscles, cold and clammy skin, slow heart rate and low blood pressure. It can even lead to difficulty breathing, lack of circulation, and heart failure. The lowest toxic dose in mice has been found to be 172mg/kg.
image of a doctor in a lab doing drug, clinical research

Numorphan Novel Uses: Which Conditions Have a Clinical Trial Featuring Numorphan?

215 active clinical trials are currently being conducted to evaluate the potential of Numorphan in alleviating Pain, providing analgesia during obstetrical therapy and managing Pain.
Condition
Clinical Trials
Trial Phases
Generalized Anxiety Disorder
244 Actively Recruiting
Not Applicable, Phase 1, Phase 2, Phase 3, Early Phase 1, Phase 4
Pain
0 Actively Recruiting
obstetrical analgesia therapy
1 Actively Recruiting
Not Applicable
Dyspnea
0 Actively Recruiting
Pain
0 Actively Recruiting
Perioperative analgesia
0 Actively Recruiting

Numorphan Reviews: What are patients saying about Numorphan?

5Patient Review
5/23/2020
Numorphan for Severe Pain
I've had a lot of surgeries, most for orthopedic issues and pain management. I have CRPS Type II on my left side and Type I on the right. The pain is really bad, and flare-ups are awful. I take morphine every day, but sometimes I need Hydromorphone to help with pain after surgery.
5Patient Review
2/9/2020
Numorphan for Severe Pain
I've been taking pain medication for over 50 years, and I can say from experience that Dilaudid is one of the best out there. However, because so many people have abused this drug, people like me who actually need it are being mistreated.
5Patient Review
11/1/2019
Numorphan for Additional Agent to Induce General Anesthesia
This medication was extremely effective at alleviating post-operative pain. I would gladly take it again, even though it did cause some nausea and vomiting.
5Patient Review
12/2/2021
Numorphan for Severe Pain
This medication is excellent for chronic pain. I get almost instantaneous relief and very few side effects!
5Patient Review
9/9/2022
Numorphan for Severe Pain
This medicine has given me more relief from chronic pain than any other opiate or opioid I've tried before, including hydrocodone, oxycodone, and morphine. The combination of Dilaudid and the Fentanyl patch is working better for me than the Duragesic patch did.
5Patient Review
10/1/2019
Numorphan for Severe Pain
I was in a car accident a few years ago and my back has been giving me a lot of trouble since. These treatments are the only things that have helped me at all.
5Patient Review
5/23/2020
Numorphan for Severe Pain
I've had a lot of surgery in my life, and pain management has been a big part of that. I was diagnosed with CRPS (Complex Regional Pain Syndrome) Type II on my left side and Type I on the right. The pain is unrelenting, flare-ups are excruciating. I take morphine daily, both ER and IR, but on occasion I've been prescribed Hydromorphone to help control pain after surgery
5Patient Review
11/1/2019
Numorphan for Additional Agent to Induce General Anesthesia
This medication was given to me before and after a bunionectomy. It did an amazing job at numbing the pain. The only downside is that I felt really nauseous and sleepy afterwards.
5Patient Review
2/9/2020
Numorphan for Severe Pain
I've been on pain medication for over 50 years, and I can say with certainty that Dilaudid works. However, there are so many people who abuse opiates these days that people like me who actually need them are being mistreated.
5Patient Review
10/1/2019
Numorphan for Severe Pain
I was in a car accident in 2010 and have been dealing with back pain ever since. These treatments are the only ones that have given me relief.
5Patient Review
1/10/2018
Numorphan for Pain
I had a great experience with this treatment until I threw up all over my bean bag collection.
5Patient Review
7/2/2020
Numorphan for Pain
This medication has been amazing in helping me to cope with my various chronic pain conditions.
5Patient Review
12/2/2021
Numorphan for Severe Pain
This medication is really great for those of us who suffer from chronic pain. It provides instant relief with very few side effects!
5Patient Review
7/2/2020
Numorphan for Pain
This treatment has been a godsend. I have severe spinal issues and this really helps to manage the pain.
5Patient Review
11/1/2019
Numorphan for Additional Agent to Induce General Anesthesia
This medication was extremely effective in numbing the pain after my surgery. I would gladly take it again, even though it caused some unpleasant side effects like drowsiness and nausea.
5Patient Review
2/9/2020
Numorphan for Severe Pain
I've been taking pain medication for over fifty years, and I can say without a doubt that Dilaudid is one of the most effective treatments I've ever tried.
5Patient Review
10/1/2019
Numorphan for Severe Pain
I've tried everything to help my back and neck pain from a car accident, but this is the only treatment that has worked for me.
5Patient Review
5/23/2020
Numorphan for Severe Pain
I've had a lot of surgeries and most of them were for orthopedic issues or pain management. I have CRPS (Complex Regional Pain Syndrome) Type II on my left side and Type I on the right. The pain is really bad and when it gets worse, it's excruciating. I take morphine every day but sometimes I'm prescribed Hydromorphone to help control the pain after surgery.
5Patient Review
12/2/2021
Numorphan for Severe Pain
This medication is excellent for those of us who suffer from chronic pain. It provides near-instant relief with very few side effects.
5Patient Review
1/10/2018
Numorphan for Pain
I had a great experience with this treatment until I threw up all over my bean bag collection.
5Patient Review
7/2/2020
Numorphan for Pain
This treatment has been amazing for my chronic pain.
5Patient Review
9/9/2022
Numorphan for Severe Pain
I've found this medicine to be the most effective of all the opiates and opioids I've tried, from hydrocodone to oxycodone and morphine. The Dilaudid together with the Fentanyl patch and now morphine sulphate extended release have given me the most relief from chronic back pain, neuropathic pain, and chronic arthritis pain.
5Patient Review
1/10/2018
Numorphan for Pain
I had a great experience with this treatment until I threw up all over my bean bag collection.
5Patient Review
9/9/2022
Numorphan for Severe Pain
This medication has given me more relief from chronic pain than any other opiate or opioid I've tried, including hydrocodone, oxycodone, and morphine. The combination of this medication with the Fentanyl patch is especially effective for me.
5Patient Review
12/2/2021
Numorphan for Severe Pain
This medication is excellent for those of us who suffer from chronic pain. The relief is almost instant, and there are very few side effects to worry about.
5Patient Review
10/1/2019
Numorphan for Severe Pain
I was in a car accident back in 2010 which really did a number on my back and neck. I tried everything to ease the pain, but nothing worked until I found this treatment. It's the only thing that's helped me so far.
5Patient Review
11/1/2019
Numorphan for Additional Agent to Induce General Anesthesia
This medication was given to me both before and after my bunionectomy surgery. I found it extremely effective in alleviating pain, though it did cause some drowsiness, nausea, and vomiting. Overall, though, the benefits outweighed the drawbacks for me.
5Patient Review
2/9/2020
Numorphan for Severe Pain
I've been on pain medication for over 50 years, and I can say from experience that Dilaudid really works. It's much better than anything else I've tried.
5Patient Review
5/23/2020
Numorphan for Severe Pain
I've had a lot of surgery and most of it was for orthopedic issues and pain management. I have CRPS (Complex Regional Pain Syndrome) Type II on my left side and Type I on the right. The pain is always there, and sometimes it gets really bad. I take morphine every day, but sometimes I need something stronger like Hydromorphone to help control the pain after surgery.
5Patient Review
1/10/2018
Numorphan for Pain
I had a great experience with this treatment until I experienced some unfortunate vomiting.
5Patient Review
7/2/2020
Numorphan for Pain
This treatment has been a godsend. I was struggling with spinal stenosis, degenerative disk disease, and apologetic spondilitis, but this really helped me out.
5Patient Review
9/9/2022
Numorphan for Severe Pain
Out of all the opiates and opioids I've tried, this one has given me the most relief. I was on hydrocodone, oxycodone, morphine, meperidine, Dilaudid, and Fentanyl patch before finally trying morphine sulphate extended release. This combination of medication has given me more relief from my chronic back pain, neuropathic pain, and chronic arthritis pain than anything else I've tried.
4.7Patient Review
7/1/2017
Numorphan for Pain
4.7Patient Review
7/1/2017
Numorphan for Pain
4.7Patient Review
7/1/2017
Numorphan for Pain
4.7Patient Review
7/1/2017
Numorphan for Pain
4Patient Review
10/18/2022
Numorphan for Severe Pain
This medication was very effective for me after my colon surgery. The pain relief it provided was much appreciated, though it didn't last as long as I would have liked.
4Patient Review
10/18/2022
Numorphan for Severe Pain
This medication was very effective for me after my colon surgery. The initial dose didn't last very long, but the follow-up 2mg doses did the trick. I just wish it lasted a bit longer!
4Patient Review
10/18/2022
Numorphan for Severe Pain
This medication was a life-saver after my colon surgery. The morphine wasn't doing anything for me, but this kicked in within an hour and really took the edge off the pain. The only downside is that it doesn't last very long - maybe an hour at most.
4Patient Review
10/18/2022
Numorphan for Severe Pain
I had colon surgery and was struggling with the painkillers. The morphine wasn't helping me, so my doctor put me on this medication. It worked well, but unfortunately it doesn't last very long. I would get relief for maybe an hour before needing another dose.
3.7Patient Review
7/30/2022
Numorphan for Severe Pain
Mallingkrodt 8mg. is much weaker than the previous brand I was taking.
3.7Patient Review
7/30/2022
Numorphan for Severe Pain
Mallingkrodt's 8mg. dosage is much weaker compared to the previous brand I was taking.
3.7Patient Review
7/30/2022
Numorphan for Severe Pain
Mallingkrodt 8mg. is much weaker in comparison to the other brands I've tried.
3.7Patient Review
7/30/2022
Numorphan for Severe Pain
Mallingkrodt 8mg didn't provide the same level of relief as my previous medication.
3.3Patient Review
6/30/2022
Numorphan for Severe Pain
I was prescribed this medication for a severe foot infection. I am a 60 year old man who weighs 300 pounds. I took one pill that was provided by the ER doctor and will not be filling the prescription for 10 more pills. This medication is too powerful for me as it is synthetic morphine. It knocked me off my feet and I would not be able to legally drive in Canada if I were on this medication.
3.3Patient Review
6/30/2022
Numorphan for Severe Pain
I was prescribed this medication for a severe foot infection. I took one pill and it knocked me off my feet. It's too high powered for me, as it is a synthetic morphine. I wouldn't be able to legally drive in Canada if I were on this medication.
3.3Patient Review
6/30/2022
Numorphan for Severe Pain
I was given this medication for a severe foot infection. I'm a 60 year old man weighing 300 pounds. After taking just one pill, I decided that it was too strong for me. It's basically synthetic morphine and would knock anyone off their feet. I wouldn't be able to legally drive in Canada if I were on this medication.
3.3Patient Review
6/30/2022
Numorphan for Severe Pain
I was prescribed this medication for a severe foot infection. I'm 60 years old and 300 pounds, so maybe that's why the one pill had such a strong effect on me. It's like synthetic morphine—I wouldn't be able to legally drive in Canada if I were on this stuff.
1.7Patient Review
12/5/2018
Numorphan for Severe Pain
I take 4mg of dilaudid 3x per day as needed, but it does nothing for me. I had cancer on my tongue and underwent a robotic operation to remove seven teeth. The doctor said I shouldn't be in pain, but I am. Please let me know if there's anything else that can be done.
1.7Patient Review
12/5/2018
Numorphan for Severe Pain
I take 4mg of dilaudid 3x a day as needed, but it doesn't help at all. I had cancer on my tongue and had a robotic operation to remove seven teeth. The doctor said I shouldn't be in pain, but I am. Can somebody please explain this to me?
1.7Patient Review
12/5/2018
Numorphan for Severe Pain
I take 4mg of dilaudid 3x per day as needed, but it does nothing for me. I had cancer in my tongue and a robotic operation to remove seven teeth, but the doctor said I shouldn't be in pain. Unfortunately, I am still in pain. Can somebody please help?
1.7Patient Review
12/5/2018
Numorphan for Severe Pain
I take 4mg of dilaudid 3x per day as needed, but it doesn't seem to help at all. I had cancer in my tongue and underwent a robotic operation to remove seven teeth. The doctor said I shouldn't be in pain, but I am. Can anyone offer any suggestions?
image of drug pills surrounding a glass of water symbolizing drug consumption

Patient Q&A Section about numorphan

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

Clinical Trials for Numorphan

Have you considered Numorphan clinical trials? We made a collection of clinical trials featuring Numorphan, we think they might fit your search criteria.
Have you considered Numorphan clinical trials? We made a collection of clinical trials featuring Numorphan, we think they might fit your search criteria.
Have you considered Numorphan clinical trials? We made a collection of clinical trials featuring Numorphan, we think they might fit your search criteria.