Red cell units that are genotype matched at the RHD and RHCE loci for Sickle Cell Disease

Phase-Based Progress Estimates
1
Effectiveness
1
Safety
Sickle Cell DiseaseRed cell units that are genotype matched at the RHD and RHCE loci - Biological
Eligibility
Any Age
All Sexes
What conditions do you have?
Select

Study Summary

This trial will test whether it's possible to match donor red cells by RH genotype for patients with SCD who regularly need transfusions.

Eligible Conditions
  • Sickle Cell Disease

Treatment Effectiveness

Study Objectives

1 Primary · 1 Secondary · Reporting Duration: 5.5 years

5.5 years
Determine the occurrence of Rh alloimmunization
Feasibility of identifying sufficient RH genotype matched units

Trial Safety

Trial Design

1 Treatment Group

RH genotype matched red cell transfusions
1 of 1

Experimental Treatment

35 Total Participants · 1 Treatment Group

Primary Treatment: Red cell units that are genotype matched at the RHD and RHCE loci · No Placebo Group · Phase < 1

RH genotype matched red cell transfusions
Biological
Experimental Group · 1 Intervention: Red cell units that are genotype matched at the RHD and RHCE loci · Intervention Types: Biological

Trial Logistics

Trial Timeline

Screening: ~3 weeks
Treatment: Varies
Reporting: 5.5 years

Who is running the clinical trial?

New York Blood CenterOTHER
23 Previous Clinical Trials
26,706 Total Patients Enrolled
National Heart, Lung, and Blood Institute (NHLBI)NIH
3,598 Previous Clinical Trials
46,956,399 Total Patients Enrolled
Children's Hospital of PhiladelphiaLead Sponsor
651 Previous Clinical Trials
7,849,922 Total Patients Enrolled
Stella Chou, MDPrincipal InvestigatorChildren's Hospital of Philadelphia
1 Previous Clinical Trials
20 Total Patients Enrolled

Eligibility Criteria

Age Any Age · All Participants · 3 Total Inclusion Criteria

Mark “Yes” if the following statements are true for you:
The diagnosis of SCD is confirmed by the detection of the HbS gene
In order to require a period of chronic red cell transfusion therapy, your doctor will need to determine if you have anemia
You are 12 months of age or older.
References