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What is Noxafil
PosaconazoleThe Generic name of this drug
Treatment SummaryPosaconazole is a type of antifungal medication used to treat serious infections caused by Candida and Aspergillus fungi in people with weakened immune systems.
Noxafilis the brand name
Noxafil Overview & Background
Brand Name
Generic Name
First FDA Approval
How many FDA approvals?
Noxafil
Posaconazole
2006
25
Approved as Treatment by the FDA
Posaconazole, also known as Noxafil, is approved by the FDA for 1 uses including Bronchopulmonary Aspergillosis .Bronchopulmonary Aspergillosis
Effectiveness
How Noxafil Affects PatientsPosaconazole is a type of antifungal medication. It is related to another drug, itraconazole, but has been modified to be more effective and work against a wider range of fungi. Posaconazole can either kill fungi or stop them from growing.
How Noxafil works in the bodyPosaconazole is an antifungal drug that works by blocking the production of a key part of fungal cells, called ergosterol. It does this by targeting a special enzyme in the cells called sterol 14α-demethylase. When this enzyme is blocked, the production of ergosterol is also blocked, leading to the death of the fungal cells.
When to interrupt dosage
The endorsed amount of Noxafil relies on the diagnosed disorder, like prophylaxis of Aspergillus contamination, HIV and Coccidioidomycosis. The dosage also depends on the technique of delivery (e.g. Intravenous or Solution - Intravenous) as specified in the accompanying table.Condition
Dosage
Administration
prophylaxis of Aspergillus infection
, 100.0 mg, 40.0 mg/mL, 300.0 mg, 18.0 mg/mL, 30.0 mg/mL, 200.0 mg/mL
, Suspension, Oral, Suspension - Oral, Tablet, delayed release, Tablet, delayed release - Oral, Intravenous, Solution, Solution - Intravenous, Injection, solution, concentrate, Injection, solution, concentrate - Intravenous, Tablet, coated, Tablet, coated - Oral, Powder, for suspension, Powder, for suspension - Oral
Esophageal Candidiasis
, 100.0 mg, 40.0 mg/mL, 300.0 mg, 18.0 mg/mL, 30.0 mg/mL, 200.0 mg/mL
, Suspension, Oral, Suspension - Oral, Tablet, delayed release, Tablet, delayed release - Oral, Intravenous, Solution, Solution - Intravenous, Injection, solution, concentrate, Injection, solution, concentrate - Intravenous, Tablet, coated, Tablet, coated - Oral, Powder, for suspension, Powder, for suspension - Oral
Oropharyngeal Candidiasis
, 100.0 mg, 40.0 mg/mL, 300.0 mg, 18.0 mg/mL, 30.0 mg/mL, 200.0 mg/mL
, Suspension, Oral, Suspension - Oral, Tablet, delayed release, Tablet, delayed release - Oral, Intravenous, Solution, Solution - Intravenous, Injection, solution, concentrate, Injection, solution, concentrate - Intravenous, Tablet, coated, Tablet, coated - Oral, Powder, for suspension, Powder, for suspension - Oral
prophylaxis of Candida Infections
, 100.0 mg, 40.0 mg/mL, 300.0 mg, 18.0 mg/mL, 30.0 mg/mL, 200.0 mg/mL
, Suspension, Oral, Suspension - Oral, Tablet, delayed release, Tablet, delayed release - Oral, Intravenous, Solution, Solution - Intravenous, Injection, solution, concentrate, Injection, solution, concentrate - Intravenous, Tablet, coated, Tablet, coated - Oral, Powder, for suspension, Powder, for suspension - Oral
HIV
, 100.0 mg, 40.0 mg/mL, 300.0 mg, 18.0 mg/mL, 30.0 mg/mL, 200.0 mg/mL
, Suspension, Oral, Suspension - Oral, Tablet, delayed release, Tablet, delayed release - Oral, Intravenous, Solution, Solution - Intravenous, Injection, solution, concentrate, Injection, solution, concentrate - Intravenous, Tablet, coated, Tablet, coated - Oral, Powder, for suspension, Powder, for suspension - Oral
Mucormycosis
, 100.0 mg, 40.0 mg/mL, 300.0 mg, 18.0 mg/mL, 30.0 mg/mL, 200.0 mg/mL
, Suspension, Oral, Suspension - Oral, Tablet, delayed release, Tablet, delayed release - Oral, Intravenous, Solution, Solution - Intravenous, Injection, solution, concentrate, Injection, solution, concentrate - Intravenous, Tablet, coated, Tablet, coated - Oral, Powder, for suspension, Powder, for suspension - Oral
Coccidioidomycosis
, 100.0 mg, 40.0 mg/mL, 300.0 mg, 18.0 mg/mL, 30.0 mg/mL, 200.0 mg/mL
, Suspension, Oral, Suspension - Oral, Tablet, delayed release, Tablet, delayed release - Oral, Intravenous, Solution, Solution - Intravenous, Injection, solution, concentrate, Injection, solution, concentrate - Intravenous, Tablet, coated, Tablet, coated - Oral, Powder, for suspension, Powder, for suspension - Oral
Yeast Infection
, 100.0 mg, 40.0 mg/mL, 300.0 mg, 18.0 mg/mL, 30.0 mg/mL, 200.0 mg/mL
, Suspension, Oral, Suspension - Oral, Tablet, delayed release, Tablet, delayed release - Oral, Intravenous, Solution, Solution - Intravenous, Injection, solution, concentrate, Injection, solution, concentrate - Intravenous, Tablet, coated, Tablet, coated - Oral, Powder, for suspension, Powder, for suspension - Oral
Chronic Graft Versus Host Disease
, 100.0 mg, 40.0 mg/mL, 300.0 mg, 18.0 mg/mL, 30.0 mg/mL, 200.0 mg/mL
, Suspension, Oral, Suspension - Oral, Tablet, delayed release, Tablet, delayed release - Oral, Intravenous, Solution, Solution - Intravenous, Injection, solution, concentrate, Injection, solution, concentrate - Intravenous, Tablet, coated, Tablet, coated - Oral, Powder, for suspension, Powder, for suspension - Oral
Neutropenia
, 100.0 mg, 40.0 mg/mL, 300.0 mg, 18.0 mg/mL, 30.0 mg/mL, 200.0 mg/mL
, Suspension, Oral, Suspension - Oral, Tablet, delayed release, Tablet, delayed release - Oral, Intravenous, Solution, Solution - Intravenous, Injection, solution, concentrate, Injection, solution, concentrate - Intravenous, Tablet, coated, Tablet, coated - Oral, Powder, for suspension, Powder, for suspension - Oral
Cryptococcosis
, 100.0 mg, 40.0 mg/mL, 300.0 mg, 18.0 mg/mL, 30.0 mg/mL, 200.0 mg/mL
, Suspension, Oral, Suspension - Oral, Tablet, delayed release, Tablet, delayed release - Oral, Intravenous, Solution, Solution - Intravenous, Injection, solution, concentrate, Injection, solution, concentrate - Intravenous, Tablet, coated, Tablet, coated - Oral, Powder, for suspension, Powder, for suspension - Oral
Invasive Aspergillosis
, 100.0 mg, 40.0 mg/mL, 300.0 mg, 18.0 mg/mL, 30.0 mg/mL, 200.0 mg/mL
, Suspension, Oral, Suspension - Oral, Tablet, delayed release, Tablet, delayed release - Oral, Intravenous, Solution, Solution - Intravenous, Injection, solution, concentrate, Injection, solution, concentrate - Intravenous, Tablet, coated, Tablet, coated - Oral, Powder, for suspension, Powder, for suspension - Oral
Bronchopulmonary Aspergillosis
, 100.0 mg, 40.0 mg/mL, 300.0 mg, 18.0 mg/mL, 30.0 mg/mL, 200.0 mg/mL
, Suspension, Oral, Suspension - Oral, Tablet, delayed release, Tablet, delayed release - Oral, Intravenous, Solution, Solution - Intravenous, Injection, solution, concentrate, Injection, solution, concentrate - Intravenous, Tablet, coated, Tablet, coated - Oral, Powder, for suspension, Powder, for suspension - Oral
Immunocompromised
, 100.0 mg, 40.0 mg/mL, 300.0 mg, 18.0 mg/mL, 30.0 mg/mL, 200.0 mg/mL
, Suspension, Oral, Suspension - Oral, Tablet, delayed release, Tablet, delayed release - Oral, Intravenous, Solution, Solution - Intravenous, Injection, solution, concentrate, Injection, solution, concentrate - Intravenous, Tablet, coated, Tablet, coated - Oral, Powder, for suspension, Powder, for suspension - Oral
Warnings
Noxafil ContraindicationsCondition
Risk Level
Notes
Pulse Frequency
Do Not Combine
Pulse Frequency
Do Not Combine
Pulse Frequency
Do Not Combine
Common Noxafil Drug Interactions
Drug Name
Risk Level
Description
(R)-warfarin
Major
The metabolism of (R)-warfarin can be decreased when combined with Posaconazole.
(S)-Warfarin
Major
The metabolism of (S)-Warfarin can be decreased when combined with Posaconazole.
1,2-Benzodiazepine
Major
The metabolism of 1,2-Benzodiazepine can be decreased when combined with Posaconazole.
3,5-diiodothyropropionic acid
Major
The metabolism of 3,5-diiodothyropropionic acid can be decreased when combined with Posaconazole.
5-androstenedione
Major
The metabolism of 5-androstenedione can be decreased when combined with Posaconazole.
Noxafil Toxicity & Overdose RiskDuring clinical trials, no negative side effects were seen from taking up to 1600 mg/day of posaconazole. There was one instance of an accidental overdose of 1200 mg twice a day for 3 days, but no harmful effects were reported.
Noxafil Novel Uses: Which Conditions Have a Clinical Trial Featuring Noxafil?
187 active clinical trials are examining the potential of Noxafil for prophylaxis of Aspergillus infection, Candida Infections and HIV.Condition
Clinical Trials
Trial Phases
HIV
146 Actively Recruiting
Phase 2, Not Applicable, Phase 1, Phase 3, Phase 4, Early Phase 1
Bronchopulmonary Aspergillosis
0 Actively Recruiting
Invasive Aspergillosis
1 Actively Recruiting
Phase 3
Cryptococcosis
0 Actively Recruiting
Mucormycosis
0 Actively Recruiting
Esophageal Candidiasis
0 Actively Recruiting
Immunocompromised
4 Actively Recruiting
Phase 3, Not Applicable, Phase 1
prophylaxis of Aspergillus infection
0 Actively Recruiting
Oropharyngeal Candidiasis
0 Actively Recruiting
Neutropenia
14 Actively Recruiting
Phase 3, Phase 1, Phase 2, Not Applicable, Phase 4
Coccidioidomycosis
1 Actively Recruiting
Phase 2
Yeast Infection
6 Actively Recruiting
Phase 1, Phase 2, Phase 3, Early Phase 1, Not Applicable
Chronic Graft Versus Host Disease
29 Actively Recruiting
Not Applicable, Phase 2, Phase 4, Phase 1, Phase 3, Early Phase 1
prophylaxis of Candida Infections
0 Actively Recruiting
Noxafil Reviews: What are patients saying about Noxafil?
4Patient Review
1/25/2014 The only problem I had with this treatment is that it left me feeling cold all the time, even when other people said the water was just right. Otherwise, it did a great job of clearing up my infection.
3Patient Review
11/12/2009Patient Q&A Section about noxafil
These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.What is the generic for Noxafil?
"This is a delayed release tablet of the drug posaconazole, to be taken by mouth."
Answered by AI
How long do you take Noxafil?
"The standard dosage for adults is 5 mL for the first day, then 2.5 mL each day for 13 days."
Answered by AI
What is the drug Noxafil used for?
"Posaconazole is used as a prophylactic measure against fungal infections in immunocompromised patients, such as those undergoing chemotherapy. It is classified as an azole antifungal and works by suppressing the growth of fungi."
Answered by AI
Is Noxafil an antibiotic?
"Noxafil is an antifungal medicine used to treat or prevent fungal infections that can spread throughout your body. This medicine may be used in people with weak immune systems caused by certain treatments, such as chemotherapy or stem cell transplantation."
Answered by AI