Novocain

Low body temperature, Ischemic Stroke, Sudden Cardiac Arrest + 6 more

Treatment

4 FDA approvals

7 Active Studies for Novocain

What is Novocain

Procaine

The Generic name of this drug

Treatment Summary

Procaine is a type of anesthetic that is used to numb a specific area of the body. It is commonly used for injections to numb the skin, nerves or spine. It works quickly but its effects don’t last very long. It has also been studied as an oral medication to help treat HIV patients who have already tried other treatments.

Novocaine

is the brand name

image of different drug pills on a surface

Novocain Overview & Background

Brand Name

Generic Name

First FDA Approval

How many FDA approvals?

Novocaine

Procaine

2006

4

Approved as Treatment by the FDA

Procaine, commonly known as Novocaine, is approved by the FDA for 4 uses including Regional Anesthetic Nerve Block and Local Anesthetic Nerve Block .

Regional Anesthetic Nerve Block

Local Anesthetic Nerve Block

Regional Analgesia

Local Analgesia

Effectiveness

How Novocain Affects Patients

Procaine is a type of anesthetic used to produce local or regional numbing, often used during oral surgery. Compared to other anesthetics like lidocaine, procaine has the additional benefit of reducing bleeding due to its ability to narrow blood vessels. It works by being broken down by the enzyme pseudocholinesterase in the blood. The resulting product is then passed through the kidneys and out of the body in the urine.

How Novocain works in the body

Procaine works by stopping nerve signals from being sent. It does this by blocking sodium from entering the nerves, which prevents the signal from being sent. It also works to block certain receptors in the nerve cells that are used to send signals.

When to interrupt dosage

The quantity of Novocain is contingent upon the diagnosed disorder, including Cold Exposure, Regional Analgesia and Ischemic Stroke. The measure can be found in the table below, based on the administration procedure.

Condition

Dosage

Administration

Earache

, 2.0 %, 100.0 mg/mL, 10.0 mg/mL, 20.0 mg/mL

, Infiltration, Liquid, Liquid - Infiltration, Solution, Solution - Infiltration, Injection, solution, Intraspinal; Intrathecal; Subarachnoid, Injection, solution - Intraspinal; Intrathecal; Subarachnoid, Injection, solution - Infiltration

Local Anesthetic Nerve Block

, 2.0 %, 100.0 mg/mL, 10.0 mg/mL, 20.0 mg/mL

, Infiltration, Liquid, Liquid - Infiltration, Solution, Solution - Infiltration, Injection, solution, Intraspinal; Intrathecal; Subarachnoid, Injection, solution - Intraspinal; Intrathecal; Subarachnoid, Injection, solution - Infiltration

Regional Analgesia

, 2.0 %, 100.0 mg/mL, 10.0 mg/mL, 20.0 mg/mL

, Infiltration, Liquid, Liquid - Infiltration, Solution, Solution - Infiltration, Injection, solution, Intraspinal; Intrathecal; Subarachnoid, Injection, solution - Intraspinal; Intrathecal; Subarachnoid, Injection, solution - Infiltration

Regional Anesthetic Nerve Block

, 2.0 %, 100.0 mg/mL, 10.0 mg/mL, 20.0 mg/mL

, Infiltration, Liquid, Liquid - Infiltration, Solution, Solution - Infiltration, Injection, solution, Intraspinal; Intrathecal; Subarachnoid, Injection, solution - Intraspinal; Intrathecal; Subarachnoid, Injection, solution - Infiltration

Sudden Cardiac Arrest

, 2.0 %, 100.0 mg/mL, 10.0 mg/mL, 20.0 mg/mL

, Infiltration, Liquid, Liquid - Infiltration, Solution, Solution - Infiltration, Injection, solution, Intraspinal; Intrathecal; Subarachnoid, Injection, solution - Intraspinal; Intrathecal; Subarachnoid, Injection, solution - Infiltration

Low body temperature

, 2.0 %, 100.0 mg/mL, 10.0 mg/mL, 20.0 mg/mL

, Infiltration, Liquid, Liquid - Infiltration, Solution, Solution - Infiltration, Injection, solution, Intraspinal; Intrathecal; Subarachnoid, Injection, solution - Intraspinal; Intrathecal; Subarachnoid, Injection, solution - Infiltration

Ischemic Stroke

, 2.0 %, 100.0 mg/mL, 10.0 mg/mL, 20.0 mg/mL

, Infiltration, Liquid, Liquid - Infiltration, Solution, Solution - Infiltration, Injection, solution, Intraspinal; Intrathecal; Subarachnoid, Injection, solution - Intraspinal; Intrathecal; Subarachnoid, Injection, solution - Infiltration

Open Heart Surgery

, 2.0 %, 100.0 mg/mL, 10.0 mg/mL, 20.0 mg/mL

, Infiltration, Liquid, Liquid - Infiltration, Solution, Solution - Infiltration, Injection, solution, Intraspinal; Intrathecal; Subarachnoid, Injection, solution - Intraspinal; Intrathecal; Subarachnoid, Injection, solution - Infiltration

Local Analgesia

, 2.0 %, 100.0 mg/mL, 10.0 mg/mL, 20.0 mg/mL

, Infiltration, Liquid, Liquid - Infiltration, Solution, Solution - Infiltration, Injection, solution, Intraspinal; Intrathecal; Subarachnoid, Injection, solution - Intraspinal; Intrathecal; Subarachnoid, Injection, solution - Infiltration

Warnings

Novocain Contraindications

Condition

Risk Level

Notes

Severe Hypersensitivity Reactions

Do Not Combine

Procaine may interact with Pulse Frequency

There are 20 known major drug interactions with Novocain.

Common Novocain Drug Interactions

Drug Name

Risk Level

Description

2,5-Dimethoxy-4-ethylamphetamine

Major

Procaine may increase the hypertensive activities of 2,5-Dimethoxy-4-ethylamphetamine.

2,5-Dimethoxy-4-ethylthioamphetamine

Major

Procaine may increase the hypertensive activities of 2,5-Dimethoxy-4-ethylthioamphetamine.

4-Bromo-2,5-dimethoxyamphetamine

Major

Procaine may increase the hypertensive activities of 4-Bromo-2,5-dimethoxyamphetamine.

4-Methoxyamphetamine

Major

Procaine may increase the hypertensive activities of 4-Methoxyamphetamine.

5-methoxy-N,N-dimethyltryptamine

Major

The metabolism of 5-methoxy-N,N-dimethyltryptamine can be decreased when combined with Procaine.

image of a doctor in a lab doing drug, clinical research

Novocain Novel Uses: Which Conditions Have a Clinical Trial Featuring Novocain?

28 active studies are currently investigating the potential of Novocain to provide therapeutic relief for Heart attack, Regional Anesthetic Nerve Block and Otalgia.

Condition

Clinical Trials

Trial Phases

Low body temperature

1 Actively Recruiting

Not Applicable

Open Heart Surgery

1 Actively Recruiting

Phase 1, Phase 2

Local Analgesia

0 Actively Recruiting

Earache

0 Actively Recruiting

Sudden Cardiac Arrest

5 Actively Recruiting

Not Applicable

Local Anesthetic Nerve Block

0 Actively Recruiting

Ischemic Stroke

1 Actively Recruiting

Not Applicable

Regional Analgesia

0 Actively Recruiting

Regional Anesthetic Nerve Block

0 Actively Recruiting

Patient Q&A Section about novocain

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

What does the drug Novocaine do?

"Novocaine is a local anesthetic drug. It numbs a specific part of the body, but does not make the person lose consciousness."

Answered by AI

Does Novocain make you loopy?

"Novocaine does not make you feel sleepy, however it does numb tissue. Many patients report feeling sluggish, as if they were tired or a little drunk. Novocaine can cause headaches, but usually not at the doses and locations used in dentistry."

Answered by AI

Is Novocain still used?

"Nowadays, Novocaine is not used as much because it takes too long to work and doesn't last very long. Lidocaine and Septocaine are better choices because they work more quickly and last longer. They also have a very small chance of causing allergic reactions."

Answered by AI

Does Novocain make you high?

"There is no potential for abuse with this anesthetic as it does not have any euphoric or addictive effects, though it can cause increased bleeding due to its ability to dilate blood vessels. A similar anesthetic compound is lidocaine, which was first synthesized in 1943."

Answered by AI

Clinical Trials for Novocain

Image of Columbia University Irving Medical Center in New York, United States.

Mindfulness-Based Exposure Therapy for PTSD After Cardiac Arrest

18 - 81
All Sexes
New York, NY

The goal of this clinical trial is to learn if a new therapy called Acceptance- and Mindfulness-Based Exposure Therapy (AMBET) helps treat post-traumatic stress disorder (PTSD) in people who survived a cardiac arrest. This study will compare AMBET to another psychotherapy treatment called Present Centered Therapy (PCT) to see which therapy is more effective in treating PTSD. The main questions it aims to answer are: Does AMBET reduce PTSD symptoms in survivors of cardiac arrest? How do the benefits of AMBET compare to PCT? Participants will: * Be randomly assigned to receive either AMBET or PCT * Attend 12 hours of individual psychotherapy sessions over about 12 weeks * Complete short weekly surveys about their mood and behaviors online * Wear a Fitbit device to track sleep and activity during the study * Do brief homework assignments between sessions

Waitlist Available
Has No Placebo

Columbia University Irving Medical Center

Yuval Neria, PhD

Image of Rush University Medical Center in Chicago, United States.

Precision-Controlled Ventilation for Cardiac Arrest

18+
All Sexes
Chicago, IL

Cardiac arrest is a life-threatening emergency that requires immediate treatment with cardiopulmonary resuscitation (CPR). While chest compressions circulate blood, manual ventilation provides oxygen to the patient. Current CPR guidelines recommend specific ventilation rates and tidal volumes, but studies show that clinicians often deliver too much or too little ventilation due to a lack of monitoring tools, potentially reducing the effectiveness of CPR and impacting survival. The PRECISION-CPR study is a multi-center, randomized controlled trial designed to evaluate whether using real-time feedback devices to precisely control ventilation during CPR can improve patient outcomes. Adult patients experiencing in-hospital cardiac arrest will be randomized to receive either standard manual ventilation guided by clinician experience or precision-controlled ventilation tailored to the patient's predicted body weight using real-time monitoring devices. The primary outcome of the study will be return of spontaneous circulation (ROSC). Secondary outcomes will include survival to hospital discharge, neurological recovery, and other clinical measures. By addressing the limitations of current ventilation practices, this study aims to generate evidence to guide future resuscitation guidelines and improve survival rates after cardiac arrest.

Waitlist Available
Has No Placebo

Rush University Medical Center

Have you considered Novocain clinical trials?

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Propranolol for Chylothorax

7 - 18
All Sexes
New York, NY

Postoperative chylothorax is a serious complication after open heart surgery for pediatric patients with congenital heart disease (CHD). While it was thought to be mechanical injury to the thoracic duct, recent research demonstrated that there are intrinsically abnormal lung lymphatics in CHD patients, and after open heart surgery, the fluid shifts that occur overwhelms these abnormal lung lymphatics. As a result, postoperative chylothorax occurs. Propranolol has been found to be helpful in resolving postoperative chylothorax very quickly (9 days) in a subset of postoperative chylothorax patients (60%). However, it is not known why some patients respond and some do not. The investigators hypothesize that propranolol is safe to use in this patient population, and that certain clinical factors will predict propranolol response, but more importantly, some clinical factors can be optimize to allow more patients with postoperative chylothorax to respond to and benefit from propranolol. In order to improve the understanding of how propranolol works and to maximize benefit to patients, the investigators propose to perform a prospective, randomized, double-blind clinical trial to learn how to best use propranolol in patients with postoperative chylothorax.

Phase 1 & 2
Recruiting

MS CHONY inpatient units, including regular floor units, stepdown units, and ICU (+1 Sites)

June Wu, MD