Novocain

Low body temperature, Ischemic Stroke, Sudden Cardiac Arrest + 6 more

Treatment

4 FDA approvals

6 Active Studies for Novocain

What is Novocain

Procaine

The Generic name of this drug

Treatment Summary

Procaine is a type of anesthetic that is used to numb a specific area of the body. It is commonly used for injections to numb the skin, nerves or spine. It works quickly but its effects don’t last very long. It has also been studied as an oral medication to help treat HIV patients who have already tried other treatments.

Novocaine

is the brand name

image of different drug pills on a surface

Novocain Overview & Background

Brand Name

Generic Name

First FDA Approval

How many FDA approvals?

Novocaine

Procaine

2006

4

Approved as Treatment by the FDA

Procaine, commonly known as Novocaine, is approved by the FDA for 4 uses including Regional Anesthetic Nerve Block and Local Anesthetic Nerve Block .

Regional Anesthetic Nerve Block

Local Anesthetic Nerve Block

Regional Analgesia

Local Analgesia

Effectiveness

How Novocain Affects Patients

Procaine is a type of anesthetic used to produce local or regional numbing, often used during oral surgery. Compared to other anesthetics like lidocaine, procaine has the additional benefit of reducing bleeding due to its ability to narrow blood vessels. It works by being broken down by the enzyme pseudocholinesterase in the blood. The resulting product is then passed through the kidneys and out of the body in the urine.

How Novocain works in the body

Procaine works by stopping nerve signals from being sent. It does this by blocking sodium from entering the nerves, which prevents the signal from being sent. It also works to block certain receptors in the nerve cells that are used to send signals.

When to interrupt dosage

The quantity of Novocain is contingent upon the diagnosed disorder, including Cold Exposure, Regional Analgesia and Ischemic Stroke. The measure can be found in the table below, based on the administration procedure.

Condition

Dosage

Administration

Earache

, 2.0 %, 100.0 mg/mL, 10.0 mg/mL, 20.0 mg/mL

, Infiltration, Liquid, Liquid - Infiltration, Solution, Solution - Infiltration, Injection, solution, Intraspinal; Intrathecal; Subarachnoid, Injection, solution - Intraspinal; Intrathecal; Subarachnoid, Injection, solution - Infiltration

Local Anesthetic Nerve Block

, 2.0 %, 100.0 mg/mL, 10.0 mg/mL, 20.0 mg/mL

, Infiltration, Liquid, Liquid - Infiltration, Solution, Solution - Infiltration, Injection, solution, Intraspinal; Intrathecal; Subarachnoid, Injection, solution - Intraspinal; Intrathecal; Subarachnoid, Injection, solution - Infiltration

Regional Analgesia

, 2.0 %, 100.0 mg/mL, 10.0 mg/mL, 20.0 mg/mL

, Infiltration, Liquid, Liquid - Infiltration, Solution, Solution - Infiltration, Injection, solution, Intraspinal; Intrathecal; Subarachnoid, Injection, solution - Intraspinal; Intrathecal; Subarachnoid, Injection, solution - Infiltration

Regional Anesthetic Nerve Block

, 2.0 %, 100.0 mg/mL, 10.0 mg/mL, 20.0 mg/mL

, Infiltration, Liquid, Liquid - Infiltration, Solution, Solution - Infiltration, Injection, solution, Intraspinal; Intrathecal; Subarachnoid, Injection, solution - Intraspinal; Intrathecal; Subarachnoid, Injection, solution - Infiltration

Sudden Cardiac Arrest

, 2.0 %, 100.0 mg/mL, 10.0 mg/mL, 20.0 mg/mL

, Infiltration, Liquid, Liquid - Infiltration, Solution, Solution - Infiltration, Injection, solution, Intraspinal; Intrathecal; Subarachnoid, Injection, solution - Intraspinal; Intrathecal; Subarachnoid, Injection, solution - Infiltration

Low body temperature

, 2.0 %, 100.0 mg/mL, 10.0 mg/mL, 20.0 mg/mL

, Infiltration, Liquid, Liquid - Infiltration, Solution, Solution - Infiltration, Injection, solution, Intraspinal; Intrathecal; Subarachnoid, Injection, solution - Intraspinal; Intrathecal; Subarachnoid, Injection, solution - Infiltration

Ischemic Stroke

, 2.0 %, 100.0 mg/mL, 10.0 mg/mL, 20.0 mg/mL

, Infiltration, Liquid, Liquid - Infiltration, Solution, Solution - Infiltration, Injection, solution, Intraspinal; Intrathecal; Subarachnoid, Injection, solution - Intraspinal; Intrathecal; Subarachnoid, Injection, solution - Infiltration

Open Heart Surgery

, 2.0 %, 100.0 mg/mL, 10.0 mg/mL, 20.0 mg/mL

, Infiltration, Liquid, Liquid - Infiltration, Solution, Solution - Infiltration, Injection, solution, Intraspinal; Intrathecal; Subarachnoid, Injection, solution - Intraspinal; Intrathecal; Subarachnoid, Injection, solution - Infiltration

Local Analgesia

, 2.0 %, 100.0 mg/mL, 10.0 mg/mL, 20.0 mg/mL

, Infiltration, Liquid, Liquid - Infiltration, Solution, Solution - Infiltration, Injection, solution, Intraspinal; Intrathecal; Subarachnoid, Injection, solution - Intraspinal; Intrathecal; Subarachnoid, Injection, solution - Infiltration

Warnings

Novocain Contraindications

Condition

Risk Level

Notes

Severe Hypersensitivity Reactions

Do Not Combine

Procaine may interact with Pulse Frequency

There are 20 known major drug interactions with Novocain.

Common Novocain Drug Interactions

Drug Name

Risk Level

Description

2,5-Dimethoxy-4-ethylamphetamine

Major

Procaine may increase the hypertensive activities of 2,5-Dimethoxy-4-ethylamphetamine.

2,5-Dimethoxy-4-ethylthioamphetamine

Major

Procaine may increase the hypertensive activities of 2,5-Dimethoxy-4-ethylthioamphetamine.

4-Bromo-2,5-dimethoxyamphetamine

Major

Procaine may increase the hypertensive activities of 4-Bromo-2,5-dimethoxyamphetamine.

4-Methoxyamphetamine

Major

Procaine may increase the hypertensive activities of 4-Methoxyamphetamine.

5-methoxy-N,N-dimethyltryptamine

Major

The metabolism of 5-methoxy-N,N-dimethyltryptamine can be decreased when combined with Procaine.

image of a doctor in a lab doing drug, clinical research

Novocain Novel Uses: Which Conditions Have a Clinical Trial Featuring Novocain?

28 active studies are currently investigating the potential of Novocain to provide therapeutic relief for Heart attack, Regional Anesthetic Nerve Block and Otalgia.

Condition

Clinical Trials

Trial Phases

Low body temperature

1 Actively Recruiting

Not Applicable

Open Heart Surgery

1 Actively Recruiting

Phase 1, Phase 2

Local Analgesia

0 Actively Recruiting

Earache

0 Actively Recruiting

Sudden Cardiac Arrest

5 Actively Recruiting

Not Applicable

Local Anesthetic Nerve Block

0 Actively Recruiting

Ischemic Stroke

1 Actively Recruiting

Not Applicable

Regional Analgesia

0 Actively Recruiting

Regional Anesthetic Nerve Block

0 Actively Recruiting

Patient Q&A Section about novocain

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

What does the drug Novocaine do?

"Novocaine is a local anesthetic drug. It numbs a specific part of the body, but does not make the person lose consciousness."

Answered by AI

Does Novocain make you loopy?

"Novocaine does not make you feel sleepy, however it does numb tissue. Many patients report feeling sluggish, as if they were tired or a little drunk. Novocaine can cause headaches, but usually not at the doses and locations used in dentistry."

Answered by AI

Is Novocain still used?

"Nowadays, Novocaine is not used as much because it takes too long to work and doesn't last very long. Lidocaine and Septocaine are better choices because they work more quickly and last longer. They also have a very small chance of causing allergic reactions."

Answered by AI

Does Novocain make you high?

"There is no potential for abuse with this anesthetic as it does not have any euphoric or addictive effects, though it can cause increased bleeding due to its ability to dilate blood vessels. A similar anesthetic compound is lidocaine, which was first synthesized in 1943."

Answered by AI

Clinical Trials for Novocain

Image of Rush University Medical Center in Chicago, United States.

Precision-Controlled Ventilation for Cardiac Arrest

18+
All Sexes
Chicago, IL

Cardiac arrest is a life-threatening emergency that requires immediate treatment with cardiopulmonary resuscitation (CPR). While chest compressions circulate blood, manual ventilation provides oxygen to the patient. Current CPR guidelines recommend specific ventilation rates and tidal volumes, but studies show that clinicians often deliver too much or too little ventilation due to a lack of monitoring tools, potentially reducing the effectiveness of CPR and impacting survival. The PRECISION-CPR study is a multi-center, randomized controlled trial designed to evaluate whether using real-time feedback devices to precisely control ventilation during CPR can improve patient outcomes. Adult patients experiencing in-hospital cardiac arrest will be randomized to receive either standard manual ventilation guided by clinician experience or precision-controlled ventilation tailored to the patient's predicted body weight using real-time monitoring devices. The primary outcome of the study will be return of spontaneous circulation (ROSC). Secondary outcomes will include survival to hospital discharge, neurological recovery, and other clinical measures. By addressing the limitations of current ventilation practices, this study aims to generate evidence to guide future resuscitation guidelines and improve survival rates after cardiac arrest.

Waitlist Available
Has No Placebo

Rush University Medical Center

Image of University of Pittsburgh Department of Emergency Medicine in Pittsburgh, United States.

Specialty Care for Cardiac Arrest

18+
All Sexes
Pittsburgh, PA

This randomized clinical trial will determine if adult participants who are in the emergency department after being resuscitated from a cardiac arrest outside of the hospital benefit from care delivered at specialized centers. The main question that it will answer is whether transferring participants to a hospital with a specialized cardiac arrest service improves recovery of function after 90 days. Participants will receive all usual medical care, but some participants will be offered transfer to a regional cardiac arrest center and others will be offered care at the closest appropriate hospital. Investigators will interview participants after 90 days to assess their recovery.

Waitlist Available
Has No Placebo

University of Pittsburgh Department of Emergency Medicine

Jonathan Elmer, MD, MS

Have you considered Novocain clinical trials?

We made a collection of clinical trials featuring Novocain, we think they might fit your search criteria.
Go to Trials