Novantrone

Advance Directives, Liver carcinoma, Leukemia + 10 more
Treatment
17 FDA approvals
20 Active Studies for Novantrone

What is Novantrone

MitoxantroneThe Generic name of this drug
Treatment SummaryA medication used to treat cancer, derived from the anthracenedione family.
Novantroneis the brand name
image of different drug pills on a surface
Novantrone Overview & Background
Brand Name
Generic Name
First FDA Approval
How many FDA approvals?
Novantrone
Mitoxantrone
1987
12

Approved as Treatment by the FDA

Mitoxantrone, otherwise known as Novantrone, is approved by the FDA for 17 uses which include relapsed Hepatocellular carcinoma and Secondary Progressive Multiple Sclerosis (SPMS) .
relapsed Hepatocellular carcinoma
Secondary Progressive Multiple Sclerosis (SPMS)
Helps manage Secondary Progressive Multiple Sclerosis (SPMS)
Metastatic Breast Cancer
Relapsed Lymphomas
Progressive Relapsing Multiple Sclerosis
Helps manage Progressive Relapsing Multiple Sclerosis
Relapsed Leukemia
Acute Myeloid Leukemia (AML)
Used to treat Acute Myeloid Leukemia (AML) in combination with null
Relapsing Remitting Multiple Sclerosis (RRMS)
Helps manage Relapsing Remitting Multiple Sclerosis (RRMS)
Leukemia
Multiple Sclerosis
Helps manage Secondary Progressive Multiple Sclerosis (SPMS)
Liver carcinoma
Metastatic Breast Cancer
Advance Directives
Multiple Sclerosis
Helps manage Progressive Relapsing Multiple Sclerosis
Lymphoma
Acute Myeloid Leukemia
Used to treat Acute Myeloid Leukemia (AML) in combination with null
Relapsing Remitting Multiple Sclerosis
Helps manage Relapsing Remitting Multiple Sclerosis (RRMS)

Effectiveness

How Novantrone Affects PatientsIn laboratory tests, mitoxantrone has been found to block the growth of B cells, T cells, and macrophages, as well as stop the release of certain proteins related to inflammation.
How Novantrone works in the bodyMitoxantrone works by attaching to DNA and RNA molecules and disrupting their normal functioning. It also stops the enzyme responsible for repairing damaged DNA, which can lead to cell death in both growing and resting cells.

When to interrupt dosage

The proposed dosage of Novantrone is contingent upon the diagnosed affliction, for example Metastatic Breast Cancer, Acute Promyelocytic Leukemia and Advance Directives. The measure of dosage fluctuates as per the method of delivery (e.g. Liquid or Injection, solution, concentrate) recorded in the table beneath.
Condition
Dosage
Administration
Hodgkin's Lymphoma
, 2.0 mg/mL, 2.5 mg/mL, 3.0 mg/mL
, Intravenous, Injection, solution, Injection, solution - Intravenous, Solution, Solution - Intravenous, Liquid - Intravenous, Liquid, Injection, solution, concentrate, Injection, solution, concentrate - Intravenous
Advance Directives
, 2.0 mg/mL, 2.5 mg/mL, 3.0 mg/mL
, Intravenous, Injection, solution, Injection, solution - Intravenous, Solution, Solution - Intravenous, Liquid - Intravenous, Liquid, Injection, solution, concentrate, Injection, solution, concentrate - Intravenous
Lymphoma
, 2.0 mg/mL, 2.5 mg/mL, 3.0 mg/mL
, Intravenous, Injection, solution, Injection, solution - Intravenous, Solution, Solution - Intravenous, Liquid - Intravenous, Liquid, Injection, solution, concentrate, Injection, solution, concentrate - Intravenous
Multiple Sclerosis
, 2.0 mg/mL, 2.5 mg/mL, 3.0 mg/mL
, Intravenous, Injection, solution, Injection, solution - Intravenous, Solution, Solution - Intravenous, Liquid - Intravenous, Liquid, Injection, solution, concentrate, Injection, solution, concentrate - Intravenous
Relapsing Remitting Multiple Sclerosis
, 2.0 mg/mL, 2.5 mg/mL, 3.0 mg/mL
, Intravenous, Injection, solution, Injection, solution - Intravenous, Solution, Solution - Intravenous, Liquid - Intravenous, Liquid, Injection, solution, concentrate, Injection, solution, concentrate - Intravenous
Liver carcinoma
, 2.0 mg/mL, 2.5 mg/mL, 3.0 mg/mL
, Intravenous, Injection, solution, Injection, solution - Intravenous, Solution, Solution - Intravenous, Liquid - Intravenous, Liquid, Injection, solution, concentrate, Injection, solution, concentrate - Intravenous
Leukemia
, 2.0 mg/mL, 2.5 mg/mL, 3.0 mg/mL
, Intravenous, Injection, solution, Injection, solution - Intravenous, Solution, Solution - Intravenous, Liquid - Intravenous, Liquid, Injection, solution, concentrate, Injection, solution, concentrate - Intravenous
Non-Hodgkin's Lymphoma
, 2.0 mg/mL, 2.5 mg/mL, 3.0 mg/mL
, Intravenous, Injection, solution, Injection, solution - Intravenous, Solution, Solution - Intravenous, Liquid - Intravenous, Liquid, Injection, solution, concentrate, Injection, solution, concentrate - Intravenous
Acute Myeloid Leukemia
, 2.0 mg/mL, 2.5 mg/mL, 3.0 mg/mL
, Intravenous, Injection, solution, Injection, solution - Intravenous, Solution, Solution - Intravenous, Liquid - Intravenous, Liquid, Injection, solution, concentrate, Injection, solution, concentrate - Intravenous
Metastatic Breast Cancer
, 2.0 mg/mL, 2.5 mg/mL, 3.0 mg/mL
, Intravenous, Injection, solution, Injection, solution - Intravenous, Solution, Solution - Intravenous, Liquid - Intravenous, Liquid, Injection, solution, concentrate, Injection, solution, concentrate - Intravenous
Acute Lymphoblastic Leukemia
, 2.0 mg/mL, 2.5 mg/mL, 3.0 mg/mL
, Intravenous, Injection, solution, Injection, solution - Intravenous, Solution, Solution - Intravenous, Liquid - Intravenous, Liquid, Injection, solution, concentrate, Injection, solution, concentrate - Intravenous
Multiple Sclerosis
, 2.0 mg/mL, 2.5 mg/mL, 3.0 mg/mL
, Intravenous, Injection, solution, Injection, solution - Intravenous, Solution, Solution - Intravenous, Liquid - Intravenous, Liquid, Injection, solution, concentrate, Injection, solution, concentrate - Intravenous
Acute Promyelocytic Leukemia
, 2.0 mg/mL, 2.5 mg/mL, 3.0 mg/mL
, Intravenous, Injection, solution, Injection, solution - Intravenous, Solution, Solution - Intravenous, Liquid - Intravenous, Liquid, Injection, solution, concentrate, Injection, solution, concentrate - Intravenous

Warnings

There are 20 known major drug interactions with Novantrone.
Common Novantrone Drug Interactions
Drug Name
Risk Level
Description
2-Methoxyethanol
Major
The risk or severity of adverse effects can be increased when Mitoxantrone is combined with 2-Methoxyethanol.
9-(N-methyl-L-isoleucine)-cyclosporin A
Major
The risk or severity of adverse effects can be increased when Mitoxantrone is combined with 9-(N-methyl-L-isoleucine)-cyclosporin A.
Abatacept
Major
The risk or severity of adverse effects can be increased when Mitoxantrone is combined with Abatacept.
Abetimus
Major
The risk or severity of adverse effects can be increased when Mitoxantrone is combined with Abetimus.
Acteoside
Major
The risk or severity of adverse effects can be increased when Mitoxantrone is combined with Acteoside.
Novantrone Toxicity & Overdose RiskOverdosing on this drug can lead to a severe decrease in white blood cells and an increased risk of infection.
image of a doctor in a lab doing drug, clinical research

Novantrone Novel Uses: Which Conditions Have a Clinical Trial Featuring Novantrone?

At present, 785 active clinical trials are underway to ascertain the effectiveness of Novantrone in alleviating Hodgkin's Lymphoma, Metastatic Breast Cancer and Relapsed Lymphomas.
Condition
Clinical Trials
Trial Phases
Lymphoma
1 Actively Recruiting
Phase 2
Acute Myeloid Leukemia
276 Actively Recruiting
Phase 2, Phase 1, Phase 3, Phase 4, Not Applicable, Early Phase 1
Multiple Sclerosis
11 Actively Recruiting
Phase 3, Phase 2, Not Applicable, Early Phase 1, Phase 1
Liver carcinoma
0 Actively Recruiting
Relapsing Remitting Multiple Sclerosis
14 Actively Recruiting
Phase 3, Not Applicable, Phase 2, Phase 4, Early Phase 1
Leukemia
1 Actively Recruiting
Phase 1, Phase 2
Acute Promyelocytic Leukemia
0 Actively Recruiting
Metastatic Breast Cancer
1 Actively Recruiting
Phase 1, Phase 2
Advance Directives
0 Actively Recruiting
Multiple Sclerosis
0 Actively Recruiting
Non-Hodgkin's Lymphoma
124 Actively Recruiting
Phase 1, Phase 2, Early Phase 1, Not Applicable, Phase 3, Phase 4
Acute Lymphoblastic Leukemia
119 Actively Recruiting
Phase 1, Phase 2, Phase 3, Not Applicable, Early Phase 1, Phase 4
Hodgkin's Lymphoma
66 Actively Recruiting
Phase 2, Phase 1, Phase 3, Not Applicable, Early Phase 1

Novantrone Reviews: What are patients saying about Novantrone?

5Patient Review
10/11/2007
Novantrone for Multiple Sclerosis Symptoms Return then Become Less Severe
5Patient Review
4/13/2009
Novantrone for Multiple Sclerosis Symptoms Return then Become Less Severe
I had this treatment every three months for two years. Each time, I got a MUG-A scan to check for heart damage a day or two beforehand. The therapy caused me to vomit and lose my hair, but it also stopped the progression of my MS, which is all that really matters to me.
5Patient Review
6/25/2008
Novantrone for Multiple Sclerosis Symptoms Return then Become Less Severe
This medication has been an incredible help to me. I've gone from relying on a wheelchair to just using a walker, and I feel so much stronger now.
4Patient Review
1/8/2008
Novantrone for Multiple Sclerosis Symptoms Return then Become Less Severe
4Patient Review
1/16/2009
Novantrone for Multiple Sclerosis Symptoms Return then Become Less Severe
After taking three doses of the medication, I was doing well. However, when I opened a can of cat food and smelled it, I immediately vomited. My husband called my neuro who had never heard of that reaction before. He then called the company to tell them what happened.
View All Reviews
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Patient Q&A Section about novantrone

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

Is Novantrone still used for MS?

"Although Novantrone has not been approved for treating primary-progressive MS, it is still worth considering as a possible treatment option."

Answered by AI

Why was Novantrone discontinued?

"The therapy is only available as a generic medication. It was originally sold under the brand name Novantrone, but Merck KGaA, known as EMD Serono in North America, stopped distributing it after acquiring the medication from Amgen in 2002. This decision was not related to the safety or effectiveness of Novantrone."

Answered by AI

What is Novantrone used for?

"Novantrone is a cancer medication that is used to treat prostate cancer and certain types of leukemia. It can also be used to help manage the symptoms of relapsing multiple sclerosis."

Answered by AI

Is Novantrone a chemo?

"Novantrone is an anti-cancer drug that works by killing cancer cells. It is classified as an "antitumor antibiotic.""

Answered by AI

Clinical Trials for Novantrone

Have you considered Novantrone clinical trials? We made a collection of clinical trials featuring Novantrone, we think they might fit your search criteria.
Have you considered Novantrone clinical trials? We made a collection of clinical trials featuring Novantrone, we think they might fit your search criteria.
Have you considered Novantrone clinical trials? We made a collection of clinical trials featuring Novantrone, we think they might fit your search criteria.
Unbiased ResultsWe believe in providing patients with all the options.
Your Data Stays Your DataWe only share your information with the clinical trials you're trying to access.
Verified Trials OnlyAll of our trials are run by licensed doctors, researchers, and healthcare companies.
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