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What is Nizoral
KetoconazoleThe Generic name of this drug
Treatment SummarySalicylic acid is used for its anti-bacterial, anti-fungal, and skin-exfoliating properties. It is derived from the bark of the white willow tree and wintergreen leaves, but can also be synthesized in a lab. Salicylic acid is made into salts, called salicylates, which are used to ease pain.
Nizoralis the brand name
Nizoral Overview & Background
Brand Name
Generic Name
First FDA Approval
How many FDA approvals?
Nizoral
Ketoconazole
1981
135
Effectiveness
How Nizoral Affects PatientsSalicylic acid is used to treat acne by helping dead skin cells fall off more easily, keeping pores from becoming clogged. It is also an ingredient in some shampoos that treat dandruff. People with darker skin may experience discoloration if salicylic acid is not used with a broad-spectrum sunscreen. Salicylic acid, in combination with bismuth, is also used in Pepto-Bismol, which helps with stomach discomfort, nausea, heartburn, and gas. It is also slightly antibacterial.
How Nizoral works in the bodySalicylic acid is used to help reduce inflammation and pain. It is also used in skin care products to treat acne, psoriasis, calluses, corns, keratosis pilaris, and warts. It helps skin cells slough off more easily, which is why it's used in dandruff shampoos. Salicylic acid also interferes with the production of certain molecules that are needed for wound healing.
When to interrupt dosage
The proposed dosage of Nizoral is contingent upon the identified affliction, including Dermatitis, corticosteroid-responsive dermatoses and Musculoskeletal Pain. The amount of dosage is dependent upon the method of delivery (e.g. Cream - Topical or Disc - Topical) outlined in the chart below.Condition
Dosage
Administration
Vulvovaginal Candidiasis
, 0.02 mg/mg, 200.0 mg, 10.0 mg/mL, 20.0 mg, 20.0 mg/mL, 2.0 %, 20.5 mg/mL
, Topical, Cream, Cream - Topical, Oral, Tablet, Tablet - Oral, Gel, Gel - Topical, Aerosol, foam, Aerosol, foam - Topical, Kit, Shampoo, Shampoo - Topical, Shampoo, suspension, Shampoo, suspension - Topical, Suspension - Oral, Suspension, Kit - Topical
Histoplasmosis
, 0.02 mg/mg, 200.0 mg, 10.0 mg/mL, 20.0 mg, 20.0 mg/mL, 2.0 %, 20.5 mg/mL
, Topical, Cream, Cream - Topical, Oral, Tablet, Tablet - Oral, Gel, Gel - Topical, Aerosol, foam, Aerosol, foam - Topical, Kit, Shampoo, Shampoo - Topical, Shampoo, suspension, Shampoo, suspension - Topical, Suspension - Oral, Suspension, Kit - Topical
Paracoccidioidomycosis
, 0.02 mg/mg, 200.0 mg, 10.0 mg/mL, 20.0 mg, 20.0 mg/mL, 2.0 %, 20.5 mg/mL
, Topical, Cream, Cream - Topical, Oral, Tablet, Tablet - Oral, Gel, Gel - Topical, Aerosol, foam, Aerosol, foam - Topical, Kit, Shampoo, Shampoo - Topical, Shampoo, suspension, Shampoo, suspension - Topical, Suspension - Oral, Suspension, Kit - Topical
Chromoblastomycosis
, 0.02 mg/mg, 200.0 mg, 10.0 mg/mL, 20.0 mg, 20.0 mg/mL, 2.0 %, 20.5 mg/mL
, Topical, Cream, Cream - Topical, Oral, Tablet, Tablet - Oral, Gel, Gel - Topical, Aerosol, foam, Aerosol, foam - Topical, Kit, Shampoo, Shampoo - Topical, Shampoo, suspension, Shampoo, suspension - Topical, Suspension - Oral, Suspension, Kit - Topical
Blastomycosis
, 0.02 mg/mg, 200.0 mg, 10.0 mg/mL, 20.0 mg, 20.0 mg/mL, 2.0 %, 20.5 mg/mL
, Topical, Cream, Cream - Topical, Oral, Tablet, Tablet - Oral, Gel, Gel - Topical, Aerosol, foam, Aerosol, foam - Topical, Kit, Shampoo, Shampoo - Topical, Shampoo, suspension, Shampoo, suspension - Topical, Suspension - Oral, Suspension, Kit - Topical
Coccidioidomycosis
, 0.02 mg/mg, 200.0 mg, 10.0 mg/mL, 20.0 mg, 20.0 mg/mL, 2.0 %, 20.5 mg/mL
, Topical, Cream, Cream - Topical, Oral, Tablet, Tablet - Oral, Gel, Gel - Topical, Aerosol, foam, Aerosol, foam - Topical, Kit, Shampoo, Shampoo - Topical, Shampoo, suspension, Shampoo, suspension - Topical, Suspension - Oral, Suspension, Kit - Topical
Dandruff
, 0.02 mg/mg, 200.0 mg, 10.0 mg/mL, 20.0 mg, 20.0 mg/mL, 2.0 %, 20.5 mg/mL
, Topical, Cream, Cream - Topical, Oral, Tablet, Tablet - Oral, Gel, Gel - Topical, Aerosol, foam, Aerosol, foam - Topical, Kit, Shampoo, Shampoo - Topical, Shampoo, suspension, Shampoo, suspension - Topical, Suspension - Oral, Suspension, Kit - Topical
cutaneous candidiasis
, 0.02 mg/mg, 200.0 mg, 10.0 mg/mL, 20.0 mg, 20.0 mg/mL, 2.0 %, 20.5 mg/mL
, Topical, Cream, Cream - Topical, Oral, Tablet, Tablet - Oral, Gel, Gel - Topical, Aerosol, foam, Aerosol, foam - Topical, Kit, Shampoo, Shampoo - Topical, Shampoo, suspension, Shampoo, suspension - Topical, Suspension - Oral, Suspension, Kit - Topical
Candidiasis, Chronic Mucocutaneous
, 0.02 mg/mg, 200.0 mg, 10.0 mg/mL, 20.0 mg, 20.0 mg/mL, 2.0 %, 20.5 mg/mL
, Topical, Cream, Cream - Topical, Oral, Tablet, Tablet - Oral, Gel, Gel - Topical, Aerosol, foam, Aerosol, foam - Topical, Kit, Shampoo, Shampoo - Topical, Shampoo, suspension, Shampoo, suspension - Topical, Suspension - Oral, Suspension, Kit - Topical
Seborrheic Dermatitis
, 0.02 mg/mg, 200.0 mg, 10.0 mg/mL, 20.0 mg, 20.0 mg/mL, 2.0 %, 20.5 mg/mL
, Topical, Cream, Cream - Topical, Oral, Tablet, Tablet - Oral, Gel, Gel - Topical, Aerosol, foam, Aerosol, foam - Topical, Kit, Shampoo, Shampoo - Topical, Shampoo, suspension, Shampoo, suspension - Topical, Suspension - Oral, Suspension, Kit - Topical
Vaginal Candidiasis
, 0.02 mg/mg, 200.0 mg, 10.0 mg/mL, 20.0 mg, 20.0 mg/mL, 2.0 %, 20.5 mg/mL
, Topical, Cream, Cream - Topical, Oral, Tablet, Tablet - Oral, Gel, Gel - Topical, Aerosol, foam, Aerosol, foam - Topical, Kit, Shampoo, Shampoo - Topical, Shampoo, suspension, Shampoo, suspension - Topical, Suspension - Oral, Suspension, Kit - Topical
Cushing Syndrome
, 0.02 mg/mg, 200.0 mg, 10.0 mg/mL, 20.0 mg, 20.0 mg/mL, 2.0 %, 20.5 mg/mL
, Topical, Cream, Cream - Topical, Oral, Tablet, Tablet - Oral, Gel, Gel - Topical, Aerosol, foam, Aerosol, foam - Topical, Kit, Shampoo, Shampoo - Topical, Shampoo, suspension, Shampoo, suspension - Topical, Suspension - Oral, Suspension, Kit - Topical
Bacterial Vaginosis
, 0.02 mg/mg, 200.0 mg, 10.0 mg/mL, 20.0 mg, 20.0 mg/mL, 2.0 %, 20.5 mg/mL
, Topical, Cream, Cream - Topical, Oral, Tablet, Tablet - Oral, Gel, Gel - Topical, Aerosol, foam, Aerosol, foam - Topical, Kit, Shampoo, Shampoo - Topical, Shampoo, suspension, Shampoo, suspension - Topical, Suspension - Oral, Suspension, Kit - Topical
Trichophyton mentagrophytes
, 0.02 mg/mg, 200.0 mg, 10.0 mg/mL, 20.0 mg, 20.0 mg/mL, 2.0 %, 20.5 mg/mL
, Topical, Cream, Cream - Topical, Oral, Tablet, Tablet - Oral, Gel, Gel - Topical, Aerosol, foam, Aerosol, foam - Topical, Kit, Shampoo, Shampoo - Topical, Shampoo, suspension, Shampoo, suspension - Topical, Suspension - Oral, Suspension, Kit - Topical
Tinea cruris
, 0.02 mg/mg, 200.0 mg, 10.0 mg/mL, 20.0 mg, 20.0 mg/mL, 2.0 %, 20.5 mg/mL
, Topical, Cream, Cream - Topical, Oral, Tablet, Tablet - Oral, Gel, Gel - Topical, Aerosol, foam, Aerosol, foam - Topical, Kit, Shampoo, Shampoo - Topical, Shampoo, suspension, Shampoo, suspension - Topical, Suspension - Oral, Suspension, Kit - Topical
Tinea Pedis
, 0.02 mg/mg, 200.0 mg, 10.0 mg/mL, 20.0 mg, 20.0 mg/mL, 2.0 %, 20.5 mg/mL
, Topical, Cream, Cream - Topical, Oral, Tablet, Tablet - Oral, Gel, Gel - Topical, Aerosol, foam, Aerosol, foam - Topical, Kit, Shampoo, Shampoo - Topical, Shampoo, suspension, Shampoo, suspension - Topical, Suspension - Oral, Suspension, Kit - Topical
Tinea Pedis caused by Epidermophyton floccosumin
, 0.02 mg/mg, 200.0 mg, 10.0 mg/mL, 20.0 mg, 20.0 mg/mL, 2.0 %, 20.5 mg/mL
, Topical, Cream, Cream - Topical, Oral, Tablet, Tablet - Oral, Gel, Gel - Topical, Aerosol, foam, Aerosol, foam - Topical, Kit, Shampoo, Shampoo - Topical, Shampoo, suspension, Shampoo, suspension - Topical, Suspension - Oral, Suspension, Kit - Topical
Tinea corporis (disorder)
, 0.02 mg/mg, 200.0 mg, 10.0 mg/mL, 20.0 mg, 20.0 mg/mL, 2.0 %, 20.5 mg/mL
, Topical, Cream, Cream - Topical, Oral, Tablet, Tablet - Oral, Gel, Gel - Topical, Aerosol, foam, Aerosol, foam - Topical, Kit, Shampoo, Shampoo - Topical, Shampoo, suspension, Shampoo, suspension - Topical, Suspension - Oral, Suspension, Kit - Topical
Tinea Pedis
, 0.02 mg/mg, 200.0 mg, 10.0 mg/mL, 20.0 mg, 20.0 mg/mL, 2.0 %, 20.5 mg/mL
, Topical, Cream, Cream - Topical, Oral, Tablet, Tablet - Oral, Gel, Gel - Topical, Aerosol, foam, Aerosol, foam - Topical, Kit, Shampoo, Shampoo - Topical, Shampoo, suspension, Shampoo, suspension - Topical, Suspension - Oral, Suspension, Kit - Topical
recalcitrant Dermatophytosis
, 0.02 mg/mg, 200.0 mg, 10.0 mg/mL, 20.0 mg, 20.0 mg/mL, 2.0 %, 20.5 mg/mL
, Topical, Cream, Cream - Topical, Oral, Tablet, Tablet - Oral, Gel, Gel - Topical, Aerosol, foam, Aerosol, foam - Topical, Kit, Shampoo, Shampoo - Topical, Shampoo, suspension, Shampoo, suspension - Topical, Suspension - Oral, Suspension, Kit - Topical
Warnings
Nizoral ContraindicationsCondition
Risk Level
Notes
Pulse Frequency
Do Not Combine
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Liver Dysfunction
Do Not Combine
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Long QT Syndrome
Do Not Combine
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acquired long QT syndrome
Do Not Combine
Impaired Renal Function
Do Not Combine
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Severe Hypersensitivity Reactions
Do Not Combine
Ketoconazole may interact with Pulse Frequency
Common Nizoral Drug Interactions
Drug Name
Risk Level
Description
(R)-warfarin
Major
The metabolism of (R)-warfarin can be decreased when combined with Ketoconazole.
(S)-Warfarin
Major
The metabolism of (S)-Warfarin can be decreased when combined with Ketoconazole.
1,2-Benzodiazepine
Major
The metabolism of 1,2-Benzodiazepine can be decreased when combined with Ketoconazole.
3,5-diiodothyropropionic acid
Major
The metabolism of 3,5-diiodothyropropionic acid can be decreased when combined with Ketoconazole.
5-androstenedione
Major
The metabolism of 5-androstenedione can be decreased when combined with Ketoconazole.
Nizoral Toxicity & Overdose RiskThe lowest toxic dose of this drug for rats when taken orally is 891 mg/kg. When inhaled, the lowest toxic dose is greater than 900 mg/m3/1hr. Skin irritation in rabbits can be mild at 500 mg/24H and severe eye irritation has been reported with 100 mg. This drug has been investigated as a potential mutagen and has the capability to affect reproduction.
Nizoral Novel Uses: Which Conditions Have a Clinical Trial Featuring Nizoral?
81 active clinical trials are in progress to assess the potential of Nizoral to combat Palmoplantar Pustulosis (PPP), Communicable Diseases and Lichen Planus.Condition
Clinical Trials
Trial Phases
Histoplasmosis
1 Actively Recruiting
Phase 1, Phase 2
Candidiasis, Chronic Mucocutaneous
0 Actively Recruiting
Tinea Pedis
0 Actively Recruiting
Blastomycosis
0 Actively Recruiting
Coccidioidomycosis
1 Actively Recruiting
Phase 2
cutaneous candidiasis
0 Actively Recruiting
Tinea Pedis caused by Epidermophyton floccosumin
0 Actively Recruiting
Tinea Pedis
0 Actively Recruiting
Trichophyton mentagrophytes
0 Actively Recruiting
Trichophyton rubrum
0 Actively Recruiting
Paracoccidioidomycosis
0 Actively Recruiting
Chromoblastomycosis
0 Actively Recruiting
Seborrheic Dermatitis
2 Actively Recruiting
Not Applicable, Phase 2
Vaginal Candidiasis
0 Actively Recruiting
Tinea corporis (disorder)
0 Actively Recruiting
Bacterial Vaginosis
3 Actively Recruiting
Not Applicable, Phase 2, Early Phase 1
Malassezia
0 Actively Recruiting
Candidiasis, Systemic
0 Actively Recruiting
Vulvovaginal Candidiasis
0 Actively Recruiting
Cushing Syndrome
0 Actively Recruiting
Nizoral Reviews: What are patients saying about Nizoral?
5Patient Review
3/16/2008 This didn't do anything to help my child's ringworm. If anything, it made the problem worse.
5Patient Review
7/3/2012 Nizoral has been my go-to shampoo for fifteen years now. I've tried other options, but this one works the best by far for my scalp condition.
5Patient Review
8/10/2009 This ointment has helped immensely with my seborrhea.
5Patient Review
2/19/2009 I was patient and it finally paid off.
4Patient Review
5/24/2009 I usually get a fungus problem around my nose and face during winter, but this medication clears it up within three days. I've been using it on and off for ten years now.
3.7Patient Review
8/10/2012 The generic medication I used did a good job at stopping the itching, redness and spread of inflammation around my mouth. However, I needed another medication to use around my eyelids.
3.3Patient Review
8/13/2011 Nizoral was first prescribed to me in 1997 as an effective and safe treatment for tinea versicolor. I've since then used the over-the-counter version to keep up my quality of life.
3Patient Review
4/12/2009 Unfortunately, this didn't work for me at all. If anything, it made the situation worse.
2Patient Review
1/28/2009 Nizoral shampoo has been a godsend for my severe dandruff and itchy scalp. It works like a charm, usually clearing up the condition within a week or two. I can use it more often if necessary, but it always does the trick. Very satisfied with this medicine - would recommend to anyone with similar issues!
1.7Patient Review
10/16/20071.7Patient Review
1/3/2009 I use it for vericolor of the face. It works quickly to return my color.
1.7Patient Review
10/19/2022 I saw no change in my dandruff after using this product for a couple months, despite following the directions to use it 2-3 times per week. Do not bother buying this.
1Patient Review
4/10/2012 Can somebody please tell me if it's okay to take this medication? I have Parkinson's disease and one of my other medications has a warning label saying not to use ketoconazole.
Patient Q&A Section about nizoral
These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.What does Nizoral used for?
"Ketoconazole is used to treat various fungal infections of the skin such as athlete's foot, jock itch, ringworm, and dandruff. It can also treat a skin condition known as pityriasis (tinea versicolor), which is characterized by a lightening or darkening of the skin on the neck, chest, arms, or legs."
Answered by AI
Is it OK to use Nizoral shampoo everyday?
"How often should I use Nizoral?
You only need to use it every 3 to 4 days (twice a week) for 8 weeks. On the days you don't use Nizoral, you can use your regular shampoo and conditioner."
Answered by AI
How long does it take Nizoral to work?
"If you're using Nizoral to treat dandruff, you should start seeing results after the first wash. In most cases, dandruff will be gone within two weeks. If your scalp hasn't cleared up after four weeks, it's possible that you don't have dandruff and you should seek advice from a healthcare professional."
Answered by AI
What does Nizoral do to your hair?
"Ketoconazole, which is also known by the prescription name Nizoral, can help to decrease the production of testosterone. When testosterone is converted into a substance called DHT (dihydrotestosterone), it can destroy hair follicles and lead to hair loss."
Answered by AI