Nizoral

Histoplasmosis, Paracoccidioidomycosis, Chromoblastomycosis + 22 more

Treatment

4 Active Studies for Nizoral

Treatment for

Histoplasmosis

What is Nizoral

Ketoconazole

The Generic name of this drug

Treatment Summary

Salicylic acid is used for its anti-bacterial, anti-fungal, and skin-exfoliating properties. It is derived from the bark of the white willow tree and wintergreen leaves, but can also be synthesized in a lab. Salicylic acid is made into salts, called salicylates, which are used to ease pain.

Nizoral

is the brand name

image of different drug pills on a surface

Nizoral Overview & Background

Brand Name

Generic Name

First FDA Approval

How many FDA approvals?

Nizoral

Ketoconazole

1981

135

Effectiveness

How Nizoral Affects Patients

Salicylic acid is used to treat acne by helping dead skin cells fall off more easily, keeping pores from becoming clogged. It is also an ingredient in some shampoos that treat dandruff. People with darker skin may experience discoloration if salicylic acid is not used with a broad-spectrum sunscreen. Salicylic acid, in combination with bismuth, is also used in Pepto-Bismol, which helps with stomach discomfort, nausea, heartburn, and gas. It is also slightly antibacterial.

How Nizoral works in the body

Salicylic acid is used to help reduce inflammation and pain. It is also used in skin care products to treat acne, psoriasis, calluses, corns, keratosis pilaris, and warts. It helps skin cells slough off more easily, which is why it's used in dandruff shampoos. Salicylic acid also interferes with the production of certain molecules that are needed for wound healing.

When to interrupt dosage

The proposed dosage of Nizoral is contingent upon the identified affliction, including Dermatitis, corticosteroid-responsive dermatoses and Musculoskeletal Pain. The amount of dosage is dependent upon the method of delivery (e.g. Cream - Topical or Disc - Topical) outlined in the chart below.

Condition

Dosage

Administration

Histoplasmosis

, 0.02 mg/mg, 200.0 mg, 10.0 mg/mL, 20.0 mg, 20.0 mg/mL, 2.0 %, 20.5 mg/mL

, Topical, Cream, Cream - Topical, Oral, Tablet, Tablet - Oral, Gel, Gel - Topical, Aerosol, foam, Aerosol, foam - Topical, Kit, Shampoo, Shampoo - Topical, Shampoo, suspension, Shampoo, suspension - Topical, Suspension - Oral, Suspension, Kit - Topical

Paracoccidioidomycosis

, 0.02 mg/mg, 200.0 mg, 10.0 mg/mL, 20.0 mg, 20.0 mg/mL, 2.0 %, 20.5 mg/mL

, Topical, Cream, Cream - Topical, Oral, Tablet, Tablet - Oral, Gel, Gel - Topical, Aerosol, foam, Aerosol, foam - Topical, Kit, Shampoo, Shampoo - Topical, Shampoo, suspension, Shampoo, suspension - Topical, Suspension - Oral, Suspension, Kit - Topical

Chromoblastomycosis

, 0.02 mg/mg, 200.0 mg, 10.0 mg/mL, 20.0 mg, 20.0 mg/mL, 2.0 %, 20.5 mg/mL

, Topical, Cream, Cream - Topical, Oral, Tablet, Tablet - Oral, Gel, Gel - Topical, Aerosol, foam, Aerosol, foam - Topical, Kit, Shampoo, Shampoo - Topical, Shampoo, suspension, Shampoo, suspension - Topical, Suspension - Oral, Suspension, Kit - Topical

Blastomycosis

, 0.02 mg/mg, 200.0 mg, 10.0 mg/mL, 20.0 mg, 20.0 mg/mL, 2.0 %, 20.5 mg/mL

, Topical, Cream, Cream - Topical, Oral, Tablet, Tablet - Oral, Gel, Gel - Topical, Aerosol, foam, Aerosol, foam - Topical, Kit, Shampoo, Shampoo - Topical, Shampoo, suspension, Shampoo, suspension - Topical, Suspension - Oral, Suspension, Kit - Topical

Coccidioidomycosis

, 0.02 mg/mg, 200.0 mg, 10.0 mg/mL, 20.0 mg, 20.0 mg/mL, 2.0 %, 20.5 mg/mL

, Topical, Cream, Cream - Topical, Oral, Tablet, Tablet - Oral, Gel, Gel - Topical, Aerosol, foam, Aerosol, foam - Topical, Kit, Shampoo, Shampoo - Topical, Shampoo, suspension, Shampoo, suspension - Topical, Suspension - Oral, Suspension, Kit - Topical

Dandruff

, 0.02 mg/mg, 200.0 mg, 10.0 mg/mL, 20.0 mg, 20.0 mg/mL, 2.0 %, 20.5 mg/mL

, Topical, Cream, Cream - Topical, Oral, Tablet, Tablet - Oral, Gel, Gel - Topical, Aerosol, foam, Aerosol, foam - Topical, Kit, Shampoo, Shampoo - Topical, Shampoo, suspension, Shampoo, suspension - Topical, Suspension - Oral, Suspension, Kit - Topical

cutaneous candidiasis

, 0.02 mg/mg, 200.0 mg, 10.0 mg/mL, 20.0 mg, 20.0 mg/mL, 2.0 %, 20.5 mg/mL

, Topical, Cream, Cream - Topical, Oral, Tablet, Tablet - Oral, Gel, Gel - Topical, Aerosol, foam, Aerosol, foam - Topical, Kit, Shampoo, Shampoo - Topical, Shampoo, suspension, Shampoo, suspension - Topical, Suspension - Oral, Suspension, Kit - Topical

Candidiasis, Vulvovaginal

, 0.02 mg/mg, 200.0 mg, 10.0 mg/mL, 20.0 mg, 20.0 mg/mL, 2.0 %, 20.5 mg/mL

, Topical, Cream, Cream - Topical, Oral, Tablet, Tablet - Oral, Gel, Gel - Topical, Aerosol, foam, Aerosol, foam - Topical, Kit, Shampoo, Shampoo - Topical, Shampoo, suspension, Shampoo, suspension - Topical, Suspension - Oral, Suspension, Kit - Topical

Candidiasis, Chronic Mucocutaneous

, 0.02 mg/mg, 200.0 mg, 10.0 mg/mL, 20.0 mg, 20.0 mg/mL, 2.0 %, 20.5 mg/mL

, Topical, Cream, Cream - Topical, Oral, Tablet, Tablet - Oral, Gel, Gel - Topical, Aerosol, foam, Aerosol, foam - Topical, Kit, Shampoo, Shampoo - Topical, Shampoo, suspension, Shampoo, suspension - Topical, Suspension - Oral, Suspension, Kit - Topical

Dermatitis, Seborrheic

, 0.02 mg/mg, 200.0 mg, 10.0 mg/mL, 20.0 mg, 20.0 mg/mL, 2.0 %, 20.5 mg/mL

, Topical, Cream, Cream - Topical, Oral, Tablet, Tablet - Oral, Gel, Gel - Topical, Aerosol, foam, Aerosol, foam - Topical, Kit, Shampoo, Shampoo - Topical, Shampoo, suspension, Shampoo, suspension - Topical, Suspension - Oral, Suspension, Kit - Topical

Candidiasis, Vulvovaginal

, 0.02 mg/mg, 200.0 mg, 10.0 mg/mL, 20.0 mg, 20.0 mg/mL, 2.0 %, 20.5 mg/mL

, Topical, Cream, Cream - Topical, Oral, Tablet, Tablet - Oral, Gel, Gel - Topical, Aerosol, foam, Aerosol, foam - Topical, Kit, Shampoo, Shampoo - Topical, Shampoo, suspension, Shampoo, suspension - Topical, Suspension - Oral, Suspension, Kit - Topical

Cushing Syndrome

, 0.02 mg/mg, 200.0 mg, 10.0 mg/mL, 20.0 mg, 20.0 mg/mL, 2.0 %, 20.5 mg/mL

, Topical, Cream, Cream - Topical, Oral, Tablet, Tablet - Oral, Gel, Gel - Topical, Aerosol, foam, Aerosol, foam - Topical, Kit, Shampoo, Shampoo - Topical, Shampoo, suspension, Shampoo, suspension - Topical, Suspension - Oral, Suspension, Kit - Topical

Bacterial Vaginosis

, 0.02 mg/mg, 200.0 mg, 10.0 mg/mL, 20.0 mg, 20.0 mg/mL, 2.0 %, 20.5 mg/mL

, Topical, Cream, Cream - Topical, Oral, Tablet, Tablet - Oral, Gel, Gel - Topical, Aerosol, foam, Aerosol, foam - Topical, Kit, Shampoo, Shampoo - Topical, Shampoo, suspension, Shampoo, suspension - Topical, Suspension - Oral, Suspension, Kit - Topical

Trichophyton mentagrophytes

, 0.02 mg/mg, 200.0 mg, 10.0 mg/mL, 20.0 mg, 20.0 mg/mL, 2.0 %, 20.5 mg/mL

, Topical, Cream, Cream - Topical, Oral, Tablet, Tablet - Oral, Gel, Gel - Topical, Aerosol, foam, Aerosol, foam - Topical, Kit, Shampoo, Shampoo - Topical, Shampoo, suspension, Shampoo, suspension - Topical, Suspension - Oral, Suspension, Kit - Topical

Tinea cruris

, 0.02 mg/mg, 200.0 mg, 10.0 mg/mL, 20.0 mg, 20.0 mg/mL, 2.0 %, 20.5 mg/mL

, Topical, Cream, Cream - Topical, Oral, Tablet, Tablet - Oral, Gel, Gel - Topical, Aerosol, foam, Aerosol, foam - Topical, Kit, Shampoo, Shampoo - Topical, Shampoo, suspension, Shampoo, suspension - Topical, Suspension - Oral, Suspension, Kit - Topical

Tinea Pedis

, 0.02 mg/mg, 200.0 mg, 10.0 mg/mL, 20.0 mg, 20.0 mg/mL, 2.0 %, 20.5 mg/mL

, Topical, Cream, Cream - Topical, Oral, Tablet, Tablet - Oral, Gel, Gel - Topical, Aerosol, foam, Aerosol, foam - Topical, Kit, Shampoo, Shampoo - Topical, Shampoo, suspension, Shampoo, suspension - Topical, Suspension - Oral, Suspension, Kit - Topical

Tinea Pedis

, 0.02 mg/mg, 200.0 mg, 10.0 mg/mL, 20.0 mg, 20.0 mg/mL, 2.0 %, 20.5 mg/mL

, Topical, Cream, Cream - Topical, Oral, Tablet, Tablet - Oral, Gel, Gel - Topical, Aerosol, foam, Aerosol, foam - Topical, Kit, Shampoo, Shampoo - Topical, Shampoo, suspension, Shampoo, suspension - Topical, Suspension - Oral, Suspension, Kit - Topical

Tinea corporis (disorder)

, 0.02 mg/mg, 200.0 mg, 10.0 mg/mL, 20.0 mg, 20.0 mg/mL, 2.0 %, 20.5 mg/mL

, Topical, Cream, Cream - Topical, Oral, Tablet, Tablet - Oral, Gel, Gel - Topical, Aerosol, foam, Aerosol, foam - Topical, Kit, Shampoo, Shampoo - Topical, Shampoo, suspension, Shampoo, suspension - Topical, Suspension - Oral, Suspension, Kit - Topical

Tinea Pedis

, 0.02 mg/mg, 200.0 mg, 10.0 mg/mL, 20.0 mg, 20.0 mg/mL, 2.0 %, 20.5 mg/mL

, Topical, Cream, Cream - Topical, Oral, Tablet, Tablet - Oral, Gel, Gel - Topical, Aerosol, foam, Aerosol, foam - Topical, Kit, Shampoo, Shampoo - Topical, Shampoo, suspension, Shampoo, suspension - Topical, Suspension - Oral, Suspension, Kit - Topical

recalcitrant Dermatophytosis

, 0.02 mg/mg, 200.0 mg, 10.0 mg/mL, 20.0 mg, 20.0 mg/mL, 2.0 %, 20.5 mg/mL

, Topical, Cream, Cream - Topical, Oral, Tablet, Tablet - Oral, Gel, Gel - Topical, Aerosol, foam, Aerosol, foam - Topical, Kit, Shampoo, Shampoo - Topical, Shampoo, suspension, Shampoo, suspension - Topical, Suspension - Oral, Suspension, Kit - Topical

Warnings

Nizoral Contraindications

Condition

Risk Level

Notes

Pulse Frequency

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Liver Dysfunction

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Long QT Syndrome

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Long QT Syndrome

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Renal Insufficiency

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Severe Hypersensitivity Reactions

Do Not Combine

Ketoconazole may interact with Pulse Frequency

There are 20 known major drug interactions with Nizoral.

Common Nizoral Drug Interactions

Drug Name

Risk Level

Description

(R)-warfarin

Major

The metabolism of (R)-warfarin can be decreased when combined with Ketoconazole.

(S)-Warfarin

Major

The metabolism of (S)-Warfarin can be decreased when combined with Ketoconazole.

1,2-Benzodiazepine

Major

The metabolism of 1,2-Benzodiazepine can be decreased when combined with Ketoconazole.

3,5-diiodothyropropionic acid

Major

The metabolism of 3,5-diiodothyropropionic acid can be decreased when combined with Ketoconazole.

5-androstenedione

Major

The metabolism of 5-androstenedione can be decreased when combined with Ketoconazole.

Nizoral Toxicity & Overdose Risk

The lowest toxic dose of this drug for rats when taken orally is 891 mg/kg. When inhaled, the lowest toxic dose is greater than 900 mg/m3/1hr. Skin irritation in rabbits can be mild at 500 mg/24H and severe eye irritation has been reported with 100 mg. This drug has been investigated as a potential mutagen and has the capability to affect reproduction.

image of a doctor in a lab doing drug, clinical research

Nizoral Novel Uses: Which Conditions Have a Clinical Trial Featuring Nizoral?

81 active clinical trials are in progress to assess the potential of Nizoral to combat Palmoplantar Pustulosis (PPP), Communicable Diseases and Lichen Planus.

Condition

Clinical Trials

Trial Phases

Coccidioidomycosis

0 Actively Recruiting

Chromoblastomycosis

0 Actively Recruiting

Paracoccidioidomycosis

0 Actively Recruiting

Tinea corporis (disorder)

0 Actively Recruiting

Tinea corporis (disorder)

0 Actively Recruiting

Blastomycosis

0 Actively Recruiting

Candidiasis, Chronic Mucocutaneous

0 Actively Recruiting

Tinea Pedis

0 Actively Recruiting

Malassezia

0 Actively Recruiting

Candidiasis, Vulvovaginal

2 Actively Recruiting

Not Applicable, Phase 3

recalcitrant Dermatophytosis

0 Actively Recruiting

Candidiasis, Systemic

0 Actively Recruiting

Cushing Syndrome

0 Actively Recruiting

Trichophyton mentagrophytes

0 Actively Recruiting

Tinea cruris

0 Actively Recruiting

Tinea Corporis caused by Trichophyton mentagrophytes

0 Actively Recruiting

Trichophyton rubrum

0 Actively Recruiting

cutaneous candidiasis

0 Actively Recruiting

Candidiasis, Vulvovaginal

0 Actively Recruiting

Bacterial Vaginosis

2 Actively Recruiting

Phase 2, Early Phase 1

Nizoral Reviews: What are patients saying about Nizoral?

5

Patient Review

3/16/2008

Nizoral for Ringworm of Scalp

This didn't do anything to help my child's ringworm. If anything, it made the problem worse.

5

Patient Review

7/3/2012

Nizoral for Scaly Oily Skin Problem Primarily On Face and Scalp

Nizoral has been my go-to shampoo for fifteen years now. I've tried other options, but this one works the best by far for my scalp condition.

5

Patient Review

8/10/2009

Nizoral for Fungal Infection of the Skin with Yellow Patches

This ointment has helped immensely with my seborrhea.

5

Patient Review

2/19/2009

Nizoral for Fungal Infection of the Skin with Yellow Patches

I was patient and it finally paid off.

4

Patient Review

5/24/2009

Nizoral for Scaly Oily Skin Problem Primarily On Face and Scalp

I usually get a fungus problem around my nose and face during winter, but this medication clears it up within three days. I've been using it on and off for ten years now.

3.7

Patient Review

8/10/2012

Nizoral for Fungal Infection of Skin

The generic medication I used did a good job at stopping the itching, redness and spread of inflammation around my mouth. However, I needed another medication to use around my eyelids.

3.3

Patient Review

8/13/2011

Nizoral for Skin Infection due to a Candida Yeast

Nizoral was first prescribed to me in 1997 as an effective and safe treatment for tinea versicolor. I've since then used the over-the-counter version to keep up my quality of life.

3

Patient Review

4/12/2009

Nizoral for Ringworm of Groin Area

Unfortunately, this didn't work for me at all. If anything, it made the situation worse.

2

Patient Review

1/28/2009

Nizoral for Scaly Oily Skin Problem Primarily On Face and Scalp

Nizoral shampoo has been a godsend for my severe dandruff and itchy scalp. It works like a charm, usually clearing up the condition within a week or two. I can use it more often if necessary, but it always does the trick. Very satisfied with this medicine - would recommend to anyone with similar issues!

1.7

Patient Review

10/16/2007

Nizoral for Ringworm of the Body

1.7

Patient Review

1/3/2009

Nizoral for Ringworm of Groin Area

I use it for vericolor of the face. It works quickly to return my color.

1.7

Patient Review

10/19/2022

Nizoral for Dandruff

I saw no change in my dandruff after using this product for a couple months, despite following the directions to use it 2-3 times per week. Do not bother buying this.

1

Patient Review

4/10/2012

Nizoral for Scaly Oily Skin Problem Primarily On Face and Scalp

Can somebody please tell me if it's okay to take this medication? I have Parkinson's disease and one of my other medications has a warning label saying not to use ketoconazole.

image of drug pills surrounding a glass of water symbolizing drug consumption

Patient Q&A Section about nizoral

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

What does Nizoral used for?

"Ketoconazole is used to treat various fungal infections of the skin such as athlete's foot, jock itch, ringworm, and dandruff. It can also treat a skin condition known as pityriasis (tinea versicolor), which is characterized by a lightening or darkening of the skin on the neck, chest, arms, or legs."

Answered by AI

Is it OK to use Nizoral shampoo everyday?

"How often should I use Nizoral?

You only need to use it every 3 to 4 days (twice a week) for 8 weeks. On the days you don't use Nizoral, you can use your regular shampoo and conditioner."

Answered by AI

How long does it take Nizoral to work?

"If you're using Nizoral to treat dandruff, you should start seeing results after the first wash. In most cases, dandruff will be gone within two weeks. If your scalp hasn't cleared up after four weeks, it's possible that you don't have dandruff and you should seek advice from a healthcare professional."

Answered by AI

What does Nizoral do to your hair?

"Ketoconazole, which is also known by the prescription name Nizoral, can help to decrease the production of testosterone. When testosterone is converted into a substance called DHT (dihydrotestosterone), it can destroy hair follicles and lead to hair loss."

Answered by AI

Clinical Trials for Nizoral