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What is Nicotine Polacrilex
NicotineThe Generic name of this drug
Treatment SummaryNicotine is an extremely toxic chemical found in tobacco smoke. It activates nerve cells and blocks signals from being sent between them. Nicotine is especially dangerous because of its presence in cigarettes and other tobacco products.
equate Nicotineis the brand name
Nicotine Polacrilex Overview & Background
Brand Name
Generic Name
First FDA Approval
How many FDA approvals?
equate Nicotine
Nicotine
1990
1005
Approved as Treatment by the FDA
Nicotine, otherwise called equate Nicotine, is approved by the FDA for 2 uses which include Smoke and nicotine .Smoke
Helps manage Smoking cessation therapy
nicotine
Helps manage Withdrawal Nicotine
Effectiveness
How Nicotine Polacrilex Affects PatientsNicotine, the main chemical in tobacco products, binds to certain receptors in the brain, nerves, and other organs. It can cause a stimulating effect and a feeling of reward. Nicotine also leads to increased heart rate, higher blood pressure, and constricted blood vessels. Nicotine replacements in the form of inhalers and patches are used to help people quit smoking. Nicotine is a very addictive substance and is classified as a stimulant.
How Nicotine Polacrilex works in the bodyNicotine stimulates the body in two ways. First, it binds to nicotinic acetylcholine receptors in the brain, causing dopamine to be released. This dopamine release is responsible for the euphoric and addictive properties of nicotine. Secondly, nicotine binds to nicotinic acetylcholine receptors in the adrenal medulla, which triggers the release of epinephrine. Epinephrine causes increases in blood pressure, heart rate, and blood sugar levels.
When to interrupt dosage
The suggested measure of Nicotine Polacrilex is contingent upon the identified ailment. The amount of dosage is contingent upon the procedure of administration specified in the table below.Condition
Dosage
Administration
Smoke
, 1.4 mg/hour, 14.0 mg, 0.7 mg/hour, 2.1 mg/hour, 7.0 mg, 21.0 mg, 4.0 mg, 2.0 mg, 1.0 mL/mL, 1.0 mg/mg, 114.0 mg, 78.0 mg, 36.0 mg, 10.0 mg/mL, 0.18 mg/mg, 0.15 mg/mg, 0.2 mg/mg, 2.0 mg/hour, 4.0 mg/hour, 8.0 mg, 2.5 mg/hour, 0.06 mg/mg, 0.12 mg/mg, 0.21 mg/mg
, Transdermal, Patch, extended release, Patch, extended release - Transdermal, Topical, Patch, extended release - Topical, Kit, Oral, Gum, chewing, Gum, chewing - Oral, Lozenge, Lozenge - Oral, Buccal, Gum, chewing - Buccal, Kit - Transdermal, Respiratory (inhalation), Inhalant - Respiratory (inhalation), Inhalant, Patch, Patch - Transdermal, Liquid, Liquid - Oral, Powder, Powder - Oral, Nasal, Spray, metered - Nasal, Spray, metered, Dental; Oral, Patch - Topical
nicotine
, 1.4 mg/hour, 14.0 mg, 0.7 mg/hour, 2.1 mg/hour, 7.0 mg, 21.0 mg, 4.0 mg, 2.0 mg, 1.0 mL/mL, 1.0 mg/mg, 114.0 mg, 78.0 mg, 36.0 mg, 10.0 mg/mL, 0.18 mg/mg, 0.15 mg/mg, 0.2 mg/mg, 2.0 mg/hour, 4.0 mg/hour, 8.0 mg, 2.5 mg/hour, 0.06 mg/mg, 0.12 mg/mg, 0.21 mg/mg
, Transdermal, Patch, extended release, Patch, extended release - Transdermal, Topical, Patch, extended release - Topical, Kit, Oral, Gum, chewing, Gum, chewing - Oral, Lozenge, Lozenge - Oral, Buccal, Gum, chewing - Buccal, Kit - Transdermal, Respiratory (inhalation), Inhalant - Respiratory (inhalation), Inhalant, Patch, Patch - Transdermal, Liquid, Liquid - Oral, Powder, Powder - Oral, Nasal, Spray, metered - Nasal, Spray, metered, Dental; Oral, Patch - Topical
Warnings
There are 20 known major drug interactions with Nicotine Polacrilex.Common Nicotine Polacrilex Drug Interactions
Drug Name
Risk Level
Description
Aminophylline
Major
The metabolism of Aminophylline can be increased when combined with Nicotine.
Cisplatin
Major
The serum concentration of Cisplatin can be increased when it is combined with Nicotine.
Clofarabine
Major
The serum concentration of Clofarabine can be increased when it is combined with Nicotine.
Cyclophosphamide
Major
The metabolism of Cyclophosphamide can be decreased when combined with Nicotine.
Dalfampridine
Major
The serum concentration of Dalfampridine can be increased when it is combined with Nicotine.
Nicotine Polacrilex Toxicity & Overdose RiskOverdosing on the drug can cause nausea, stomach cramps, vomiting, diarrhea, sweating, blushing, dizziness, blurred vision and hearing, confusion, weakness, heart palpitations, changes in breathing rate, and low blood pressure. The lowest toxic dose for mice is 24mg/kg taken orally.
Nicotine Polacrilex Novel Uses: Which Conditions Have a Clinical Trial Featuring Nicotine Polacrilex?
Five active clinical trials are investigating the potential of Nicotine Polacrilex to provide relief from Nicotine addiction.Condition
Clinical Trials
Trial Phases
nicotine
4 Actively Recruiting
Not Applicable, Phase 1, Phase 2
Smoke
0 Actively Recruiting
Nicotine Polacrilex Reviews: What are patients saying about Nicotine Polacrilex?
5Patient Review
8/8/2012 I've been using this treatment for 5 years now and it's really helped me.
5Patient Review
11/15/2013 I was 15 when a friend gave me this from a gas station. It worked great for my addiction.
5Patient Review
4/27/20085Patient Review
1/6/2009 I've been chewing this product for two years now. Is it dangerous?
4.7Patient Review
10/14/2010 I was able to successfully quit smoking by using Chantix. I started taking it when my cravings were really bad and now, two years later, I still take the lozenges or gum occasionally. Will this have any negative effect on my organs?
4.7Patient Review
5/6/2009 I found that using 2mg lozenges on a daily basis helped me to significantly reduce the dizziness, irritability and problems with concentration that I experienced when quitting nicotine (approximately 10-12 lozenges per day for the first three weeks).
3.3Patient Review
3/29/2022 I experienced some dizziness and gastrointestinal distress while taking this medication. It was bad enough that I couldn't work. However, it did help me quit smoking, so I still think it's effective overall.
Patient Q&A Section about nicotine polacrilex
These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.Is Nicotine polacrilex safe?
"If a child sucks or chews on a used or unused lozenge or piece of gum containing Leader Nicotine Polacrilex, it could be fatal. Seek emergency medical attention if this happens. Symptoms of an overdose may include severe dizziness, nausea, vomiting, diarrhea, weakness, and fast heart rate."
Answered by AI
Is Nicotine polacrilex the same as nicotine?
"Nicotine Polacrilex is a smoking cessation aid that comes in generic and brand name forms. The generic form is called Nicotine Polacrilex, and the brand names are Nicotrol NS, Nicorelief, and Nicorette. Nicotine Polacrilex helps reduce withdrawal symptoms for people who are trying to quit smoking."
Answered by AI
What is Nicotine polacrilex made of?
"Nicotine polacrilex is a version of nicotine that is bound to an ion-exchange resin. This type of nicotine is often used in gums and hard lozenges that are meant to help people quit smoking. Products that contain nicotine polacrilex are often part of smoking cessation programs."
Answered by AI
Does Nicotine polacrilex have nicotine?
"The active ingredient in each piece of gum is nicotine polacrilex, which is equivalent to 4 mg of nicotine. This gum is a stop smoking aid."
Answered by AI