Nayzilam

Amnesia, Sedation, Anaesthesia + 14 more

Treatment

2 FDA approvals

5 Active Studies for Nayzilam

What is Nayzilam

Midazolam

The Generic name of this drug

Treatment Summary

Midazolam is a short-acting drug used to help patients relax and sleep. It is part of a group of drugs called benzodiazepines and works quickly but doesn’t last long. Midazolam comes in many forms, including oral, rectal, intranasal, intramuscular, and intravenous. It is used to help people feel more relaxed before a medical procedure, like dentistry or surgery. The FDA approved midazolam for different uses in 1985 and added more uses in 2018 and 2019. Midazolam has a low potential for abuse and dependence, so it is

Midazolam

is the brand name

image of different drug pills on a surface

Nayzilam Overview & Background

Brand Name

Generic Name

First FDA Approval

How many FDA approvals?

Midazolam

Midazolam

2000

132

Approved as Treatment by the FDA

Midazolam, also known as Midazolam, is approved by the FDA for 2 uses which include Status Epilepticus (Convulsive) and Status Epilepticus .

Status Epilepticus (Convulsive)

Status Epilepticus

Effectiveness

How Nayzilam Affects Patients

Midazolam is a short-acting medicine that relaxes the central nervous system and reduces anxiety. It works by binding to GABA receptors, which are responsible for controlling certain brain functions. After taking midazolam, adults usually start feeling sedated within 15 minutes, with peak effects occurring 30-60 minutes later. In children, the sedative effects usually begin in 5 minutes and peak in 15-30 minutes. When injected, the effects are felt much faster, with sedation starting in 3-5 minutes. Midazolam can also be used to induce anesthesia, with the effects taking place in about 1.5 minutes

How Nayzilam works in the body

Midazolam works by enhancing the activity of the neurotransmitter GABA. GABA is a calming chemical in the brain, and midazolam increases its effects. This leads to a sedative effect, muscle relaxation, and can even cause you to forget things. Midazolam acts on special receptors in the body, mainly concentrated in the brain, which allow it to interact with GABA and increase its effects.

When to interrupt dosage

The suggested dosage of Nayzilam is contingent upon the determined condition, for example Induction of General Anaesthesia, Sedation and Seizures. The amount of dosage changes as per the technique of administration featured in the table beneath.

Condition

Dosage

Administration

Seizures

, 2.0 mg/mL, 0.5 mg/mL, 5.0 mg/mL, 1.0 mg/mL, 10.0 mg/mL, 5.0 mg, 2.5 mg, 7.5 mg, 10.0 mg, 50.0 mg/mL, 3.0 mg

, Oral, Syrup, Syrup - Oral, Intravenous, Injection, solution, Injection, solution - Intravenous, Intramuscular; Intravenous, Injection, solution - Intramuscular; Intravenous, Injection, Injection - Intramuscular; Intravenous, Solution, Liquid - Intramuscular; Intravenous, Tablet - Oral, Liquid, Solution - Intramuscular; Intravenous, Nasal, Spray - Nasal, Injection, solution - Intramuscular, Intramuscular, Sublingual, Troche - Sublingual, Troche, Buccal, Solution - Buccal, Solution - Intravenous, Tablet, Spray

Seizures

, 2.0 mg/mL, 0.5 mg/mL, 5.0 mg/mL, 1.0 mg/mL, 10.0 mg/mL, 5.0 mg, 2.5 mg, 7.5 mg, 10.0 mg, 50.0 mg/mL, 3.0 mg

, Oral, Syrup, Syrup - Oral, Intravenous, Injection, solution, Injection, solution - Intravenous, Intramuscular; Intravenous, Injection, solution - Intramuscular; Intravenous, Injection, Injection - Intramuscular; Intravenous, Solution, Liquid - Intramuscular; Intravenous, Tablet - Oral, Liquid, Solution - Intramuscular; Intravenous, Nasal, Spray - Nasal, Injection, solution - Intramuscular, Intramuscular, Sublingual, Troche - Sublingual, Troche, Buccal, Solution - Buccal, Solution - Intravenous, Tablet, Spray

preoperative sedation therapy

, 2.0 mg/mL, 0.5 mg/mL, 5.0 mg/mL, 1.0 mg/mL, 10.0 mg/mL, 5.0 mg, 2.5 mg, 7.5 mg, 10.0 mg, 50.0 mg/mL, 3.0 mg

, Oral, Syrup, Syrup - Oral, Intravenous, Injection, solution, Injection, solution - Intravenous, Intramuscular; Intravenous, Injection, solution - Intramuscular; Intravenous, Injection, Injection - Intramuscular; Intravenous, Solution, Liquid - Intramuscular; Intravenous, Tablet - Oral, Liquid, Solution - Intramuscular; Intravenous, Nasal, Spray - Nasal, Injection, solution - Intramuscular, Intramuscular, Sublingual, Troche - Sublingual, Troche, Buccal, Solution - Buccal, Solution - Intravenous, Tablet, Spray

induction of anxiolysis

, 2.0 mg/mL, 0.5 mg/mL, 5.0 mg/mL, 1.0 mg/mL, 10.0 mg/mL, 5.0 mg, 2.5 mg, 7.5 mg, 10.0 mg, 50.0 mg/mL, 3.0 mg

, Oral, Syrup, Syrup - Oral, Intravenous, Injection, solution, Injection, solution - Intravenous, Intramuscular; Intravenous, Injection, solution - Intramuscular; Intravenous, Injection, Injection - Intramuscular; Intravenous, Solution, Liquid - Intramuscular; Intravenous, Tablet - Oral, Liquid, Solution - Intramuscular; Intravenous, Nasal, Spray - Nasal, Injection, solution - Intramuscular, Intramuscular, Sublingual, Troche - Sublingual, Troche, Buccal, Solution - Buccal, Solution - Intravenous, Tablet, Spray

Anaesthesia

, 2.0 mg/mL, 0.5 mg/mL, 5.0 mg/mL, 1.0 mg/mL, 10.0 mg/mL, 5.0 mg, 2.5 mg, 7.5 mg, 10.0 mg, 50.0 mg/mL, 3.0 mg

, Oral, Syrup, Syrup - Oral, Intravenous, Injection, solution, Injection, solution - Intravenous, Intramuscular; Intravenous, Injection, solution - Intramuscular; Intravenous, Injection, Injection - Intramuscular; Intravenous, Solution, Liquid - Intramuscular; Intravenous, Tablet - Oral, Liquid, Solution - Intramuscular; Intravenous, Nasal, Spray - Nasal, Injection, solution - Intramuscular, Intramuscular, Sublingual, Troche - Sublingual, Troche, Buccal, Solution - Buccal, Solution - Intravenous, Tablet, Spray

Epilepsy

, 2.0 mg/mL, 0.5 mg/mL, 5.0 mg/mL, 1.0 mg/mL, 10.0 mg/mL, 5.0 mg, 2.5 mg, 7.5 mg, 10.0 mg, 50.0 mg/mL, 3.0 mg

, Oral, Syrup, Syrup - Oral, Intravenous, Injection, solution, Injection, solution - Intravenous, Intramuscular; Intravenous, Injection, solution - Intramuscular; Intravenous, Injection, Injection - Intramuscular; Intravenous, Solution, Liquid - Intramuscular; Intravenous, Tablet - Oral, Liquid, Solution - Intramuscular; Intravenous, Nasal, Spray - Nasal, Injection, solution - Intramuscular, Intramuscular, Sublingual, Troche - Sublingual, Troche, Buccal, Solution - Buccal, Solution - Intravenous, Tablet, Spray

Central Nervous System Depressants

, 2.0 mg/mL, 0.5 mg/mL, 5.0 mg/mL, 1.0 mg/mL, 10.0 mg/mL, 5.0 mg, 2.5 mg, 7.5 mg, 10.0 mg, 50.0 mg/mL, 3.0 mg

, Oral, Syrup, Syrup - Oral, Intravenous, Injection, solution, Injection, solution - Intravenous, Intramuscular; Intravenous, Injection, solution - Intramuscular; Intravenous, Injection, Injection - Intramuscular; Intravenous, Solution, Liquid - Intramuscular; Intravenous, Tablet - Oral, Liquid, Solution - Intramuscular; Intravenous, Nasal, Spray - Nasal, Injection, solution - Intramuscular, Intramuscular, Sublingual, Troche - Sublingual, Troche, Buccal, Solution - Buccal, Solution - Intravenous, Tablet, Spray

Sedation

, 2.0 mg/mL, 0.5 mg/mL, 5.0 mg/mL, 1.0 mg/mL, 10.0 mg/mL, 5.0 mg, 2.5 mg, 7.5 mg, 10.0 mg, 50.0 mg/mL, 3.0 mg

, Oral, Syrup, Syrup - Oral, Intravenous, Injection, solution, Injection, solution - Intravenous, Intramuscular; Intravenous, Injection, solution - Intramuscular; Intravenous, Injection, Injection - Intramuscular; Intravenous, Solution, Liquid - Intramuscular; Intravenous, Tablet - Oral, Liquid, Solution - Intramuscular; Intravenous, Nasal, Spray - Nasal, Injection, solution - Intramuscular, Intramuscular, Sublingual, Troche - Sublingual, Troche, Buccal, Solution - Buccal, Solution - Intravenous, Tablet, Spray

Therapeutic procedure

, 2.0 mg/mL, 0.5 mg/mL, 5.0 mg/mL, 1.0 mg/mL, 10.0 mg/mL, 5.0 mg, 2.5 mg, 7.5 mg, 10.0 mg, 50.0 mg/mL, 3.0 mg

, Oral, Syrup, Syrup - Oral, Intravenous, Injection, solution, Injection, solution - Intravenous, Intramuscular; Intravenous, Injection, solution - Intramuscular; Intravenous, Injection, Injection - Intramuscular; Intravenous, Solution, Liquid - Intramuscular; Intravenous, Tablet - Oral, Liquid, Solution - Intramuscular; Intravenous, Nasal, Spray - Nasal, Injection, solution - Intramuscular, Intramuscular, Sublingual, Troche - Sublingual, Troche, Buccal, Solution - Buccal, Solution - Intravenous, Tablet, Spray

Anxiolytic therapy therapy

, 2.0 mg/mL, 0.5 mg/mL, 5.0 mg/mL, 1.0 mg/mL, 10.0 mg/mL, 5.0 mg, 2.5 mg, 7.5 mg, 10.0 mg, 50.0 mg/mL, 3.0 mg

, Oral, Syrup, Syrup - Oral, Intravenous, Injection, solution, Injection, solution - Intravenous, Intramuscular; Intravenous, Injection, solution - Intramuscular; Intravenous, Injection, Injection - Intramuscular; Intravenous, Solution, Liquid - Intramuscular; Intravenous, Tablet - Oral, Liquid, Solution - Intramuscular; Intravenous, Nasal, Spray - Nasal, Injection, solution - Intramuscular, Intramuscular, Sublingual, Troche - Sublingual, Troche, Buccal, Solution - Buccal, Solution - Intravenous, Tablet, Spray

Therapeutic procedure

, 2.0 mg/mL, 0.5 mg/mL, 5.0 mg/mL, 1.0 mg/mL, 10.0 mg/mL, 5.0 mg, 2.5 mg, 7.5 mg, 10.0 mg, 50.0 mg/mL, 3.0 mg

, Oral, Syrup, Syrup - Oral, Intravenous, Injection, solution, Injection, solution - Intravenous, Intramuscular; Intravenous, Injection, solution - Intramuscular; Intravenous, Injection, Injection - Intramuscular; Intravenous, Solution, Liquid - Intramuscular; Intravenous, Tablet - Oral, Liquid, Solution - Intramuscular; Intravenous, Nasal, Spray - Nasal, Injection, solution - Intramuscular, Intramuscular, Sublingual, Troche - Sublingual, Troche, Buccal, Solution - Buccal, Solution - Intravenous, Tablet, Spray

Anxiolysis

, 2.0 mg/mL, 0.5 mg/mL, 5.0 mg/mL, 1.0 mg/mL, 10.0 mg/mL, 5.0 mg, 2.5 mg, 7.5 mg, 10.0 mg, 50.0 mg/mL, 3.0 mg

, Oral, Syrup, Syrup - Oral, Intravenous, Injection, solution, Injection, solution - Intravenous, Intramuscular; Intravenous, Injection, solution - Intramuscular; Intravenous, Injection, Injection - Intramuscular; Intravenous, Solution, Liquid - Intramuscular; Intravenous, Tablet - Oral, Liquid, Solution - Intramuscular; Intravenous, Nasal, Spray - Nasal, Injection, solution - Intramuscular, Intramuscular, Sublingual, Troche - Sublingual, Troche, Buccal, Solution - Buccal, Solution - Intravenous, Tablet, Spray

Amnesia

, 2.0 mg/mL, 0.5 mg/mL, 5.0 mg/mL, 1.0 mg/mL, 10.0 mg/mL, 5.0 mg, 2.5 mg, 7.5 mg, 10.0 mg, 50.0 mg/mL, 3.0 mg

, Oral, Syrup, Syrup - Oral, Intravenous, Injection, solution, Injection, solution - Intravenous, Intramuscular; Intravenous, Injection, solution - Intramuscular; Intravenous, Injection, Injection - Intramuscular; Intravenous, Solution, Liquid - Intramuscular; Intravenous, Tablet - Oral, Liquid, Solution - Intramuscular; Intravenous, Nasal, Spray - Nasal, Injection, solution - Intramuscular, Intramuscular, Sublingual, Troche - Sublingual, Troche, Buccal, Solution - Buccal, Solution - Intravenous, Tablet, Spray

induction of Sedation

, 2.0 mg/mL, 0.5 mg/mL, 5.0 mg/mL, 1.0 mg/mL, 10.0 mg/mL, 5.0 mg, 2.5 mg, 7.5 mg, 10.0 mg, 50.0 mg/mL, 3.0 mg

, Oral, Syrup, Syrup - Oral, Intravenous, Injection, solution, Injection, solution - Intravenous, Intramuscular; Intravenous, Injection, solution - Intramuscular; Intravenous, Injection, Injection - Intramuscular; Intravenous, Solution, Liquid - Intramuscular; Intravenous, Tablet - Oral, Liquid, Solution - Intramuscular; Intravenous, Nasal, Spray - Nasal, Injection, solution - Intramuscular, Intramuscular, Sublingual, Troche - Sublingual, Troche, Buccal, Solution - Buccal, Solution - Intravenous, Tablet, Spray

induction of Amnesia

, 2.0 mg/mL, 0.5 mg/mL, 5.0 mg/mL, 1.0 mg/mL, 10.0 mg/mL, 5.0 mg, 2.5 mg, 7.5 mg, 10.0 mg, 50.0 mg/mL, 3.0 mg

, Oral, Syrup, Syrup - Oral, Intravenous, Injection, solution, Injection, solution - Intravenous, Intramuscular; Intravenous, Injection, solution - Intramuscular; Intravenous, Injection, Injection - Intramuscular; Intravenous, Solution, Liquid - Intramuscular; Intravenous, Tablet - Oral, Liquid, Solution - Intramuscular; Intravenous, Nasal, Spray - Nasal, Injection, solution - Intramuscular, Intramuscular, Sublingual, Troche - Sublingual, Troche, Buccal, Solution - Buccal, Solution - Intravenous, Tablet, Spray

Status Epilepticus

, 2.0 mg/mL, 0.5 mg/mL, 5.0 mg/mL, 1.0 mg/mL, 10.0 mg/mL, 5.0 mg, 2.5 mg, 7.5 mg, 10.0 mg, 50.0 mg/mL, 3.0 mg

, Oral, Syrup, Syrup - Oral, Intravenous, Injection, solution, Injection, solution - Intravenous, Intramuscular; Intravenous, Injection, solution - Intramuscular; Intravenous, Injection, Injection - Intramuscular; Intravenous, Solution, Liquid - Intramuscular; Intravenous, Tablet - Oral, Liquid, Solution - Intramuscular; Intravenous, Nasal, Spray - Nasal, Injection, solution - Intramuscular, Intramuscular, Sublingual, Troche - Sublingual, Troche, Buccal, Solution - Buccal, Solution - Intravenous, Tablet, Spray

Sedation for mechanically-ventilated patients

, 2.0 mg/mL, 0.5 mg/mL, 5.0 mg/mL, 1.0 mg/mL, 10.0 mg/mL, 5.0 mg, 2.5 mg, 7.5 mg, 10.0 mg, 50.0 mg/mL, 3.0 mg

, Oral, Syrup, Syrup - Oral, Intravenous, Injection, solution, Injection, solution - Intravenous, Intramuscular; Intravenous, Injection, solution - Intramuscular; Intravenous, Injection, Injection - Intramuscular; Intravenous, Solution, Liquid - Intramuscular; Intravenous, Tablet - Oral, Liquid, Solution - Intramuscular; Intravenous, Nasal, Spray - Nasal, Injection, solution - Intramuscular, Intramuscular, Sublingual, Troche - Sublingual, Troche, Buccal, Solution - Buccal, Solution - Intravenous, Tablet, Spray

Warnings

Nayzilam has nine contraindications, so it should not be taken in combination with the afflictions indicated in the following table.

Nayzilam Contraindications

Condition

Risk Level

Notes

Glaucoma, Open-Angle

Do Not Combine

Glaucoma, Open-Angle

Do Not Combine

Respiratory Insufficiency

Do Not Combine

Respiratory Distress Syndrome

Do Not Combine

Intrathecal or epidural administration

Do Not Combine

Obstructive Sleep Apnea (OSA)

Do Not Combine

Myasthenia Gravis

Do Not Combine

Severe Hepatic Impairment

Do Not Combine

Severe Hypersensitivity Reactions

Do Not Combine

Midazolam may interact with Pulse Frequency

There are 20 known major drug interactions with Nayzilam.

Common Nayzilam Drug Interactions

Drug Name

Risk Level

Description

Abemaciclib

Major

The metabolism of Abemaciclib can be decreased when combined with Midazolam.

Alectinib

Major

The metabolism of Alectinib can be decreased when combined with Midazolam.

Aminophylline

Major

The metabolism of Aminophylline can be decreased when combined with Midazolam.

Axitinib

Major

The metabolism of Axitinib can be decreased when combined with Midazolam.

Azelastine

Major

Midazolam may increase the central nervous system depressant (CNS depressant) activities of Azelastine.

Nayzilam Toxicity & Overdose Risk

The lethal dose of midazolam for rats has been found to be 215mg/kg. Signs of overdose can include drowsiness, confusion, clumsiness, coma, and changes in vital signs. Severe breathing or heart complications can occur, sometimes leading to death or permanent damage. If someone overdoses on midazolam, they should be monitored closely and given resuscitative drugs if necessary. People over 60, those with chronic illnesses or substance abuse problems, and children should take lower doses and be monitored more closely. Midazolam has not been found to be genotoxic and did not affect fertility in rats.

Nayzilam Novel Uses: Which Conditions Have a Clinical Trial Featuring Nayzilam?

12 active clinical trials are presently evaluating the potential of Nayzilam to provide General Anesthesia, Central Nervous System Depressants and induce Amnesia for certain conditions.

Condition

Clinical Trials

Trial Phases

Sedation for mechanically-ventilated patients

0 Actively Recruiting

Sedation

2 Actively Recruiting

Early Phase 1, Not Applicable

preoperative sedation therapy

0 Actively Recruiting

Anaesthesia

0 Actively Recruiting

Therapeutic procedure

0 Actively Recruiting

Anxiolytic therapy therapy

0 Actively Recruiting

Epilepsy

0 Actively Recruiting

Seizures

0 Actively Recruiting

Seizures

0 Actively Recruiting

Anxiolysis

0 Actively Recruiting

Central Nervous System Depressants

1 Actively Recruiting

Phase 4

Amnesia

2 Actively Recruiting

Early Phase 1

induction of anxiolysis

0 Actively Recruiting

induction of Sedation

0 Actively Recruiting

Therapeutic procedure

0 Actively Recruiting

induction of Amnesia

0 Actively Recruiting

Status Epilepticus

0 Actively Recruiting

Nayzilam Reviews: What are patients saying about Nayzilam?

4

Patient Review

6/15/2021

Nayzilam for Acute Repetitive Seizures

This medication has been a lifesaver. I have seizure clusters, and before this, I would often wake up in the ER. Now, my husband is able to give me the nasal spray and stop the clusters at home. I usually sleep for a few hours but am pretty clear headed when I wake compared to other emergency meds which either didn’t work or had me sleeping all day and drowsy/confused for days after.

1

Patient Review

8/7/2020

Nayzilam for Acute Repetitive Seizures

I found this treatment to be incredibly painful. It felt like someone was shoving a red hot needle down my throat, and I had trouble eating for days afterwards.

Patient Q&A Section about nayzilam

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

What is Nayzilam used for?

"NAYZILAM is a prescription medicine that is used for the short-term treatment of seizure clusters in patients that are at least 12 years old."

Answered by AI

Is Nayzilam a diazepam?

"The drugs Valtoco and Nayzilam are used to treat occasional seizure activity that is different from a patient's usual seizure pattern."

Answered by AI

Is Nayzilam a narcotic?

"Selling or giving away NAYZILAM may harm others and is against the law.

The Controlled Substances Act (CSA) schedules NAYZILAM as a schedule IV substance because it has a low potential for abuse relative to the other controlled substances in schedule IV and because it has a currently accepted medical use in treatment in the United States."

Answered by AI

How quickly does Nayzilam work?

"According to the study, Nayzilam helped the majority of patients to stop a seizure cluster fast and return to function within 90 minutes. Nayzilam may help you to: stop seizure clusters so they don't stop you. with Nayzilam within reach, now you can be ready to treat them quickly."

Answered by AI

Clinical Trials for Nayzilam

Image of CAMC Memorial in Charleston, United States.

Ketamine vs Fentanyl for Sedation in Interventional Radiology

18 - 90
All Sexes
Charleston, WV

This study aims to reduce pain during interventional radiology (IR) procedures, making the experience better for patients. Typically, doctors use medications like fentanyl and midazolam for sedation. This research will focus on patients undergoing biopsies and drainage procedures, often associated with significant discomfort. Patients will be randomly assigned to receive either fentanyl/midazolam or ketamine/midazolam combinations for sedation. A coordinator will collect information on pain levels and satisfaction, as well as monitor any extra medications needed and side effects. The investigators hope to find that ketamine helps decrease pain and improves satisfaction compared to fentanyl, without increasing complications.

Phase < 1
Recruiting

CAMC Memorial

Amy R Deipolyi, M.D., Ph.D.

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