What is Naproxen Sodium
NaproxenThe Generic name of this drug
Treatment SummaryNaproxen is a pain reliever and anti-inflammatory drug that is available with a prescription or over-the-counter. It has been used since 1976 to reduce pain, including pain caused by rheumatic diseases, and is generally well tolerated. Naproxen comes in both immediate and delayed release forms and can be combined with other drugs like sumatriptan and esomeprazole to treat migraines or reduce the risk of developing gastric ulcers, respectively.
Naprosynis the brand name
Naproxen Sodium Overview & Background
Brand Name
Generic Name
First FDA Approval
How many FDA approvals?
Naprosyn
Naproxen
1976
1260
Approved as Treatment by the FDA
Naproxen, otherwise known as Naprosyn, is approved by the FDA for 11 uses including Back and Osteoarthritis (OA) .Back
Osteoarthritis (OA)
Used to treat Osteoarthritis (OA) in combination with Esomeprazole
Menstrual Distress (Dysmenorrhea)
Fever
Toothache
Acute Coryza
Used to treat Acute Migraine in combination with Sumatriptan
Juvenile arthritis
Used to treat Juvenile Idiopathic Arthritis (JIA) in combination with Esomeprazole
Rheumatoid Arthritis
Used to treat Rheumatoid Arthritis in combination with Esomeprazole
Ankylosing Spondylitis
Used to treat Ankylosing Spondylitis (AS) in combination with Esomeprazole
Inflammation
Used to treat articular inflammation in combination with Esomeprazole
Migraine
Effectiveness
How Naproxen Sodium Affects PatientsNaproxen is a type of non-selective NSAID used to reduce pain, inflammation, and fever. It works by blocking the enzyme cyclo-oxygenase, which helps lower the amount of prostaglandins in the body. Taking naproxen can increase blood pressure, although not as much as ibuprofen. Additionally, it can increase the risk of upper gastrointestinal bleeding, especially if taken with other medications such as corticosteroids or anticoagulants, or if the person has a history of stomach ulcers.
How Naproxen Sodium works in the bodyNaproxen works by blocking two enzyme pathways, COX-1 and COX-2. The COX-1 enzyme is always on and can be found in normal parts of the body, such as the stomach lining. The COX-2 enzyme is triggered by pain and inflammation and is responsible for the desired effects of naproxen, like relieving pain and inflammation. However, blocking the COX-1 enzyme can lead to unwanted side effects, like stomach upset and kidney problems.
When to interrupt dosage
The prescribed dosage of Naproxen Sodium hinges on the diagnosed disorder, including Menstrual Distress (Dysmenorrhea), Migraine and Toothache. The quantity of dosage is contingent upon the administration technique (e.g. Tablet, extended release or Tablet, delayed release) represented in the table beneath.Condition
Dosage
Administration
Menstrual Distress (Dysmenorrhea)
, 220.0 mg, 750.0 mg, 500.0 mg, 5.0 mg/mg, 250.0 mg, 550.0 mg, 200.0 mg, 50.0 mg/mL, 25.0 mg/mL, 375.0 mg, 275.0 mg, 125.0 mg, 125.0 mg/mL, 60.0 mg, 1.0 mg/mg, 1000.0 mg, 2.2 mg/mg, 105.0 mg, 210.0 mg
Tablet, extended release, Tablet, delayed release, Oral, Tablet - Oral, Tablet, film coated, Capsule, liquid filled - Oral, Tablet, coated - Oral, Capsule - Oral, Kit, , Tablet, for suspension, Kit - Oral, Tablet, delayed release - Oral, Cream - Topical, Tablet, extended release - Oral, Oral; Topical, Capsule, liquid filled, Tablet, Tablet, multilayer, extended release - Oral, Suspension - Oral, Suppository - Rectal, Tablet, film coated - Oral, Tablet, film coated, extended release, Kit; Tablet - Oral, Suspension, Cream; Kit; Tablet, Rectal, Kit - Oral; Topical, Cream; Kit; Tablet - Oral; Topical, Tablet, film coated, extended release - Oral, Kit; Tablet, Capsule, Tablet, multilayer, extended release, Tablet, coated, Topical, Suppository, Kit - Topical, Tablet, for suspension - Oral
Postoperative Pain
, 220.0 mg, 750.0 mg, 500.0 mg, 5.0 mg/mg, 250.0 mg, 550.0 mg, 200.0 mg, 50.0 mg/mL, 25.0 mg/mL, 375.0 mg, 275.0 mg, 125.0 mg, 125.0 mg/mL, 60.0 mg, 1.0 mg/mg, 1000.0 mg, 2.2 mg/mg, 105.0 mg, 210.0 mg
Tablet, extended release, Tablet, delayed release, Oral, Tablet - Oral, Tablet, film coated, Capsule, liquid filled - Oral, Tablet, coated - Oral, Capsule - Oral, Kit, , Tablet, for suspension, Kit - Oral, Tablet, delayed release - Oral, Cream - Topical, Tablet, extended release - Oral, Oral; Topical, Capsule, liquid filled, Tablet, Tablet, multilayer, extended release - Oral, Suspension - Oral, Suppository - Rectal, Tablet, film coated - Oral, Tablet, film coated, extended release, Kit; Tablet - Oral, Suspension, Cream; Kit; Tablet, Rectal, Kit - Oral; Topical, Cream; Kit; Tablet - Oral; Topical, Tablet, film coated, extended release - Oral, Kit; Tablet, Capsule, Tablet, multilayer, extended release, Tablet, coated, Topical, Suppository, Kit - Topical, Tablet, for suspension - Oral
Back
, 220.0 mg, 750.0 mg, 500.0 mg, 5.0 mg/mg, 250.0 mg, 550.0 mg, 200.0 mg, 50.0 mg/mL, 25.0 mg/mL, 375.0 mg, 275.0 mg, 125.0 mg, 125.0 mg/mL, 60.0 mg, 1.0 mg/mg, 1000.0 mg, 2.2 mg/mg, 105.0 mg, 210.0 mg
Tablet, extended release, Tablet, delayed release, Oral, Tablet - Oral, Tablet, film coated, Capsule, liquid filled - Oral, Tablet, coated - Oral, Capsule - Oral, Kit, , Tablet, for suspension, Kit - Oral, Tablet, delayed release - Oral, Cream - Topical, Tablet, extended release - Oral, Oral; Topical, Capsule, liquid filled, Tablet, Tablet, multilayer, extended release - Oral, Suspension - Oral, Suppository - Rectal, Tablet, film coated - Oral, Tablet, film coated, extended release, Kit; Tablet - Oral, Suspension, Cream; Kit; Tablet, Rectal, Kit - Oral; Topical, Cream; Kit; Tablet - Oral; Topical, Tablet, film coated, extended release - Oral, Kit; Tablet, Capsule, Tablet, multilayer, extended release, Tablet, coated, Topical, Suppository, Kit - Topical, Tablet, for suspension - Oral
prophylaxis of migraine headaches
, 220.0 mg, 750.0 mg, 500.0 mg, 5.0 mg/mg, 250.0 mg, 550.0 mg, 200.0 mg, 50.0 mg/mL, 25.0 mg/mL, 375.0 mg, 275.0 mg, 125.0 mg, 125.0 mg/mL, 60.0 mg, 1.0 mg/mg, 1000.0 mg, 2.2 mg/mg, 105.0 mg, 210.0 mg
Tablet, extended release, Tablet, delayed release, Oral, Tablet - Oral, Tablet, film coated, Capsule, liquid filled - Oral, Tablet, coated - Oral, Capsule - Oral, Kit, , Tablet, for suspension, Kit - Oral, Tablet, delayed release - Oral, Cream - Topical, Tablet, extended release - Oral, Oral; Topical, Capsule, liquid filled, Tablet, Tablet, multilayer, extended release - Oral, Suspension - Oral, Suppository - Rectal, Tablet, film coated - Oral, Tablet, film coated, extended release, Kit; Tablet - Oral, Suspension, Cream; Kit; Tablet, Rectal, Kit - Oral; Topical, Cream; Kit; Tablet - Oral; Topical, Tablet, film coated, extended release - Oral, Kit; Tablet, Capsule, Tablet, multilayer, extended release, Tablet, coated, Topical, Suppository, Kit - Topical, Tablet, for suspension - Oral
Fever
, 220.0 mg, 750.0 mg, 500.0 mg, 5.0 mg/mg, 250.0 mg, 550.0 mg, 200.0 mg, 50.0 mg/mL, 25.0 mg/mL, 375.0 mg, 275.0 mg, 125.0 mg, 125.0 mg/mL, 60.0 mg, 1.0 mg/mg, 1000.0 mg, 2.2 mg/mg, 105.0 mg, 210.0 mg
Tablet, extended release, Tablet, delayed release, Oral, Tablet - Oral, Tablet, film coated, Capsule, liquid filled - Oral, Tablet, coated - Oral, Capsule - Oral, Kit, , Tablet, for suspension, Kit - Oral, Tablet, delayed release - Oral, Cream - Topical, Tablet, extended release - Oral, Oral; Topical, Capsule, liquid filled, Tablet, Tablet, multilayer, extended release - Oral, Suspension - Oral, Suppository - Rectal, Tablet, film coated - Oral, Tablet, film coated, extended release, Kit; Tablet - Oral, Suspension, Cream; Kit; Tablet, Rectal, Kit - Oral; Topical, Cream; Kit; Tablet - Oral; Topical, Tablet, film coated, extended release - Oral, Kit; Tablet, Capsule, Tablet, multilayer, extended release, Tablet, coated, Topical, Suppository, Kit - Topical, Tablet, for suspension - Oral
Migraine
, 220.0 mg, 750.0 mg, 500.0 mg, 5.0 mg/mg, 250.0 mg, 550.0 mg, 200.0 mg, 50.0 mg/mL, 25.0 mg/mL, 375.0 mg, 275.0 mg, 125.0 mg, 125.0 mg/mL, 60.0 mg, 1.0 mg/mg, 1000.0 mg, 2.2 mg/mg, 105.0 mg, 210.0 mg
Tablet, extended release, Tablet, delayed release, Oral, Tablet - Oral, Tablet, film coated, Capsule, liquid filled - Oral, Tablet, coated - Oral, Capsule - Oral, Kit, , Tablet, for suspension, Kit - Oral, Tablet, delayed release - Oral, Cream - Topical, Tablet, extended release - Oral, Oral; Topical, Capsule, liquid filled, Tablet, Tablet, multilayer, extended release - Oral, Suspension - Oral, Suppository - Rectal, Tablet, film coated - Oral, Tablet, film coated, extended release, Kit; Tablet - Oral, Suspension, Cream; Kit; Tablet, Rectal, Kit - Oral; Topical, Cream; Kit; Tablet - Oral; Topical, Tablet, film coated, extended release - Oral, Kit; Tablet, Capsule, Tablet, multilayer, extended release, Tablet, coated, Topical, Suppository, Kit - Topical, Tablet, for suspension - Oral
Ankylosing Spondylitis
, 220.0 mg, 750.0 mg, 500.0 mg, 5.0 mg/mg, 250.0 mg, 550.0 mg, 200.0 mg, 50.0 mg/mL, 25.0 mg/mL, 375.0 mg, 275.0 mg, 125.0 mg, 125.0 mg/mL, 60.0 mg, 1.0 mg/mg, 1000.0 mg, 2.2 mg/mg, 105.0 mg, 210.0 mg
Tablet, extended release, Tablet, delayed release, Oral, Tablet - Oral, Tablet, film coated, Capsule, liquid filled - Oral, Tablet, coated - Oral, Capsule - Oral, Kit, , Tablet, for suspension, Kit - Oral, Tablet, delayed release - Oral, Cream - Topical, Tablet, extended release - Oral, Oral; Topical, Capsule, liquid filled, Tablet, Tablet, multilayer, extended release - Oral, Suspension - Oral, Suppository - Rectal, Tablet, film coated - Oral, Tablet, film coated, extended release, Kit; Tablet - Oral, Suspension, Cream; Kit; Tablet, Rectal, Kit - Oral; Topical, Cream; Kit; Tablet - Oral; Topical, Tablet, film coated, extended release - Oral, Kit; Tablet, Capsule, Tablet, multilayer, extended release, Tablet, coated, Topical, Suppository, Kit - Topical, Tablet, for suspension - Oral
Acute Coryza
, 220.0 mg, 750.0 mg, 500.0 mg, 5.0 mg/mg, 250.0 mg, 550.0 mg, 200.0 mg, 50.0 mg/mL, 25.0 mg/mL, 375.0 mg, 275.0 mg, 125.0 mg, 125.0 mg/mL, 60.0 mg, 1.0 mg/mg, 1000.0 mg, 2.2 mg/mg, 105.0 mg, 210.0 mg
Tablet, extended release, Tablet, delayed release, Oral, Tablet - Oral, Tablet, film coated, Capsule, liquid filled - Oral, Tablet, coated - Oral, Capsule - Oral, Kit, , Tablet, for suspension, Kit - Oral, Tablet, delayed release - Oral, Cream - Topical, Tablet, extended release - Oral, Oral; Topical, Capsule, liquid filled, Tablet, Tablet, multilayer, extended release - Oral, Suspension - Oral, Suppository - Rectal, Tablet, film coated - Oral, Tablet, film coated, extended release, Kit; Tablet - Oral, Suspension, Cream; Kit; Tablet, Rectal, Kit - Oral; Topical, Cream; Kit; Tablet - Oral; Topical, Tablet, film coated, extended release - Oral, Kit; Tablet, Capsule, Tablet, multilayer, extended release, Tablet, coated, Topical, Suppository, Kit - Topical, Tablet, for suspension - Oral
Rheumatoid Arthritis, Juvenile
, 220.0 mg, 750.0 mg, 500.0 mg, 5.0 mg/mg, 250.0 mg, 550.0 mg, 200.0 mg, 50.0 mg/mL, 25.0 mg/mL, 375.0 mg, 275.0 mg, 125.0 mg, 125.0 mg/mL, 60.0 mg, 1.0 mg/mg, 1000.0 mg, 2.2 mg/mg, 105.0 mg, 210.0 mg
Tablet, extended release, Tablet, delayed release, Oral, Tablet - Oral, Tablet, film coated, Capsule, liquid filled - Oral, Tablet, coated - Oral, Capsule - Oral, Kit, , Tablet, for suspension, Kit - Oral, Tablet, delayed release - Oral, Cream - Topical, Tablet, extended release - Oral, Oral; Topical, Capsule, liquid filled, Tablet, Tablet, multilayer, extended release - Oral, Suspension - Oral, Suppository - Rectal, Tablet, film coated - Oral, Tablet, film coated, extended release, Kit; Tablet - Oral, Suspension, Cream; Kit; Tablet, Rectal, Kit - Oral; Topical, Cream; Kit; Tablet - Oral; Topical, Tablet, film coated, extended release - Oral, Kit; Tablet, Capsule, Tablet, multilayer, extended release, Tablet, coated, Topical, Suppository, Kit - Topical, Tablet, for suspension - Oral
Bursitis
, 220.0 mg, 750.0 mg, 500.0 mg, 5.0 mg/mg, 250.0 mg, 550.0 mg, 200.0 mg, 50.0 mg/mL, 25.0 mg/mL, 375.0 mg, 275.0 mg, 125.0 mg, 125.0 mg/mL, 60.0 mg, 1.0 mg/mg, 1000.0 mg, 2.2 mg/mg, 105.0 mg, 210.0 mg
Tablet, extended release, Tablet, delayed release, Oral, Tablet - Oral, Tablet, film coated, Capsule, liquid filled - Oral, Tablet, coated - Oral, Capsule - Oral, Kit, , Tablet, for suspension, Kit - Oral, Tablet, delayed release - Oral, Cream - Topical, Tablet, extended release - Oral, Oral; Topical, Capsule, liquid filled, Tablet, Tablet, multilayer, extended release - Oral, Suspension - Oral, Suppository - Rectal, Tablet, film coated - Oral, Tablet, film coated, extended release, Kit; Tablet - Oral, Suspension, Cream; Kit; Tablet, Rectal, Kit - Oral; Topical, Cream; Kit; Tablet - Oral; Topical, Tablet, film coated, extended release - Oral, Kit; Tablet, Capsule, Tablet, multilayer, extended release, Tablet, coated, Topical, Suppository, Kit - Topical, Tablet, for suspension - Oral
Rheumatoid Arthritis
, 220.0 mg, 750.0 mg, 500.0 mg, 5.0 mg/mg, 250.0 mg, 550.0 mg, 200.0 mg, 50.0 mg/mL, 25.0 mg/mL, 375.0 mg, 275.0 mg, 125.0 mg, 125.0 mg/mL, 60.0 mg, 1.0 mg/mg, 1000.0 mg, 2.2 mg/mg, 105.0 mg, 210.0 mg
Tablet, extended release, Tablet, delayed release, Oral, Tablet - Oral, Tablet, film coated, Capsule, liquid filled - Oral, Tablet, coated - Oral, Capsule - Oral, Kit, , Tablet, for suspension, Kit - Oral, Tablet, delayed release - Oral, Cream - Topical, Tablet, extended release - Oral, Oral; Topical, Capsule, liquid filled, Tablet, Tablet, multilayer, extended release - Oral, Suspension - Oral, Suppository - Rectal, Tablet, film coated - Oral, Tablet, film coated, extended release, Kit; Tablet - Oral, Suspension, Cream; Kit; Tablet, Rectal, Kit - Oral; Topical, Cream; Kit; Tablet - Oral; Topical, Tablet, film coated, extended release - Oral, Kit; Tablet, Capsule, Tablet, multilayer, extended release, Tablet, coated, Topical, Suppository, Kit - Topical, Tablet, for suspension - Oral
Toothache
, 220.0 mg, 750.0 mg, 500.0 mg, 5.0 mg/mg, 250.0 mg, 550.0 mg, 200.0 mg, 50.0 mg/mL, 25.0 mg/mL, 375.0 mg, 275.0 mg, 125.0 mg, 125.0 mg/mL, 60.0 mg, 1.0 mg/mg, 1000.0 mg, 2.2 mg/mg, 105.0 mg, 210.0 mg
Tablet, extended release, Tablet, delayed release, Oral, Tablet - Oral, Tablet, film coated, Capsule, liquid filled - Oral, Tablet, coated - Oral, Capsule - Oral, Kit, , Tablet, for suspension, Kit - Oral, Tablet, delayed release - Oral, Cream - Topical, Tablet, extended release - Oral, Oral; Topical, Capsule, liquid filled, Tablet, Tablet, multilayer, extended release - Oral, Suspension - Oral, Suppository - Rectal, Tablet, film coated - Oral, Tablet, film coated, extended release, Kit; Tablet - Oral, Suspension, Cream; Kit; Tablet, Rectal, Kit - Oral; Topical, Cream; Kit; Tablet - Oral; Topical, Tablet, film coated, extended release - Oral, Kit; Tablet, Capsule, Tablet, multilayer, extended release, Tablet, coated, Topical, Suppository, Kit - Topical, Tablet, for suspension - Oral
Sinusitis
, 220.0 mg, 750.0 mg, 500.0 mg, 5.0 mg/mg, 250.0 mg, 550.0 mg, 200.0 mg, 50.0 mg/mL, 25.0 mg/mL, 375.0 mg, 275.0 mg, 125.0 mg, 125.0 mg/mL, 60.0 mg, 1.0 mg/mg, 1000.0 mg, 2.2 mg/mg, 105.0 mg, 210.0 mg
Tablet, extended release, Tablet, delayed release, Oral, Tablet - Oral, Tablet, film coated, Capsule, liquid filled - Oral, Tablet, coated - Oral, Capsule - Oral, Kit, , Tablet, for suspension, Kit - Oral, Tablet, delayed release - Oral, Cream - Topical, Tablet, extended release - Oral, Oral; Topical, Capsule, liquid filled, Tablet, Tablet, multilayer, extended release - Oral, Suspension - Oral, Suppository - Rectal, Tablet, film coated - Oral, Tablet, film coated, extended release, Kit; Tablet - Oral, Suspension, Cream; Kit; Tablet, Rectal, Kit - Oral; Topical, Cream; Kit; Tablet - Oral; Topical, Tablet, film coated, extended release - Oral, Kit; Tablet, Capsule, Tablet, multilayer, extended release, Tablet, coated, Topical, Suppository, Kit - Topical, Tablet, for suspension - Oral
Tendinitis
, 220.0 mg, 750.0 mg, 500.0 mg, 5.0 mg/mg, 250.0 mg, 550.0 mg, 200.0 mg, 50.0 mg/mL, 25.0 mg/mL, 375.0 mg, 275.0 mg, 125.0 mg, 125.0 mg/mL, 60.0 mg, 1.0 mg/mg, 1000.0 mg, 2.2 mg/mg, 105.0 mg, 210.0 mg
Tablet, extended release, Tablet, delayed release, Oral, Tablet - Oral, Tablet, film coated, Capsule, liquid filled - Oral, Tablet, coated - Oral, Capsule - Oral, Kit, , Tablet, for suspension, Kit - Oral, Tablet, delayed release - Oral, Cream - Topical, Tablet, extended release - Oral, Oral; Topical, Capsule, liquid filled, Tablet, Tablet, multilayer, extended release - Oral, Suspension - Oral, Suppository - Rectal, Tablet, film coated - Oral, Tablet, film coated, extended release, Kit; Tablet - Oral, Suspension, Cream; Kit; Tablet, Rectal, Kit - Oral; Topical, Cream; Kit; Tablet - Oral; Topical, Tablet, film coated, extended release - Oral, Kit; Tablet, Capsule, Tablet, multilayer, extended release, Tablet, coated, Topical, Suppository, Kit - Topical, Tablet, for suspension - Oral
Muscle Spasms
, 220.0 mg, 750.0 mg, 500.0 mg, 5.0 mg/mg, 250.0 mg, 550.0 mg, 200.0 mg, 50.0 mg/mL, 25.0 mg/mL, 375.0 mg, 275.0 mg, 125.0 mg, 125.0 mg/mL, 60.0 mg, 1.0 mg/mg, 1000.0 mg, 2.2 mg/mg, 105.0 mg, 210.0 mg
Tablet, extended release, Tablet, delayed release, Oral, Tablet - Oral, Tablet, film coated, Capsule, liquid filled - Oral, Tablet, coated - Oral, Capsule - Oral, Kit, , Tablet, for suspension, Kit - Oral, Tablet, delayed release - Oral, Cream - Topical, Tablet, extended release - Oral, Oral; Topical, Capsule, liquid filled, Tablet, Tablet, multilayer, extended release - Oral, Suspension - Oral, Suppository - Rectal, Tablet, film coated - Oral, Tablet, film coated, extended release, Kit; Tablet - Oral, Suspension, Cream; Kit; Tablet, Rectal, Kit - Oral; Topical, Cream; Kit; Tablet - Oral; Topical, Tablet, film coated, extended release - Oral, Kit; Tablet, Capsule, Tablet, multilayer, extended release, Tablet, coated, Topical, Suppository, Kit - Topical, Tablet, for suspension - Oral
Post Traumatic Pain
, 220.0 mg, 750.0 mg, 500.0 mg, 5.0 mg/mg, 250.0 mg, 550.0 mg, 200.0 mg, 50.0 mg/mL, 25.0 mg/mL, 375.0 mg, 275.0 mg, 125.0 mg, 125.0 mg/mL, 60.0 mg, 1.0 mg/mg, 1000.0 mg, 2.2 mg/mg, 105.0 mg, 210.0 mg
Tablet, extended release, Tablet, delayed release, Oral, Tablet - Oral, Tablet, film coated, Capsule, liquid filled - Oral, Tablet, coated - Oral, Capsule - Oral, Kit, , Tablet, for suspension, Kit - Oral, Tablet, delayed release - Oral, Cream - Topical, Tablet, extended release - Oral, Oral; Topical, Capsule, liquid filled, Tablet, Tablet, multilayer, extended release - Oral, Suspension - Oral, Suppository - Rectal, Tablet, film coated - Oral, Tablet, film coated, extended release, Kit; Tablet - Oral, Suspension, Cream; Kit; Tablet, Rectal, Kit - Oral; Topical, Cream; Kit; Tablet - Oral; Topical, Tablet, film coated, extended release - Oral, Kit; Tablet, Capsule, Tablet, multilayer, extended release, Tablet, coated, Topical, Suppository, Kit - Topical, Tablet, for suspension - Oral
Primary Dysmenorrhoea
, 220.0 mg, 750.0 mg, 500.0 mg, 5.0 mg/mg, 250.0 mg, 550.0 mg, 200.0 mg, 50.0 mg/mL, 25.0 mg/mL, 375.0 mg, 275.0 mg, 125.0 mg, 125.0 mg/mL, 60.0 mg, 1.0 mg/mg, 1000.0 mg, 2.2 mg/mg, 105.0 mg, 210.0 mg
Tablet, extended release, Tablet, delayed release, Oral, Tablet - Oral, Tablet, film coated, Capsule, liquid filled - Oral, Tablet, coated - Oral, Capsule - Oral, Kit, , Tablet, for suspension, Kit - Oral, Tablet, delayed release - Oral, Cream - Topical, Tablet, extended release - Oral, Oral; Topical, Capsule, liquid filled, Tablet, Tablet, multilayer, extended release - Oral, Suspension - Oral, Suppository - Rectal, Tablet, film coated - Oral, Tablet, film coated, extended release, Kit; Tablet - Oral, Suspension, Cream; Kit; Tablet, Rectal, Kit - Oral; Topical, Cream; Kit; Tablet - Oral; Topical, Tablet, film coated, extended release - Oral, Kit; Tablet, Capsule, Tablet, multilayer, extended release, Tablet, coated, Topical, Suppository, Kit - Topical, Tablet, for suspension - Oral
Arthritis, Gouty
, 220.0 mg, 750.0 mg, 500.0 mg, 5.0 mg/mg, 250.0 mg, 550.0 mg, 200.0 mg, 50.0 mg/mL, 25.0 mg/mL, 375.0 mg, 275.0 mg, 125.0 mg, 125.0 mg/mL, 60.0 mg, 1.0 mg/mg, 1000.0 mg, 2.2 mg/mg, 105.0 mg, 210.0 mg
Tablet, extended release, Tablet, delayed release, Oral, Tablet - Oral, Tablet, film coated, Capsule, liquid filled - Oral, Tablet, coated - Oral, Capsule - Oral, Kit, , Tablet, for suspension, Kit - Oral, Tablet, delayed release - Oral, Cream - Topical, Tablet, extended release - Oral, Oral; Topical, Capsule, liquid filled, Tablet, Tablet, multilayer, extended release - Oral, Suspension - Oral, Suppository - Rectal, Tablet, film coated - Oral, Tablet, film coated, extended release, Kit; Tablet - Oral, Suspension, Cream; Kit; Tablet, Rectal, Kit - Oral; Topical, Cream; Kit; Tablet - Oral; Topical, Tablet, film coated, extended release - Oral, Kit; Tablet, Capsule, Tablet, multilayer, extended release, Tablet, coated, Topical, Suppository, Kit - Topical, Tablet, for suspension - Oral
Collagen Diseases
, 220.0 mg, 750.0 mg, 500.0 mg, 5.0 mg/mg, 250.0 mg, 550.0 mg, 200.0 mg, 50.0 mg/mL, 25.0 mg/mL, 375.0 mg, 275.0 mg, 125.0 mg, 125.0 mg/mL, 60.0 mg, 1.0 mg/mg, 1000.0 mg, 2.2 mg/mg, 105.0 mg, 210.0 mg
Tablet, extended release, Tablet, delayed release, Oral, Tablet - Oral, Tablet, film coated, Capsule, liquid filled - Oral, Tablet, coated - Oral, Capsule - Oral, Kit, , Tablet, for suspension, Kit - Oral, Tablet, delayed release - Oral, Cream - Topical, Tablet, extended release - Oral, Oral; Topical, Capsule, liquid filled, Tablet, Tablet, multilayer, extended release - Oral, Suspension - Oral, Suppository - Rectal, Tablet, film coated - Oral, Tablet, film coated, extended release, Kit; Tablet - Oral, Suspension, Cream; Kit; Tablet, Rectal, Kit - Oral; Topical, Cream; Kit; Tablet - Oral; Topical, Tablet, film coated, extended release - Oral, Kit; Tablet, Capsule, Tablet, multilayer, extended release, Tablet, coated, Topical, Suppository, Kit - Topical, Tablet, for suspension - Oral
Osteoarthritis
, 220.0 mg, 750.0 mg, 500.0 mg, 5.0 mg/mg, 250.0 mg, 550.0 mg, 200.0 mg, 50.0 mg/mL, 25.0 mg/mL, 375.0 mg, 275.0 mg, 125.0 mg, 125.0 mg/mL, 60.0 mg, 1.0 mg/mg, 1000.0 mg, 2.2 mg/mg, 105.0 mg, 210.0 mg
Tablet, extended release, Tablet, delayed release, Oral, Tablet - Oral, Tablet, film coated, Capsule, liquid filled - Oral, Tablet, coated - Oral, Capsule - Oral, Kit, , Tablet, for suspension, Kit - Oral, Tablet, delayed release - Oral, Cream - Topical, Tablet, extended release - Oral, Oral; Topical, Capsule, liquid filled, Tablet, Tablet, multilayer, extended release - Oral, Suspension - Oral, Suppository - Rectal, Tablet, film coated - Oral, Tablet, film coated, extended release, Kit; Tablet - Oral, Suspension, Cream; Kit; Tablet, Rectal, Kit - Oral; Topical, Cream; Kit; Tablet - Oral; Topical, Tablet, film coated, extended release - Oral, Kit; Tablet, Capsule, Tablet, multilayer, extended release, Tablet, coated, Topical, Suppository, Kit - Topical, Tablet, for suspension - Oral
Warnings
Naproxen Sodium has four contraindications and must not be amalgamated with the conditions listed in the following table.Naproxen Sodium ContraindicationsCondition
Risk Level
Notes
Coronary Artery Bypass Grafting
Do Not Combine
Severe Hypersensitivity Reactions
Do Not Combine
Naproxen may interact with Toxoplasma Infections
Severe Hypersensitivity Reactions
Do Not Combine
Naproxen may interact with Toxoplasma Infections
Severe Hypersensitivity Reactions
Do Not Combine
Naproxen may interact with Toxoplasma Infections
Common Naproxen Sodium Drug Interactions
Drug Name
Risk Level
Description
Amiodarone
Major
The metabolism of Amiodarone can be decreased when combined with Naproxen.
Brigatinib
Major
The metabolism of Brigatinib can be decreased when combined with Naproxen.
Enasidenib
Major
The metabolism of Enasidenib can be decreased when combined with Naproxen.
Erlotinib
Major
The metabolism of Erlotinib can be decreased when combined with Naproxen.
Fluorouracil
Major
The metabolism of Fluorouracil can be decreased when combined with Naproxen.
Naproxen Sodium Toxicity & Overdose RiskNaproxen is sold over-the-counter and can be taken without a doctor's prescription. If taken in excess, the side effects may include drowsiness, fatigue, stomach pain, nausea, and vomiting. There is no specific antidote for naproxen overdose, but symptoms will usually go away with supportive care. Naproxen should not be taken by pregnant women during their third trimester as it may harm the baby.
Naproxen Sodium Novel Uses: Which Conditions Have a Clinical Trial Featuring Naproxen Sodium?
635 active clinical trials are underway to assess the efficacy of Naproxen Sodium in relieving Chronic Pain, Migraine and Juvenile Rheumatoid Arthritis.Condition
Clinical Trials
Trial Phases
Chronic Pain
172 Actively Recruiting
Phase 2, Phase 3, Not Applicable, Phase 1, Phase 4, Early Phase 1
Osteoarthritis
157 Actively Recruiting
Not Applicable, Phase 3, Phase 4, Phase 2, Phase 1, Early Phase 1
Muscle Spasms
0 Actively Recruiting
Fever
18 Actively Recruiting
Phase 3, Phase 4, Phase 2, Not Applicable, Phase 1
Toothache
2 Actively Recruiting
Phase 3
Bursitis
9 Actively Recruiting
Phase 4, Not Applicable, Phase 1
Sinusitis
16 Actively Recruiting
Not Applicable, Early Phase 1, Phase 1, Phase 2, Phase 3
Back
8 Actively Recruiting
Not Applicable, Phase 4, Phase 3, Early Phase 1
Menstrual Distress (Dysmenorrhea)
1 Actively Recruiting
Phase 4
Postoperative Pain
15 Actively Recruiting
Phase 4, Not Applicable, Phase 3, Early Phase 1
Primary Dysmenorrhoea
3 Actively Recruiting
Phase 4, Not Applicable
Osteoarthritis (OA)
0 Actively Recruiting
Hay Fever
3 Actively Recruiting
Phase 3
Ankylosing Spondylitis
2 Actively Recruiting
Phase 3, Not Applicable
Arthritis, Gouty
0 Actively Recruiting
Rheumatoid Arthritis, Juvenile
4 Actively Recruiting
Not Applicable, Phase 3
Rheumatoid Arthritis
62 Actively Recruiting
Not Applicable, Phase 4, Phase 3, Phase 2, Phase 1
Tendinitis
1 Actively Recruiting
Not Applicable
prophylaxis of migraine headaches
0 Actively Recruiting
Post Traumatic Pain
0 Actively Recruiting
Naproxen Sodium Reviews: What are patients saying about Naproxen Sodium?
5Patient Review
9/18/2017 Please be aware that naproxen can have serious side effects, such as hallucinations and suicidal thoughts. I am personally allergic to the drug and it took me a while to figure out what was happening to me.
5Patient Review
5/30/2022 I was pleasantly surprised at how quickly this medication began to work. Within just a few days, my chronic pain had significantly decreased.
5Patient Review
12/21/2018 I've been using this medication for four months now to help with my RLS and back pain. I'm really pleased with how much it's helped me; the relief is significant.
5Patient Review
1/2/2016 This medication is excellent for severe cramps. However, it can make you drowsy so I only take it at night or on days when I don't have to go anywhere.
5Patient Review
11/25/2017 This medication is very effective for me in managing pain.
5Patient Review
6/21/2015 Dysmenorrhea is no joke, but Naproxen Sodium has been a life-saver for me. It's the only medication that has been able to keep me from being incapacitated by my symptoms.
5Patient Review
10/22/2015 Unfortunately, this treatment didn't work for me. I tried it for two weeks and saw no improvement.
4.7Patient Review
3/20/20154.7Patient Review
3/23/20154.3Patient Review
7/9/2015 Advil didn't even come close to how effective this is. I'm definitely switching over!
4Patient Review
3/19/2019 I've used this daily for over three years and it's been great for managing my pain. However, I have recently developed gastric reflux so I am decreasing the dosage. Additionally, I've started to notice a slight ringing in my ears (tinnitus) which is concerning. If the warmer months allow me to stop use of this medication without increased pain, I will do so. Otherwise, I will consult with my primary physician about other options such as steroid injections.
3.3Patient Review
4/10/20153Patient Review
9/10/2017 I didn't experience any pain relief from my shin splints injury. It was like taking nothing at all.
2.7Patient Review
12/2/2015 Naproxen sodium (Aleve) is usually my go-to for menstrual cramps and it works like a charm. In less than half an hour, I start feeling better.
2.7Patient Review
4/13/2016 I was hopeful that this would help with my migraines but unfortunately it didn't. However, it did work well on my joint pain.
2.3Patient Review
8/30/2018 I was surprised to find that Benedryl helped me more than Aleve for my lower back pain. NSAIDS have never worked in the past, but allergy medication seems to help calm the nerves involved. I'm happy to have discovered this!
2.3Patient Review
8/30/2018 I was never helped by Aleve, but discovered that allergy medication (chlorpheniramine maleate + phenylephrine HCL) does wonders for reducing lower back pain! I have tight glut, piriformis & hamstring muscles on left side. NSAIDS have never helped. "Allergy" meds seem to calm the involved nerves. Happy to have discovered this & wanted to share.
1.7Patient Review
5/18/20151.7Patient Review
4/4/2017 I took 500 mg. twice daily for 2 weeks as prescribed, but I found that it didn't really help with the pain I've been experiencing for 8 months after breaking my ankle and wrist.
Patient Q&A Section about naproxen sodium
These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.Is naproxen stronger than ibuprofen?
"Both drugs were well-tolerated. Another small study comparing naproxen to ibuprofen found both drugs to be helpful in reducing stiffness, resting pain, movement pain, night pain, interference of the disease with daily activities, and overall disease severity. Naproxen was found to be more effective in this study."
Answered by AI
Is naproxen sodium the same as ibuprofen?
"Ibuprofen and naproxen are similar, but not exactly the same. Ibuprofen doesn't provide as much pain relief as naproxen, meaning you don't have to take it as often."
Answered by AI
What is naproxen sodium used for?
"Naproxen is a medication that can be bought without a prescription. It is used to reduce fever and to relieve mild pain from headaches, muscle aches, arthritis, menstrual periods, the common cold, toothaches, and backaches. Naproxen belongs to a class of medications called NSAIDs."
Answered by AI