Naproxen Sodium

Toothache, Chronic Pain, Migraine + 24 more

Treatment

18 FDA approvals

20 Active Studies for Naproxen Sodium

What is Naproxen Sodium

Naproxen

The Generic name of this drug

Treatment Summary

Naproxen is a pain reliever and anti-inflammatory drug that is available with a prescription or over-the-counter. It has been used since 1976 to reduce pain, including pain caused by rheumatic diseases, and is generally well tolerated. Naproxen comes in both immediate and delayed release forms and can be combined with other drugs like sumatriptan and esomeprazole to treat migraines or reduce the risk of developing gastric ulcers, respectively.

Naprosyn

is the brand name

image of different drug pills on a surface

Naproxen Sodium Overview & Background

Brand Name

Generic Name

First FDA Approval

How many FDA approvals?

Naprosyn

Naproxen

1976

1260

Approved as Treatment by the FDA

Naproxen, otherwise known as Naprosyn, is approved by the FDA for 18 uses including Juvenile arthritis and Juvenile Idiopathic Arthritis (JIA) .

Juvenile arthritis

Used to treat Juvenile Idiopathic Arthritis (JIA) in combination with Esomeprazole

Juvenile Idiopathic Arthritis (JIA)

Used to treat Juvenile Idiopathic Arthritis (JIA) in combination with Esomeprazole

Toothache

Osteoarthritis (OA)

Used to treat Osteoarthritis (OA) in combination with Esomeprazole

Migraine

Rheumatoid Arthritis

Used to treat Rheumatoid Arthritis in combination with Esomeprazole

articular inflammation

Used to treat articular inflammation in combination with Esomeprazole

Inflammation

Used to treat articular inflammation in combination with Esomeprazole

Back

Ankylosing Spondylitis

Used to treat Ankylosing Spondylitis (AS) in combination with Esomeprazole

Dysmenorrhea

Osteoarthritis

Used to treat Osteoarthritis (OA) in combination with Esomeprazole

Headache

Back pain

Ankylosing Spondylitis (AS)

Used to treat Ankylosing Spondylitis (AS) in combination with Esomeprazole

Menstrual Distress (Dysmenorrhea)

Fever

Acute Coryza

Used to treat Acute Migraine in combination with Sumatriptan

Effectiveness

How Naproxen Sodium Affects Patients

Naproxen is a type of non-selective NSAID used to reduce pain, inflammation, and fever. It works by blocking the enzyme cyclo-oxygenase, which helps lower the amount of prostaglandins in the body. Taking naproxen can increase blood pressure, although not as much as ibuprofen. Additionally, it can increase the risk of upper gastrointestinal bleeding, especially if taken with other medications such as corticosteroids or anticoagulants, or if the person has a history of stomach ulcers.

How Naproxen Sodium works in the body

Naproxen works by blocking two enzyme pathways, COX-1 and COX-2. The COX-1 enzyme is always on and can be found in normal parts of the body, such as the stomach lining. The COX-2 enzyme is triggered by pain and inflammation and is responsible for the desired effects of naproxen, like relieving pain and inflammation. However, blocking the COX-1 enzyme can lead to unwanted side effects, like stomach upset and kidney problems.

When to interrupt dosage

The prescribed dosage of Naproxen Sodium hinges on the diagnosed disorder, including Menstrual Distress (Dysmenorrhea), Migraine and Toothache. The quantity of dosage is contingent upon the administration technique (e.g. Tablet, extended release or Tablet, delayed release) represented in the table beneath.

Condition

Dosage

Administration

Acute Coryza

125.0 mg/mL, , 220.0 mg, 200.0 mg, 550.0 mg, 275.0 mg, 500.0 mg, 750.0 mg, 375.0 mg, 250.0 mg, 5.0 mg/mg, 125.0 mg, 60.0 mg, 1000.0 mg, 2.2 mg/mg, 1.0 mg/mg, 210.0 mg, 105.0 mg, 50.0 mg/mL, 25.0 mg/mL

, Suspension, Oral, Suspension - Oral, Capsule, liquid filled, Capsule, liquid filled - Oral, Tablet - Oral, Tablet, Tablet, film coated - Oral, Tablet, film coated, Kit, Kit - Topical, Topical, Tablet, film coated, extended release, Tablet, film coated, extended release - Oral, Tablet, delayed release, Tablet, delayed release - Oral, Capsule - Oral, Capsule, Tablet, coated, Tablet, coated - Oral, Kit - Oral, Rectal, Suppository, Suppository - Rectal, Tablet, extended release, Tablet, extended release - Oral, Cream - Topical, Tablet, for suspension, Tablet, for suspension - Oral, Tablet, multilayer, extended release, Tablet, multilayer, extended release - Oral, Oral; Topical, Kit - Oral; Topical

Inflammation

125.0 mg/mL, , 220.0 mg, 200.0 mg, 550.0 mg, 275.0 mg, 500.0 mg, 750.0 mg, 375.0 mg, 250.0 mg, 5.0 mg/mg, 125.0 mg, 60.0 mg, 1000.0 mg, 2.2 mg/mg, 1.0 mg/mg, 210.0 mg, 105.0 mg, 50.0 mg/mL, 25.0 mg/mL

, Suspension, Oral, Suspension - Oral, Capsule, liquid filled, Capsule, liquid filled - Oral, Tablet - Oral, Tablet, Tablet, film coated - Oral, Tablet, film coated, Kit, Kit - Topical, Topical, Tablet, film coated, extended release, Tablet, film coated, extended release - Oral, Tablet, delayed release, Tablet, delayed release - Oral, Capsule - Oral, Capsule, Tablet, coated, Tablet, coated - Oral, Kit - Oral, Rectal, Suppository, Suppository - Rectal, Tablet, extended release, Tablet, extended release - Oral, Cream - Topical, Tablet, for suspension, Tablet, for suspension - Oral, Tablet, multilayer, extended release, Tablet, multilayer, extended release - Oral, Oral; Topical, Kit - Oral; Topical

Collagen Diseases

125.0 mg/mL, , 220.0 mg, 200.0 mg, 550.0 mg, 275.0 mg, 500.0 mg, 750.0 mg, 375.0 mg, 250.0 mg, 5.0 mg/mg, 125.0 mg, 60.0 mg, 1000.0 mg, 2.2 mg/mg, 1.0 mg/mg, 210.0 mg, 105.0 mg, 50.0 mg/mL, 25.0 mg/mL

, Suspension, Oral, Suspension - Oral, Capsule, liquid filled, Capsule, liquid filled - Oral, Tablet - Oral, Tablet, Tablet, film coated - Oral, Tablet, film coated, Kit, Kit - Topical, Topical, Tablet, film coated, extended release, Tablet, film coated, extended release - Oral, Tablet, delayed release, Tablet, delayed release - Oral, Capsule - Oral, Capsule, Tablet, coated, Tablet, coated - Oral, Kit - Oral, Rectal, Suppository, Suppository - Rectal, Tablet, extended release, Tablet, extended release - Oral, Cream - Topical, Tablet, for suspension, Tablet, for suspension - Oral, Tablet, multilayer, extended release, Tablet, multilayer, extended release - Oral, Oral; Topical, Kit - Oral; Topical

Migraine

125.0 mg/mL, , 220.0 mg, 200.0 mg, 550.0 mg, 275.0 mg, 500.0 mg, 750.0 mg, 375.0 mg, 250.0 mg, 5.0 mg/mg, 125.0 mg, 60.0 mg, 1000.0 mg, 2.2 mg/mg, 1.0 mg/mg, 210.0 mg, 105.0 mg, 50.0 mg/mL, 25.0 mg/mL

, Suspension, Oral, Suspension - Oral, Capsule, liquid filled, Capsule, liquid filled - Oral, Tablet - Oral, Tablet, Tablet, film coated - Oral, Tablet, film coated, Kit, Kit - Topical, Topical, Tablet, film coated, extended release, Tablet, film coated, extended release - Oral, Tablet, delayed release, Tablet, delayed release - Oral, Capsule - Oral, Capsule, Tablet, coated, Tablet, coated - Oral, Kit - Oral, Rectal, Suppository, Suppository - Rectal, Tablet, extended release, Tablet, extended release - Oral, Cream - Topical, Tablet, for suspension, Tablet, for suspension - Oral, Tablet, multilayer, extended release, Tablet, multilayer, extended release - Oral, Oral; Topical, Kit - Oral; Topical

Migraine

125.0 mg/mL, , 220.0 mg, 200.0 mg, 550.0 mg, 275.0 mg, 500.0 mg, 750.0 mg, 375.0 mg, 250.0 mg, 5.0 mg/mg, 125.0 mg, 60.0 mg, 1000.0 mg, 2.2 mg/mg, 1.0 mg/mg, 210.0 mg, 105.0 mg, 50.0 mg/mL, 25.0 mg/mL

, Suspension, Oral, Suspension - Oral, Capsule, liquid filled, Capsule, liquid filled - Oral, Tablet - Oral, Tablet, Tablet, film coated - Oral, Tablet, film coated, Kit, Kit - Topical, Topical, Tablet, film coated, extended release, Tablet, film coated, extended release - Oral, Tablet, delayed release, Tablet, delayed release - Oral, Capsule - Oral, Capsule, Tablet, coated, Tablet, coated - Oral, Kit - Oral, Rectal, Suppository, Suppository - Rectal, Tablet, extended release, Tablet, extended release - Oral, Cream - Topical, Tablet, for suspension, Tablet, for suspension - Oral, Tablet, multilayer, extended release, Tablet, multilayer, extended release - Oral, Oral; Topical, Kit - Oral; Topical

Sinusitis

125.0 mg/mL, , 220.0 mg, 200.0 mg, 550.0 mg, 275.0 mg, 500.0 mg, 750.0 mg, 375.0 mg, 250.0 mg, 5.0 mg/mg, 125.0 mg, 60.0 mg, 1000.0 mg, 2.2 mg/mg, 1.0 mg/mg, 210.0 mg, 105.0 mg, 50.0 mg/mL, 25.0 mg/mL

, Suspension, Oral, Suspension - Oral, Capsule, liquid filled, Capsule, liquid filled - Oral, Tablet - Oral, Tablet, Tablet, film coated - Oral, Tablet, film coated, Kit, Kit - Topical, Topical, Tablet, film coated, extended release, Tablet, film coated, extended release - Oral, Tablet, delayed release, Tablet, delayed release - Oral, Capsule - Oral, Capsule, Tablet, coated, Tablet, coated - Oral, Kit - Oral, Rectal, Suppository, Suppository - Rectal, Tablet, extended release, Tablet, extended release - Oral, Cream - Topical, Tablet, for suspension, Tablet, for suspension - Oral, Tablet, multilayer, extended release, Tablet, multilayer, extended release - Oral, Oral; Topical, Kit - Oral; Topical

Influenza

125.0 mg/mL, , 220.0 mg, 200.0 mg, 550.0 mg, 275.0 mg, 500.0 mg, 750.0 mg, 375.0 mg, 250.0 mg, 5.0 mg/mg, 125.0 mg, 60.0 mg, 1000.0 mg, 2.2 mg/mg, 1.0 mg/mg, 210.0 mg, 105.0 mg, 50.0 mg/mL, 25.0 mg/mL

, Suspension, Oral, Suspension - Oral, Capsule, liquid filled, Capsule, liquid filled - Oral, Tablet - Oral, Tablet, Tablet, film coated - Oral, Tablet, film coated, Kit, Kit - Topical, Topical, Tablet, film coated, extended release, Tablet, film coated, extended release - Oral, Tablet, delayed release, Tablet, delayed release - Oral, Capsule - Oral, Capsule, Tablet, coated, Tablet, coated - Oral, Kit - Oral, Rectal, Suppository, Suppository - Rectal, Tablet, extended release, Tablet, extended release - Oral, Cream - Topical, Tablet, for suspension, Tablet, for suspension - Oral, Tablet, multilayer, extended release, Tablet, multilayer, extended release - Oral, Oral; Topical, Kit - Oral; Topical

Bursitis

125.0 mg/mL, , 220.0 mg, 200.0 mg, 550.0 mg, 275.0 mg, 500.0 mg, 750.0 mg, 375.0 mg, 250.0 mg, 5.0 mg/mg, 125.0 mg, 60.0 mg, 1000.0 mg, 2.2 mg/mg, 1.0 mg/mg, 210.0 mg, 105.0 mg, 50.0 mg/mL, 25.0 mg/mL

, Suspension, Oral, Suspension - Oral, Capsule, liquid filled, Capsule, liquid filled - Oral, Tablet - Oral, Tablet, Tablet, film coated - Oral, Tablet, film coated, Kit, Kit - Topical, Topical, Tablet, film coated, extended release, Tablet, film coated, extended release - Oral, Tablet, delayed release, Tablet, delayed release - Oral, Capsule - Oral, Capsule, Tablet, coated, Tablet, coated - Oral, Kit - Oral, Rectal, Suppository, Suppository - Rectal, Tablet, extended release, Tablet, extended release - Oral, Cream - Topical, Tablet, for suspension, Tablet, for suspension - Oral, Tablet, multilayer, extended release, Tablet, multilayer, extended release - Oral, Oral; Topical, Kit - Oral; Topical

Fever

125.0 mg/mL, , 220.0 mg, 200.0 mg, 550.0 mg, 275.0 mg, 500.0 mg, 750.0 mg, 375.0 mg, 250.0 mg, 5.0 mg/mg, 125.0 mg, 60.0 mg, 1000.0 mg, 2.2 mg/mg, 1.0 mg/mg, 210.0 mg, 105.0 mg, 50.0 mg/mL, 25.0 mg/mL

, Suspension, Oral, Suspension - Oral, Capsule, liquid filled, Capsule, liquid filled - Oral, Tablet - Oral, Tablet, Tablet, film coated - Oral, Tablet, film coated, Kit, Kit - Topical, Topical, Tablet, film coated, extended release, Tablet, film coated, extended release - Oral, Tablet, delayed release, Tablet, delayed release - Oral, Capsule - Oral, Capsule, Tablet, coated, Tablet, coated - Oral, Kit - Oral, Rectal, Suppository, Suppository - Rectal, Tablet, extended release, Tablet, extended release - Oral, Cream - Topical, Tablet, for suspension, Tablet, for suspension - Oral, Tablet, multilayer, extended release, Tablet, multilayer, extended release - Oral, Oral; Topical, Kit - Oral; Topical

Arthritis, Juvenile

125.0 mg/mL, , 220.0 mg, 200.0 mg, 550.0 mg, 275.0 mg, 500.0 mg, 750.0 mg, 375.0 mg, 250.0 mg, 5.0 mg/mg, 125.0 mg, 60.0 mg, 1000.0 mg, 2.2 mg/mg, 1.0 mg/mg, 210.0 mg, 105.0 mg, 50.0 mg/mL, 25.0 mg/mL

, Suspension, Oral, Suspension - Oral, Capsule, liquid filled, Capsule, liquid filled - Oral, Tablet - Oral, Tablet, Tablet, film coated - Oral, Tablet, film coated, Kit, Kit - Topical, Topical, Tablet, film coated, extended release, Tablet, film coated, extended release - Oral, Tablet, delayed release, Tablet, delayed release - Oral, Capsule - Oral, Capsule, Tablet, coated, Tablet, coated - Oral, Kit - Oral, Rectal, Suppository, Suppository - Rectal, Tablet, extended release, Tablet, extended release - Oral, Cream - Topical, Tablet, for suspension, Tablet, for suspension - Oral, Tablet, multilayer, extended release, Tablet, multilayer, extended release - Oral, Oral; Topical, Kit - Oral; Topical

Dysmenorrhea

125.0 mg/mL, , 220.0 mg, 200.0 mg, 550.0 mg, 275.0 mg, 500.0 mg, 750.0 mg, 375.0 mg, 250.0 mg, 5.0 mg/mg, 125.0 mg, 60.0 mg, 1000.0 mg, 2.2 mg/mg, 1.0 mg/mg, 210.0 mg, 105.0 mg, 50.0 mg/mL, 25.0 mg/mL

, Suspension, Oral, Suspension - Oral, Capsule, liquid filled, Capsule, liquid filled - Oral, Tablet - Oral, Tablet, Tablet, film coated - Oral, Tablet, film coated, Kit, Kit - Topical, Topical, Tablet, film coated, extended release, Tablet, film coated, extended release - Oral, Tablet, delayed release, Tablet, delayed release - Oral, Capsule - Oral, Capsule, Tablet, coated, Tablet, coated - Oral, Kit - Oral, Rectal, Suppository, Suppository - Rectal, Tablet, extended release, Tablet, extended release - Oral, Cream - Topical, Tablet, for suspension, Tablet, for suspension - Oral, Tablet, multilayer, extended release, Tablet, multilayer, extended release - Oral, Oral; Topical, Kit - Oral; Topical

Spasm

125.0 mg/mL, , 220.0 mg, 200.0 mg, 550.0 mg, 275.0 mg, 500.0 mg, 750.0 mg, 375.0 mg, 250.0 mg, 5.0 mg/mg, 125.0 mg, 60.0 mg, 1000.0 mg, 2.2 mg/mg, 1.0 mg/mg, 210.0 mg, 105.0 mg, 50.0 mg/mL, 25.0 mg/mL

, Suspension, Oral, Suspension - Oral, Capsule, liquid filled, Capsule, liquid filled - Oral, Tablet - Oral, Tablet, Tablet, film coated - Oral, Tablet, film coated, Kit, Kit - Topical, Topical, Tablet, film coated, extended release, Tablet, film coated, extended release - Oral, Tablet, delayed release, Tablet, delayed release - Oral, Capsule - Oral, Capsule, Tablet, coated, Tablet, coated - Oral, Kit - Oral, Rectal, Suppository, Suppository - Rectal, Tablet, extended release, Tablet, extended release - Oral, Cream - Topical, Tablet, for suspension, Tablet, for suspension - Oral, Tablet, multilayer, extended release, Tablet, multilayer, extended release - Oral, Oral; Topical, Kit - Oral; Topical

Epilepsy, Post-Traumatic

125.0 mg/mL, , 220.0 mg, 200.0 mg, 550.0 mg, 275.0 mg, 500.0 mg, 750.0 mg, 375.0 mg, 250.0 mg, 5.0 mg/mg, 125.0 mg, 60.0 mg, 1000.0 mg, 2.2 mg/mg, 1.0 mg/mg, 210.0 mg, 105.0 mg, 50.0 mg/mL, 25.0 mg/mL

, Suspension, Oral, Suspension - Oral, Capsule, liquid filled, Capsule, liquid filled - Oral, Tablet - Oral, Tablet, Tablet, film coated - Oral, Tablet, film coated, Kit, Kit - Topical, Topical, Tablet, film coated, extended release, Tablet, film coated, extended release - Oral, Tablet, delayed release, Tablet, delayed release - Oral, Capsule - Oral, Capsule, Tablet, coated, Tablet, coated - Oral, Kit - Oral, Rectal, Suppository, Suppository - Rectal, Tablet, extended release, Tablet, extended release - Oral, Cream - Topical, Tablet, for suspension, Tablet, for suspension - Oral, Tablet, multilayer, extended release, Tablet, multilayer, extended release - Oral, Oral; Topical, Kit - Oral; Topical

Back

125.0 mg/mL, , 220.0 mg, 200.0 mg, 550.0 mg, 275.0 mg, 500.0 mg, 750.0 mg, 375.0 mg, 250.0 mg, 5.0 mg/mg, 125.0 mg, 60.0 mg, 1000.0 mg, 2.2 mg/mg, 1.0 mg/mg, 210.0 mg, 105.0 mg, 50.0 mg/mL, 25.0 mg/mL

, Suspension, Oral, Suspension - Oral, Capsule, liquid filled, Capsule, liquid filled - Oral, Tablet - Oral, Tablet, Tablet, film coated - Oral, Tablet, film coated, Kit, Kit - Topical, Topical, Tablet, film coated, extended release, Tablet, film coated, extended release - Oral, Tablet, delayed release, Tablet, delayed release - Oral, Capsule - Oral, Capsule, Tablet, coated, Tablet, coated - Oral, Kit - Oral, Rectal, Suppository, Suppository - Rectal, Tablet, extended release, Tablet, extended release - Oral, Cream - Topical, Tablet, for suspension, Tablet, for suspension - Oral, Tablet, multilayer, extended release, Tablet, multilayer, extended release - Oral, Oral; Topical, Kit - Oral; Topical

Primary Dysmenorrhoea

125.0 mg/mL, , 220.0 mg, 200.0 mg, 550.0 mg, 275.0 mg, 500.0 mg, 750.0 mg, 375.0 mg, 250.0 mg, 5.0 mg/mg, 125.0 mg, 60.0 mg, 1000.0 mg, 2.2 mg/mg, 1.0 mg/mg, 210.0 mg, 105.0 mg, 50.0 mg/mL, 25.0 mg/mL

, Suspension, Oral, Suspension - Oral, Capsule, liquid filled, Capsule, liquid filled - Oral, Tablet - Oral, Tablet, Tablet, film coated - Oral, Tablet, film coated, Kit, Kit - Topical, Topical, Tablet, film coated, extended release, Tablet, film coated, extended release - Oral, Tablet, delayed release, Tablet, delayed release - Oral, Capsule - Oral, Capsule, Tablet, coated, Tablet, coated - Oral, Kit - Oral, Rectal, Suppository, Suppository - Rectal, Tablet, extended release, Tablet, extended release - Oral, Cream - Topical, Tablet, for suspension, Tablet, for suspension - Oral, Tablet, multilayer, extended release, Tablet, multilayer, extended release - Oral, Oral; Topical, Kit - Oral; Topical

Tendinopathy

125.0 mg/mL, , 220.0 mg, 200.0 mg, 550.0 mg, 275.0 mg, 500.0 mg, 750.0 mg, 375.0 mg, 250.0 mg, 5.0 mg/mg, 125.0 mg, 60.0 mg, 1000.0 mg, 2.2 mg/mg, 1.0 mg/mg, 210.0 mg, 105.0 mg, 50.0 mg/mL, 25.0 mg/mL

, Suspension, Oral, Suspension - Oral, Capsule, liquid filled, Capsule, liquid filled - Oral, Tablet - Oral, Tablet, Tablet, film coated - Oral, Tablet, film coated, Kit, Kit - Topical, Topical, Tablet, film coated, extended release, Tablet, film coated, extended release - Oral, Tablet, delayed release, Tablet, delayed release - Oral, Capsule - Oral, Capsule, Tablet, coated, Tablet, coated - Oral, Kit - Oral, Rectal, Suppository, Suppository - Rectal, Tablet, extended release, Tablet, extended release - Oral, Cream - Topical, Tablet, for suspension, Tablet, for suspension - Oral, Tablet, multilayer, extended release, Tablet, multilayer, extended release - Oral, Oral; Topical, Kit - Oral; Topical

Arthritis, Gouty

125.0 mg/mL, , 220.0 mg, 200.0 mg, 550.0 mg, 275.0 mg, 500.0 mg, 750.0 mg, 375.0 mg, 250.0 mg, 5.0 mg/mg, 125.0 mg, 60.0 mg, 1000.0 mg, 2.2 mg/mg, 1.0 mg/mg, 210.0 mg, 105.0 mg, 50.0 mg/mL, 25.0 mg/mL

, Suspension, Oral, Suspension - Oral, Capsule, liquid filled, Capsule, liquid filled - Oral, Tablet - Oral, Tablet, Tablet, film coated - Oral, Tablet, film coated, Kit, Kit - Topical, Topical, Tablet, film coated, extended release, Tablet, film coated, extended release - Oral, Tablet, delayed release, Tablet, delayed release - Oral, Capsule - Oral, Capsule, Tablet, coated, Tablet, coated - Oral, Kit - Oral, Rectal, Suppository, Suppository - Rectal, Tablet, extended release, Tablet, extended release - Oral, Cream - Topical, Tablet, for suspension, Tablet, for suspension - Oral, Tablet, multilayer, extended release, Tablet, multilayer, extended release - Oral, Oral; Topical, Kit - Oral; Topical

Rheumatoid Arthritis

125.0 mg/mL, , 220.0 mg, 200.0 mg, 550.0 mg, 275.0 mg, 500.0 mg, 750.0 mg, 375.0 mg, 250.0 mg, 5.0 mg/mg, 125.0 mg, 60.0 mg, 1000.0 mg, 2.2 mg/mg, 1.0 mg/mg, 210.0 mg, 105.0 mg, 50.0 mg/mL, 25.0 mg/mL

, Suspension, Oral, Suspension - Oral, Capsule, liquid filled, Capsule, liquid filled - Oral, Tablet - Oral, Tablet, Tablet, film coated - Oral, Tablet, film coated, Kit, Kit - Topical, Topical, Tablet, film coated, extended release, Tablet, film coated, extended release - Oral, Tablet, delayed release, Tablet, delayed release - Oral, Capsule - Oral, Capsule, Tablet, coated, Tablet, coated - Oral, Kit - Oral, Rectal, Suppository, Suppository - Rectal, Tablet, extended release, Tablet, extended release - Oral, Cream - Topical, Tablet, for suspension, Tablet, for suspension - Oral, Tablet, multilayer, extended release, Tablet, multilayer, extended release - Oral, Oral; Topical, Kit - Oral; Topical

Hay Fever

125.0 mg/mL, , 220.0 mg, 200.0 mg, 550.0 mg, 275.0 mg, 500.0 mg, 750.0 mg, 375.0 mg, 250.0 mg, 5.0 mg/mg, 125.0 mg, 60.0 mg, 1000.0 mg, 2.2 mg/mg, 1.0 mg/mg, 210.0 mg, 105.0 mg, 50.0 mg/mL, 25.0 mg/mL

, Suspension, Oral, Suspension - Oral, Capsule, liquid filled, Capsule, liquid filled - Oral, Tablet - Oral, Tablet, Tablet, film coated - Oral, Tablet, film coated, Kit, Kit - Topical, Topical, Tablet, film coated, extended release, Tablet, film coated, extended release - Oral, Tablet, delayed release, Tablet, delayed release - Oral, Capsule - Oral, Capsule, Tablet, coated, Tablet, coated - Oral, Kit - Oral, Rectal, Suppository, Suppository - Rectal, Tablet, extended release, Tablet, extended release - Oral, Cream - Topical, Tablet, for suspension, Tablet, for suspension - Oral, Tablet, multilayer, extended release, Tablet, multilayer, extended release - Oral, Oral; Topical, Kit - Oral; Topical

Nasal Congestion

125.0 mg/mL, , 220.0 mg, 200.0 mg, 550.0 mg, 275.0 mg, 500.0 mg, 750.0 mg, 375.0 mg, 250.0 mg, 5.0 mg/mg, 125.0 mg, 60.0 mg, 1000.0 mg, 2.2 mg/mg, 1.0 mg/mg, 210.0 mg, 105.0 mg, 50.0 mg/mL, 25.0 mg/mL

, Suspension, Oral, Suspension - Oral, Capsule, liquid filled, Capsule, liquid filled - Oral, Tablet - Oral, Tablet, Tablet, film coated - Oral, Tablet, film coated, Kit, Kit - Topical, Topical, Tablet, film coated, extended release, Tablet, film coated, extended release - Oral, Tablet, delayed release, Tablet, delayed release - Oral, Capsule - Oral, Capsule, Tablet, coated, Tablet, coated - Oral, Kit - Oral, Rectal, Suppository, Suppository - Rectal, Tablet, extended release, Tablet, extended release - Oral, Cream - Topical, Tablet, for suspension, Tablet, for suspension - Oral, Tablet, multilayer, extended release, Tablet, multilayer, extended release - Oral, Oral; Topical, Kit - Oral; Topical

Warnings

Naproxen Sodium has four contraindications and must not be amalgamated with the conditions listed in the following table.

Naproxen Sodium Contraindications

Condition

Risk Level

Notes

Severe Hypersensitivity Reactions

Do Not Combine

Naproxen may interact with Pulse Frequency

Coronary Artery Bypass Grafting

Do Not Combine

Severe Hypersensitivity Reactions

Do Not Combine

Naproxen may interact with Pulse Frequency

Severe Hypersensitivity Reactions

Do Not Combine

Naproxen may interact with Pulse Frequency

There are 20 known major drug interactions with Naproxen Sodium.

Common Naproxen Sodium Drug Interactions

Drug Name

Risk Level

Description

Amiodarone

Major

The metabolism of Amiodarone can be decreased when combined with Naproxen.

Brigatinib

Major

The metabolism of Brigatinib can be decreased when combined with Naproxen.

Cabazitaxel

Major

The metabolism of Cabazitaxel can be decreased when combined with Naproxen.

Enasidenib

Major

The metabolism of Enasidenib can be decreased when combined with Naproxen.

Erlotinib

Major

The metabolism of Erlotinib can be decreased when combined with Naproxen.

Naproxen Sodium Toxicity & Overdose Risk

Naproxen is sold over-the-counter and can be taken without a doctor's prescription. If taken in excess, the side effects may include drowsiness, fatigue, stomach pain, nausea, and vomiting. There is no specific antidote for naproxen overdose, but symptoms will usually go away with supportive care. Naproxen should not be taken by pregnant women during their third trimester as it may harm the baby.

image of a doctor in a lab doing drug, clinical research

Naproxen Sodium Novel Uses: Which Conditions Have a Clinical Trial Featuring Naproxen Sodium?

635 active clinical trials are underway to assess the efficacy of Naproxen Sodium in relieving Chronic Pain, Migraine and Juvenile Rheumatoid Arthritis.

Condition

Clinical Trials

Trial Phases

Influenza

29 Actively Recruiting

Not Applicable, Phase 4, Phase 2, Phase 1, Phase 3

Postoperative Pain

19 Actively Recruiting

Phase 4, Phase 2, Phase 1, Phase 3, Not Applicable

Chronic Pain

130 Actively Recruiting

Not Applicable, Phase 4, Phase 2, Phase 3, Early Phase 1, Phase 1

Inflammation

0 Actively Recruiting

Bursitis

0 Actively Recruiting

Tendinopathy

0 Actively Recruiting

Nasal Congestion

0 Actively Recruiting

Juvenile arthritis

8 Actively Recruiting

Phase 2, Not Applicable, Phase 3

Rheumatoid Arthritis

55 Actively Recruiting

Not Applicable, Phase 4, Phase 3, Phase 2, Phase 1

Spasm

0 Actively Recruiting

Back

8 Actively Recruiting

Not Applicable, Phase 3, Early Phase 1, Phase 1

Fever

2 Actively Recruiting

Not Applicable, Phase 4

Collagen Diseases

0 Actively Recruiting

Osteoarthritis

0 Actively Recruiting

Migraine

13 Actively Recruiting

Not Applicable, Phase 2, Phase 1, Phase 3, Phase 4

Arthritis, Juvenile

1 Actively Recruiting

Not Applicable

Migraine

51 Actively Recruiting

Phase 4, Not Applicable, Phase 1, Phase 3, Phase 2, Early Phase 1

Arthritis, Gouty

0 Actively Recruiting

Acute Coryza

0 Actively Recruiting

Epilepsy, Post-Traumatic

0 Actively Recruiting

Naproxen Sodium Reviews: What are patients saying about Naproxen Sodium?

5

Patient Review

9/18/2017

Naproxen Sodium for Pain

Please be aware that naproxen can have serious side effects, such as hallucinations and suicidal thoughts. I am personally allergic to the drug and it took me a while to figure out what was happening to me.

5

Patient Review

5/30/2022

Naproxen Sodium for Mild Pain associated with Arthritis

I was pleasantly surprised at how quickly this medication began to work. Within just a few days, my chronic pain had significantly decreased.

5

Patient Review

12/21/2018

Naproxen Sodium for Muscle Pain

I've been using this medication for four months now to help with my RLS and back pain. I'm really pleased with how much it's helped me; the relief is significant.

5

Patient Review

1/2/2016

Naproxen Sodium for Pain

This medication is excellent for severe cramps. However, it can make you drowsy so I only take it at night or on days when I don't have to go anywhere.

5

Patient Review

11/25/2017

Naproxen Sodium for Muscle Pain

This medication is very effective for me in managing pain.

5

Patient Review

6/21/2015

Naproxen Sodium for Painful Periods

Dysmenorrhea is no joke, but Naproxen Sodium has been a life-saver for me. It's the only medication that has been able to keep me from being incapacitated by my symptoms.

5

Patient Review

10/22/2015

Naproxen Sodium for Migraine Headache

Unfortunately, this treatment didn't work for me. I tried it for two weeks and saw no improvement.

4.7

Patient Review

3/20/2015

Naproxen Sodium for Painful Periods

4.7

Patient Review

3/23/2015

Naproxen Sodium for Toothache

4.3

Patient Review

7/9/2015

Naproxen Sodium for Painful Periods

Advil didn't even come close to how effective this is. I'm definitely switching over!

4

Patient Review

3/19/2019

Naproxen Sodium for Mild Pain associated with Arthritis

I've used this daily for over three years and it's been great for managing my pain. However, I have recently developed gastric reflux so I am decreasing the dosage. Additionally, I've started to notice a slight ringing in my ears (tinnitus) which is concerning. If the warmer months allow me to stop use of this medication without increased pain, I will do so. Otherwise, I will consult with my primary physician about other options such as steroid injections.

3.3

Patient Review

4/10/2015

Naproxen Sodium for Pain

3

Patient Review

9/10/2017

Naproxen Sodium for Head Pain

I didn't experience any pain relief from my shin splints injury. It was like taking nothing at all.

2.7

Patient Review

12/2/2015

Naproxen Sodium for Migraine Headache

Naproxen sodium (Aleve) is usually my go-to for menstrual cramps and it works like a charm. In less than half an hour, I start feeling better.

2.7

Patient Review

4/13/2016

Naproxen Sodium for Minor Musculoskeletal Injury

I was hopeful that this would help with my migraines but unfortunately it didn't. However, it did work well on my joint pain.

2.3

Patient Review

8/30/2018

Naproxen Sodium for Pain

I was surprised to find that Benedryl helped me more than Aleve for my lower back pain. NSAIDS have never worked in the past, but allergy medication seems to help calm the nerves involved. I'm happy to have discovered this!

2.3

Patient Review

8/30/2018

Naproxen Sodium for Muscle Pain

I was never helped by Aleve, but discovered that allergy medication (chlorpheniramine maleate + phenylephrine HCL) does wonders for reducing lower back pain! I have tight glut, piriformis & hamstring muscles on left side. NSAIDS have never helped. "Allergy" meds seem to calm the involved nerves. Happy to have discovered this & wanted to share.

1.7

Patient Review

5/18/2015

Naproxen Sodium for Migraine Headache

1.7

Patient Review

4/4/2017

Naproxen Sodium for Head Pain

I took 500 mg. twice daily for 2 weeks as prescribed, but I found that it didn't really help with the pain I've been experiencing for 8 months after breaking my ankle and wrist.
image of drug pills surrounding a glass of water symbolizing drug consumption

Patient Q&A Section about naproxen sodium

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

Is naproxen stronger than ibuprofen?

"Both drugs were well-tolerated. Another small study comparing naproxen to ibuprofen found both drugs to be helpful in reducing stiffness, resting pain, movement pain, night pain, interference of the disease with daily activities, and overall disease severity. Naproxen was found to be more effective in this study."

Answered by AI

Is naproxen 500 mg a strong painkiller?

"Naproxen is an anti-inflammatory painkiller that can be used to relieve pain and inflammation associated with arthritis, gout, or menstrual pain."

Answered by AI

Is naproxen sodium the same as ibuprofen?

"Ibuprofen and naproxen are similar, but not exactly the same. Ibuprofen doesn't provide as much pain relief as naproxen, meaning you don't have to take it as often."

Answered by AI

What is naproxen sodium used for?

"Naproxen is a medication that can be bought without a prescription. It is used to reduce fever and to relieve mild pain from headaches, muscle aches, arthritis, menstrual periods, the common cold, toothaches, and backaches. Naproxen belongs to a class of medications called NSAIDs."

Answered by AI

Clinical Trials for Naproxen Sodium

Image of University Center for Ambulatory Surgery in Somerset, United States.

Infusion Pump for Postoperative Pain

18+
All Sexes
Somerset, NJ

This study will be a pragmatic, prospective cluster randomized trial, where clusters will formed based on sequential 2 week time increments across the study recruitment period.. Patients 18 years or older undergoing ACL reconstruction, open shoulder labrum or rotator cuff surgery, arthroscopic rotator cuff repair, proximal or distal patellar realignment surgery, open knee arthrotomy cases (i.e. inside out meniscus repair, osteochondral allograft transplantation (OCA), meniscal allograft transplantation (MAT)) at University Center for Ambulatory Surgery, LLC (UOA) will be reviewed for eligibility. Once identified, potential study subjects will be asked whether they are interested in participating in the project. If the patient agrees, the subject will be given the informed consent to read and sign. Objectives: The primary objective is to compare the effectiveness of postoperative infusion pain pump versus preoperative nerve block in reducing visual analog pain scores/numerical pain rating scale (VAS/NPRS) in the postoperative period. The second objective is to evaluate the requirement of narcotic and non-narcotic analgesic medications between the two groups. Hypotheses: Use of continuous infusion pain pump or single shot peripheral block will result in similar post-operative pain control after outpatient sports medicine surgical cases.

Phase 4
Recruiting

University Center for Ambulatory Surgery

Image of University of North Carolina at Chapel Hill in Chapel Hill, United States.

Pain Medicines for Period Pain in Crohn's Disease

18 - 44
Female
Chapel Hill, NC

The purpose of this pilot study is to prepare for a larger study that will compare the effectiveness and safety of two common pain medications, ibuprofen and acetaminophen, to help treat period cramps in women with Crohn's disease. The goal of this study is to identify any challenges in running a larger study. The investigators will track how many people sign up for the study, how well participants follow the study plan, how many people stay in the study, and whether they are able to complete all the study activities, such as taking the medication, submitting samples, and filling out surveys. During the study, participants will undergo a screening visit that includes a blood draw, physical exam, pregnancy test, stool testing, and complete surveys about Crohn's disease and menstrual cycles. Once this visit is complete, the rest of the study will occur at home. Participants will be assigned to take either ibuprofen or acetaminophen to help treat period cramps for four menstrual cycles in a row. Participants will take ibuprofen for two cycles and acetaminophen for two cycles. Participants will know which medication is being taken at any given time, but the order in which they take the medications will be randomly assigned. Before each menstrual cycle, participants will submit a stool sample and fill out a short (\<1 minute) electronic survey. When participants develop period cramps, they will take the assigned medication for three days and fill out short (\<1 minute) electronic surveys about their cramps. After participants finish taking the medication for three days, they will submit another stool sample and fill out two more short (\<1 minute) electronic surveys. After have completing this process for four menstrual cycles, a remote interview with a researcher to give feedback on the study will be conducted.

Waitlist Available
Has No Placebo

University of North Carolina at Chapel Hill

Erica J Brenner, MD, MSCR

Image of AltaSciences, Inc in Cypress, United States.

SBS-147 Safety Study

18 - 55
All Sexes
Cypress, CA

This study is part of the HEAL Initiative supported by the NIH. The purpose of this study is to learn how safe the study drug, SBS-147, is and how people's bodies respond to and process it. Researchers will also look for any side effects that may occur when taking SBS-147. Some participants will receive SBS-147, and others will receive a placebo, which looks the same but does not contain any medicine. This helps researchers fairly compare results. The study includes two parts: Single-Dose Group, where Participants receive SBS-147 or placebo one time. Multiple-Dose Group, where Participants receive SBS-147 or placebo once or twice daily for 7 days.

Phase 1
Waitlist Available

AltaSciences, Inc

Jeff Reich, MD

Sparian Biosciences, Inc

Have you considered Naproxen Sodium clinical trials?

We made a collection of clinical trials featuring Naproxen Sodium, we think they might fit your search criteria.
Go to Trials

Have you considered Naproxen Sodium clinical trials?

We made a collection of clinical trials featuring Naproxen Sodium, we think they might fit your search criteria.
Go to Trials

Have you considered Naproxen Sodium clinical trials?

We made a collection of clinical trials featuring Naproxen Sodium, we think they might fit your search criteria.
Go to Trials