Naltrexone Hydrochloride

Pruritus, Caloric Restriction, BMI >27 kg/m2 + 8 more
Treatment
5 FDA approvals
20 Active Studies for Naltrexone Hydrochloride

What is Naltrexone Hydrochloride

NaltrexoneThe Generic name of this drug
Treatment SummaryNaltrexone is a medication derived from noroxymorphone that works as an opioid antagonist. It is a stronger and longer-lasting version of naloxone and has been used to treat heroin addiction. The FDA has also approved naltrexone for the treatment of alcohol dependence.
Naltrexone Hydrochlorideis the brand name
image of different drug pills on a surface
Naltrexone Hydrochloride Overview & Background
Brand Name
Generic Name
First FDA Approval
How many FDA approvals?
Naltrexone Hydrochloride
Naltrexone
1998
59

Approved as Treatment by the FDA

Naltrexone, otherwise known as Naltrexone Hydrochloride, is approved by the FDA for 5 uses including Alcoholism and Opioid Dependence .
Alcoholism
Helps manage Alcohol Dependency
Opioid Dependence
Helps manage Opioid Dependence
Pain
Used to treat Severe Pain in combination with Morphine
Therapeutic procedure
Used to treat inadequate alternative treatment options in combination with Morphine
Opiate Substitution Treatment
Used to treat requiring long-term opioid treatment in combination with Morphine

Effectiveness

How Naltrexone Hydrochloride Affects PatientsNaltrexone is a drug that works to prevent the effects of opioids. It has no opioid properties of its own and is often used to treat alcohol dependence. When taken with other opioids, it blocks the physical effects of these drugs and can help to reduce addiction. In people already addicted to opioids, taking naltrexone can cause withdrawal symptoms.
How Naltrexone Hydrochloride works in the bodyNaltrexone blocks the effects of opioids in the brain. It achieves this by binding to opioid receptors, preventing any opiates from having an effect. This blocks the calming, pleasurable effects of opioids, as well as the respiratory depression. It also reduces cravings. The drug's major metabolite, 6-β-naltrexol, is also an opioid antagonist, helping to make naltrexone even more effective.

When to interrupt dosage

The measurement of Naltrexone Hydrochloride depends on the determined disease, including Opioid Dependence, low-calorie diet and BMI >27 kg/m2. The quantity of dosage varies in accordance to the method of administration specified in the table beneath.
Condition
Dosage
Administration
Pruritus
, 50.0 mg, 0.8 mg, 1.2 mg, 2.0 mg, 4.0 mg, 2.4 mg, 3.2 mg, 8.0 mg, 4.8 mg, 3.6 mg, 7.2 mg, 9.6 mg, 380.0 mg, 200.0 mg, 380.0 mg/mL, 90.0 mg
, Oral, Tablet, film coated, Tablet, film coated - Oral, Capsule, extended release, Capsule, extended release - Oral, Tablet, film coated, extended release, Tablet, film coated, extended release - Oral, Kit, Tablet, Tablet - Oral, Tablet, extended release, Tablet, extended release - Oral, Subcutaneous, Implant, Implant - Subcutaneous, Intramuscular, Kit - Intramuscular
Caloric Restriction
, 50.0 mg, 0.8 mg, 1.2 mg, 2.0 mg, 4.0 mg, 2.4 mg, 3.2 mg, 8.0 mg, 4.8 mg, 3.6 mg, 7.2 mg, 9.6 mg, 380.0 mg, 200.0 mg, 380.0 mg/mL, 90.0 mg
, Oral, Tablet, film coated, Tablet, film coated - Oral, Capsule, extended release, Capsule, extended release - Oral, Tablet, film coated, extended release, Tablet, film coated, extended release - Oral, Kit, Tablet, Tablet - Oral, Tablet, extended release, Tablet, extended release - Oral, Subcutaneous, Implant, Implant - Subcutaneous, Intramuscular, Kit - Intramuscular
BMI >27 kg/m2
, 50.0 mg, 0.8 mg, 1.2 mg, 2.0 mg, 4.0 mg, 2.4 mg, 3.2 mg, 8.0 mg, 4.8 mg, 3.6 mg, 7.2 mg, 9.6 mg, 380.0 mg, 200.0 mg, 380.0 mg/mL, 90.0 mg
, Oral, Tablet, film coated, Tablet, film coated - Oral, Capsule, extended release, Capsule, extended release - Oral, Tablet, film coated, extended release, Tablet, film coated, extended release - Oral, Kit, Tablet, Tablet - Oral, Tablet, extended release, Tablet, extended release - Oral, Subcutaneous, Implant, Implant - Subcutaneous, Intramuscular, Kit - Intramuscular
Increased physical activity levels
, 50.0 mg, 0.8 mg, 1.2 mg, 2.0 mg, 4.0 mg, 2.4 mg, 3.2 mg, 8.0 mg, 4.8 mg, 3.6 mg, 7.2 mg, 9.6 mg, 380.0 mg, 200.0 mg, 380.0 mg/mL, 90.0 mg
, Oral, Tablet, film coated, Tablet, film coated - Oral, Capsule, extended release, Capsule, extended release - Oral, Tablet, film coated, extended release, Tablet, film coated, extended release - Oral, Kit, Tablet, Tablet - Oral, Tablet, extended release, Tablet, extended release - Oral, Subcutaneous, Implant, Implant - Subcutaneous, Intramuscular, Kit - Intramuscular
Opioid Dependence
, 50.0 mg, 0.8 mg, 1.2 mg, 2.0 mg, 4.0 mg, 2.4 mg, 3.2 mg, 8.0 mg, 4.8 mg, 3.6 mg, 7.2 mg, 9.6 mg, 380.0 mg, 200.0 mg, 380.0 mg/mL, 90.0 mg
, Oral, Tablet, film coated, Tablet, film coated - Oral, Capsule, extended release, Capsule, extended release - Oral, Tablet, film coated, extended release, Tablet, film coated, extended release - Oral, Kit, Tablet, Tablet - Oral, Tablet, extended release, Tablet, extended release - Oral, Subcutaneous, Implant, Implant - Subcutaneous, Intramuscular, Kit - Intramuscular
Pain
, 50.0 mg, 0.8 mg, 1.2 mg, 2.0 mg, 4.0 mg, 2.4 mg, 3.2 mg, 8.0 mg, 4.8 mg, 3.6 mg, 7.2 mg, 9.6 mg, 380.0 mg, 200.0 mg, 380.0 mg/mL, 90.0 mg
, Oral, Tablet, film coated, Tablet, film coated - Oral, Capsule, extended release, Capsule, extended release - Oral, Tablet, film coated, extended release, Tablet, film coated, extended release - Oral, Kit, Tablet, Tablet - Oral, Tablet, extended release, Tablet, extended release - Oral, Subcutaneous, Implant, Implant - Subcutaneous, Intramuscular, Kit - Intramuscular
Alcoholism
, 50.0 mg, 0.8 mg, 1.2 mg, 2.0 mg, 4.0 mg, 2.4 mg, 3.2 mg, 8.0 mg, 4.8 mg, 3.6 mg, 7.2 mg, 9.6 mg, 380.0 mg, 200.0 mg, 380.0 mg/mL, 90.0 mg
, Oral, Tablet, film coated, Tablet, film coated - Oral, Capsule, extended release, Capsule, extended release - Oral, Tablet, film coated, extended release, Tablet, film coated, extended release - Oral, Kit, Tablet, Tablet - Oral, Tablet, extended release, Tablet, extended release - Oral, Subcutaneous, Implant, Implant - Subcutaneous, Intramuscular, Kit - Intramuscular
Opiate Substitution Treatment
, 50.0 mg, 0.8 mg, 1.2 mg, 2.0 mg, 4.0 mg, 2.4 mg, 3.2 mg, 8.0 mg, 4.8 mg, 3.6 mg, 7.2 mg, 9.6 mg, 380.0 mg, 200.0 mg, 380.0 mg/mL, 90.0 mg
, Oral, Tablet, film coated, Tablet, film coated - Oral, Capsule, extended release, Capsule, extended release - Oral, Tablet, film coated, extended release, Tablet, film coated, extended release - Oral, Kit, Tablet, Tablet - Oral, Tablet, extended release, Tablet, extended release - Oral, Subcutaneous, Implant, Implant - Subcutaneous, Intramuscular, Kit - Intramuscular
Comorbidity
, 50.0 mg, 0.8 mg, 1.2 mg, 2.0 mg, 4.0 mg, 2.4 mg, 3.2 mg, 8.0 mg, 4.8 mg, 3.6 mg, 7.2 mg, 9.6 mg, 380.0 mg, 200.0 mg, 380.0 mg/mL, 90.0 mg
, Oral, Tablet, film coated, Tablet, film coated - Oral, Capsule, extended release, Capsule, extended release - Oral, Tablet, film coated, extended release, Tablet, film coated, extended release - Oral, Kit, Tablet, Tablet - Oral, Tablet, extended release, Tablet, extended release - Oral, Subcutaneous, Implant, Implant - Subcutaneous, Intramuscular, Kit - Intramuscular
Chronic Weight Management therapy
, 50.0 mg, 0.8 mg, 1.2 mg, 2.0 mg, 4.0 mg, 2.4 mg, 3.2 mg, 8.0 mg, 4.8 mg, 3.6 mg, 7.2 mg, 9.6 mg, 380.0 mg, 200.0 mg, 380.0 mg/mL, 90.0 mg
, Oral, Tablet, film coated, Tablet, film coated - Oral, Capsule, extended release, Capsule, extended release - Oral, Tablet, film coated, extended release, Tablet, film coated, extended release - Oral, Kit, Tablet, Tablet - Oral, Tablet, extended release, Tablet, extended release - Oral, Subcutaneous, Implant, Implant - Subcutaneous, Intramuscular, Kit - Intramuscular
Therapeutic procedure
, 50.0 mg, 0.8 mg, 1.2 mg, 2.0 mg, 4.0 mg, 2.4 mg, 3.2 mg, 8.0 mg, 4.8 mg, 3.6 mg, 7.2 mg, 9.6 mg, 380.0 mg, 200.0 mg, 380.0 mg/mL, 90.0 mg
, Oral, Tablet, film coated, Tablet, film coated - Oral, Capsule, extended release, Capsule, extended release - Oral, Tablet, film coated, extended release, Tablet, film coated, extended release - Oral, Kit, Tablet, Tablet - Oral, Tablet, extended release, Tablet, extended release - Oral, Subcutaneous, Implant, Implant - Subcutaneous, Intramuscular, Kit - Intramuscular

Warnings

Naltrexone Hydrochloride Contraindications
Condition
Risk Level
Notes
Pulse Frequency
Do Not Combine
Pulse Frequency
Do Not Combine
Withdrawal syndrome
Do Not Combine
Adrenal gland hypofunction
Do Not Combine
There are 20 known major drug interactions with Naltrexone Hydrochloride.
Common Naltrexone Hydrochloride Drug Interactions
Drug Name
Risk Level
Description
Eluxadoline
Major
The risk or severity of constipation can be increased when Naltrexone is combined with Eluxadoline.
Methylene blue
Major
Naltrexone may increase the serotonergic activities of Methylene blue.
Methylnaltrexone
Major
Naltrexone may increase the opioid antagonism activities of Methylnaltrexone.
Mirtazapine
Major
Naltrexone may increase the serotonergic activities of Mirtazapine.
Naloxegol
Major
Naltrexone may increase the opioid antagonism activities of Naloxegol.
Naltrexone Hydrochloride Toxicity & Overdose RiskIn mice, rats, and guinea pigs, the toxic dose of naltrexone is between 1,100 and 1,550 mg/kg. Taking large doses of naltrexone (over 1,000 mg/kg) can lead to excessive salivation, decreased energy, tremors, and seizures.
image of a doctor in a lab doing drug, clinical research

Naltrexone Hydrochloride Novel Uses: Which Conditions Have a Clinical Trial Featuring Naltrexone Hydrochloride?

30 active studies are testing the ability of Naltrexone Hydrochloride to attenuate reduced-calorie diet, Pruritus and increased physical activity in treating certain conditions.
Condition
Clinical Trials
Trial Phases
Increased physical activity levels
0 Actively Recruiting
Chronic Weight Management therapy
0 Actively Recruiting
Therapeutic procedure
0 Actively Recruiting
Alcoholism
8 Actively Recruiting
Phase 3, Not Applicable, Phase 2
Pruritus
0 Actively Recruiting
Opioid Dependence
12 Actively Recruiting
Phase 3, Not Applicable, Phase 2, Phase 4, Phase 1, Early Phase 1
Opiate Substitution Treatment
0 Actively Recruiting
Pain
0 Actively Recruiting
BMI >27 kg/m2
0 Actively Recruiting
Caloric Restriction
0 Actively Recruiting
Comorbidity
0 Actively Recruiting

Naltrexone Hydrochloride Reviews: What are patients saying about Naltrexone Hydrochloride?

5Patient Review
9/18/2022
Naltrexone Hydrochloride for Habit of Drinking Too Much Alcohol
I've been pleasantly surprised by this medication. I'm a heavy drinker and it's helped me cut down to less than one drink per day. I didn't experience any major side effects, just felt a bit tired the first day. Fingers crossed it keeps working like this!
5Patient Review
8/30/2021
Naltrexone Hydrochloride for Habit of Drinking Too Much Alcohol
I was really struggling with my drinking before I found this treatment. It worked great from the first pill and I haven't had a drink or any urge to drink for 3 days now.
5Patient Review
4/9/2022
Naltrexone Hydrochloride for Habit of Drinking Too Much Alcohol
I'm glad I found this sooner rather than later! It worked within 15 minutes.
2Patient Review
10/25/2021
Naltrexone Hydrochloride for Habit of Drinking Too Much Alcohol
I'm on day one of the 50mg dosage, and I don't know if I can continue. The nausea is really bad, and I feel shaky and sweaty all the time. It's hard to breathe, and I can't sleep or get up and move around. This isn't like withdrawals from drinking--I haven't had a drink in over two weeks. I'm not sure if this medication is right for me.
1.7Patient Review
10/24/2022
Naltrexone Hydrochloride for Habit of Drinking Too Much Alcohol
The website for this medication does not mention any of the harmful side effects that I experienced, like the full body rash that took a month to get rid of. I had to go to the doctor and get skin grafts just to figure out what it was from, and it turns out it was from this medication. Do not recommend.
1Patient Review
3/21/2022
Naltrexone Hydrochloride for Habit of Drinking Too Much Alcohol
I took the medication as directed, but I woke up feeling awful just a few hours later. I was vomiting and shaking uncontrollably, and had to leave work early as a result. This medication has caused me nothing but problems, and I would not recommend it to anyone.
1Patient Review
7/10/2022
Naltrexone Hydrochloride for Prevention of Opiate Drug Abuse
I was given this drug to help me wean off of opiates, but my first dose made me so sick that I would rather go through withdrawal on my own than use this again.
1Patient Review
9/16/2022
Naltrexone Hydrochloride for Habit of Drinking Too Much Alcohol
DO NOT ORDER FROM THIS WEBSITE. I am currently in the ICU because of this medication. It's a legitimate drug, but the website doesn't ask about enough drug interactions. I coded twice and had to call 911 within 30 seconds of swallowing the pill.
image of drug pills surrounding a glass of water symbolizing drug consumption

Patient Q&A Section about naltrexone hydrochloride

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

How does naltrexone make you feel?

"Naltrexone blocks the effects of alcohol and narcotics on the brain, making it easier to stop drinking."

Answered by AI

Is naltrexone used for weight loss?

"Naltrexone and bupropion, when combined with a reduced calorie diet and exercise, can help with weight loss and maintenance. This medicine is indicated for people who are overweight or obese and also have weight-related medical problems."

Answered by AI

Does naltrexone help with anxiety?

"Low doses of naltrexone have been shown to decrease anxiety and pain in patients with fibromyalgia, according to a new study. The study, which is published in the journal Pain, examined the effects of naltrexone on a group of fibromyalgia patients. Patients who took low doses of naltrexone reported significantly lower levels of anxiety and pain than those who did not take the drug. Naltrexone is an opioid receptor antagonist that is typically used to treat addiction. However, the new study suggests that the drug may also be effective in treating other conditions, such as fibromyalgia."

Answered by AI

What is naltrexone hydrochloride prescribed for?

"What is Naltrexone?

Naltrexone is a medication that is approved by the FDA to treat both Opioid Use Disorder and Alcohol Use Disorder. Naltrexone is an extended release medication that is given intramuscularly. Naltrexone is a Medication-Assisted Treatment option."

Answered by AI

Clinical Trials for Naltrexone Hydrochloride

Have you considered Naltrexone Hydrochloride clinical trials? We made a collection of clinical trials featuring Naltrexone Hydrochloride, we think they might fit your search criteria.
Have you considered Naltrexone Hydrochloride clinical trials? We made a collection of clinical trials featuring Naltrexone Hydrochloride, we think they might fit your search criteria.
Have you considered Naltrexone Hydrochloride clinical trials? We made a collection of clinical trials featuring Naltrexone Hydrochloride, we think they might fit your search criteria.