Exercise for Insulin Resistance in Type 2 Diabetes
(EXPET Trial)
What You Need to Know Before You Apply
What is the purpose of this trial?
The overall aim of this pilot study is to investigate the effects of exercise training on skeletal muscle and adipose tissue insulin resistance in subjects with Type 2 Diabetes (T2D).
Will I have to stop taking my current medications?
The trial requires that you are not currently taking insulin, injectable incretin mimetics, thiazolidinediones, or more than two glucose-lowering medications. You also cannot be on certain medications like blood thinners, anti-inflammatory drugs, or beta-blockers. If you are on these medications, you may need to stop them to participate.
Is the exercise treatment for insulin resistance in type 2 diabetes safe?
The procedures involved in the study, such as adipose tissue biopsy and muscle biopsy, are generally safe. Adipose tissue biopsy using a mini-liposuction technique is safe with minimal restrictions on activities post-procedure. Muscle biopsy has a low incidence of minor side effects like pain and bruising, with no significant difference in safety between healthy and chronically ill individuals.12345
How does the treatment of adipose and muscle biopsy differ from other treatments for insulin resistance in type 2 diabetes?
Adipose and muscle biopsies are unique because they are not treatments themselves but diagnostic procedures that help researchers understand how exercise affects insulin resistance in type 2 diabetes. Unlike medications or lifestyle changes, these biopsies provide direct insights into the cellular and metabolic changes in muscle and fat tissue, which can guide more personalized treatment strategies.678910
What data supports the effectiveness of the treatment Exercise for Insulin Resistance in Type 2 Diabetes?
Who Is on the Research Team?
Bret Goodpaster, PhD
Principal Investigator
Scientific Director | Senior Investigator
Are You a Good Fit for This Trial?
This trial is for adults aged 30-65 with Type 2 Diabetes who are sedentary, have a BMI of 25-45 kg/m2, and haven't had significant weight changes recently. They must not be on more than two glucose-lowering medications or insulin and should be free from major diseases or conditions that could interfere with the study.Inclusion Criteria
Exclusion Criteria
Timeline for a Trial Participant
Screening
Participants are screened for eligibility to participate in the trial
Exercise Intervention
Participants undergo exercise training to assess effects on skeletal muscle and adipose tissue insulin resistance
Assessment
Muscle glucose uptake is assessed pre and post exercise intervention using PET imaging and hyperinsulinemic euglycemic clamp
Follow-up
Participants are monitored for safety and effectiveness after the exercise intervention
What Are the Treatments Tested in This Trial?
Interventions
- Adipose Tissue Biopsy
- Exercise Testing (VO2max)
- Hyperinsulinemic euglycemic clamp
- Maximal ATP Production (ATPmax)
- Muscle Biopsy
- PET imaging
Find a Clinic Near You
Who Is Running the Clinical Trial?
Translational Research Institute for Metabolism and Diabetes, Florida
Lead Sponsor
AdventHealth Translational Research Institute
Lead Sponsor