Exercise for Insulin Resistance in Type 2 Diabetes
(EXPET Trial)
Trial Summary
Will I have to stop taking my current medications?
The trial requires that you are not currently taking insulin, injectable incretin mimetics, thiazolidinediones, or more than two glucose-lowering medications. You also cannot be on certain medications like blood thinners, anti-inflammatory drugs, or beta-blockers. If you are on these medications, you may need to stop them to participate.
What data supports the effectiveness of the treatment Exercise for Insulin Resistance in Type 2 Diabetes?
Is the exercise treatment for insulin resistance in type 2 diabetes safe?
The procedures involved in the study, such as adipose tissue biopsy and muscle biopsy, are generally safe. Adipose tissue biopsy using a mini-liposuction technique is safe with minimal restrictions on activities post-procedure. Muscle biopsy has a low incidence of minor side effects like pain and bruising, with no significant difference in safety between healthy and chronically ill individuals.56789
How does the treatment of adipose and muscle biopsy differ from other treatments for insulin resistance in type 2 diabetes?
Adipose and muscle biopsies are unique because they are not treatments themselves but diagnostic procedures that help researchers understand how exercise affects insulin resistance in type 2 diabetes. Unlike medications or lifestyle changes, these biopsies provide direct insights into the cellular and metabolic changes in muscle and fat tissue, which can guide more personalized treatment strategies.1011121314
What is the purpose of this trial?
The overall aim of this pilot study is to investigate the effects of exercise training on skeletal muscle and adipose tissue insulin resistance in subjects with Type 2 Diabetes (T2D).
Research Team
Bret Goodpaster, PhD
Principal Investigator
Scientific Director | Senior Investigator
Eligibility Criteria
This trial is for adults aged 30-65 with Type 2 Diabetes who are sedentary, have a BMI of 25-45 kg/m2, and haven't had significant weight changes recently. They must not be on more than two glucose-lowering medications or insulin and should be free from major diseases or conditions that could interfere with the study.Inclusion Criteria
Exclusion Criteria
Timeline
Screening
Participants are screened for eligibility to participate in the trial
Exercise Intervention
Participants undergo exercise training to assess effects on skeletal muscle and adipose tissue insulin resistance
Assessment
Muscle glucose uptake is assessed pre and post exercise intervention using PET imaging and hyperinsulinemic euglycemic clamp
Follow-up
Participants are monitored for safety and effectiveness after the exercise intervention
Treatment Details
Interventions
- Adipose Tissue Biopsy
- Exercise Testing (VO2max)
- Hyperinsulinemic euglycemic clamp
- Maximal ATP Production (ATPmax)
- Muscle Biopsy
- PET imaging
Find a Clinic Near You
Who Is Running the Clinical Trial?
Translational Research Institute for Metabolism and Diabetes, Florida
Lead Sponsor
AdventHealth Translational Research Institute
Lead Sponsor