388 Participants Needed

Virtual Rehabilitation for Cancer Survivors

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JJ
Overseen ByJennifer Jones, PhD
Age: 18+
Sex: Any
Trial Phase: Academic
Sponsor: University Health Network, Toronto
No Placebo GroupAll trial participants will receive the active study treatment (no placebo)
Approved in 1 JurisdictionThis treatment is already approved in other countries

Trial Summary

Will I have to stop taking my current medications?

The trial does not specify if you need to stop taking your current medications. However, it mentions that participants can be on certain ongoing therapies like trastuzumab, immunotherapy, and others, so it seems likely you can continue your current medications.

What data supports the effectiveness of the treatment CaRE@Home intervention for cancer survivors?

Research suggests that telehealth-based cancer rehabilitation, like CaRE@Home, can effectively improve physical and mental health in cancer survivors, similar to traditional in-clinic programs. Studies show that hybrid and telehealth delivery modes can provide comparable benefits in health outcomes and patient satisfaction, making them a promising option for increasing access to rehabilitation services.12345

Is virtual rehabilitation safe for cancer survivors?

The studies suggest that virtual rehabilitation, including telehealth and hybrid delivery methods, is generally safe for cancer survivors, as no significant safety concerns were reported in the research.12367

How is the CaRE@Home treatment different from other cancer rehabilitation treatments?

CaRE@Home is unique because it offers a virtual, online rehabilitation and exercise program for cancer survivors, making it accessible to those who cannot attend facility-based programs due to distance, cost, or other commitments. This telehealth approach allows for scalable and remote interventions, potentially reaching a larger population of cancer survivors.12489

What is the purpose of this trial?

Pragmatic hybrid type 1 effectiveness-implementation (E-I) trial of a virtual cancer rehabilitation program: The study team will conduct a multi-center hybrid type I effectiveness-implementation study to examine the clinical effectiveness and implementation potential of an 8-week multidimensional virtual cancer rehabilitation intervention (CaRE@Home) for cancer survivors with identified cancer-related impairments on level of overall disability (primary outcome) and patient reported physical and social functioning, anxiety, work status, quality of life, and physiologic changes (secondary outcomes). The study team will conduct a multi-centre pragmatic randomized controlled trial (RCT) (Vancouver, Toronto, Saint John and St. John's) to evaluate effectiveness and using the CIFR, the study team will identify potential factors that may affect successful implementation and integration of CaRE@Home in different cancer settings.

Research Team

JJ

Jennifer Jones, PhD

Principal Investigator

UHN Princess Margaret Cancer Centre

Eligibility Criteria

This trial is for cancer survivors aged 18+ who've finished primary treatment within the last 2 years. It's open to those with breast, colorectal, head and neck cancers or lymphoma if they're responding well to ongoing therapies like immunotherapy. Participants need good enough English for the intervention, internet access, and a WHO-DAS score over 5 indicating a need for rehab.

Inclusion Criteria

I need help because my daily activities are affected by my cancer.
I am still on maintenance therapy after my main cancer treatment and have responded well to it.
Communicate sufficiently in English to complete intervention and questionnaires
See 4 more

Exclusion Criteria

My health condition prevents me from participating in rehabilitation.
You have health conditions or injuries that make it unsuitable for you to do exercises that involve moving over long distances.
I have been diagnosed with major depression.
See 1 more

Timeline

Screening

Participants are screened for eligibility to participate in the trial

2-4 weeks
1 visit (in-person)

Treatment

Participants undergo an 8-week virtual cancer rehabilitation program (CaRE@Home) with weekly e-modules, exercise prescriptions, and counseling

8 weeks
Weekly virtual sessions

Follow-up

Participants are monitored for safety and effectiveness after treatment with assessments at 3 and 6 months post-intervention

6 months
2 visits (in-person) at 3 and 6 months

Maintenance Assessment

Additional follow-up at 6 months post-intervention to assess maintenance of treatment gains

6 months
1 visit (in-person)

Treatment Details

Interventions

  • CaRE@Home intervention
Trial Overview The CaRE@Home program is being tested in this study. It's an 8-week virtual rehabilitation designed to help cancer survivors manage impairments related to their condition. The effectiveness of this online program on disability levels and other aspects like anxiety and quality of life will be measured across several Canadian centers.
Participant Groups
2Treatment groups
Experimental Treatment
Active Control
Group I: CaRE@Home interventionExperimental Treatment1 Intervention
Group II: Usual Care groupActive Control1 Intervention

CaRE@Home intervention is already approved in Canada for the following indications:

🇨🇦
Approved in Canada as CaRE@Home for:
  • Rehabilitation for cancer survivors with identified cancer-related impairments

Find a Clinic Near You

Who Is Running the Clinical Trial?

University Health Network, Toronto

Lead Sponsor

Trials
1,555
Recruited
526,000+

Findings from Research

Telehealth-based cancer rehabilitation interventions, primarily delivered via telephone and lasting an average of 16.5 weeks, show potential for improving disability in adult cancer survivors, although the effects are generally small.
The review of 68 studies highlights the need for standardized measures of disability, as the variability in outcomes makes it difficult to draw strong conclusions about the effectiveness of these interventions.
The influence of telehealth-based cancer rehabilitation interventions on disability: a systematic review.Brick, R., Padgett, L., Jones, J., et al.[2023]
The ReStOre@Home telehealth rehabilitation program for cancer survivors was feasible, with a 32.4% recruitment rate and a 75% retention rate among 12 participants, indicating strong adherence and satisfaction with the program.
Participants reported significant improvements in physical and psychological wellbeing, although some preferred in-person interactions, suggesting that future programs could benefit from a hybrid approach that combines online and face-to-face support.
Telehealth Delivery of a Multi-Disciplinary Rehabilitation Programme for Upper Gastro-Intestinal Cancer: ReStOre@Home Feasibility Study.Brennan, L., Sadeghi, F., O'Neill, L., et al.[2022]
A study involving 2,611 cancer survivors found that hybrid rehabilitation delivery (combining in-clinic and telehealth visits) resulted in similar improvements in health-related quality of life measures compared to traditional in-clinic-only rehabilitation.
Both delivery methods showed comparable patient experiences and outcomes, suggesting that hybrid rehabilitation could be an effective alternative to increase access to care for cancer survivors.
In-Clinic versus Hybrid Cancer Rehabilitation Service Delivery during the COVID-19 Pandemic: An Outcome Comparison Study.Wood, KC., Giri, S., Kendig, TD., et al.[2023]

References

The influence of telehealth-based cancer rehabilitation interventions on disability: a systematic review. [2023]
Telehealth Delivery of a Multi-Disciplinary Rehabilitation Programme for Upper Gastro-Intestinal Cancer: ReStOre@Home Feasibility Study. [2022]
In-Clinic versus Hybrid Cancer Rehabilitation Service Delivery during the COVID-19 Pandemic: An Outcome Comparison Study. [2023]
CaRE @ Home: Pilot Study of an Online Multidimensional Cancer Rehabilitation and Exercise Program for Cancer Survivors. [2020]
Development of a Web Portal for Physical Activity and Symptom Tracking in Oncology Patients: Protocol for a Prospective Cohort Study. [2020]
Thirty-day hospital readmission rate, reasons, and risk factors after acute inpatient cancer rehabilitation. [2022]
Real-time interactive digital healthcare system for post-operative breast cancer patients: study protocol for a randomized controlled trial. [2022]
Patient Experiences of Rehabilitation and the Potential for an mHealth System with Biofeedback After Breast Cancer Surgery: Qualitative Study. [2021]
Virtual care models for cancer survivorship. [2023]
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