Mydriacyl
Cycloplegia, Induced Hyperthermia, diagnostic procedures + 6 more
Treatment
17 Active Studies for Mydriacyl
Treatment for
Cycloplegia
What is Mydriacyl
Tropicamide
The Generic name of this drug
Treatment Summary
Tropicamide is a type of medication that blocks the action of the chemical acetylcholine, which helps to relax the muscles in the eyes. It is used to dilate the pupils and paralyze the ciliary muscle during eye exams and ocular procedures. It is also used in combination with another drug, hydroxyamphetamine, for the same purpose. Tropicamide has also been studied as a potential treatment for drooling in people with Parkinson's disease when taken orally.
Mydriacyl
is the brand name
Mydriacyl Overview & Background
Brand Name
Generic Name
First FDA Approval
How many FDA approvals?
Mydriacyl
Tropicamide
1959
16
Effectiveness
How Mydriacyl Affects Patients
Tropicamide is a drug used to widen the pupils and temporarily paralyze the muscles in the eye. It usually starts to work within 10-15 minutes, and can last up to 24 hours. It can also increase the pressure in the eye, but serious side effects are not normally seen. It has been used in Parkinson's Disease to reduce saliva production, and has also been shown to reduce tremors in rodent models.
How Mydriacyl works in the body
Tropicamide is a drug that blocks the activity of muscarinic receptors, which are found in the eye and salivary glands. In the eyes, these receptors play a role in pupil constriction and near vision. By blocking these receptors, tropicamide causes the pupil to dilate and prevents near vision. It also blocks muscarinic receptors found in salivary glands, which helps reduce excessive saliva production.
When to interrupt dosage
The dosage of Mydriacyl is contingent upon the recognized affliction, comprising diagnostic tests, induction of Cycloplegia and Cycloplegia. The amount is additionally dependent on the mode of delivery (e.g. Solution or Solution - Ophthalmic) specified in the table below.
Condition
Dosage
Administration
diagnostic procedures
, 10.0 mg/mL, 5.0 mg/mL, 2.5 mg/mL, 0.8 %, 1.0 %, 0.5 %
Solution / drops, Solution / drops - Ophthalmic, Ophthalmic, , Solution, Solution - Ophthalmic, Liquid, Liquid - Ophthalmic
induction of partial cycloplegia
, 10.0 mg/mL, 5.0 mg/mL, 2.5 mg/mL, 0.8 %, 1.0 %, 0.5 %
Solution / drops, Solution / drops - Ophthalmic, Ophthalmic, , Solution, Solution - Ophthalmic, Liquid, Liquid - Ophthalmic
Epilepsies, Partial
, 10.0 mg/mL, 5.0 mg/mL, 2.5 mg/mL, 0.8 %, 1.0 %, 0.5 %
Solution / drops, Solution / drops - Ophthalmic, Ophthalmic, , Solution, Solution - Ophthalmic, Liquid, Liquid - Ophthalmic
Induced Hyperthermia
, 10.0 mg/mL, 5.0 mg/mL, 2.5 mg/mL, 0.8 %, 1.0 %, 0.5 %
Solution / drops, Solution / drops - Ophthalmic, Ophthalmic, , Solution, Solution - Ophthalmic, Liquid, Liquid - Ophthalmic
induction of Cycloplegia
, 10.0 mg/mL, 5.0 mg/mL, 2.5 mg/mL, 0.8 %, 1.0 %, 0.5 %
Solution / drops, Solution / drops - Ophthalmic, Ophthalmic, , Solution, Solution - Ophthalmic, Liquid, Liquid - Ophthalmic
Ocular Anesthesia
, 10.0 mg/mL, 5.0 mg/mL, 2.5 mg/mL, 0.8 %, 1.0 %, 0.5 %
Solution / drops, Solution / drops - Ophthalmic, Ophthalmic, , Solution, Solution - Ophthalmic, Liquid, Liquid - Ophthalmic
Pupil
, 10.0 mg/mL, 5.0 mg/mL, 2.5 mg/mL, 0.8 %, 1.0 %, 0.5 %
Solution / drops, Solution / drops - Ophthalmic, Ophthalmic, , Solution, Solution - Ophthalmic, Liquid, Liquid - Ophthalmic
Cycloplegia
, 10.0 mg/mL, 5.0 mg/mL, 2.5 mg/mL, 0.8 %, 1.0 %, 0.5 %
Solution / drops, Solution / drops - Ophthalmic, Ophthalmic, , Solution, Solution - Ophthalmic, Liquid, Liquid - Ophthalmic
Cataract Surgery
, 10.0 mg/mL, 5.0 mg/mL, 2.5 mg/mL, 0.8 %, 1.0 %, 0.5 %
Solution / drops, Solution / drops - Ophthalmic, Ophthalmic, , Solution, Solution - Ophthalmic, Liquid, Liquid - Ophthalmic
Warnings
Mydriacyl has one recognized contraindication, so it should not be employed for the situations listed in the subsequent table.
Mydriacyl Contraindications
Condition
Risk Level
Notes
Severe Hypersensitivity Reactions
Do Not Combine
Tropicamide may interact with Pulse Frequency
There are 20 known major drug interactions with Mydriacyl.
Common Mydriacyl Drug Interactions
Drug Name
Risk Level
Description
Aclidinium
Minor
The risk or severity of adverse effects can be increased when Tropicamide is combined with Aclidinium.
Agmatine
Minor
The risk or severity of adverse effects can be increased when Tropicamide is combined with Agmatine.
Alcuronium
Minor
The risk or severity of adverse effects can be increased when Tropicamide is combined with Alcuronium.
Alloin
Minor
The therapeutic efficacy of Alloin can be decreased when used in combination with Tropicamide.
Amantadine
Minor
The risk or severity of adverse effects can be increased when Tropicamide is combined with Amantadine.
Mydriacyl Toxicity & Overdose Risk
The lowest toxic dose of tropicamide found in rats was 865mg/kg when taken orally, 1210mg/kg when taken intraperitoneally, and 872mg/kg when taken subcutaneously. While there is limited information about tropicamide overdose, some adverse effects such as rapid heart rate, changes to the nervous system, muscle stiffness, or reactions such as psychosis and vasomotor or cardio-respiratory collapse have been reported in children.
Mydriacyl Novel Uses: Which Conditions Have a Clinical Trial Featuring Mydriacyl?
A single investigation is being conducted to assess the potency of Mydriacyl in achieving partial cycloplegia, Ocular Anesthesia and Pupillary dilation for treatment of various disorders.
Condition
Clinical Trials
Trial Phases
Cycloplegia
0 Actively Recruiting
Ocular Anesthesia
0 Actively Recruiting
Pupil
0 Actively Recruiting
induction of Cycloplegia
0 Actively Recruiting
Epilepsies, Partial
16 Actively Recruiting
Phase 2, Early Phase 1, Phase 1, Not Applicable, Phase 3, Phase 4
diagnostic procedures
0 Actively Recruiting
Cataract Surgery
3 Actively Recruiting
Not Applicable, Phase 4
Induced Hyperthermia
0 Actively Recruiting
induction of partial cycloplegia
0 Actively Recruiting
Mydriacyl Reviews: What are patients saying about Mydriacyl?
3.7
Patient Review
4/19/2019
Mydriacyl for Dilated Pupils Before or After Surgery
1
Patient Review
12/8/2008
Mydriacyl for Dilated Pupils Before or After Surgery
Patient Q&A Section about mydriacyl
These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.
How long does Mydriacyl take to work?
"Mydriacyl is typically used 15 to 20 minutes before an eye examination. One or two drops is the standard dose. Some people may feel a slight burning sensation in their eye(s) after using Mydriacyl."
Answered by AI
What is the generic name for Mydriacyl?
"TROPICamide is used for dilating the eye for examination and treating crossed eyes.
The generic name for TROPICamide is tropicamide. It is used for dilating the eye for examination and treating crossed eyes."
Answered by AI
Is Mydriacyl same as tropicamide?
"Tropicamide is a medication that dilates the pupil and prevents the muscle needed to focus from working, so that a person's eyes can be checked."
Answered by AI
What is Mydriacyl eye drops used for?
"This medication is used to widen the pupil of the eye in preparation for certain eye examinations. It belongs to a class of drugs known as cholinergics."
Answered by AI