Your session is about to expire
What is Mycobutin
RifabutinThe Generic name of this drug
Treatment SummaryClarithromycin is an antibiotic used to prevent the spread of a bacterial infection called Mycobacterium avium complex in people with HIV.
Mycobutinis the brand name
Mycobutin Overview & Background
Brand Name
Generic Name
First FDA Approval
How many FDA approvals?
Mycobutin
Rifabutin
1992
10
Approved as Treatment by the FDA
Rifabutin, also known as Mycobutin, is approved by the FDA for 3 uses like Mycobacterium avium complex infection and prophylaxis of Mycobacterium avium complex infection .Mycobacterium avium complex infection
prophylaxis of Mycobacterium avium complex infection
HIV
Effectiveness
How Mycobutin Affects PatientsRifabutin is an antibiotic that targets bacteria by interfering with its RNA polymerase. It can be used to effectively kill a wide range of bacteria, including those that cause tuberculosis. It is usually taken orally and is quickly absorbed into the body and distributed throughout the tissues and fluids, including the brain. The drug is processed by the liver and mostly eliminated in bile, though some is also passed out in urine. It does not require a dose adjustment for those with kidney problems.
How Mycobutin works in the bodyRifabutin works by stopping an enzyme in bacteria that helps make RNA. When this enzyme is stopped, the bacteria cannot make more RNA and will eventually die.
When to interrupt dosage
The measure of Mycobutin is contingent upon the determined illness, including HIV, Stomach Ulcer and Tuberculosis (TB). The amount of dosage varies, in accordance with the given administration technique (e.g. Capsule - Oral or Capsule, delayed release) featured in the table below.Condition
Dosage
Administration
Tuberculosis (TB)
150.0 mg, , 12.5 mg
, Oral, Capsule, Capsule - Oral, Capsule, delayed release - Oral, Capsule, delayed release
HIV
150.0 mg, , 12.5 mg
, Oral, Capsule, Capsule - Oral, Capsule, delayed release - Oral, Capsule, delayed release
Helicobacter Pylori Infection
150.0 mg, , 12.5 mg
, Oral, Capsule, Capsule - Oral, Capsule, delayed release - Oral, Capsule, delayed release
prophylaxis of Mycobacterium avium complex infection
150.0 mg, , 12.5 mg
, Oral, Capsule, Capsule - Oral, Capsule, delayed release - Oral, Capsule, delayed release
late phase Tuberculosis
150.0 mg, , 12.5 mg
, Oral, Capsule, Capsule - Oral, Capsule, delayed release - Oral, Capsule, delayed release
Mycobacterium avium complex infection
150.0 mg, , 12.5 mg
, Oral, Capsule, Capsule - Oral, Capsule, delayed release - Oral, Capsule, delayed release
Warnings
Mycobutin has one contraindication, which should be considered when presented with the conditions in the following table.Mycobutin ContraindicationsCondition
Risk Level
Notes
Pulse Frequency
Do Not Combine
Common Mycobutin Drug Interactions
Drug Name
Risk Level
Description
Abemaciclib
Major
The metabolism of Abemaciclib can be increased when combined with Rifabutin.
Acalabrutinib
Major
The metabolism of Acalabrutinib can be increased when combined with Rifabutin.
Alectinib
Major
The metabolism of Alectinib can be increased when combined with Rifabutin.
Alpelisib
Major
The metabolism of Alpelisib can be increased when combined with Rifabutin.
Aminophylline
Major
The metabolism of Aminophylline can be increased when combined with Rifabutin.
Mycobutin Toxicity & Overdose RiskThe lethal dose of this drug in male mice is 4.8g/kg.
Mycobutin Novel Uses: Which Conditions Have a Clinical Trial Featuring Mycobutin?
127 active studies are currently in progress to evaluate the potential of Mycobutin in providing prophylactic defense against Mycobacterium avium complex infection, Stomach Ulcer and Tuberculosis (TB).Condition
Clinical Trials
Trial Phases
late phase Tuberculosis
0 Actively Recruiting
prophylaxis of Mycobacterium avium complex infection
0 Actively Recruiting
Mycobacterium avium complex infection
3 Actively Recruiting
Phase 2, Phase 3
HIV
146 Actively Recruiting
Phase 2, Not Applicable, Phase 1, Phase 3, Phase 4, Early Phase 1
Helicobacter Pylori Infection
0 Actively Recruiting
Tuberculosis (TB)
3 Actively Recruiting
Not Applicable, Phase 3, Phase 2
Mycobutin Reviews: What are patients saying about Mycobutin?
4.7Patient Review
12/1/2011 I've been dealing with MAC for a year now, and my first doctor put me on Biaxon. I was very sick every day while taking it, so he eventually took me off the medication. However, even after stopping the Biaxon, the MAC was still evident. My new doctor has put me on Myambutol Oral 3 times a day, and I'm feeling much better. There are still some pains here and there, but I believe that's due to the colder weather we're having.
4.7Patient Review
3/20/2010 I've been taking this medication for over a year now and it has kept my MAC at bay. I have experienced some joint pain and stiffness, as well as nausea and diarrhea, but it is unclear if these side effects are due to the medication or the other two MAC medications I am taking. Overall, though, I am pleased with the results of this drug.
1Patient Review
2/19/2010 Within two weeks of taking this medication, I experienced such intense depression and fatigue that all I wanted to do was cry and take hot baths. Thankfully, my doctor took me off the drug and I recovered within a week.
1Patient Review
3/12/2008 This medication made me so sick that I had to go to the hospital.
Patient Q&A Section about mycobutin
These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.What is rifabutin used to treat?
"Rifabutin is used to help prevent Mycobacterium avium complex (MAC) disease from causing disease throughout the body in patients with advanced human immunodeficiency virus (HIV) infection. MAC is an infection caused by two similar bacteria, Mycobacterium avium and Mycobacterium intracellulare."
Answered by AI
Is mycobutin the same as rifabutin?
"Mycobutin capsules are supplied as hard gelatin capsules with an opaque red-brown cap and body. Each capsule contains 150 mg of rifabutin. The capsules are imprinted with MYCOBUTIN/PHARMACIA & UPJOHN in white ink."
Answered by AI
What is mycobutin used for?
"It will not work for viral infections (such as common cold, flu).
This medication is used to help prevent a certain serious infection (Mycobacterium avium complex-MAC) by either being used alone or with another medication. Rifabutin, which is known as a rifamycin antibiotic, works by stopping the growth of bacteria. This antibiotic is only able to treat and prevent bacterial infections and won't work for viral infections (such as common cold, flu)."
Answered by AI
What are the side effects of rifabutin?
"If you experience any of the following symptoms, call your doctor immediately: burning, dry, or itching eyes; discharge, excessive tearing; redness, pain, swelling of the eye, eyelid, or inner lining of the eyelid; stomach cramps, pain, or tenderness; watery and severe diarrhea, which may also be bloody."
Answered by AI