Your session is about to expire
What is Motegrity
PrucaloprideThe Generic name of this drug
Treatment SummaryPrucalopride is a medication used to treat chronic constipation. It works by activating serotonin receptors in the gut, promoting the movement of food through the digestive tract. Prucalopride was developed by Shire Development LLC and approved for use in Europe in 2009 and in Canada in 2011. It was approved for use in the United States by the FDA in 2018.
Motegrityis the brand name
Motegrity Overview & Background
Brand Name
Generic Name
First FDA Approval
How many FDA approvals?
Motegrity
Prucalopride
2018
2
Approved as Treatment by the FDA
Prucalopride, otherwise called Motegrity, is approved by the FDA for 2 uses including chronic idiopathic constipation (CIC) and refractory Chronic idiopathic constipation .chronic idiopathic constipation (CIC)
refractory Chronic idiopathic constipation
Effectiveness
How Motegrity Affects PatientsPrucalopride is a drug that helps to speed up how quickly food moves through the colon and intestines. Studies in animals have shown that it increases the contractions in the beginning part of the colon, and slows down contractions in the end part. It also increases a type of contraction that signals the body to go to the bathroom. In clinical trials, people taking prucalopride had more bowel movements than those taking a placebo. Most people who tried it liked it and wanted to keep taking it. Finally, the trials showed that more people taking prucalopride had more than 3 bowel movements per week than those
How Motegrity works in the bodyPrucalopride works by targeting certain receptors in your digestive system. It stimulates 5-HT4 receptors, which release a chemical called acetylcholine that helps to contract the muscles in your colon and relax the circular muscles, which helps to move food through your digestive system. Prucalopride does not interact with other receptors, such as hERG channel or 5-HT1, which helps reduce the risk of cardiovascular side effects.
When to interrupt dosage
The advised portion of Motegrity is contingent upon the confirmed condition, including Opioid-Induced Constipation, obdurate Chronic idiopathic constipation and chronic idiopathic constipation (CIC). The dosage amount is contingent upon the delivery approach (e.g. Tablet - Oral or Tablet) featured in the table beneath.Condition
Dosage
Administration
chronic idiopathic constipation (CIC)
, 1.0 mg, 2.0 mg
, Tablet, Oral, Tablet - Oral, Tablet, film coated - Oral, Tablet, film coated
refractory Chronic idiopathic constipation
, 1.0 mg, 2.0 mg
, Tablet, Oral, Tablet - Oral, Tablet, film coated - Oral, Tablet, film coated
Opioid-Induced Constipation
, 1.0 mg, 2.0 mg
, Tablet, Oral, Tablet - Oral, Tablet, film coated - Oral, Tablet, film coated
Warnings
Motegrity ContraindicationsCondition
Risk Level
Notes
Ulcerative Colitis
Do Not Combine
Severe Hypersensitivity Reactions
Do Not Combine
Prucalopride may interact with Pulse Frequency
Ileus
Do Not Combine
Intestinal Perforations
Do Not Combine
Intestinal Obstruction
Do Not Combine
Megacolon, Toxic
Do Not Combine
Crohn's Disease
Do Not Combine
Dialysis therapy
Do Not Combine
Common Motegrity Drug Interactions
Drug Name
Risk Level
Description
Acrivastine
Minor
Prucalopride may decrease the excretion rate of Acrivastine which could result in a higher serum level.
Albutrepenonacog alfa
Minor
Prucalopride may decrease the excretion rate of Albutrepenonacog alfa which could result in a higher serum level.
Alloin
Minor
The risk or severity of adverse effects can be increased when Prucalopride is combined with Alloin.
Almasilate
Minor
Prucalopride may decrease the excretion rate of Almasilate which could result in a higher serum level.
Ammonium chloride
Minor
Prucalopride may decrease the excretion rate of Ammonium chloride which could result in a higher serum level.
Motegrity Toxicity & Overdose RiskPrucalopride is generally safe to take in doses up to 10 times the recommended amount. Signs of overdose are usually mild and can include headaches, nausea, and diarrhea. In mice, a dose of 80mg/kg/day may result in mammary gland adenocarcinoma, while in rats high doses may lead to benign tumors in the adrenal glands, pituitary, pancreas, liver, and thyroid. Prucalopride has been tested for its ability to cause genetic mutations and no serious effects were found at high concentrations. There is also no evidence that prucalopride has any negative effects
Motegrity Novel Uses: Which Conditions Have a Clinical Trial Featuring Motegrity?
One active clinical trial is investigating the possibility of utilizing Motegrity to alleviate Opioid-Induced Constipation, chronic idiopathic constipation (CIC) and refractory Chronic idiopathic constipation.Condition
Clinical Trials
Trial Phases
refractory Chronic idiopathic constipation
0 Actively Recruiting
Opioid-Induced Constipation
0 Actively Recruiting
chronic idiopathic constipation (CIC)
0 Actively Recruiting
Motegrity Reviews: What are patients saying about Motegrity?
5Patient Review
7/8/2022 This is the only medication that has worked for me after trying many different ones (Linzess, Amitiza, etc). It takes a little bit of time to get used to, but it's worth it. I would definitely recommend this to others.
4.3Patient Review
12/10/2019 I unfortunately had a really negative reaction to this medication. A few hours after my first dose I was incredibly ill with symptoms like insomnia, sweats, muscle spasms, and nausea. However, it did work in that I had a bowel movement the next morning and everyday after. Still hoping I'll adjust though.
4.3Patient Review
8/1/2020 Despite the nausea and cramps I experience in the morning, this treatment regimen has been worth it because it generally leads to full evacuation for me.
4.3Patient Review
8/1/2020 Even though this regimen of medication and treatments causes me a lot of nausea and cramps in the morning, it's worth it because I generally fully evacuate.
4Patient Review
6/26/2022 I started using this medication less than a month ago and, while it has been effective, I've experienced every single one of the listed side effects. I'm going to continue taking it for now and see how I feel in a few weeks. constipation is a real issue for me and this is the first time I've found anything that helps with that.
3Patient Review
3/18/2022 This drug works very well for its intended purpose. However, it comes with the serious side effect of severe depression and suicidal ideation. If you have a history of mental illness or have reacted badly to SSRIs in the past, I would exercise caution before taking this medication.
3Patient Review
6/13/2021 This drug helped with my constipation, but the stomach cramps it caused were really intense and long-lasting. I stopped taking it after two weeks and will be trying a different laxative instead.
2.7Patient Review
1/2/2020 At first this was helpful, but then it stopped working and made my headaches worse. I also started having suicidal thoughts, which is obviously a huge red flag.
2.3Patient Review
4/22/2020 I got terrible diarrhea from this, to the point of dehydration. It's by far one of the worst laxatives I've ever taken.
2.3Patient Review
8/29/2019 Unfortunately, this medication caused me a great deal of discomfort due to excessive gas. Additionally, it wasn't all that effective. I strongly advise against taking this drug.
2Patient Review
9/16/2022 I started taking Motegrity about a week ago and have not found it to be helpful at all.
2Patient Review
7/19/2022 I experienced some really uncomfortable side effects after taking this pill. I would rather stick with my current medication.
1.7Patient Review
10/3/2022 If you have a history of migraines, I would highly recommend avoiding this medication. Unfortunately, I didn't know that and ended up having one of the most severe migraines of my life.
1Patient Review
11/30/2019 I used this product for seven weeks with little results in the beginning, but no results since then. Additionally, I experienced very severe gas, bloating and abdominal pain from this treatment. Therefore, I will not be using it again.
Patient Q&A Section about motegrity
These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.What are the side effects of Motegrity?
"The most common side effects of Motegrity include: headaches, stomach pain or bloating, nausea, diarrhea, dizziness, vomiting, gas, and fatigue. These side effects are typically mild and go away after a few days of continued use."
Answered by AI
What is the difference between linzess and Motegrity?
"Linzess and Motegrity work differently in the body, but they share some common side effects, including diarrhea, stomach/abdominal pain or discomfort, gas, bloating, vomiting, and headache."
Answered by AI
Is Motegrity an opioid?
"The drugs Viberzi and Motegrity are approved to treat chronic idiopathic constipation in adults. Viberzi is a mu-opioid receptor agonist and Motegrity is a serotonin-4 (5-HT4) receptor agonist."
Answered by AI
What is Motegrity supposed to do?
"MOTEGRITY is a prescription medicine used to treat a type of constipation called chronic idiopathic constipation (CIC) in adults. The cause of CIC is unknown. MOTEGRITY has not been studied in children and it is not known if it is safe and effective for them."
Answered by AI